Frontiers of Physics
·
2015
·Vol. 11
·期 2
·1-5
·
IF 2.086
Zhang Xin-Fang,Zhang Zheng-Wei,He Yan-Lan,Liu Yi-Xing,Li Shuang,Fang Jing-Yue,Zhang Xue-Ao,Peng Gang
Decane is one of the volatile organic compounds (VOCs) in human breath. Successful detection of decane in human breath has vast prospects for early lung cancer diagnosis. In this paper, a novel detecting device based on a filter surface acoustic wave (SAW) gas sensor is presented. SAW sensors coated with a thin oxidized graphene film were used to detect decane in parts per million (ppm) concentrations. Control and signal detection circuits were designed using a vector network analyzer with a detection resolution of insertion loss down to 0.0001 dB. The results showed that the SAW sensor could respond quickly with great sensitivity when exposed to 0.2 ppm decane. This device shows tremendous potential in medical diagnosis and environmental assessment.
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JOURNAL OF COASTAL RESEARCH
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2020
·
IF 0.793
Gao Nan,Kong Xiangfeng,Lv Hongmin,Sun Zhongliang,Liu Yan
Gao, N.; Kong, X.; Lv, H.; Sun, Z., and Liu, Y., 2020. An effective fluorescent probe method applied in the analysis of microplastics. In: Liu, X. and Zhao, L. (eds.), Today's Modern Coastal Society: Technical and Sociological Aspects of Coastal Research. Journal of Coastal Research , Special Issue No. 111, pp. 70–77. Coconut Creek (Florida), ISSN 0749-0208. Microplastic pollution has received global attention because of the durable hazards it brings to the environment. Methods used to analyze microplastics are mainly limited by laboratory conditions, instruments, and labor. This study investigated a method to analyze microplastics, and in situ verification was carried out to prove the feasibility of the technique. The method employed the fluorescent probe Nile red, followed by identification with Raman spectroscopy. Six kinds of common polymers were tested to verify the optimal operating condition of the technique. Possible fluorescence interference that obscured the Raman signal was excluded through verification of the Laman spectrum. Using this method, four kinds of polymers were found in Qingdao coastal waters, and the size of microplastics was confirmed. The results demonstrate that the fluorescent probe technique may offer considerable application in further monitoring studies to obtain reliable microplastic data.
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Plasma Processes and Polymers
·
2017
·Vol. 15
·期 4
·1700176
·
IF 2.846
Lei Wang,Jinxiu Wang,Junxin Lin,Songlin Zhang,Yongjun Liu
Degradation of metronidazole (MNZ) by radio frequency discharge in water was examined. Results showed that • OH, H • , and • O were produced. Decay of MNZ followed pseudo-first order kinetics, where the apparent rate constant was independent of its initial concentration in the range 0–0.5 mM, decreased in the range 0.5–1.0 mM, and leveled off in the range higher than 1.0 mM. pH had no effects on MNZ degradation. • OH scavengers enhanced the MNZ removal. Formic acid, nitrite ion, oxalic acid, nitrate ion, and acetic acid were determined as the primary intermediate byproducts. The eventual products were ammonia and inorganic carbon. Both • OH and H • participated in the MNZ degradation. H • played more efficient role than • OH in the early stage.
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DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 24
·8314-8321
·
IF 4.39
Qianqian Yang,Yijie Wang,Jianjian Yang,Jianbo Yin,Di Liu,Ning Liu,Rongming Wang,Daofeng Sun,Xiyou Li,Jianzhuang Jiang
Effective and selective removal of radioactive metal ions from aqueous solutions is of great importance due to their harmful effects on humans and other living species. However, it is a big challenge for researchers to develop effective adsorbents with high selectivity and a wide pH application range even if some progress has been achieved. Herein, we report an anionic potassium organic framework (UPC-K1) with protonated dimethylamine (Me2NH2+) residing inside the rhomboid channels. The unique 3D firm structure of UPC-K1 is constructed by the cross-linking of the 2D arrangement using weak K–O bonds (2.9270 Å) and strong hydrogen bonds (1.6498 Å), which endows it with excellent chemical stability in organic solvents, boiling water, and aqueous solution in the pH range 3–10. Based on the cation exchange, depending on pore size selectivity, UPC-K1 shows excellent adsorption performance towards UO22+ in aqueous solutions at 298 K with the following characteristics: (1) effective removal in the pH range 3–10; (2) high selectivity over other metal cations; (3) a high adsorption capacity of 551.4 mg g−1; (4) a rapid adsorption equilibrium within 3 hours under stirring; and (5) effective adsorption at low concentrations, with a residual concentration of 0.69 ppm even at an initial concentration of 10.3 ppm after stirring for 24 hours. These results indicate the great potential of UPC-K1 in the treatment of uranium-containing nuclear wastewater.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Wutao Liu,Bo Zhang,Jin Zhao,Xubo Yuan
Hemostasis of noncompressible wounds represents a significant challenge in surgical medicine and trauma care. Unlike compressible wounds, noncompressible wounds pose considerable difficulties in applying effective external pressure, identifying and managing bleeding sites, and are characterized by a high risk of hemorrhage and complex wound morphology. Currently available hemostatic materials possess certain hemostatic capabilities but are often limiting, including inadequate mechanical strength, suboptimal hemostatic efficacy, and lack of adaptability to complex wound geometries. These limitations prevent them from fully addressing the clinical needs of noncompressible wound management. We developed an injectable hydrogel with high hemostatic efficiency, excellent mechanical properties, and the ability to adapt to complex wound morphologies. The hydrogel was synthesized using the cationic monomer 3-(methacryloylamino)propyltrimethylammonium chloride and acrylamide to form a PMPTC-AAM hydrogel (PMA). PMA microgel particles with polyethylene glycol (PEG) as the solvent were injected into the wound, where solvent exchange occurred to form the gel. In vivo experimental results demonstrated that PMA could achieve rapid hemostasis for penetrating noncompressible wounds within 30 s, effectively accommodating complex wound morphologies. In conclusion, the injectable hydrogel suspension formed by mixing PMA with PEG undergoes solvent exchange to reorganize into a gel, showing significant potential for managing irregularly shaped, noncompressible wounds.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Kun Liu,Yuan Wang,Dayong Ren,Wujie Dong,Hui Bi,Wei Zhao,Fuqiang Huang
Natural wood, re-engineered at the nanoscale, is emerging as a promising lightweight structural material. To fully harness its potential, it is essential to upcycle the growing volumes of waste generated during bulk wood processing. Here, the selective removal of hemicellulose from wood powder particles is achieved through a mild and simple chemical treatment, effectively overcoming challenges associated with hemicellulose, such as high water absorption and thermal instability, thus enabling the engineering of cell wall fragments into micro-nano building blocks. An efficient “oriented concentrating assembly” strategy is proposed to assemble these building blocks into a unique upcycled wood with layered “flake-and-filament” structures. The resulting upcycled wood outperforms typical conventional petroleum-based polymers in terms of high flexural strength (180 MPa), high flexural stiffness (11 GPa), high toughness (1.1 kJ m −2 ), high thermal conductivity (0.48 W m −1 K −1 ), and low coefficient of thermal expansion (17 × 10 −6 K −1 ), along with enhanced fire retardancy. Together with the all-natural characteristics, the obtained upcycled wood exhibits considerable potential as a high-performance, lightweight structural material for plastics replacement.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2019
·Vol. 20
·期 24
·6239
·
IF 4.183
Yu-Jiao Liu,Xiao-Yang Fan,An-Dong Wang,Yin-Zheng Xia,Wen-Rong Fu,Jun-Yi Liu,Feng-Lei Jiang,Yi Liu
Based on the potential therapeutic value in targeting metabolism for the treatment of cancer, an organic arsenical PDT-BIPA was fabricated, which exerted selective anti-cancer activity in vitro and in vivo via targeting lactate dehydrogenase A (LDHA) to remodel the metabolic pathway. In details, the precursor PDT-BIPA directly inhibited the function of LDHA and converted the glycolysis to oxidative phosphorylation causing ROS burst and mitochondrial dysfunction. PDT-BIPA also altered several gene expression, such as HIF-1α and C-myc, to support the metabolic remodeling. All these changes lead to caspase family-dependent cell apoptosis in vivo and in vitro without obvious side effect. Our results provided this organic arsenical precursor as a promising anticancer candidate and suggested metabolism as a target for cancer therapies.Keywords:organic arsenicals;lactate dehydrogenase A;metabolism;ROS;mitochondria;apoptosis
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PubMed
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Natural Product Communications
·
2019
·
IF 0.554
Zhi Yang,Wen-Jia Dan,Yi-Xiao Li,Guang-Rui Peng,An-Ling Zhang,Jin-Ming Gao
Six metabolites (1–6), including 1 new fusaric acid derivative, designated atransfusarin (1), and 5 known compounds, (3R,6R)-3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione (2), daucoterol (3), adenosine (4), cerebroside B (5), and 2,3-dihydroxypropyl (Z,Z)-9,12-octadecadienate (6), were isolated from the solid culture of an endophytic Alternaria atrans MP-7, associated with the medicinal plant Psidium guajava. The structure of the new compound was elucidated by spectral data. The antifungal test indicated that (3R,6R)-3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione (2) showed obvious inhibitory activity against Alternaria solani, Colletotrichum gloeosporioides, and Phyricularia grisea. Compared to fusaric acid (1a), even though the antifungal activity of atransfusarin (1) against A. solani, C. gloeosporioides, and P. grisea was greatly decreased, its inhibitory effect against Botrytis cinerea was still retained.
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iScience
·
2024
·
IF 4.6
Jiawei Wang,Xingyu Ouyang,Shiyu Meng,Jiayi Li,Liangxu Liu,Chaofeng Li,Hengrun Li,Haotian Zheng,Chao Liao,Yi-Lei Zhao,Jun Ni
Lignin valorization is crucial for achieving economic and sustainable biorefinery processes. However, the enzyme substrate preferences involved in lignin degradation remain poorly understood, and low activity toward specific substrates presents a significant challenge to the efficient utilization of lignin. In this study, we investigated the substrate promiscuity of Th Ado, a key enzyme involved in lignin valorization. Pre-reaction state analysis revealed that a hydrogen bond network is critical in determining substrate selectivity. By performing targeted saturation mutagenesis on residues surrounding the substrate tunnels, we identified the Y205W and Y205Q mutants, which demonstrated 0.73-fold and 0.72-fold enhancements in activity, respectively. Structural analysis indicated that the redirection of the original substrate tunnel may be responsible for the improved activity. Our study provides essential insights into the substrate preference mechanisms of lignin degrading enzymes and suggests that this tunnel-redirection strategy can be extended to other promiscuous enzymes.
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PubMed
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Gaobo Lou,Xingwei He,Wangbin Zhang,Qingqing Rao,Shenyuan Fu,Lina Liu,Yi Kuang,Jinfeng Dai
In this study, phytic acid (PA) and 1,10-diaminodecane (DAD) were neutralized in a single step to develop the biobased ionic complex PA-DAD, which was then utilized as a toughener to increase the toughness of epoxy resin (EP). As a result of the sacrificial ionic bonds between DAD and PA, the fracture toughness of composites containing PA-DAD was substantially enhanced. Compared to neat EP, the tensile and flexural toughness of composited EP increased by 697 and 1028%, respectively, when PA-DAD was added at 6 wt %. Additionally, impact, tensile, and flexural strengths were enhanced by 201, 42, and 45%, respectively. Moreover, the modified EP had favorable flame retardancy due to the high phosphorus concentration of PA-DAD. The EP/6% PA-DAD showed a 27.7, 24.2, and 29.6% decrease in total smoke production, total heat release, and peak heat release rate, respectively, as compared to neat EP. The results of this investigation suggested a simple approach to toughening EP systems, which would expand the use of biobased tougheners.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mengqian Zhao,Yu Zheng,Yefei Wu,Jingjing Jiang,Jianwei Lu,Jian Yin,Xuwei Long
The development of efficient and biocompatible antibacterial agents is crucial to address multidrug resistance resulting from the abundant abuse of antibiotics; however, this endeavor remains challenging. This study prepared a zwitterionic rhamnolipid derivative (di-RLs-Arg-OH) containing both guanidine and carboxyl groups via amide condensation and demethylation reactions. This new derivative manifested improved antibacterial activity and reduced cytotoxicity against blood and NIH/3T3 cells compared with di-rhamnolipids. The MIC of di-RLs-Arg-OH against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) was lowered to 32–256 mg/L, while the HC 50 was as high as 917 mg/L. The involved mechanism might be attributed to the zwitterionic property of di-RLs-Arg-OH, which contains both carboxyl and guanidine groups. The findings in the present study facilitate the design of biosurfactant-based derivatives as bio-friendly antibacterial agents.
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PHARMACOLOGICAL RESEARCH
·
2025
·
IF 10.5
Ning Yu,Shule Zhang,Rui Fang,Yingxin Zhang,Xi Xu,Lijuan Cao,Jianfa Zhang
Clinically approved thrombolytic agents carry significant bleeding risks due to systemic plasminogen activation. Heparin analogs prevent thrombus formation but lack direct thrombolytic activity. Here, we report a previously unrecognized thrombolytic mechanism of octaparin, a synthetic heparin analog. Studies demonstrated that octaparin exhibits potent anticoagulant and thrombolytic activity both in vitro and in vivo , with a lower bleeding risk compared to conventional heparin-based agents. Octaparin directly binds fibrin monomers, altering their secondary conformation to inhibit polymerization and destabilize preformed thrombi, while preserving tissue factor-driven coagulation. In murine models of pulmonary embolism and inferior vena cava thrombosis, octaparin both prevented and dose-dependently dissolved established clots without compromising hemostatic integrity, sharply contrasting with conventional thrombolytics that induce hemorrhage. Further analyses using molecular docking, microscale thermophoresis, and spectroscopy confirmed that octaparin induces changes in fibrin monomer folding that compromise fibrin network stability. In human systems, octaparin selectively prolonged intrinsic coagulation time, reduced clot retraction, did not induce platelet activation, and its effects were reversible with protamine sulfate. This study establishes targeted fibrin destabilization as a viable therapeutic strategy, revealing a previously unrecognized thrombolytic mechanism achievable through heparin-based molecular design.
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PubMed
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