INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Youjing Shi,Lijie Wang,Wei Wei,Sheng Ding,Wen Zhang,Fan Li,Zhaoming Li,Xin Meng
Rapid and effective hemostasis can immediately control blood loss and prevent fatal complications. Chitosan sponge loaded with carbon nanospheres PC-800 for rapid hemostasis was first reported here. Preparation process is simple, green and low-cost. Specifically, microporous carbon nanospheres (PC-800) were synthesized by hydrothermal method and followed by calcination in high yield. Afterwards, PC-800 was homogeneously dispersed in the chitosan solution and lyophilized to obtain the composite sponge. The aim of this study is to explore the synergistic hemostatic effect of chitosan and PC-800 and validate its feasibility in trauma therapy. The composite sponges exhibited porous structure, suitable mechanical properties, strong water absorption capacity (49.2 ± 0.8 g/g), good hemocompatibility (hemolysis rate<5 %) and low cytotoxicity. However, cytotoxicity occurs with excessive PC-800 loads. The blood coagulation index of CS-1.0 with 9.5 % was significantly lower than the commercially available Celox Rapid. Upon application to a wound, CS-1.0 sponge rapidly forms a wound seal, achieving effective hemostasis through the synergistic action of chitosan and PC-800. Compared to Celox Rapid, tail hemorrhage and hepatic hemorrhage time in rats decreased to 73 s and 34 s, respectively. The composite sponges were expected to be a safe and fast hemostatic dressing for uncontrolled bleeding during emergencies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yanhao Liu,Shubin Li,Jiang Zhu,Lili Fan,Lu Wang
Excessive blood loss caused by severe trauma is often life-threatening, so a kind of hemostatic material with superior performance is urgently needed to achieve rapid hemostasis of wounds. Here, we prepared CDCS/PF/PVA/Agar hydrogels by blending chitosan modified by catechol groups, PF127-NH 2 micelles, PVA and agarose. The hydrogel showed adjustable swelling and degradation properties. The CDCS/PF/PVA/Agar hydrogel exhibited exceptional mechanical properties with an elastic modulus of 351.4 kPa after four freeze-thaw cycles, surpassing traditional polysaccharide hydrogels by 7–20 fold. Its tissue adhesion strength reached 16.24 kPa in air and 11.23 kPa under wet conditions, enabled by catechol-mediated covalent bonding and amino group interactions. In vivo experiments demonstrated rapid hemostasis within 170 s in mouse liver injury models, reducing blood loss by 75.4 % compared to untreated controls. This study provides a robust strategy for designing polysaccharide hydrogels integrating mechanical resilience, rapid hemostasis, antibacterial activity, and biosafety, offering significant potential for clinical wound management.
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INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Jing Zhou,Rourou Wang,Ming Niu,Zhenghua Zhang,Minrui Zhu,Lumei Pu,Weibing Xu,Runtian Ma
The infection caused by Fusarium oxysporum severely threatens cotton production. Herein, carvacrol-chitosan nanoparticles (CS@CAR) are facilely fabricated using tripolyphosphate as a crosslinker. When the initial mass ratio of chitosan to carvacrol is 1:0.4, the nanoparticles show the best stability and drug loading. Morphological analysis reveals that the CS@CAR nanoparticles possesses a uniform spherical structure with an average diameter of approximately 150 nm. About 51.23 % of total CAR is released within the 48 h in the simulated fungal infection environment. The contact angle of drug-loaded particles decreases by 12.2 and 6.6 ° compares with that of pure water and unloaded particles. The fluorescence intensity of leaves before and after rain erosion is 1.3 times and 1.2 times that of the pure water control group by fluorescence imaging analysis. The bacteriostatic activity of drug-loaded nanoparticles is 6–7 times that of non-drug-loaded nanoparticles. The contents of nucleic acid, protein, and malondialdehyde leaked by spores after treatment with drug-loaded particles are 1.4, 1.5 and 2.3 times those in the non-drug-loaded particle treatment group, respectively. The CS@CAR entirely prevents Fusarium oxysporum from infecting cotton leaves in spore inoculation experiments. The CS@CAR nanoparticles are expected to be used to prevent and control the infection of Fusarium oxysporum on cotton.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Zhicheng Zhang,Wei Zou,Hong Wang,Zhongjie Du,Chen Zhang
A high-performance biomass-based adsorption materials could be the promising trend for CO 2 capture and storage technology. However, the direct application of biomass-based porous materials as a CO 2 adsorbent with enhanced performance is an emerging issue. Herein, a facile synthesis and a biomimetic strategy were combined to prepare amine-functionalized chitosan foam for CO 2 capture, and then a porous biomass is achieved for the application on the environment protection field. Firstly, the chitosan foam was synthesized by the emulsion-templating method at room temperature. Depended on stabilizing n-octane in the chitosan hydrogel with Span 80, a tunable three-dimensional network porous structure was obtained. Subsequently, co -deposition with dopamine (DA) and polyethyleneimine (PEI) was applied to load abundant amine content on the surface of chitosan foam and thereby improving CO 2 adsorption capacity. Finally, the as-prepared amine-functionalized chitosan foam exhibited the impressive adsorption capacity of 3.59 mmol/g at 333 K and atmospheric pressure, and the better adsorption selectivity and stability. The results extend the preparation approach of biomass porous materials, and also its application in CO 2 adsorption technology.
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ACS Biomaterials Science & Engineering
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2024
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IF 5.4
Xin Wang,Zheng Wei,Zuoyao Wu,Yanping Li,Chenjiao Miao,Zheng Cao
Endometritis, a prevalent obstetric condition primarily caused by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), significantly threatens the reproductive performance of female animals. In this study, thermosensitive injectable chitosan (CS)/β-glycerophosphate (β-GP) hydrogels loaded with berberine (BBR) and carvacrol (CAR) were prepared for endometritis treatment. In vitro, BBR/CAR-CS/β-GP hydrogels exhibited rapid gelation within 5 min at 37 °C, excellent injectability, and more than 90% degradation within 30 days under enzymatic action. The dual drug-loaded system also exhibited controlled release of BBR and CAR and demonstrated the antimicrobial activity against E. coli and S. aureus. In vivo, uterine injection of BBR/CAR-CS/β-GP hydrogels alleviated infection-induced injuries and reduced the bacterial load in infected uterine tissues. In summary, these findings highlight the potential of BBR/CAR-CS/β-GP hydrogels as innovative carriers for drug delivery targeting endometritis.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yinggang Jia,Ronghao Man,Liannan Shang,Jian Chen
Developing an environmentally friendly adsorbent with high adsorption capacity and economic advantages is crucial for the treatment of cadmium (Cd)-contaminated wastewater. In this study, Bentonite (Bt), which is widely distributed in nature, was used to prepare a new type of chitosan (CS)-grafted polymerized aluminum-pillared bentonite (i.e., Al@Bt): CS@Al@Bt. This new material effectively addresses the issues of chitosan’s poor mechanical strength , limited load capacity, and the weak adsorption properties of raw bentonite for Cd. The effects of synthesis conditions on Cd adsorption by modified bentonite were investigated through batch experiments. The adsorption mechanism was revealed by characterization tests such as X-ray diffraction (XRD), N 2 adsorption-desorption experiments, Scanning and Transmission electron microscopy (SEM-TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The results showed that compared to raw Bt, when the ratio of Al in polymerized aluminum to the cation exchange capacity (CEC) of Bt was increased to 5 (i.e., Al/CEC=5), the specific surface area (SSA) of Bt increased from 78.46 m²/g to 195.99 m²/g. Additionally, the interlayer spacing and total pore volume increased by 1.22 and 1.13 times, respectively. After grafting chitosan onto Al@Bt, CS@Al@Bt reached adsorption equilibrium rapidly within 15 min, achieving a removal rate of up to 99.82% (initial concentration of Cd(II) was 20 mg/L, and the solid-liquid ratio was 1 g/L). Additionally, CS@Al@Bt showed good adsorption performance over a wide pH range. The rich pore structure of CS@Al@Bt and the complexation between amino (-NH 2 ) and hydroxyl (-OH) groups with Cd(II) were the main mechanisms for the removal of Cd(II) from the solution. The application showed that CS@Al@Bt effectively reduced Cd-containing mining wastewater from class V to class II quality, underscoring its significant potential for treating Cd(II)-contaminated wastewater.
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Journal of Burn Care & Research
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2025
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IF 1.8
Deng Yuchen,Wen Chao,Wang Fang
BackgroundDespite the advancements of pharmacological treatments and gauze dressings in the field of skin wound healing, these methods present numerous limitations. Therefore, developing a multifunctional material capable of efficiently promoting skin wound healing is particularly crucial.MethodsCitric acid (CA)-modified chitosan (CS) loaded with Shikonin (SK) (CA-CS-SK) hydrogel was prepared via the freeze–thaw method. The physical properties of the hydrogel were profiled through FTIR, SEM, rotational rheometry, swelling experiment, degradation rate analysis, and drug release experiments. Furthermore, the biocompatibility of the hydrogel was comprehensively evaluated through hemolysis assay, CCK-8 cytotoxicity detection, and live/dead cell staining. Antimicrobial activity against E. coli and S. aureus of the hydrogel was gauged in vitro, and its therapeutic performance was ultimately validated in a mouse full-thickness wound model through H&E staining and ELISA.ResultsThe CA-CS-SK hydrogel exhibited appropriate rheological properties, swelling ratio, degradation rate, and drug release rate. It effectively suppressed the proliferation of E. coli and S. aureus, with superior inhibitory effects compared to CA-CS hydrogel and SK alone. Additionally, the hydrogel showed no significant toxicity to human dermal fibroblasts and did not cause erythrocyte rupture. Animal model experiments demonstrated that, compared to cotton gauze, CA-CS hydrogel, and SK, the CA-CS-SK hydrogel reduced levels of TNF-α and IL-6 at the wound site, alleviated the inflammatory response, and promoted wound healing.ConclusionThe CA-CS-SK hydrogel possesses high antibacterial activity, excellent biocompatibility, and efficient wound healing promotion capabilities, making it a highly promising material for skin wound treatment.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Ding Zhou,XinQing Li,Ying Zhu,Yaxin Hu,Siying Zhang,Zan Tong,Yingshan Zhou,Yun Chen
Persistent bacterial infections hinder wound healing by disrupting tissue repair and perpetuating inflammatory states. However, conventional therapies adopting antibiotics and passive dressings could only suppress pathogens temporarily and ignore antibiotic resistance or actively promote regenerative microenvironments. Herein, based on fungal-derived chitosan, guanidinium-functionalized chitosan (GCS) and aldehyde-modified chitosan (ACS) were synthesized, then chitosan hydrogels (SCgel) with self-healing capacity were prepared via the Schiff base reaction between GCS and ACS. Through a simple local injection through a dual-barrel syringe, a protective SCgel hydrogel barrier can be rapidly established on the wound. This hydrogel not only quickly eliminates bacteria in infected wounds but also reduces the level of wound inflammation, thereby promoting wound healing. In infected full-thickness rat wounds, SCgel achieved a 94.5 ± 1.1 % wound closure rate within 14 days, significantly superior to commercial silver-coated Aquacel™ Ag + . By integrating potent antimicrobial activity with inflammation control, this design reduces the reliance on systemic antibiotics and addresses the unmet need for microenvironment-responsive wound dressings.
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Current Research in Food Science
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2024
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IF 6.2
Jianfei Zhu,Tingting Huang,Xiaomei Chen,Dongling Tian
In this study, the effect of chitosan-vanillin Schiff base emulsions (CSVAEs) on dough and bread characteristics was investigated. The results revealed that CSVAEs were embedded in the gluten and that the viscoelasticity and mechanical strength of the dough gradually increased with increasing CSVAEs concentration, α-helical and β-fold content, and elastic structure in the dough increased with the same patterns. The basic properties of bread were measured, and it was found that low concentrations of CSVAEs were effective in improving the quality of bread and slowing the staling rate. As the storage time increased, CSVAEs had less effect on the rate of moisture loss, hardness and springiness of the bread and more effect on the inhibition of the acidity of the bread. The addition of CSVAEs slowed the increase in bacteria and molds and extended the shelf life of the bread.
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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2015
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IF 2.101
Xiu-Rong Zhang,Nian-Qiu Shi,Yang Zhao,He-Yun Zhu,Jiao Guan,Ying Jin
Mitomycin C (MTC) was incorporated to a micelle system preparing from a polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA was synthesized and characterized by 1H nuclear magnetic resonance (1H-NMR) and Fourier transform infrared spectroscopy. mPEG-CS-DA formed a core-shell micellar structure with a critical micelle concentration of 6.57 µg/mL. The mPEG-CS-DA micelles were spherical with a hydrodynamic diameter of about 231 nm. After poly(ethylene glycol)ylation of deoxycholic acid chitosan (CS-DA), the encapsulation efficiency and drug loading efficiency increased from 50.62% to 56.42% and from 20.51% to 24.13%, respectively. The mPEG-CS-DA micelles possessed a higher drug release rate than the CS-DA micelles. For pharmacokinetics, the area under the curve (AUC) of the mPEG-CS-DA micelles was 1.5 times higher than that of MTC injection, and these micelles can enhance the bioavailability of MTC. mPEG-CS-DA micelles reduced the distribution of MTC in almost all normal tissues and had the potential to improve the kidney toxicity caused by MTC injection.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2020
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IF 7.489
Lihuan Wang,Haijun Lv,Lifang Liu,Qi Zhang,Pawel Nakielski,Yang Si,Jianping Cao,Xiaoran Li,Filippo Pierini,Jianyong Yu,Bin Ding
The poor intrinsic mechanical properties of chitosan hydrogels have greatly hindered their practical applications. Inspired by nature, we proposed a strategy to enhance the mechanical properties of chitosan hydrogels by construction of a nanofibrous and cellular architecture in the hydrogel without toxic chemical crosslinking. To this end, electrospun nanofibers including cellulose acetate, polyacrylonitrile , and SiO 2 nanofibers were introduced into chitosan hydrogels by homogenous dispersion and lyophilization. With the addition of 30% cellulose acetate nanofibers, the cellular structure could be maintained even in water without crosslinking, and integration of 60% of the nanofibers could guarantee the free-standing structure of the chitosan hydrogel with a low solid content of 1%. Moreover, the SiO 2 nanofiber-reinforced chitosan (SiO 2 NF/CS) three-dimensional (3D) matrices exhibit complete shape recovery from 80% compressive strain and excellent injectability. The cellular architecture and nanofibrous structure in the SiO 2 NF/CS matrices are beneficial for human mesenchymal stem cell adhesion and stretching. Furthermore, the SiO 2 NF/CS matrices can also act as powerful vehicles for drug delivery. As an example, bone morphogenetic protein 2 could be immobilized on SiO 2 NF/CS matrices to induce osteogenic differentiation. Together, the electrospun nanofiber-reinforced 3D chitosan matrices exhibited improved mechanical properties and enhanced biofunctionality, showing great potential in tissue engineering.
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Advanced Materials Technologies
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2025
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IF 6.2
Mingyu Cui,Suiyuan Huang,Jianwei Xin,Panpan Ma,Liping Heng,Yuqi Zhang,Ji-Jiang Wang
Dexamethasone sodium phosphate (DSP) and betamethasone sodium phosphate (BSP) are synthetic corticosteroids used for anti-inflammatory and immunosuppressive purposes. However, prolonged use may cause severe side effects, necessitating sensitive detection methods. Conventional techniques often suffer from complexity, signal interference, and a lack of real-time capability. This study develops molecularly imprinted 2D photonic hydrogels (DSP/BSP-MIPH) for selective, sensitive, and regenerable detection of DSP and BSP. The DSP-MIPH sensor exhibits swelling in DSP solution, enabling linear detection in three ranges (0.1–9, 10–100, and 100–1000 µ M ) with a limit of detection (LoD) of 41 nM. BSP-MIPH shows shrinkage upon binding, with linear responses in 0.05–1 and 5–1000 µ M ranges and a LoD of 28 n M . The limits of quantitation are 1.2 µ M and 146 n M for DSP and BSP, respectively. The opposite volume changes stem from distinct hydrogen bonding interactions between drug functional groups and the hydrogel network. The sensors successfully quantify DSP and BSP in commercial injections, achieving recovery rates of 96.7%–109.5% for DSP and 97.9%–104.8% for BSP, with RSDs 3.91%–6.21% for DSP and 3.57%–5.76% for BSP. These results demonstrate that the MIPH sensors provide accurate, reliable, and straightforward detection for DSP and BSP in real samples, giving a promising strategy for precise hormone drug monitoring.
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