SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xiaobin Zhou,Ting Zou,Dan Wang,Zhifang Tu,Yinming Fan,Jianwen Wei,Lei Liao,Zongqiang Zhu,Yinian Zhu,Dunqiu Wang,Guohua Jing
Solid-liquid biphasic solvents (SLBSs) hold promise as energy-efficient candidates for CO 2 capture. Nevertheless, the premature phase transition of current SLBSs leads to inopportune solid precipitation, posing operational challenges for the CO 2 capture system. This study proposed a promising strategy that using aminoethylethanolamine (AEEA) as a regulator to fine-tune the phase transition time node of the 2-amino-2-methyl-1-propanol (AMP)/N-methylpyrrolidone (NMP) SLBS, enabling the phase transition to occur precisely as desired. Experimental results showed that the AEEA/AMP/NMP (A/A/N) SLBS exhibited tunable phase transition time nodes, modulated by the concentration of AEEA. Specifically, with the addition of 0.2 mol·L −1 AEEA, the CO 2 loading associated with the phase transition increased significantly, from 0.19 to 0.54 mol·mol −1 , approaching the saturation loading of 0.57 mol·mol −1 . The delayed phase transition would facilitate the CO 2 absorption operation. The regulatory mechanism of AEEA on the phase transition were thoroughly studied via 13 C NMR and quantum calculations. AMP reacted with CO 2 to produce AMPCOO − and AMPH + , which had a significantly stronger affinity for each other than for the solvent NMP, mediated by strong hydrogen bond interactions. Consequently, the continuous and fast aggregation of AMPCOO − and AMPH + caused their swift precipitation from NMP. With the introduction of AEEA, the derived product AEEAH + (S) COO – (P) acted as a bridge-builder, connecting AMPCOO − or AMPH + and NMP via hydrogen bonds, increasing the solubility of the AMP-derived products in NMP, thus effectively delaying the phase transition. Thermodynamic analysis revealed that the A/A/N SLBS exhibited a total regeneration energy consumption of 1.94 GJ·ton −1 CO 2 , representing a significant reduction of 48.9 % compared to that of 30 wt% MEA. This study provided a novel idea for designing SLBSs with controllable phase transition behavior, and offered a promising A/A/N SLBS for energy-efficient CO 2 capture.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2024
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IF 4.1
Yuxiang Jiao,Yifei Li,Huaijun Tang,Shanglan Xian,Yonghui He,Long Wang,Jinghao Zhang
Herein, a cationic iridium(III) complex [(ppy) 2 Ir(IPP)]PF 6 (ppy: 2-phenylpyridine; IPP: 2-(1 H -imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol) was synthesized. Under the excitation of 328 nm (λ ex = 328 nm) UV light, this complex emitted bright yellow orange light (500 ∼ 700 nm, λ em,max = 582 nm), the Stokes shift was up to 254 nm, mainly due to excited-state intramolecular proton transfer (ESIPT) occurring in its ancillary ligand IPP. [(ppy) 2 Ir(IPP)]PF 6 was very sensitive to Ni 2+ , which was caused by the ESIPT being hindered by the coordination of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ . Its bright yellow orange light disappeared within 1 min when Ni 2+ (1.0 equiv.) was added in its solution (in DMSO/H 2 O, v/v = 999/1), therefore, it can be used for “turn-off” chemiluminescent detection of Ni 2+ . The recognition of [(ppy) 2 Ir(IPP)]PF 6 to Ni 2+ was not interfered by many common metal ions (such as Na + , K + , Li + , Mg 2+ , Al 3+ , Ca 2+ , Fe 3+ , Ag + , Zn 2+ , Hg 2+ , Co 2+ , Pb 2+ , Mn 2+ , Ba 2+ or Cr 3+ ), however, Cu 2+ was an interfering metal ion, but its interference can be completely masked by thiourea. The detection limit was as low as 3.31 × 10 −7 mol∙L -1 (0.331 μM). The Job’s plot analysis revealed that the stoichiometry of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ was 1:1, its detecting mechanism based on ESIPT effect was demonstrated by 1 H NMR spectra and density functional theory (DFT) calculation.
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FOOD CHEMISTRY
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2025
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IF 9.8
Feng Wang,Xianhong Bi,Yun Cui,Kewei Lin,Charles Brennan,Soottawat Benjakul,Gengsheng Xiao,Lukai Ma
Toxic compounds in fried food products attract increasing attention, but studies regarding the levels of common toxins, such as malondialdehyde (MDA), 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE), in fried starch-based food (FSBF) are scarce. Herein, we investigated the formation and distributions of these aldehydes in FSBF, and the frying oil and FSBF retained higher levels of low-molecular-weight aldehydes. The highest aldehyde concentrations were observed in French fries. Simulated frying experiments revealed that the distributions of the toxic aldehydes in FSBF were mainly determined by the amylose content. Molecular dynamics simulations indicated that amylose interacted strongly with 4-HNE, but its interactions with MDA and 4-HHE were weaker. The migration of MDA, 4-HHE, and 4-HNE into FSBFs was primarily attributed to the interactions between the toxic aldehydes and amylose. This study should provide a novel basis for the control and elimination of toxic aldehydes in fried food.
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CHEMISTRY OF MATERIALS
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2025
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IF 7
Lingying Chen,Jiangchuan Liu,Qinke Tang,Qingzhu Wang,Zeyang Zhang,Kai Liu,Wenrui Li,Jiguang Zhang,Rui Shi,Yana Liu,Jun Wang,Yunfeng Zhu
Active metal hydrolysis is favored for safety and environmental friendliness in the field of hydrogen generation. In practice, however, dense oxide/hydroxide films form instantaneously on the metal surface; these passivating layers act as electronic insulators that severely curtail charge transfer and, consequently, suppress hydrogen evolution. Herein, a novel heterostructure of NiO/Ni(OH)2 was designed to enhance the electron transfer rate in the magnesium powder hydrolysis system, achieving rapid hydrogen production. Surprisingly, Mg-2 wt % NiO/Ni(OH)2 achieved a near 100% conversion rate, producing 880.2 mL g–1 of H2 in only 20 s at 30 °C. Its maximum hydrogen generation rate (mHGR) surpassed that of pure magnesium by 35-fold, and such hydrolysis performance is superior to all the reported results of catalyzed-Mg systems so far. Theoretical studies confirmed that the space charge region in NiO/Ni(OH)2 affects the electronic structure; thus, the correspondingly generated built-in electric field accelerated the hydrolysis of magnesium and greatly facilitated the electron transfer of the system. This work provides a strategy for designing nickel-based oxides/hydroxides catalysts for light metal hydrolysis and facilitates the understanding of the catalytic mechanism in multiphase catalytic systems.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2026
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IF 3
Zhiyuan Wang,Xiaohe Zhang,Yong Yang,Xiaobin Zhong,Suping Jia,Zongsheng Zhang,Yuan Gao,Junjie Guo,Xiaoping Han
Synthesis of highly uniform rutile TiO 2 nanorod arrays has long been a priority for fabricating the high-performance memristors, given its great potential as active-layer materials in memristive devices. Herein, a controllable hydrothermal synthesis of highly uniform rutile TiO 2 nanorod arrays on fluorine-doped tin oxide (FTO) substrates is presented. Through systematic investigations, it is revealed that the highly uniform rutile TiO 2 nanorod arrays are obtained via a 3-hour hydrothermal synthesis at 160 °C on vertical FTO substrates, postannealing at 450 °C for 1 hour, followed by 25-minute ultraviolet (UV) irradiation. The obtained TiO 2 nanorod arrays exhibit excellent substrate adhesion and pinhole-free morphology, with well-defined nanorod dimensions (an average diameter of 171 nm and a length of 2.44 μm) and high crystallinity (an average crystallite size of 16.66 nm). Using such nanorod arrays as the active layers, the Ag/TiO 2 /FTO memristive devices demonstrate remarkable resistive switching characteristics: (i) the ratio of high resistance state (HRS) and low resistance state (LRS) reaches 17.7, and (ii) the retention time is predicted to be more than 10 years. Current-voltage analysis indicates that the resistive switching behavior follows a synergistic combination of ohmic conduction and space-charge-limited current (SCLC) mechanisms. The current work offers valuable guidelines for structure-property optimization in highly uniform rutile TiO 2 nanorod array films, demonstrating their promising applications in high-performance memristive devices.
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FOOD MICROBIOLOGY
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2026
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IF 5.4
Liangliang Gao,Tengjie Li,Zengrong Xiong,Mingnan You,Jun Zhang,Nengguo Tao
In this study, N'-(4-fluorophenyl)-2-pyridinecarbohydrazide (2-FPH), N'-(4-fluorophenyl)-3-pyridinecarbohydrazide (3-FPH), and N'-(4-fluorophenyl)-4-pyridinecarbohydrazide (4-FPH), which showed considerable antifungal activities against the prochloraz-resistant Penicillium italicum strain (PiR2), were designed and synthesized. Among these, 2-FPH displayed the strongest antifungal activity against PiR2 growth, with minimum inhibitory concentrations (MIC) of 12.5 μg/mL and minimum fungicidal concentrations (MFC) of 25 μg/mL. In vivo antifungal and hemolytic toxicity tests showed that 2-FPH effectively prevented PiR2 infection of citrus fruits, but exhibited exceptionally low hemolytic toxicity. At equivalent concentrations, its biological safety and control efficacy were far superior to those of prochloraz. According to morphological findings, 2-FPH increased cell membrane permeability, caused cell swelling and morphological abnormalities, disrupted structural integrity, and decreased chitin content in cell walls. Physiological, biochemical, and molecular biology investigations indicated that 2-FPH binds to succinate dehydrogenase (SDH), inhibits its enzymatic activity, and suppresses associated gene expression. This decreases intracellular ATP levels, disrupts normal mitochondrial function, and triggers a substantial increase in reactive oxygen species (ROS). In summary, 2-FPH shows promising potential as a possible fungicide and succinate dehydrogenase inhibitor for managing citrus blue mold.
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高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
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2026
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IF 7.3
Renli Ai,Kai Yan,Changyu Shao,Longfeng Wei,Qinqin He,Junxian Chen,Qinyi Hu,Yao Wang,Zhu Li
The exploration of effective biocontrol agents and the characterization of their functional components are crucial for precisely preventing and managing carrot postharvest disease. Herein, Aspergillus niger xj was shown to effectively inhibit the bacterial soft-rot pathogen named Pectobacterium aroidearum , with the functional compounds primarily localized in the extracellular fermentation broth. Correlation analysis between the inhibitory activity and content of 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) across 224 atmospheric and room-temperature plasma mutant strains and original strain xj indicated that HMFCA was an important inhibitory agent. The bioactivity of the bio-derived HMFCA isolated from the positive mutant strain 350–28 was validated through assays. In vitro inhibitory assays revealed that the half-maximal effective concentration (EC 50 ) of HMFCA against P. aroidearum was 1121 ± 8 μg mL −1 , with a minimum inhibitory concentration of 1.25 mg mL −1 and a minimum bactericidal concentration of 2.5 mg mL −1 . Moreover, HMFCA exhibited considerable potential to impede the growth of P. aroidearum . Furthermore, in vivo inhibitory assays indicated that HMFCA could assist carrot in resisting the infection caused by P. aroidearum within 24 h at three concentrations: EC 20 , EC 50 , and EC 80. However, the required effective concentration markedly increased at 48 h. These findings indicated that A. niger exhibited biocontrol activity through the extracellular secretion of active secondary metabolites, which directly suppressed the growth and reproduction of P. aroidearum . In particular, HMFCA was a functional compound, which offered a promising approach for the targeted postharvest management of carrot.
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OPTICAL MATERIALS
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2026
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IF 4.2
Kaiyuan Gou,Jin Huang,Huiya Cao,Siyu Chong,Yufan Zhou,Shuya Ning
Defects in perovskite solar cells (PSCs) critically hinder both device stability and power conversion efficiency (PCE). Incorporating multifunctional organic additives into the perovskite precursor offers a promising approach to overcome these limitations. Here, we report methyl 2-aminobenzoate (MA) as a novel multifunctional additive containing –COOCH 3 , –NH 2 groups, and a benzene ring. The benzene ring enhances hydrophobicity, while the ester (–COOCH 3 ) functional group, through its carbonyl oxygen and the –NH 2 group, coordinates with undercoordinated Pb 2+ ions, thereby effectively passivating Pb-related defects. Consequently, MA-modified PSCs deliver a PCE of 16.85 %, markedly higher than the 14.09 % achieved by the control devices. Moreover, the optimized devices retained 88 % of their initial efficiency after 700 h of continuous illumination at 25 °C under ambient air, underscoring their excellent long-term operational stability.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Jinling Wu,Runmiao Chen,Pengjing Yin,Yuanzhen Zhou,Jieli Tang,Chengbin Du,Qi Xue
S-modified MnO 2 /Ni(OH) 2 hollow nanosheets were constructed for enhanced UOR. • Requires 1.30 V at 10 mA cm −2 and remains stable for 48 h. • MnO 2 phase transformation promotes the generation of Ni 3+ active species. • S-modification enhances urea adsorption while suppressing competitive OH − adsorption. The urea oxidation reaction (UOR) provides an alternative anodic process for electrochemical hydrogen generation, but developing catalysts with high activity and sustained performance remains challenging. In this study, we report an S-modified nickel-based catalyst with a hollow nanosheet architecture (α/γ-MnO 2 /Ni(OH) 2 -S), demonstrating enhanced UOR performance in alkaline media. α/γ-MnO 2 /Ni(OH) 2 -S attains a current density of 10 mA cm −2 at a potential of 1.30 V and maintains reliable durability for 48 h without significant degradation. The improved activity and durability are associated with the hollow nanosheet structure, the phase transformation of MnO 2 , and S-modification, which facilitate mass transport and charge transfer, modulate the electronic structure of Ni(OH) 2 to promote the formation of Ni 3+ active species, and enhance the electrochemical response to urea at different concentrations. This research establishes a practical avenue for constructing advanced nickel-based UOR catalysts through rational structural optimization, phase regulation, and surface modification. Download: Download high-res image (125KB) Download: Download full-size image
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Cell Reports Medicine
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2026
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IF 14
Jingkun Qin,Xinyu Hu,Lei Wang,Ying Cai,Ziming Hu,Xiuxiu Xu,Zhigang Nian,Zhenbang Liu,Xiaoyu Ding,Yan Jiang,Yuanhao Lin,Ke Ruan,Binqing Fu,Zhigang Tian,Yonggang Zhou,Haiming Wei
Lipid metabolic reprogramming can facilitate immune escape by promoting a suppressive phenotype in tumor-infiltrating immune cells, although this process remains poorly understood. Here, we identify the lipoprotein, Lipocalin-2 (LCN2), as an essential factor driving natural killer (NK) cell dysfunction and immunosuppressive phenotype. Spatial metabolomics with crystal structure analysis demonstrates that LCN2 binding to phosphatidylserine (PS) and PS enrichment is required for tumor-associated lipid reprogramming. Increased LCN2-PS binding limits IL-15-mediated JAK-STAT pathway activation in NK cells, while inhibiting tumor-infiltrating neutrophil maintenance of anti-tumor potential in NK cells via suppression of IFN-I response. Structure-based drug screening identifies semapimod as an LCN2 inhibitor that blocks interaction with PS, disrupting the LCN2-PS immunosuppressive axis and inducing tumor control. Overall, this study uncovers a lipid metabolic reprogramming mechanism that mediates innate immune evasion and proposes a tumor treatment strategy through enhanced innate immune surveillance.
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NATURE MEDICINE
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2026
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IF 52.5
Li Huiyuan,Xu Yuan,Chen Yunfei,Ji Lulu,Xu Yanmei,Zheng Wenting,Sun Ting,Fu Rongfeng,Pei Xiaolei,Liu Xiaofan,Xue Feng,Liu Wei,Wang Wentian,Chi Ying,Yang Renchi,Wei Jun,Zhang Lei
Autoimmunity remains challenging to treat without broad immunosuppression. We previously showed that anti-CD38 antibody can rapidly elevate platelet counts in refractory immune thrombocytopenia (ITP), but the underlying mechanism was unclear. Here we report that anti-CD38 antibody induces platelet recovery within 3 days, including after retreatment in relapsed cases. Mechanistically, CD38-mediated nicotinamide adenine dinucleotide (NAD + ) depletion drives M1-like macrophage polarization with increased Fc gamma receptor I (FcγRI) expression, thereby promoting macrophage phagocytosis of opsonized platelets. In mice, CD38 inhibition or nicotinamide mononucleotide (NMN) supplementation restores NAD + , reprograms macrophages, downregulates FcγRI and prevents thrombocytopenia. In an ovalbumin immunization model, NMN treatment does not impair antigen-specific antibody production, supporting preservation of humoral responses. Based on these findings, we conducted a single-arm, open-label phase 1/2 trial of low-dose oral NMN (450 mg twice daily for 2 weeks) in adults with steroid-refractory or steroid-dependent ITP. Primary endpoints were safety/tolerability and platelet response (≥50 × 10 9 per liter within 2 weeks, confirmed by two consecutive measurements one or more days apart, without rescue therapy or dose escalation of thrombopoietin receptor agonists or corticosteroids). Among 25 enrolled patients, no dose-limiting toxicities or treatment-related serious adverse events occurred; NMN was well tolerated, with only mild treatment-related adverse events in 12% and non-severe infections (grade 1) in 8% of patients while immunoglobulin levels remained stable, consistent with preserved humoral immunity. Five patients (20.0%) met the primary platelet-response endpoint. In exploratory analyses, overall, 60% of patients achieved platelet counts more than 1.5× baseline during treatment, and 52% maintained responses through week 8. Together, these data identify the CD38−NAD + axis as an immunometabolic checkpoint in ITP and support further exploration of NMN as a non-antibody-depleting metabolic strategy for antibody-mediated disease. ClinicalTrials.gov identifier: NCT06776510 .
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DYES AND PIGMENTS
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2026
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IF 3.9
Xin Zeng,Ranran Bu,Fengjiao Zhao,Yan Ding,Haizhen Song,Hongming Yin
Photoresponsive functional materials, especially photochromic materials, have recently emerged as key players in advancing cutting-edge optical applications. The photochromic film AQ-2-COOH-PMMA was prepared by introducing 2-anthraquinonecarboxylic acid ( AQ-2-COOH ) into the poly(methyl methacrylate) ( PMMA ) matrix. The AQ-2-COOH-PMMA film immediately exhibits a distinct color change (300 ms) under 365 nm UV light, demonstrating rapid photo-induced patterning ability and fine image formation. The images on the film exhibit reversible behavior. When heated in a 110 °C oven for 10 min, the written pattern is completely erased. The film exhibits excellent fatigue resistance, maintaining reproducible coloring-decolorization behavior for at least 10 consecutive cycles without significant performance degradation. This work provides a cost-effective, feasible and efficient strategy for developing information storage materials with rapid light response capability, excellent thermal reversibility and anti-fatigue properties.
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