CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Bingyun Xi,Xianming Zhang,Shuhan Chen,Shi Qian,Xuanyong Liu
For guided bone regeneration (GBR) membranes, biodegradable magnesium has emerged as a highly promising candidate owing to its intrinsic biofunctionality associated with Mg 2+ release and its superior mechanical properties. However, achieving spatiotemporally controlled degradation that precisely matches the kinetics of new bone formation remains a critical challenge. To address this issue, a self-reinforcing interfacial diffusion system was engineered on magnesium in this study. Based on this concept, a multilayered magnesium oxide (MgO)/sodium alginate (SA) composite coating was fabricated and stabilized via Ga 3+ -mediated coordination and ionic crosslinking. This coating was strategically designed as a three-dimensional barrier to govern Mg 2+ release through diffusion-limited transport across the solid–hydrogel interface. Notably, during degradation, the released Mg 2+ dynamically coordinate with SA chains on top of the pre-existing trivalent ion-mediated crosslinked network, triggering progressive hydrogel network densification and consequent in situ formation of a self-reinforcing protective layer. Comprehensive in vitro biological evaluations demonstrate that the coating exerts multifunctional bioactivity via synergistic release of Mg 2+ and Ga 3+ . Specifically, it enhances osteogenic differentiation and proliferation of osteoblast, while also promoting human umbilical vein endothelial cell proliferation, migration, and tube formation for pro-angiogenic capacity. Furthermore, the sustained, low-dose release of Ga 3+ endows the system with broad-spectrum antibacterial activity. By integrating corrosion resistance, osteogenesis, pro-angiogenic functionality and antibacterial efficacy into a single dynamic platform, this system transcends conventional passive barrier strategies and enables active, biology-informed regulation of the regenerative microenvironment. Consequently, it establishes a robust and translational foundation for next-generation magnesium-based GBR membranes, with strong potential for clinical application in oral and maxillofacial bone reconstruction.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Zhao Rui,Li Jian,Ma Yunze,Zhang Huajiang,Geng Zhanhui,Li Hanyu,Wang Yuepeng,Xia Ning,Xu Lina
Cooked beef is susceptible to moisture loss and oxidative reactions during long-term frozen storage, resulting in quality degradation and considerable loss of commercial value. This research develops an edible antioxidant coating utilising gelatin hydrolysate (GH) and sodium alginate (SA) to establish a safe and effective preservation technology. The GH-4 sample with high antioxidant activity was prepared via controlled enzymatic hydrolysis, leveraging the efficient hydrolytic activity of alkaline proteases and their specific cleavage of hydrophobic amino acid sites in gelatin macromolecules. Research indicates that GH-4 primarily consists of bioactive peptides with molecular weights below 2000 Da (91.63%). The incorporation of GH significantly enhanced the rheological properties, thermal stability, and barrier performance of the SA-based coating while substantially improving its antioxidant activity. FTIR and XRD analyses confirmed excellent compatibility between the two components. This composite coating significantly reduced thawing loss, color and texture deterioration, and microbial growth in cooked beef during six months of frozen storage, while effectively inhibiting increases in TVB-N and TBARS levels. This study demonstrates that the GH/SA composite coating combines physical barrier properties with bioactive characteristics, establishing it as a highly promising natural preservation method for maintaining the quality and extending the shelf life of frozen cooked meat products. Graphical abstract The alternative text for this image may have been generated using AI.
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 1
·121008
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IF 7.2
Bihe Chen,Ruoshan Yang,Mengyang Li,Yajing Niu,Jinyao Hu,Yingying Wang,Wenzhi Tang,Jingbo Zhou,Zhonghong Li
The threat of Pb(II) and Cd(II) in water demands advanced adsorbents. While metal-organic frameworks (MOFs) have demonstrated great potential for heavy metal ions adsorption, their microporous nature and powdery form limit practicality. Thus, we engineered a sodium alginate composite aerogel bead loaded with salicylic acid-modified defective NH 2 -MIL-125, for the efficient removal of Pb(II) and Cd(II) from aqueous solutions. By adjusting the solvent volume ratio to regulate the crystal morphology and introducing salicylic acid as a fragmented ligand to compete with NH 2 -BDC to coordinate with Ti-oxo clusters, a defective Ti-MOFs with mesoporous structure (pore size increased from 2.30 to 8.93 nm) and abundant active sites was successfully developed. Further integration with sodium alginate formed millimeter-scale aerogel beads, improving the reusability and enhancing adsorption performance: the maximum adsorption capacities of 428.01 mg g −1 for Pb(II) and 179.67 mg g −1 for Cd(II), respectively. The adsorption process, described by the pseudo-second-order kinetic and Sips isotherm models, is driven by multilayer chemical adsorption via electrostatic attraction, ion exchange and coordination reactions with −COOH, −NH 2 and −OH groups. The beads also exhibit excellent selectivity and reusability, maintaining high efficiency of ∼97 % for Pb(II) over 5 cycles. This work provides a promising strategy for designing high-performance and recyclable adsorbents for adsorbing heavy metal ions from water.
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Food Packaging and Shelf Life
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2022
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IF 8.749
Jinsong Li,Xiaoli Qin,Xiong Liu,Jiaqi Li,Jinfeng Zhong
This study aimed to develop rice protein (RP)/sodium alginate (SA)-based biodegradable films with excellent properties by incorporating cellulose nanocrystals (CNCs) and rosemary extract. Effects of the RP/SA weight ratio and CNCs content on the physical properties of the films were investigated, and the improved performance was illustrated by Fourier Transform Infrared spectroscopy and molecular dynamics (MD) simulation. As the RP/SA weight ratio varied from 5:0–1:1, the tensile strength (TS) of the films was increased by 143%, water vapor permeability (WVP) and oil permeability were significantly reduced by 22% and 99.2%, respectively. As the CNCs content increased to 0.3%, the TS was enhanced by 51% and the WVP was reduced by 14%. The improved mechanical and barrier properties of the films were possibly attributed to the formation of a more homogeneous and compact structure observed by scanning electron microscopy. In addition, MD simulation results revealed that there were high number of hydrogen bonds and strong electrostatic interactions in the RP/SA/CNCs/RE system, which may also lead to the improvement of mechanical and barrier properties of films. Finally, the films effectively attenuated oil oxidation . The developed films with enhanced properties are potential food packaging materials.
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CHEMOSPHERE
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2022
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IF 8.943
Yu Du,Qizhen Zhang,Manli Yu,Bin Jiao,Fuliang Chen,Mingming Yin
Excessive copper (Cu) concentrations pose significant health risks to both plants and humans. In this study, sodium alginate (SA)-gelatin (GEL)-polyvinyl pyrrolidone (PVP)- embedded dinotefuran (DIN) microspheres were prepared using spray-drying technology . The loading content and encapsulation efficiency of optimal microspheres determined by physical modifications were 19.77% and 99.32%, respectively. In addition, the microspheres showed variable stimuli-responsive controlled release capacities in different temperatures and types of soil, as well as showed better control efficiency of larvae of Protaetia brevitarsis at pesticide application in the early stage, with the potential ability to control pest outbreaks at high temperatures. In addition, blank microspheres improved the growth and physiological activity of cucumber seedlings, reduced copper content in leaves, increased soil nutrient content, and prevented soil acidification . Further, the use of blank microspheres increased the relative abundance of soil beneficial functional bacteria communities, which mediate heavy metal (HM) immobilization/tolerance and promote plant growth. Redundancy analysis (RDA) and Spearman correlation analysis showed that these beneficial functional bacteria were mainly positively correlated with soil EC, A-N, and N–N. In summary, this study showed that the technique of combining physically modified carrier materials with pesticides has the potential to reduce Cu contamination in the surrounding agricultural soil during pesticide application, thereby reducing Cu uptake by crops.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Xuecui Song,Jing Guo,Yuanfa Liu,Feng Li,Qiang Yang,Fucheng Guan,Chunqiu Di
Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with “covalent bond―ion complex―hydrogen bond” multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials. The effects of ion species (Fe 3+ , Ba 2+ , Sr 2+ , Ca 2+ , and Zn 2+ ) on the structure, morphology, and properties of multi-network hydrogels were studied in detail. The results showed that the mechanical strength of ionic cross-linked hydrogels increased significantly. The compressive strength of Fe 3+ cross-linked hydrogels was 5.56 MPa, 16.13 times that of non-ionic crosslinked hydrogels. The results of ionic conductivity measurements showed that hydrogels had significant ionic conductivity and were sensitive to external forces. Interestingly, the hydrogel can be used as a capacitive pen in mobile phone writing, painting and dialing numbers. Moreover, ionic cross-linked hydrogels had a unique three-dimensional porous structure with gradient distribution, excellent shape memory effect, and good biocompatibility. Fe 3+ , Ba 2+ , Sr 2+ , and Ca 2+ cross-linked hydrogels were nontoxic and conducive to the adhesion and growth of Schwann cells. These excellent properties of ionic cross-linked SA/AKP/PAM hydrogels have broad applications prospects in flexible electronic devices, sensors, soft electronic skins, and tissue engineering.
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JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Yimin Huang,Bing Wang,Jiapei Lv,Yingnan He,Hucai Zhang,Wenyan Li,Yongtao Li,Thomas Wågberg,Guangzhi Hu
Chromium (VI) is a widely occurring toxic heavy metal ion in industrial wastewater that seriously impacts the environment. In this study, we used environmentally friendly sodium lignosulfonate (SL), polyethyleneimine (PEI), and sodium alginate (SA) to synthesize SL/PEI/SA beads by employing a simple crosslinking method with to develop a novel absorbent with excellent adsorption capacity and practical application in wastewater treatment. We studied the adsorption performance of SL/PEI/SA through batch adsorption and continuous dynamic adsorption experiments. SL/PEI/SA has ultra-high adsorption capacity (2500 mg·g -1 ) at 25 ℃, which is much higher than that of existing adsorbents. Humic acids and coexisting anions commonly found in wastewater have minimal effect on the adsorption performance of SL/PEI/SA. In the column system, 1 g SL/PEI/SA can treat 8.1 L secondary electroplating wastewater at a flow rate of 0.5 mLmin -1 , thereby enabling the concentration of Cr(VI) in secondary electroplating wastewater to meet the discharge standard (< 0.2 mg·L -1 ). It is worth noting that the concentration of competitive ions in secondary electroplating wastewater is more than 500 times higher than that of Cr(VI). These results demonstrate that the novel SL/PEI/SA beads can be effectively applied in the removal of Cr(VI) in wastewater.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Ruonan Sun,Junxiang Zhu,Hao Wu,Shiqing Wang,Wenxiang Li,Qingjie Sun
In this work, 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized cellulose nanocrystals (TOCNs) were loaded into sodium alginate/chitosan multilayer film as nanofillers to investigate the modulation of the surface charge density of TOCNs on the film properties. First, the surface charge density of TOCNs was controlled by adjusting the carboxyl content and morphological size by varying the oxidant dosage. After oxidation , TOCN with higher surface charge density was observed to display a higher crystallinity, a more open internal structure, a better dispersibility and a slightly weaker thermal stability . In addition, a 15-layer film composed of sodium alginate and chitosan, called (SA/CH) 15 , was constructed by layer-by-layer assembly. Both in situ deposition monitoring and free-standing multilayer film formation indicated that TOCNs relied on strong electrostatic interactions and hydrogen bonding to achieve a compact and uniform interlayer and a thinner thickness of (SA/CH) 15 , which was more evident at a high surface charge density. The addition of TOCNs also enhanced the mechanical properties, thermal stability, hydrophobicity , and barrier properties of (SA/CH) 15 . In particular, the resulting sodium alginate/chitosan multilayer film exhibited an improved packaging performance when nanocomposite was performed using TOCN with a surface charge density of 3.22 ± 0.11 e nm −2 .
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NANOTECHNOLOGY
·
2021
·Vol. 32
·期 37
·375712
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IF 3.874
Bin Nie,Hong Wang,Chaohui Rao,Yanwei Zhang,Huifang Wang,Xiaojie Lian,Xianghua Gao,Baolong Niu,Wenfeng Li
Phosphate-stabilized amorphous calcium carbonate (ACCP) has excellent biocompatibility, bioactivity, and biodegradability, and can be easily synthesized and stored. However, unmodified ACCP, as a controlled drug release carrier, decomposes rapidly in an acidic environment and highly depends on the system's pH value, which can not meet the need for long-term release of active substances, thus limiting its application scope. To realize the specific pH responsiveness of ACCP nanoparticles, we designed and synthesized monodisperse sodium alginate/ACCP (Alginate/ACCP) composite nanoparticles in this paper. After ultrasonic treatment, nanoparticles with an average particle size less than 200 nm could form stable water dispersion that could be dispersed for up to 10 d. Based on the specific pH sensitivity of sodium alginate, the drug-controlled release performance of composite nanoparticles and the therapeutic effect of drug-loaded nanoparticles on A549 cancer cells were studied. The results indicated that under the same pH condition, the curcumin (Cur) release rate of composite nanoparticles gradually decreased with sodium alginate addition. When the dosage of sodium alginate was 1.0 mg ml−1, the cumulative drug release rate of nanoparticles in 40 h was only about 35%. Besides, the drug-loaded nanoparticles showed the excellent killing ability of cancer cells, and the survival rate of cancer cells decreased in a concentration-dependent manner. Therefore, through reasonable optimization design, we can synthesize composite nanoparticles with excellent sustained-release properties to provide a new strategy for cancer cells' long-term treatment.
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Analytical Methods
·
2021
·Vol. 13
·期 9
·1110-1120
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IF 2.896
Liang Wei,Xinlong Huang,Xianqian Zhang,Xiande Yang,Jing Yang,Feiyan Yan,Yu Ya
Three-dimensional hierarchically porous carbon (denoted as SA-900) with a microporous, mesoporous and macroporous structure was facilely fabricated via direct carbonization of sodium alginate. SA-900 was fully characterized by N2 adsorption–desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction and Raman spectroscopy to confirm its structure. SA-900 was coated onto a glassy carbon electrode surface to construct an ultrasensitive electrochemical sensing platform (SA-900/GCE). Electrochemical behaviors of hydroquinone (HQ), catechol (CC) and resorcinol (RC) on the SA-900/GCE surface were investigated, and it was found that SA-900 possesses excellent electrocatalytic activity towards them. Experimental conditions including carbonization temperature, pH value, SA-900 concentration, accumulation potential and accumulation time were optimized for quantitative assay. Under optimized conditions, linear ranges for simultaneous determination of HQ, CC and RC are 0.05–1.50 μM, 0.05–1.50 μM and 0.50–15.00 μM, respectively. Detection limits for HQ, CC and RC are calculated to be 0.0183 μM, 0.0303 μM and 0.3193 μM (S/N = 3). The SA-900/GCE based electrochemical sensing platform is applied for determining HQ, CC and RC in lake water samples with satisfactory results.
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CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Shuxian Tang,Jueying Yang,Lizhi Lin,Kelin Peng,Yu Chen,Shaohua Jin,Weishang Yao
Chemical hydrogels have been extensively applied to the removal of heavy metal pollutants. However, most of chemical hydrogels inevitably contain toxic chemical crosslinker residues, which impose serious threats on the environment. Herein, a novel eco-friendly physically-crosslinked double-network hydrogel of chitosan/sodium alginate/calcium ion (CTS/SA/Ca 2+ PCDNH) was prepared by the combination of the semi-dissolution acidification sol–gel transition method with the internal gelation method. The PCDNH is formed via the physical crosslinking of sustainable biopolymers, which avoids the excessive use of toxic chemical reagents. In addition, the PCDNH exhibits significantly better mechanical properties than the single-network physical hydrogel crosslinked via electrostatic interactions, which overcomes the weak mechanical properties of physical hydrogels. The formation mechanism and structure of the hydrogel were determined by Fourier-transform infrared spectroscopy (FTIR), 13 C solid state nuclear magnetic resonance spectroscopy ( 13 C-SSNMR) and scanning electron microscopy (SEM). The heavy metal ions adsorption mechanism was explored by X-ray photoelectron spectroscopy (XPS) analysis. The adsorption kinetics, isotherms and thermodynamics were further studied to understand the adsorption mechanism. Our work has provided a new method for the fabrication of natural polymers-based eco-friendly, low-cost and robust physical hydrogels for the heavy metal ions removal.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Oudong Hu,Guoqi Chen,Jianfeng Gu,Jing Lu,Jin Zhang,Xi Zhang,Linxi Hou,Xiancai Jiang
Facile preparation of organohydrogel electrolyte integrated with good anti-freezing property, toughness, transparency, conductivity and thermoplasticity is important and still remains challenging. Novel conductive and tough poly(vinyl alcohol)/sodium alginate/glycerol (PVA/SA/Gly) composite organohydrogel electrolytes were obtained by a simple method in this paper. PVA and SA was firstly dissolved in a mixed solution of distilled water and glycerol and the PVA/SA/Gly organohydrogel was obtained by the freezing-thawing process, then PVA/SA/Gly organohydrogel was immersed into the saturated NaCl aqueous solution. During the soaking process NaCl would enter into the PVA/SA/Gly organohydrogel to increase the gel strength and conductivity. The PVA/SA/Gly organohydrogel electrolytes performed the high toughness with the tensile strength and elongation at break of 1.43 MPa and 558%, respectively. Moreover, the PVA/SA/Gly organohydrogel electrolytes behaved high transparency, anti-freezing property, conductivity and thermoplasticity due to the incorporation of glycerol. This paper provides a new preparation method for the high-performance organohydrogel electrolyte.
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