ANALYTICAL LETTERS
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2021
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IF 2.329
Qian Wang,Li Zhu,Yi Yu,Huashi Guan,Zhe Xu
Aminoglycoside antibiotics exhibit broad-spectrum antibacterial activity, good efficacy, and stability. However, due to the emergence of antibiotic resistance, their use as broad-spectrum antibiotics is restricted. Bacteria producing the bifunctional enzyme, 6′-aminoglycoside acetyltransferase 2″-aminoglycoside phosphotransferase [AAC(6′)-APH(2″)], can modify aminoglycoside antibiotics, leading to the emergence of clinical drug resistance. A method based on ultra-high performance liquid chromatography–mass spectrometry (UHPLC-MS) is reported to monitor the modification of aminoglycoside antibiotics and to screen potential inhibitors of AAC(6′)-APH(2″) from marine natural products. Instead of using purified AAC(6′)-APH(2″), Escherichia coli cells harboring AAC(6′)-APH(2″) were employed. In vivo enzyme assays, conducted in the physiological environment, compensated for the disparity between in vitro responses and those in living cells. The inhibition zone method was used to verify the reliability of the UHPLC-MS results. From a library of 63 marine natural products, Mer-C-3 and Mer-c-8e pyridine alkaloids were shown to provide inhibitory activity against AAC(6′)-APH(2″) in living bacteria. The UHPLC-MS-based approach offers improved speed, convenience, and sensitivity compared with the traditional inhibition zone assay for the screening of enzyme inhibitors.
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Sustainable Energy & Fuels
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2020
·Vol. 4
·期 4
·1780-1788
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IF 5.503
Jing Wang,Jing Li,Meiri Wang,Yuanyuan Liu,Hongtao Cui
Battery-type electrode materials such as Ni(OH)2 applied in Faraday supercapacitors could present a low cycling stability due to the microstructure damage of materials, originating from their cyclic volume swelling and shrinking. It is well established that the structural stability of materials is crucial for their cycling stability. However, the lack of knowledge about the structural relevance of materials to their cycling stability somehow results in a chaotic understanding on the material design. In this study, we try to reveal the structural relevance by comparing an orderly built nanostructure with a randomly packed nanostructure using Ni(OH)2 as the target material. It is found that the branched nanosheet-interlaced nanostructure of Ni(OH)2 has its self-supportive function in favor of its structural stability, thus promoting its cycling stability. Also, the orderly nanostructured Ni(OH)2 presents high electrochemical performance due to the reduced interfacial charge-transfer resistance and Warburg resistance.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2024
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IF 4.1
Yuxiang Jiao,Yifei Li,Huaijun Tang,Shanglan Xian,Yonghui He,Long Wang,Jinghao Zhang
Herein, a cationic iridium(III) complex [(ppy) 2 Ir(IPP)]PF 6 (ppy: 2-phenylpyridine; IPP: 2-(1 H -imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol) was synthesized. Under the excitation of 328 nm (λ ex = 328 nm) UV light, this complex emitted bright yellow orange light (500 ∼ 700 nm, λ em,max = 582 nm), the Stokes shift was up to 254 nm, mainly due to excited-state intramolecular proton transfer (ESIPT) occurring in its ancillary ligand IPP. [(ppy) 2 Ir(IPP)]PF 6 was very sensitive to Ni 2+ , which was caused by the ESIPT being hindered by the coordination of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ . Its bright yellow orange light disappeared within 1 min when Ni 2+ (1.0 equiv.) was added in its solution (in DMSO/H 2 O, v/v = 999/1), therefore, it can be used for “turn-off” chemiluminescent detection of Ni 2+ . The recognition of [(ppy) 2 Ir(IPP)]PF 6 to Ni 2+ was not interfered by many common metal ions (such as Na + , K + , Li + , Mg 2+ , Al 3+ , Ca 2+ , Fe 3+ , Ag + , Zn 2+ , Hg 2+ , Co 2+ , Pb 2+ , Mn 2+ , Ba 2+ or Cr 3+ ), however, Cu 2+ was an interfering metal ion, but its interference can be completely masked by thiourea. The detection limit was as low as 3.31 × 10 −7 mol∙L -1 (0.331 μM). The Job’s plot analysis revealed that the stoichiometry of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ was 1:1, its detecting mechanism based on ESIPT effect was demonstrated by 1 H NMR spectra and density functional theory (DFT) calculation.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xiaobin Zhou,Ting Zou,Dan Wang,Zhifang Tu,Yinming Fan,Jianwen Wei,Lei Liao,Zongqiang Zhu,Yinian Zhu,Dunqiu Wang,Guohua Jing
Solid-liquid biphasic solvents (SLBSs) hold promise as energy-efficient candidates for CO 2 capture. Nevertheless, the premature phase transition of current SLBSs leads to inopportune solid precipitation, posing operational challenges for the CO 2 capture system. This study proposed a promising strategy that using aminoethylethanolamine (AEEA) as a regulator to fine-tune the phase transition time node of the 2-amino-2-methyl-1-propanol (AMP)/N-methylpyrrolidone (NMP) SLBS, enabling the phase transition to occur precisely as desired. Experimental results showed that the AEEA/AMP/NMP (A/A/N) SLBS exhibited tunable phase transition time nodes, modulated by the concentration of AEEA. Specifically, with the addition of 0.2 mol·L −1 AEEA, the CO 2 loading associated with the phase transition increased significantly, from 0.19 to 0.54 mol·mol −1 , approaching the saturation loading of 0.57 mol·mol −1 . The delayed phase transition would facilitate the CO 2 absorption operation. The regulatory mechanism of AEEA on the phase transition were thoroughly studied via 13 C NMR and quantum calculations. AMP reacted with CO 2 to produce AMPCOO − and AMPH + , which had a significantly stronger affinity for each other than for the solvent NMP, mediated by strong hydrogen bond interactions. Consequently, the continuous and fast aggregation of AMPCOO − and AMPH + caused their swift precipitation from NMP. With the introduction of AEEA, the derived product AEEAH + (S) COO – (P) acted as a bridge-builder, connecting AMPCOO − or AMPH + and NMP via hydrogen bonds, increasing the solubility of the AMP-derived products in NMP, thus effectively delaying the phase transition. Thermodynamic analysis revealed that the A/A/N SLBS exhibited a total regeneration energy consumption of 1.94 GJ·ton −1 CO 2 , representing a significant reduction of 48.9 % compared to that of 30 wt% MEA. This study provided a novel idea for designing SLBSs with controllable phase transition behavior, and offered a promising A/A/N SLBS for energy-efficient CO 2 capture.
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FOOD CHEMISTRY
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2025
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IF 9.8
Feng Wang,Xianhong Bi,Yun Cui,Kewei Lin,Charles Brennan,Soottawat Benjakul,Gengsheng Xiao,Lukai Ma
Toxic compounds in fried food products attract increasing attention, but studies regarding the levels of common toxins, such as malondialdehyde (MDA), 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE), in fried starch-based food (FSBF) are scarce. Herein, we investigated the formation and distributions of these aldehydes in FSBF, and the frying oil and FSBF retained higher levels of low-molecular-weight aldehydes. The highest aldehyde concentrations were observed in French fries. Simulated frying experiments revealed that the distributions of the toxic aldehydes in FSBF were mainly determined by the amylose content. Molecular dynamics simulations indicated that amylose interacted strongly with 4-HNE, but its interactions with MDA and 4-HHE were weaker. The migration of MDA, 4-HHE, and 4-HNE into FSBFs was primarily attributed to the interactions between the toxic aldehydes and amylose. This study should provide a novel basis for the control and elimination of toxic aldehydes in fried food.
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PubMed
高影响因子
Journal of Cleaner Production
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2024
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IF 9.7
Zhonghua Niu,Taoshan Xu,Licheng Zhang,Lianmin Ji,Lijuan Li
With the increasing demand for lithium resources, recovery of lithium from solution with high Na/Li ratio is an effective way to meet the growing demand. Salicylate extraction system has been found to be an effective system for Li/Na separation. In this work, the studies of equilibrium, process and mechanism were carried out for the 2-ethylhexyl salicylate (ES) and trialkyl phosphine oxide (TRPO) co-extraction system. The factors affecting lithium extraction such as composition of the organic phase, the conditions of aqueous phase, extraction time and acid-alkali tolerance of the ES extraction system were systematically investigated; According to the equilibrium study, a series of process studies were carried out for lithium recovery from mother solution of lithium carbonate, and the whole process including extraction, elution, stripping and regeneration was designed, and through the process, 99% of lithium was recovered and lithium-rich solution containing 25.85 g/L Li and 0.08 g/L Na was obtained. In the mechanism study, the extraction process was proved as a thermodynamic spontaneous entropy increase process; At the molecular level, the coordination mechanism was first expounded by ultraviolet–visible (UV–Vis) and fluorescence spectrum (Fl), which was further confirmed by 1 H NMR and Fourier transform infrared (FT-IR). The current study points a way to separation of lithium from alkaline solutions, which will support the future supply of lithium in a more economical and sustainable manner.
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RSC Advances
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2026
·Vol. 16
·期 9
·8166-8177
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IF 6.1
Yifei Meng,Xuan Ou,Zhenghui Liu,Shun Yao,Chuxiao Hu,Qiuchi Yu,Wenjie Xia
Achieving sustainable and cost-effective production and modulating the structure of biosurfactants is increasingly obtaining attention due to carbon neutrality and eco-safety. Nanotechnology-assisted approaches have been emerging as a promising strategy for this purpose. Here, we investigated the effect of metal oxide nanoparticles on the yield and molecular structure of trehalose lipids produced by Rhodococcus erythropolis WJ-2. Sunflower oil was identified as the optimal carbon source against other oils, yielding 12.60 g L−1. Subsequent optimization of four key medium components (sunflower oil, ZnSO4, (NH4)2SO4, and yeast extract) using a Box–Behnken design elevated the baseline yield to 24.75 g L−1. Interestingly, the trehalose lipid yield was further enhanced to 28.12 g L−1 compared to the optimized medium without NPs when supplemented with 0.5 g per L Fe2O3 NPs (≈20 nm). Furthermore, structural diversity analyzed by FTIR and HPLC-MS showed the obvious m/z value shifts of trehalose lipids with NPs comprising longer hydrophobic fatty acid chains and more unsaturated fatty acid derivatives. In the absence of Fe2O3 NPs, the main m/z peaks were detected at m/z 496, 694, 877, and 1044 (relative abundances: 14.19%, 27.08%, 44.18%, 14.55%), corresponding to short-to-medium-chain fatty acid derivatives (e.g., methyl hexanoate, methyl octanoate). In contrast, the dominant peaks shifted to m/z 673, 807, 874, and 1043 (relative abundances: 22.21%, 18.39%, 47.64%, 11.76%) with Fe2O3 NP supplementation. These findings suggest that the unique redox properties and high surface area of Fe2O3 nanoparticles could enhance the yield and modulate the structures to enable the tailored biosynthesis of glycolipids by influencing key-enzyme activity and metabolic flux. This nanoparticle-assisted fermentation strategy offers a promising route for the scalable production of designer biosurfactants for diverse industrial applications.
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DYES AND PIGMENTS
·
2026
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IF 3.9
Xin Zeng,Ranran Bu,Fengjiao Zhao,Yan Ding,Haizhen Song,Hongming Yin
Photoresponsive functional materials, especially photochromic materials, have recently emerged as key players in advancing cutting-edge optical applications. The photochromic film AQ-2-COOH-PMMA was prepared by introducing 2-anthraquinonecarboxylic acid ( AQ-2-COOH ) into the poly(methyl methacrylate) ( PMMA ) matrix. The AQ-2-COOH-PMMA film immediately exhibits a distinct color change (300 ms) under 365 nm UV light, demonstrating rapid photo-induced patterning ability and fine image formation. The images on the film exhibit reversible behavior. When heated in a 110 °C oven for 10 min, the written pattern is completely erased. The film exhibits excellent fatigue resistance, maintaining reproducible coloring-decolorization behavior for at least 10 consecutive cycles without significant performance degradation. This work provides a cost-effective, feasible and efficient strategy for developing information storage materials with rapid light response capability, excellent thermal reversibility and anti-fatigue properties.
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NEW JOURNAL OF CHEMISTRY
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2026
·
IF 2.6
Tao Zhou,Kun-Lang Lu,Tao Li,Rui Xiao
Decoupled water splitting offers a safe and efficient route for hydrogen production. However, its practical application remains constrained by issues such as low electrode discharge capacity and poor structural stability. In this study, framework-integrated Ni(OH)2 anodes for membrane-free decoupled water splitting are fabricated. The framework-integrated electrode structure with a carboxymethyl cellulose-based binder affords a well-developed conductive network and robust interfacial contact. This architecture delivers higher discharge capacity and enhanced cycling stability relative to conventional coated electrodes. In addition, the use of nickel powder as the conductive additive improves electronic conductivity, resulting in higher discharge capacity and excellent hydrogen-production performance. The framework-integrated Ni(OH)2 anode maintains a stable structure and electrochemical performance over 100 decoupled cycles, achieving a Faradaic efficiency of 97.3%. The electrical energy consumption for hydrogen production is 3.40 kWh m-3 H2 at 50 mA cm-2.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Zheng Bian,Jiaxin Xiong,Bowen Li,Cailian Wang,Chunyang Wang,Benzhong Zhu
Abstract Tomato fruit ripening is a critical developmental process that determines the fruit quality. However, the regulatory mechanisms underlying the ripening initiation remain incompletely understood. Here, we characterized SlVTE3(2), a tocopherol-biosynthesis-related methyltransferase, and investigated its role in tomato fruit ripening. CRISPR/Cas9-mediated mutation of SlVTE3(2) accelerated ripening initiation, resulting in earlier ethylene production, faster softening, and an earlier color transition, whereas overexpression delayed these processes. Transcriptome analysis showed that SlVTE3(2) affected multiple ripening-related pathways, including ethylene biosynthesis and signaling, carotenoid metabolism, and cell wall modification. Although SlVTE3(2) significantly altered the tocopherol composition in tomato fruits, exogenous tocopherol treatment did not affect ripening initiation. These findings provide new insights into the regulation of tomato fruit ripening by the metabolic enzymes.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Jinling Wu,Runmiao Chen,Pengjing Yin,Yuanzhen Zhou,Jieli Tang,Chengbin Du,Qi Xue
S-modified MnO 2 /Ni(OH) 2 hollow nanosheets were constructed for enhanced UOR. • Requires 1.30 V at 10 mA cm −2 and remains stable for 48 h. • MnO 2 phase transformation promotes the generation of Ni 3+ active species. • S-modification enhances urea adsorption while suppressing competitive OH − adsorption. The urea oxidation reaction (UOR) provides an alternative anodic process for electrochemical hydrogen generation, but developing catalysts with high activity and sustained performance remains challenging. In this study, we report an S-modified nickel-based catalyst with a hollow nanosheet architecture (α/γ-MnO 2 /Ni(OH) 2 -S), demonstrating enhanced UOR performance in alkaline media. α/γ-MnO 2 /Ni(OH) 2 -S attains a current density of 10 mA cm −2 at a potential of 1.30 V and maintains reliable durability for 48 h without significant degradation. The improved activity and durability are associated with the hollow nanosheet structure, the phase transformation of MnO 2 , and S-modification, which facilitate mass transport and charge transfer, modulate the electronic structure of Ni(OH) 2 to promote the formation of Ni 3+ active species, and enhance the electrochemical response to urea at different concentrations. This research establishes a practical avenue for constructing advanced nickel-based UOR catalysts through rational structural optimization, phase regulation, and surface modification. Download: Download high-res image (125KB) Download: Download full-size image
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JOURNAL OF CHEMICAL RESEARCH
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2026
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IF 1.5
Guoqiang Song,Tongtong Zhou,Qiulin Hu,Ming Ni,Xiaoqing Feng,Long Tang
The level of phosphodiesterase type 2 (PDE2) in the body is closely associated with human health. From the L6000 natural compound library, the natural coumarin compound coumestrol was identified as possessing PDE2 inhibitory activity. Using computer-aided drug design software, we modified and synthesized coumestrol derivatives and subsequently evaluated their PDE2 inhibitory activity. Among the synthesized compounds, B2-1 exhibited the strongest activity, with an IC₅₀ value of 1.09 ± 0.07 μM, approximately 7 times higher than that of coumestrol. Finally, ADMET prediction of coumestrol and B2-1 found that B2-1’s ability is equal to or better than coumestrol in terms of intestinal absorption, hepatotoxicity, protein binding, and so on.
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