ACS Biomaterials Science & Engineering
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2023
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IF 5.8
Zhengjiang Xu,Yuan Zhang,Danping Lu,Guofang Zhang,Yang Li,Zufu Lu,Fei Wang,Guocheng Wang
Accumulation of senescent cells in the elderly impairs bone homeostasis. It is important to alleviate cell senescence and scavenge excessive oxidative stress for enhanced bone fracture healing in elderly patients. In this study, resveratrol (RSV), an antioxidant drug, was encapsulated in a biocompatible zeolitic imidazolate framework-8 (ZIF-8) nanoparticle to protect it from oxidation and improve its bioavailability. Cells responsible for bone healing, including osteoblasts, bone marrow-derived mesenchymal stem cells (BMSCs), macrophages, and endothelial cells, were used to evaluate the regulatory role of the nanoformulation in the alleviation of cellular senescence and promotion of cell functions. It was proved that the nanoformulation sustainably released RSV with well-preserved bioactivity and improved bioavailability. Cell experiments confirmed that ZIF-8/RSV was capable of alleviating the senescence of cells [human osteoblasts (HOBs), BMSCs, H2O2-induced senescent vascular endothelial cells (HUVECs)] and scavenging excessive intracellular reactive oxygen species (ROS). Excitingly, the ZIF-8/RSV improved the osteogenic ability of senescent osteoblasts and promoted macrophage M2 polarization. In addition, the ZIF-8/RSV also enhanced the angiogenic function of senescent HUVECs. More importantly, the ZIF-8/RSV nanoformulation outperformed the REV alone, indicating the critical role of encapsulation using ZIF-8. These findings suggest that the ZIF-8/RSV nanoformulation exhibits potential for bone fracture treatment in elderly patients.
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JOURNAL OF SOLID STATE CHEMISTRY
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2022
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IF 3.656
Yunyun Lei,Xiaoxun Liu,Jilin Zhang,Zi Dai,Xiaoya Zhao,Guixia Liu
Metal-organic framework materials (MOFs) have shown efficient adsorption performance in organic dye removal . However, its relatively poor capacity and slow adsorption kinetics often limit its further application. Herein, polyethyleneimine (PEI) was cross-linked and encapsulated in ZIF-8 to prepare novel composite (ZIF-8@PEI-CC) by using cyanuric chloride (CC). It was found that the composite exhibited excellent adsorption performance for methyl orange (MO). Compared with ZIF-8 (183 mg g −1 ), the adsorption capacity (710 mg g −1 ) was significantly enhanced, and it was easier to separate than ZIF-8. Moreover, it shows a faster adsorption rate than ZIF-8. The adsorption kinetics of the ZIF-8@PEI-CC is more consistent with the pseudo-secondary kinetic model . Isotherm of the ZIF-8@PEI-CC is more in line with the Langmuir model. In addition, the ZIF-8@PEI-CC shows high adsorption capacity in a wide pH range (4-11). Therefore, the synthesized composite ZIF-8@PEI-CC has great potential as an effective adsorbent for removing MO.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 8
·1782-1797
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IF 7
Qiuyue Wang,Mingming Li,Xinxing Sun,Naiying Chen,Sicheng Yao,Xun Feng,Yang Chen
Metal–organic frameworks (MOFs) are highly promising as a novel class of drug delivery carriers; however, there are few reports about their application in nanoparticle-based formulations for dermal administration. In this work, we developed a novel kind of nanoparticular system based on zeolitic imidazolate framework-8 (ZIF-8) and polydopamine (PDA) modification for improving the dermal delivery of 5-fluorouracil (5-FU). The structures and properties of the prepared nanoparticles were characterized using a variety of analytical methods. Their ex vivo delivery performance in the skin was investigated using Franz cells, and the underlying mechanisms were studied via confocal laser scanning microscopy (CLSM) and hematoxylin-eosin (HE) experiments which were employed to probe the penetration pathway and the interaction between nanoparticles and the skin. The results revealed that both 5-FU@ZIF-8 and ZIF-8@5-FU@PDA had an enhancement effect on the deposition of 5-FU in the skin, and the surface coating of PDA could further reduce drug permeation across the skin, especially in the case of impaired skin, in comparison with the drug solution. The CLSM study using rhodamine 6G as the fluorescent probe to mimic 5-FU indicated that ZIF-8 and ZIF-8@PDA could deliver their payloads into the skin via two pathways, i.e., intercellular and follicular ones, and the follicular route was shown to be particularly important for ZIF-8@PDA, in which the drug and carrier were co-delivered into the skin as an intact particle. This study provides evidence for using ZIF-8 and PDA modification for skin-specific drug delivery and offers an effective avenue to develop novel nanoplatforms for dermal application to treat skin diseases.
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Journal of Experimental Nanoscience
·
2022
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IF 2.024
Zhen-Hong He,Yuan-Yuan Wei,Na Li,Yong-Chang Sun,Shao-Yan Yang,Kuan Wang,Weitao Wang,Xiaoxue Ma,Zhao-Tie Liu
Chemical utilization of CO2 is one of the fundamental strategies to synthesize value-added chemicals and reduce the CO2 emission. N-formyl-1,2,3,4-tetrahydroisoquinoline derivatives (FTHIQs) are important chemicals for the synthesis of medical intermediates and alkaloids. N-formylation of isoquinoline derivatives (IQs) with CO2 is an ideal protocol to synthesize the FTHIQs and utilize the CO2 source. In the present work, we prepared a heterogeneous Ru/ZIF-8 catalyst with a Ru loading of 2 wt% by a simple impregnation method and assessed its performances in the N-formylation of IQs and CO2 with H2. The Ru/ZIF-8 catalyst offered high IQ conversion of 98% and FTHIQ selectivity of 93% in the reaction under relatively mild conditions (150 °C, 2 MPa CO2, and 6 MPa H2). The catalyst possessed good universality and reusability, showing a potential in wide application of N-formylation of highly unsaturated nitrogen-containing isoquinolines.
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International Journal of Electrochemical Science
·
2023
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IF 1.5
Huimin Yang,Xin Liu,Jihui Wang,Wenbin Hu
The following study is conducted to improve the corrosion resistance of magnesium alloy. First, ZnAl layered double hydroxide (ZnAl LDH) film was prepared on AZ61 magnesium alloy by using hydrothermal method. Then, as-prepared ZnAl LDH was put into 2-methylimidazole (2-mIm) solution to synthetize ZIF-8 film (ZIF-8/LDH). Finally, ZIF-8/LDH film synthesized ZIF-8-DMBIM film (ZIF-8-DMBIM/LDHs) via a shell-ligand-exchange-reaction in the methanol solution containing 5, 6-dimethylbenzimidazole (DMBIM). The surface morphology, structure, and composition of the composite film were observed and determined by scanning electronic microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy. The wettability of composite film was measured by using a water contact angle meter, and the corrosion resistance of the composite film was estimated by the polarization curve and electrochemical impedance spectroscopy techniques. Results show that the prepared ZIF-8-DMBIM/LDH composite film has a dense hexagonal plate morphology with a two-layer structure and a thickness of 3.5 μm. Compared with ZnAl LDH and ZIF-8/LDH films, ZIF-8-DMBIM/LDH composite film has a high contact angle (115.7°), low corrosion current density, and high corrosion potential and polarization resistance due to its near-smooth surface, dense two-layer structure, and hydrophobic characters.
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Surfaces and Interfaces
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2023
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IF 6.2
Ting Zhao,Hui Li,Xin Jia,Peng-Cheng Ma
Successful integration of ideal amounts of porous materials onto the fibrous substrate requires a subtle balance between the loading ratio and structural robustness. In this study, zeolitic imidazolate framework-8 (ZIF-8) crystals could be controllably coupled on the surface of the fibrous basalt fiber felt via a mild synthetic route with a combination of biomimetic mineralization and layer-by-layer growth. Specifically, by regulating the deposition time and the number of growth cycles, a high loading ratio of 47.1% for ZIF-8 could be achieved without sacrificing the strength of the substrate. The remarkable stability of the composite against varied environmental factors such as high temperature, humidity, and solution corrosion circumstances were confirmed which could be attributable to the ultra-stability of single components and strong bonding between them. The high-quality loadings of the ZIF-8 ensured the fiber composite with abundant porosity, featuring a considerable specific surface area of 822 m 2 /g, which made it a promising candidate as a high-effective pollutant adsorbent. The maximum iodine vapor capacity of the optimal sample could reach 3614 mg/g. The mechanism of iodine adsorption was further explored in kinetics and thermodynamics aspects. This study is projected to overcome the defect of the MOF powder in the real application and further outline a facile method for the construction of MOF-fiber composite in a controllable manner.
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International Journal of Electrochemical Science
·
2023
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IF 1.5
Cang Wang,Min Pan,Hang Chen,Dajing Chen,Yuquan Chen
In this study, we present a novel zeolitic imidazolate framework-8 metal-organic framework /polysulfone (PSF) stereostructure with glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF-8 as nanoreactors. This work links the high biocatalytic activity and great stability of the enzymes encapsulated in ZIF-8 with the large surface area and mass transport of the threedimensional microporous PSF and highlights the pore structure of PSF, which blocks cells during whole blood testing. The prepared ZIF-8 capsule/PSF structure exhibits a 1.2-fold and 2.4-fold increase in sensitivity compared with the ZIF-8 capsule powder and bulk mixture of GOx and HRP, respectively. The modified ZIF-8 capsule/PSF glucose biosensor exhibited a 0-18 mM linear range and good selectivity. Furthermore, the prepared sensor attenuated less than 10% after 50 replicate whole blood tests. These advanced properties give the novel biocatalytic cascade ZIF-8 capsule/polysulfone stereostructure promising applications in whole blood monitoring.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Meng Jiang,Lin Zhu,Zejun Zhang,Yijing Ai,Lina Zeng,Shuhai He,Lin Li,Wei Sun
In this article the ZIF-8 based metal-organic frameworks-derived porous carbon was mixed with aminated graphene to obtain the nanocomposite, which was used to modify the surface of glassy carbon electrode (GCE). SEM, XRD and FT-IR were used to characterize the nanocomposite, which exhibited the unique morphology with functional groups. The modified electrode was applied to the electrochemical detection of rutin. Compared with that of GCE, the current response of rutin increased obviously on the modified electrode. Square wave voltammetry was further applied to quantitative analysis of rutin with a linear relationship between the concentration and peak current in two sections from 0.25 to 0.7 μmol·L -1 and 0.7 to 1.5 μmol·L -1 with detection limit of 15 nmol∙L -1 . Consequently, the detection of real samples was realized by this method.
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POLYHEDRON
·
2023
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IF 2.6
Geng Zhang,Yuanyuan Wang,Xueqin Wang,Bolong Jiang,Yanxiu Liu,Hua Song
Zeolitic imidazolate frameworks (ZIFs) have been widely applied in many research fields, such as catalysts and adsorption. To meet the needs of scale applications, the development of simple, rapid and high-yield synthesis is a great necessity. In this work, a novel and facile strategy for the rapid synthesis of micro-mesoporous ZIF-8-H at room temperature within a very short time of 16 min using inexpensive quaternary ammonium base (tetramethylammonium hydroxide pentahydrate, TMAH) as a template was proposed. Results showed that in addition to significantly shortening crystallization time, the TMAH template also induced abundant mesopores for ZIF-8-H, which can improve the adsorption rate and fully use the adsorption active sites. More importantly, the ZIF-8-H yield of the proposed strategy is 3.6 times more than that of the conventional method, which is conducive to the realization of large-scale production. Among ZIF-8-H- x - t , ZIF-8-H-0.8-16 prepared with TMAH/Zn 2+ molar ratio x of 0.8 and reaction time t of 16 min exhibited the highest MB removal effectiveness of 96.3 ± 0.8%, a remarkable increase of 127% compared to ZIF-8-M prepared by conventional method (42.5 ± 0.9%). Additionally, the MB adsorption onto ZIF-8-M and ZIF-8-H-0.8-16 fitted well with the pseudo-first-order kinetics model and Langmuir isothermal model, suggesting the monolayer adsorption behavior is dominant. The ZIF-8-H-0.8-16 showed a maximum adsorption capacity of 47.90 mg/g, which is higher than that of ZIF-8-M.
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PROGRESS IN ORGANIC COATINGS
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2023
·
IF 6.6
Nanqi Shi,Haiyan Li,Xin Li,Hongxin Luo,Jiaying Jin,Jiayu Wang,Shuang Li
Two-dimensional hexagonal boron nitride (h-BN) has excellent corrosion resistance and barrier ability, showing unique advantages in the field of anti-corrosion. The h-BN was assembled with Zeolite imidazolate framework material (ZIF-8) and benzimidazole (BI), and an active filler (h-BN/ZIF-8@BI) with shielding and active corrosion resistance was prepared. Zeolite imidazolate framework material was in-situ grown on h-BN surface and loaded with benzimidazole (BI), prepared an active anticorrosive filler with high shielding property (h-BN/ZIF-8@BI). The microstructure, crystal form, element composition, corrosion inhibition ability and thermal stability of h-BN/ZIF-8@BI were studied. The barrier, corrosion inhibition and anti-friction properties of EP/h-BN/ZIF-8@BI combined with F51 epoxy resin were explored. EIS test shows that the corrosion inhibition efficiency of h-BN/ZIF-8@BI is as high as 81.8 %. The impedance modulus of the steel matrix protected by the composite coating was about 2 orders of magnitude higher than that of the control sample, showing excellent barrier ability. In addition, the salt spray test proves that the composite coating has excellent corrosion inhibition characteristics. Taber testing machine shows that the wear mass loss of EP/h-BN/ZIF-8@BI coating is 34.5 % lower than that of EP coating. This work provides a novel idea for the preparation of high barrier, active anticorrosive and wear resistant anticorrosive coatings, and provides a new horizon of the composite coatings.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Yang Jinpei,Wang Meng,Zheng Shuai,Huang Ruodong,Wen Ganjun,Zhou Pan,Wang Wenbo,Zhou Shihao,Jiang Xinlin,Liu Shuangjiang,Li Zhizhong,Ma Dong,Jiao Genlong
In the treatment of spinal cord injury (SCI), the complex process of secondary injury is mainly responsible for preventing SCI repair or even exacerbating the injury. In this experiment, we constructed the 8-gingerol (8G)-loaded mesoporous polydopamine (M-PDA), M@8G, as the in vivo targeting nano-delivery platform, and investigated the therapeutic effects of M@8G in secondary SCI and its related mechanisms. The results indicated that M@8G could penetrate the blood-spinal cord barrier to enrich the spinal cord injury site. Mechanism research has shown that all of the M-PDA,8G and M@8G displayed the anti-lipid peroxidation effect, and then M@8G can inhibit the secondary SCI by suppressing the ferroptosis and inflammation. In vivo assays showed that M@8G significantly diminished the local injury area, reduced axonal and myelin loss, thus improving the neurological and motor recovery in rats. Based on the analysis of cerebrospinal fluid samples from patients, ferroptosis occurred locally in SCI and continued to progress in patients during the acute phase of SCI as well as the stage after their clinical surgery. This study showcases effective treatment of SCI through the aggregation and synergistic effect of M@8G in focal areas, providing a safe and promising strategy for the clinical treatment of SCI.
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CATALYSIS COMMUNICATIONS
·
2023
·
IF 3.7
Shubo Sun,Haihan Yu,Mingzhi Hua,Lina Zhang,Chaomin Gao,Xin Cheng
Promoting the effective separation of photo-generated charge carriers is vitally crucial to enhancing the photocatalytic performance. The piezo-phototronic effect, which could regulate the directional migration of photogenerated carriers, has been regarded as an effective strategy of separating carriers. Herein, the NaNbO 3 @ZIF-8 which possesses efficient carrier separation property is prepared to achieve significant increase of H 2 evolution rate (1.16 mmol g −1 h −1 ) under the coupling effects of ultrasonic vibration and light irradiation, which is 1.9 times than that of NaNbO 3 . This work provides a strategy for studying the promotion of carrier separation and promoting photocatalytic performance under an external field.
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