Journal of Burn Care & Research
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2025
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IF 1.8
Deng Yuchen,Wen Chao,Wang Fang
BackgroundDespite the advancements of pharmacological treatments and gauze dressings in the field of skin wound healing, these methods present numerous limitations. Therefore, developing a multifunctional material capable of efficiently promoting skin wound healing is particularly crucial.MethodsCitric acid (CA)-modified chitosan (CS) loaded with Shikonin (SK) (CA-CS-SK) hydrogel was prepared via the freeze–thaw method. The physical properties of the hydrogel were profiled through FTIR, SEM, rotational rheometry, swelling experiment, degradation rate analysis, and drug release experiments. Furthermore, the biocompatibility of the hydrogel was comprehensively evaluated through hemolysis assay, CCK-8 cytotoxicity detection, and live/dead cell staining. Antimicrobial activity against E. coli and S. aureus of the hydrogel was gauged in vitro, and its therapeutic performance was ultimately validated in a mouse full-thickness wound model through H&E staining and ELISA.ResultsThe CA-CS-SK hydrogel exhibited appropriate rheological properties, swelling ratio, degradation rate, and drug release rate. It effectively suppressed the proliferation of E. coli and S. aureus, with superior inhibitory effects compared to CA-CS hydrogel and SK alone. Additionally, the hydrogel showed no significant toxicity to human dermal fibroblasts and did not cause erythrocyte rupture. Animal model experiments demonstrated that, compared to cotton gauze, CA-CS hydrogel, and SK, the CA-CS-SK hydrogel reduced levels of TNF-α and IL-6 at the wound site, alleviated the inflammatory response, and promoted wound healing.ConclusionThe CA-CS-SK hydrogel possesses high antibacterial activity, excellent biocompatibility, and efficient wound healing promotion capabilities, making it a highly promising material for skin wound treatment.
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Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 16
·2634-2642
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IF 5.047
Yulin Jiang,Yi Deng,Ying Tu,Birol Ay,Xiaodong Sun,Yubao Li,Xiaohong Wang,Xianchun Chen,Li Zhang
Chitosan-based guided tissue regeneration (GTR) membranes are extensively used in orthopedic/stomatological regenerative medicine since chitosan shares many chemical and structural similarities with glycosaminoglycans (GAGs) in the extracellular matrix. However, the available chitosan-based GTR membranes mostly lack topological features of natural tissues, resulting in unsatisfactory biocompatibility. To address this limitation, we developed a novel biologically-inspired asymmetric topological chitosan (ATCS) membrane supported by a nanoporous anodic aluminum oxide (AAO) template. We, thereafter, investigated the mechanical properties, degradation, and cytocompatibility of the ATCS membranes and compared them with those of the symmetric chitosan (SyCS) membranes, produced with a smooth Al template. The asymmetric topological structure significantly increased the tensile strength but decreased the extent of degradation of the ATCS membranes compared to those of SyCS. In the in vitro studies, the ATCS membranes outperformed the SyCS membranes in cytocompatibility due to their cell-like features. In addition to the ATCS membranes, the ethylene vinyl acetate (EVA) membranes with a similar cell-like structure were successfully fabricated using the AAO template to verify the universality of the AAO template-assisted technique. Accordingly, the AAO template-assisted strategy, defined in this study, is an innovative, universal, and facile way to fabricate polymeric asymmetric membranes with cell-like features. The bioengineered ATCS membranes with tunable degradability, prominent mechanical properties and biocompatibility are promising candidates for orthopedic healthcare applications.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Zhipeng Yang,Hongqiang Li,Shifeng Zhang,Xuejun Lai,Xingrong Zeng
Flexible and wearable pressure sensors have attracted considerable attention for the wide application prospect in robot sensing, intelligent electronic skin and healthcare monitoring. Herein, a superhydrophobic MXene-coated carboxylated carbon nanotubes (C-CNTs)/carboxymethyl chitosan (CCS) aerogel with honeycomb-like porous microstructure was proposed for piezoresistive pressure sensor. Firstly, a C-CNTs/CCS aerogel with superior robustness, resilience and durability was fabricated via directional freeze-drying method. Secondly, the C-CNTs/CCS aerogel was dip-coated with a layer of MXene nanosheets and then chemically modified with 1H,1H,2H,2H-perfluorooctyltriethoxysilane (FAS). The obtained F-MXene@C-CNTs/CCS aerogel demonstrated superhydrophobicity and the water contact angle and artificial sweat contact angle reached 157° and 154°, respectively. Thanks to the synergism of the dual-conductive MXene-CNTs network, the aerogel-based pressure sensor realized fast response time (62 ms), wide detection range (up to 80 kPa) as well as excellent electrical stability and repeatability even under humid and sweaty environments. Additionally, the sensor was successfully applied for monitoring human motions including not only large-scale actions (joint movements, walking and running) but also small-scale muscle movements (pronunciation recognition and finger tapping). Interestingly, the sensor connected to an Arduino microcontroller circuit with Bluetooth module was able to wirelessly detect real-time movements of finger joints. Our findings conceivably stand out as a new strategy to fabricate high-performance piezoresistive pressure sensors for wide applications even at special working conditions.
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CHEMICAL PHYSICS LETTERS
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2025
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IF 3.1
Guozheng Zhao
In this study, a sandwich-type immunoassay was employed for the simultaneous detection of four glucocorticoids (cortisone, clobetasol 17-propionate, triamcinolone, and dexamethasone) using graphene (GNP)-chitosan (CHI)\nanogold\glucocorticoid receptor (GR) bioimmunosensor. A novel strategy was developed, which involved the integration of surface modification technology, electrochemical detection technology, and immunoassay technology. The electrochemical characteristics of the modified bioimmunosensor were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. The GR concentration and incubation time were optimized to achieve the best detection effect. The differential pulse voltammetry (DPV) response sequence based on the identical concentration level was found to be cortisone > clobetasol 17-propionate > triamcinolone > dexamethasone. The bioimmunosensor demonstrated excellent performance characteristics with a wider linear range of 0.5–7000 ng⋅mL −1 , lower detection limit of 0.071–0.106 ng⋅mL −1 , better stability and repeatability. Cortisone and clobetasol 17-propionate were detected in skincare samples and achieved satisfactory test results.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Danyang Wang,Yuming Zhou,Xiaoting Wang,Xiaopu Ji,Yiying Wei,Shengdi Tong,Jinghui Hu,Haiqing Song,Zonglei Mou,Guofeng Zhang,Bo Cong,Wan Ru Sun,Pingyu Wang,Yuqiang Zhang,Shuyang Xie,Ranran Wang
Natural conductive hydrogels are regarded as desirable materials for motion monitoring owing to their outstanding biocompatibility and degradability. It has been reported that the occurrence rate of injuries in the final 30 % of the activity is closely associated with fatigue-induced changes in neuromuscular control. However, most hydrogels are designed solely for motion state and electromyography (EMG) detection and do not provide the capability to alleviate muscle fatigue. The development of conductive hydrogels that integrate motion monitoring with fatigue alleviation could enable simultaneous fatigue detection and on-demand fatigue relief, thereby reducing the risk of sports-related injuries. Photothermal therapy has been proven to be an effective method for relieving muscle fatigue. In this study, a double-network hydrogel composed of chitosan and sodium alginate was prepared, which incorporates lignin‑silver nanoparticles (NPs) and melanin NPs to achieve effective motion monitoring and photothermal therapy. A physical cross-linking network formed via electrostatic interactions between chitosan and sodium alginate was reinforced with a Genipin-mediated chemical cross-linking network. The addition of lignin‑silver NPs enhanced the hydrogel's conductivity and mechanical integrity, whereas melanin NPs improved adhesion and conferred photothermal responsiveness. The resulting hydrogel enabled reliable motion monitoring and real-time identification of exercise-induced fatigue through EMG. Upon fatigue detection, the photothermal properties of the hydrogel facilitated rapid fatigue alleviation.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2025
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IF 7.8
Gaotian Li,Panpan Li,Jianguo Zhang,Chi Zhao,Yirui Lan,Shuang Zhao
To overcome the low removal efficiency of common flocculants for bacterial pollutants, herein, a series of quaternary phosphine groups (QPGs)–modified chitosan (CTS)-based flocculants (CTS-P) was proposed. The removal efficiency of CTS-P for Escherichia coli ( E. coli ) and other coexisted pollutants was evaluated. The binding mode and interaction mechanism between CTS-P and E. coli were elucidated using theoretical calculations. Results showed that flocculation performance of CTS-P was the most efficient in near-neutral water (pH = 6–8). The removal efficiencies of CTS-P (10 mg/L) for humic acid and E. coli is 71 % and 1.82 1og, respectively, and the removal process was dominated by charge neutralization and adsorption bridging effects. The QPGs increased the charge density of the coagulation system and promoted the formation of large particle flocs. During the collision and growth processes of flocs, E. coli was quickly flocculated onto their surface and encapsulated within them. The binding of the QPGs to the cell membrane leads to E. coli cell death and structural rupture. Theoretical calculations show that the interfacial interaction energy of CTS-P for capturing E. coli is dominated by intermolecular interaction energy and polar interaction energy. The CTS-P flocculant proposed in this study provides a new pharmaceutical product and a theoretical basis for removing bacterial pollutants from drinking water sources.
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INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Mengting Yu,Yujing Sun,Na Ji,Lei Dai,Man Li,Xuyan Dong,Liu Xiong,Qingjie Sun
Superhydrophobic coatings have gained significant interest due to their ability to prevent liquid foods like juice and yogurt from adhering to the inner surfaces of containers, thus reducing waste. Superhydrophobic coatings limit its application due to its toxicity, degradability and other reasons. In this work, chitosan sodium phytate films were deposited on glass plates by layer-by-layer self-assembly (LBL), then SiO 2 nanoparticles were introduced to construct micro/nano-structures, and finally, surface modification with polydimethylsiloxane (PDMS) was carried out to prepare superhydrophobic films. The surface of the superhydrophobic film had a micro/nano-scale structure similar to that of lotus leaves. The water contact angle (WCA) of superhydrophobic films reached 153°, and sliding contact angle (SA) was 5°. Owing to this unique structure, different liquid food droplets could roll off freely in a near spherical form on the chitosan phytate film surfaces, effectively reducing residue during container pouring. The outcomes of this study are expected to expand the potential applications of superhydrophobic chitosan films in liquid food anti-adhesion.
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ACS Applied Bio Materials
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2025
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IF 4.7
Yuanhong Zhou,Ziyuan Zong,Xiaofang Liu,Xiang Chen,Zhifeng Hao,Mohamed S. Selim,Jian Yu
Hydrogels have received significant attention in the biomedical field, but traditional antibacterial hydrogels have certain limitations in terms of antibacterial activity, resistance, and functionality. In this study, we present a multifunctional hydrogel synthesized through a one-step process using carboxymethyl chitosan (CMCS) as the matrix, tannic acid (TA) as the cross-linking agent, and penicillin (PG)-loaded MXene as the drug additive, for antibacterial therapy. In this system, the composite hydrogel is physically cross-linked through ionic bonds and hydrogen bonds between CMCS and TA, exhibiting good injectability, self-healing properties, and tissue adhesiveness. The incorporation of MXene drug-loaded with penicillin imparts photothermal properties to the hydrogel, thereby enabling a synergistic antibacterial effect between the components, resulting in stable antibacterial activity. In addition, the hydrogel exhibits favorable biocompatibility, as well as the capacity to scavenge reactive oxygen species (ROS) and rapidly arrest hemorrhaging, showing promising applications in wound care.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Song Zhang,Yang Shen,Peng Qiu,Mengjia Fang,Peichuang Li,Xiangning Du,Zhengying Deng,Wanhao Cai,Hui-Li Wang
The specific binding capacity between chitosan and heavy metal ions is critical in food safety, which is closely regulated by its degree of deacetylation (DD). However, the underlying mechanism governing the impact of DD remains unclear. Here we employ a combination of experiments and simulations to study the interaction between chitosan and Pb 2+ across multiscale at different DD. At the molecular level, Pb 2+ can chelate individual chitosan chains simultaneously via multiple interaction sites, which is enhanced with rising DD and leads to more ordered molecular packing. This molecular arrangement then develops to a nanoscale aggregation process, where the aggregation size, rate, and mechanical stability all show a positive correlation with DD. Such aggregation ultimately leads to enhanced macroscale structures, where the strain and tensile stress are significantly increased by 2 to 3-folds and further rises with increasing DD. These observed effects are governed by a unified mechanism: deacetylation introduces more amino groups that serve as stronger chelation sites than acetyl groups, thereby enhancing Pb 2+ binding across length scales. These findings provide foundation for the development and application of chitosan in the food industry, such as food preservation, anti-heavy-metal packaging, and food purification.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Xiangtao Tang,Lihong Lu,Fang Yang,Xingyu Zhong,Hongfa Shi,Wenqing Zhang,Lingfan Zhang
The treatment of radioactive wastewater containing 90 Sr required advanced adsorbents to address the limitations of the recyclable usage. In this study, a UiO-66-NH 2 @Chitosan/Loofah Fiber Composite (UNCL) was synthesized using an impregnation strategy, enabling easy separation from the solution and efficient Sr 2+ removal. By integrating the good adsorption activity of UiO-66-NH 2 , interfacial modification capability of chitosan, and macrostructural advantages of loofah fiber, the composite achieved enhanced mass transfer efficiency and structural stability. UNCL achieved adsorption equilibrium within 120 min, demonstrating rapid and efficient strontium capture capability. The material demonstrated robust performance under alkaline conditions, and retained high efficacy in real river water and seawater environments. Adsorption behavior aligned with the Sips isotherm model (R 2 = 0.999) and pseudo-second-order kinetics (R 2 = 0.995) with maximum adsorption capacity of 7.64 mg/g, confirming monolayer chemisorption. Mechanistic investigations, supported by FT-IR and XPS analyses, revealed a synergistic mechanism involving ion exchange, surface complexation and electrostatic interactions at multiple active sites. UNCL maintained approximately 90 % removal efficiency after five adsorption–desorption cycles and enabled facile separation from aqueous solutions through simple mechanical retrieval. These results demonstrated that UNCL combined adsorption ability, reusability, and environmental adaptability, positioning it as a promising and practical solution for Sr 2+ remediation.
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RSC Advances
·
2017
·Vol. 7
·期 28
·17005-17019
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IF 3.108
Shifeng Yan,Taotao Wang,Xing Li,Yuhang Jian,Kunxi Zhang,Guifei Li,Jingbo Yin
Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(L-glutamic acid)/chitosan (PLGA/CS) hydrogels were fabricated by self-crosslinking aldehyde-modified PLGA (PLGA–CHO) and lactic acid-modified chitosan (CS–LA). The oxidation degree of PLGA–CHO and degree of substitution (DS) of CS–LA could be adjusted by the amount of sodium periodate and lactic acid, respectively. The effect of the solid content of the hydrogels, oxidation degree of PLGA–CHO and CS–LA/PLGA–CHO mass ratio on the gelation time, gel content, water uptake, mechanical properties, microscopic morphology, and in vitro degradation of the hydrogels was examined. The pH and ion sensitivity of PLGA/CS hydrogels was also examined. Encapsulation of rabbit chondrocytes within the hydrogels showed viability of the entrapped cells and cytocompatibility of the injectable hydrogels. The injectable PLGA/CS hydrogels demonstrated attractive properties for future application in pharmaceutical delivery and tissue engineering.
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JOURNAL OF POROUS MATERIALS
·
2024
·Vol. 31
·期 2
·673-684
·
IF 2.5
Zhao Dongliang,Zhou Peng,Li Xiangzhou,Song Ke
Mesoporous carbon has become a research hot spot due to its excellent properties and broad application prospects. In this study, mesoporous carbon was synthesized simply by carbonizing a composite of chitosan (CS) and nano-barium carbonate, taking advantage of the excellent flocculability of CS. The structure and morphology of chitosan-based mesoporous carbon (CSMC) were characterized using BET, SEM, FT-IR, XRD, XPS and Raman techniques. The results revealed that CSMC possessed a graphitic and diamond-like structure consisting of C (92.8%), O (6.9%) and N (0.3%). The mass ratio of BaCO 3 /CS played an important role in pore formation, with CSMC5 exhibiting a specific surface area and mesoporous surface area up to 2211 and 1119 m 2 /g, respectively. The adsorption performance of CSMC was tested with chlorogenic acid (CA) as the adsorption object. The saturated adsorption capacity of CSMC for CA was up to 742.52 mg/g and the adsorption rate was rapid. The adsorption behavior of CA by CSMC conformed to Langmuir isothermal adsorption model and pseudo-second-order kinetic model. Thermodynamic parameters indicated that the adsorption of CA by CSMC was exothermic and reversible. This study provides a promising approach for the synthesis of chitosan-based mesoporous carbon materials and potential applications in sustainable technologies.
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