Journal of Functional Foods
·
2024
·
IF 3.8
Zhi-guo Wu,Nan Jin,Yu-feng Deng,Xin-fang Shen,Cui-yun Liu,Bao-yue Ding,Long-hua Guo,Yun-xiao Liu,Zhen-rong Huang,Lei Li,Shui-lin Sun,Bao-gang Xie
The contents of selenomethionine (SeMet) and selenomethylcysteine (SeMC) in Selenium-Enriched black garlic extract (Se-BGE), a popular functional food in Asian countries, were 2.9 ± 0.6 μg/g and 12.2 ± 2.3 μg/g by PITC pre-column derivatization UPLC-MS method. Improved histological injury, significant extension of the median survival time, and attenuated serum levels of alanine aminotransferase, total bilirubin and SOD activity were observed in the acute liver failure (ALF) rats treated with Se-BGE (1.0 g/mL). 1 HNMR-based metabonomics revealed that serum levels of lactate, pyruvate, betaine, choline, taurine, and glycine were restored, and 16S rDNA sequencing analysis showed that the composition and number of the intestinal flora were regressed to healthy levels in ALF rats treated by Se-BGE. Serum choline and betaine showed significant correlations with g_Lactobacillus and g_Escherichia. Our findings demonstrated that Se-BGE protects against LPS/D-GalN-induced ALF in rats, possibly due to antioxidation, metabolism, and intestinal flora regulations of Se-BGE.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·Vol. 38
·期 3
·e10760
·
IF 26.8
Jing Li,Xiaotao Zhang,Jinpeng Li,Xiaoyu Zheng,Minghui Li,Jiadong Zhou,Erhong Song,Yao Zhou
Metal-based site, as an important type of active site, plays the benchmarking role in the redox and charge transfer processes in the heterogeneous catalysis. Modulating the valence state of metal site as a promising and simple strategy theoretically enables control over the adsorption strength of reaction intermediates. However, this strategy is intrinsically limited by the local atomic configuration, often leading to unpredictable catalytic failures. Here, it is reported that the intermediate adsorption strength of platinum active site with different valence states exhibits a linear relationship with the d-band width of Pt (W d -Pt ). Adjusting the nearest-neighbor coordination environment of Pt sites by changing the transition metals bonded to Pt effectively modulates the W d -Pt , which offers a high activity (η 10 = 14 mV) in the hydrogen evolution reaction (HER). W d -Pt broadening elevates the Pt─H anti-bonding states across the Fermi level, strengthening active site-absorbate interactions and thereby tuning HER catalytic activity. In addition, this d-band width engineering strategy can be expanded to other catalysts with the metal active site. The present study transcends limitations in valence state modulation and sheds light on deeper understanding of d-band structure of metal sites and a methodology to boost the activity of metal sites in heterogeneous catalysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Dijun Zhang,Jiaojiao Han,Yanyan Li,Bei Yuan,Jun Zhou,Lingzhi Cheong,Ye Li,Chenyang Lu,Xiurong Su
To discern whether tuna oil modulates the expression of brain proteins and the gut microbiota structure during aging induced by d-galactose, we generated an aging mouse model with d-galactose treatment, and the mice showed aging and memory deterioration symptoms according to physiological and biochemical indices. Treatment with different doses of tuna oil alleviated the symptoms; the high dose showed a better effect. Subsequently, brain proteomic analysis showed the differentially expressed proteins were involved in damaged synaptic system repairment and signal transduction system enhancement. In addition, tuna oil treatment restored the diversity of gut microbiota, 27 key operational taxonomic units, which were identified using a redundancy analysis and were significantly correlated with at least one physiological index and three proteins or genes. These findings suggest that the combination of proteomics and gut microbiota is an effective strategy to gain novel insights regarding the effect of tuna oil treatment on the microbiota–gut–brain axis.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2022
·Vol. 194
·期 11
·5274-5291
·
IF 3.094
Lei Jiping,Tang Kexin,Zhang Ting,Li Yan,Gao Zhen,Jia Honghua
2-O-α-D-Glucosyl glycerol (2-αGG) can be used as a multipurpose anti-aging, cell-stimulating, and skin moisturizing agent in the cosmetic industry. Sucrose phosphorylase (SPase) has been widely used in the production of 2-αGG. In this paper, the gene encoding sucrose phosphorylase from Bifidobacterium longum (BlSP) was inserted into pRSF-Duet-1 to construct the recombinant plasmid pRSF-BlSP and was functionally expressed in E. coli BL21(DE3) to be used as a biocatalyst for the synthesis of 2-αGG firstly. The mutations of BlSP were carried out based on alanine scanning, and a positive mutant G293A with a 50% increase in activity for 2-αGG production was identified. Mutant G293A has less K m and bigger k cat / K m towards glycerol than the parental BlSP. Subsequently, the production of 177.6 g/L 2-αGG was attained from 1 M sucrose and 1.2 M glycerol catalyzed by 17 mg/mL G293A mutant. This study indicated that BlSP has good potential in the production of 2-αGG.
✓ 已验证
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2014
·
IF 4.787
Yuling Bao,Yuanyuan Guo,Xiangting Zhuang,Dan Li,Bolin Cheng,Songwei Tan,Zhiping Zhang
To overcome the multidrug resistance (MDR) of P-glycoprotein (P-gp) substrate anticancer drugs, such as paclitaxel (PTX), a novel dual-functional prodrug, D-α-tocopherol polyethylene glycol succinate (TPGS) based PTX prodrug (TPGS-S-S-PTX), was synthesized here to fulfill the synergistic effect of P-gp inhibiting and intracellular redox-sensitive release. The prodrug could self-assemble into stable micelles in physiological environment with a diameter of ∼140 nm, while it disassociated in reductive condition and released PTX and TPGS active derivatives rapidly. High cell cytotoxicity in PTX-resistant human ovarian cell line A2780/T was observed with enhanced PTX accumulation due to the P-gp inhibition by the TPGS moiety. The IC50 of TPGS-S-S-PTX was 55% and 91% more effective than that of Taxol (clinical formulation of PTX) and uncleavable TPGS-C-C-PTX prodrug, respectively. This was found to be related with the increased apoptosis/necrosis and cell arrest in G2/M phase. In vivo evaluation of the TPGS-S-S-PTX prodrug exhibited an extended half-life, increased AUC (area under the concentration–time curve), enhanced tumor distribution and significant tumor growth inhibition with reduced side effects as compared to Taxol and TPGS-C-C-PTX. This prodrug has great potential in improving efficiency in the treatment of MDR tumors.
✓ 已验证
DOI
PubMed
高影响因子
Oxidative Medicine and Cellular Longevity
·
2018
·
IF 4.936
Kaiyue Sun,Pengyu Yang,Rong Zhao,Yuting Bai,Zijiao Guo
The present study was designed to evaluate the effects of matrine (MAT) on D-galactose- (D-gal-) induced aging and relative mechanism. Vitamin E at the dose of 100 mg/kg was used as a standard positive control. MAT significantly improved the D-gal-induced recognition and spatial memory impairment in novel object recognition and Y maze tests, and exercise endurance decreased in the weight-loaded swimming test at 2 and 10 mg/kg. We found that D-gal treatment induced noticeably aging-related changes such as reducing thymus coefficients, increasing the pathological injury and cellular senescence of liver, spleen, and hippocampus, as well as an increase in cyclin-dependent kinase inhibitor p16, p19, and p21 gene expression and the interleukin-1β expression in the liver and hippocampus. MAT showed effective protection on such changes. Furthermore, MAT decreased the oxidative stress of the liver, plasma, and brain, as evidenced by increased total antioxidant capacity, total superoxide dismutase, and catalase activities and decreased the malondialdehyde level. Additionally, there was a significant positive correlation between swimming time in weight-loaded swimming time and thymus index. MAT ameliorated aging-related disorder caused by D-gal through the inhibition of both cellular senescence and oxidative stress. The study provides further evidence for drug development of MAT for prevention or treatment of the aging-associated disorder.
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 46
·期 2
·592-598
·
IF 3.591
Rui Wang,Wei Zhang,Ying Tang,Ze-Hui Qi,Yuan-Hui Yu,Hong-Bo Tan,Dian-Yong Tang,Zhi-Gang Xu,Zhong-Zhu Chen
An efficient one-pot four-component reaction for the synthesis of a new family of novel bridgehead nitrogen-containing pyrido[1,2-d][1,4]diazepines has been described and its mechanism has been proposed, which follows a ring-closure and ring-cleavage pathway. The protocol involved a cyclization through γ-selective C–C bond formation, an intramolecular Michael addition and a ring-opening of a pyranone ring under refluxing conditions with high to excellent yields. The advantages of this methodology, including the use of easily available raw materials and an inexpensive catalyst, an open-air reaction setup, wide functional group tolerance, and gram-scale synthesis, make the developed methodology a practical way to access novel pyrido[1,2-d][1,4]diazepines and functionalized tricyclic or polycyclic fused 1,4-diazepines as well as novel analogs of important biologically active molecules.
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 6
·1595
·
IF 5.076
Jing Qi,Tianli Wu,Mengyao Xu,Dan Zhou,Zhubing Xiao
To address the challenge of highly efficient water splitting into H2, successful fabrication of novel porous three-dimensional Ni-doped CoP3nanowall arrays on carbon cloth was realized, resulting in an effective self-supported electrode for the electrocatalytic hydrogen-evolution reaction. The synthesized samples exhibit rough, curly, and porous structures, which are beneficial for gaseous transfer and diffusion during the electrocatalytic process. As expected, the obtained Ni-doped CoP3nanowall arrays with a doping concentration of 7% exhibit the promoted electrocatalytic activity. The achieved overpotentials of 176 mV for the hydrogen-evolution reaction afford a current density of 100 mA cm−2, which indicates that electrocatalytic performance can be dramatically enhanced via Ni doping. The Ni-doped CoP3electrocatalysts with increasing catalytic activity should have significant potential in the field of water splitting into H2. This study also opens an avenue for further enhancement of electrocatalytic performance through tuning of electronic structure andd-band center by doping.Keywords:transition-metal phosphide;electrocatalyst;hydrogen-evolution reaction;density-functional theory
✓ 已验证
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-7
·
IF 3.246
Wang Beilei,Shan Xiaoxiao,Lv Shujie,Zha Liqiong,Zhang Caiyun,Dong Qiannian,Chen Weidong
3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and − 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC 0→600 ) and half-life (t 1/2 ) of Gal-Res NPs were enhanced 1.82-fold and 2.19-fold higher than those of raw Gal-Res. The in vivo biodistribution results showed that Gal-Res NPs were more distributed in liver tissue than Gal-Res. Gal-Res NPs with high bioavailability and liver accumulation were hopeful drug delivery systems (DDS) to treat liver diseases. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Yingyuan Zhao,Jing Guo,Anmin Liu,Tingli Ma
2D materials and their composites are promising energy storage candidates. In this work, 2D horizontal heterostructure comprised of Ni 3 S 2 /delaminated-Ti 3 C 2 , denoted as Ni 3 S 2 /d-Ti 3 C 2 , supported on Ni foam is prepared by a two-step method and used as binder free electrode for hybrid supercapacitor . The as-obtained composites are characterized by X-ray diffraction analysis, scanning electron microscope, transmission electron microscope and X-ray photoelectron spectroscopy. The electrochemical properties of Ni 3 S 2 /d-Ti 3 C 2 on Ni foam (denoted as Ni 3 S 2 /d-Ti 3 C 2 /NF) are studied using cyclic voltammetry , galvanostatic charge-discharge analysis and electrochemical impedance spectroscopy . It is found that the Ni 3 S 2 /d-Ti 3 C 2 /NF electrode exhibits superior capacitive performance with specific capacity of 2204 F g −1 at a constant current density of 1 A g −1 . A hybrid supercapacitor is fabricated by using Ni 3 S 2 /d-Ti 3 C 2 /NF electrode as positive electrode, active carbon (AC) coated on Ni foam as negative electrode and KOH aqueous solution as electrolyte. The Ni 3 S 2 /d-Ti 3 C 2 /NF//AC hybrid supercapacitor exhibits a maximum energy density of 23.6 W h kg −1 and a maximum power density of 4004.4 W kg −1 . The results supply new strategy for constructing MXene-based 2D horizontal heterostructure, and suggest that Ni 3 S 2 /d-Ti 3 C 2 /NF composite as a binder free electrode is an ideal candidate for supercapacitor applications.
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2016
·
IF 4.055
Jia-Xiang Cheng,Zu-Sheng Huang,Lingyun Wang,Derong Cao
Four novel D–π–A–π–A metal-free organic dyes Q1-Q4 were synthesized and the impacts of the auxiliary acceptors on the photovoltaic performances were studied. Q2 with quinoxaline as the auxiliary acceptor exhibited the best photovoltaic performance due to its highest short-circuit photocurrent density (17.22 mA cm −2 ), leading to a power conversion efficiency of 7.42% under simulated AM 1.5 G illumination. Q1 with the strongest electron withdrawing group (pyrazino[2,3- g ]quinoxaline) as the auxiliary acceptor showed the weakest performance, which can be attributed to electron trap and mismatch of energy-level. The results showed that the different electron-withdrawing property of auxiliary units significantly influenced the absorption, energy levels and photovoltaic performance. Incorporating auxiliary acceptor with moderate electron-deficient ability can extend the absorption range and adjust the molecular orbital energy levels, resulting in better photovoltaic performance.
✓ 已验证
DOI
高影响因子
iScience
·
2023
·
IF 5.8
Jiancheng Zhao,Christian Marcus Pedersen,Honghong Chang,Xianglin Hou,Yingxiong Wang,Yan Qiao
Herein, we report choline chloride-based deep eutectic solvents (DESs) promoted conversion of N -acetyl- d -glucosamine (GlcNAc) into nitrogen-containing compounds, i.e., 3-acetamido-5-(1′,2′-dihydroxyethyl) furan (Chromogen III) and 3-acetamido-5-acetylfuran (3A5AF). The binary deep eutectic solvent choline chloride-glycerin (ChCl-Gly), was found to promote the dehydration of GlcNAc to form Chromogen III, which reaches a maximum yield of 31.1%. On the other hand, the ternary deep eutectic solvent, choline chloride-glycerol-B(OH) 3 (ChCl-Gly-B(OH) 3 ), promoted the further dehydration of GlcNAc into 3A5AF with a maximum yield of 39.2%. In addition, the reaction intermediate, 2-acetamido-2,3-dideoxy- d - erythro -hex-2-enofuranose (Chromogen I), was detected by in situ nuclear magnetic resonance (NMR) techniques when promoted by ChCl-Gly-B(OH) 3 . The experimental results of the 1 H NMR chemical shift titration showed ChCl-Gly interactions with α-OH-3 and α-OH-4 of GlcNAc, which is responsible for promoting the dehydration reaction. Meanwhile, the strong interaction between Cl − and GlcNAc was demonstrated by 35 Cl NMR.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）