COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Ling Li Guo,Yan Fang Cheng,Xu Ren,Kasi Gopinath,Zhi Song Lu,Chang Ming Li,Li Qun Xu
Titanium (Ti) and its alloys are primarily explored to produce biomedical implants owing to their improved mechanical stability, corrosion resistance, low density, and good biocompatibility. Despite, Ti substrate surfaces are easily contaminated by plasma proteins and bacteria. Herein, a simple one-step process for the simultaneous deposition of a polyphenol tannic acid (TA) and four-armed poly(ethylene glycol) (PEG 10k -4−OH) on the Ti substrate (Ti-TA/PEG) surface was described. Additionally, a two-step process has been employed to fabricate the Ti-TA-PEG surface via successive deposition of TA and PEG 10k -4−OH for comparison. The resultant Ti-TA/PEG surface prepared by simultaneous deposition of TA and PEG 10k -4−OH exhibits higher coating thickness and better surface coverage than the Ti-TA-PEG surface. The Ti-TA/PEG and Ti-TA-PEG surfaces could actively inhibit the non-specific adsorption of proteins, suppress the bacterial and platelet adhesion, and prevents biofilm formation. Moreover, the Ti-TA/PEG surface displays a better antifouling performance than the Ti-TA-PEG surface. Thus, the present study demonstrates a simple and convenient approach for constructing polymeric coating with good anti-adhesive properties on the Ti substrate surface.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2015
·Vol. 216
·期 23
·2270-2278
·
IF 2.616
Dan Liu,Qiulin Yuan,Ying Ling,Haoyu Tang
A series of polypeptides bearing various alkyl (i.e., propyl, hexyl, or octyl) spacers, biphenyl mesogens, and oligo-ethylene-glycol (OEG) tails (i.e., PPLG 26 -BPOEG m , PHLG 34 -BPOEG m , and POLG 32 -BPOEG m [ m = 3 or 7]) has been synthesized via 1,3-dipolar cycloaddition reactions with quantitative grafting densities. Fourier transform infrared results reveal that the polypeptides adopted an α -helical conformation in the solid-state. Differential scanning calorimetry (DSC) analysis reveals that the glass transition temperatures ( T g s) of the polypeptides with OEG 3 tails decrease with the increasing length of the alkyl spacers. For the samples containing alkyl spacers of the same length, T g significantly decreases with the increasing lengths of the OEG tails. Polarized optical microscope (POM) results reveal that all polypeptides exhibit strong birefringence at room temperature. Polypeptides with long alkyl spacers (i.e., hexyl or octyl) or OEG 7 tails show isotropic transitions, while PPLG 26 -BPOEG 3 show no clear point temperature before thermal decomposition. DSC, POM, and wide-angle X-ray scattering results collectively reveal that polypeptides with long alkyl spacers (i.e., hexyl or octyl) and OEG 3 tails undergo a reversible smectic E phase to isotropic phase transition, while polypeptides with OEG 7 tails undergo a reversible liquid crystalline phase to isotropic phase transition. The transition temperatures increase with the increasing length of alkyl spacers.
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Polymers
·
2018
·Vol. 10
·期 2
·128
·
IF 2.935
Bing Li,Qi Zhong,Dapeng Li,Ke Xu,Lu Zhang,Jiping Wang
The influence of ethylene glycol methacrylate (EGMA) to the hydration and transition behaviors of thermo-responsive interpenetrating polymeric network (IPN) hydrogels containing sodium alginate,N-isopropylacrylamide (NIPAAm), and EGMA were investigated. The molar ratios of NIPAAm and EGMA were varied from 20:0 to 19.5:0.5 and 18.5:1.5 in the thermo-responsive alginate-Ca2+/P(NIPAAm-co-EGMA) IPN hydrogels. Due to the more hydrophilicity and high flexibility of EGMA, the IPN hydrogels exhibited higher lower critical solution temperature (LCST) and lower glass transition temperature (Tg) when the ratio of EGMA increases. The swelling/deswelling kinetics of the IPN hydrogels could be controlled by adjusting the NIPAAm/EGMA molar ratio. A faster water uptake rate and a slower water loss rate could be realized by increase the amount of EGMA in the IPN hydrogel (the shrinking rate constant was decreased from 0.01207 to 0.01195 and 0.01055 with the changing of NIPAAm/EGMA ratio from 20:0, 19.5:0.5 to 18.5:1.5). By using 2-Isopropylthioxanthone (ITX) as a photo initiator, the obtained alginate-Ca2+/P(NIPAAm-co-EGMA360) IPN hydrogels were successfully immobilized on cotton fabrics. The surface and cross section of the hydrogel were probed by scanning electron microscopy (SEM). They all exhibited a porous structure, and the pore size was increased with the amount of EGMA. Moreover, the LCST values of the fabric-grafted hydrogels were close to those of the pure IPN hydrogels. Their thermal sensitivity remained unchanged. The cotton fabrics grafted with hydrogel turned out to be much softer with the continuous increase of EGMA amount. Therefore, compared with alginate-Ca2+/PNIPAAm hydrogel, alginate-Ca2+/P(NIPAAm-co-EGMA360) hydrogel is a more promising candidate for wound dressing in the field of biomedical textile.Keywords:thermo-responsive;interpenetrating polymeric network hydrogel;ethylene glycol methacrylate;N-isopropylacrylamide;cotton fabrics
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高影响因子
POLYMER
·
2023
·
IF 4.6
Xi Zeng,Junwei Zhou,Junbiao Peng,Chunsheng Zhang,Danling Wang,Yihu Song,Qiang Zheng
Rubber vulcanization generates volatile organic compounds emissions associated with the intermolecular crosslinking reactions at rather higher temperatures mediated by many kinds of indispensable additive. To achieve the carbon peaking and neutrality targets in China, rubber processing industries call for ecofriendly, green additives to satisfy demands of high-efficiency vulcanization at low temperatures. Herein an oligomer deep eutectic solvent (DES) based on polyethylene glycol is used for the first time for regulating vulcanization kinetics of natural rubber (NR) gums. It is found that DES at 0.2–1.0 phr (parts per hundred parts of rubber) dosages could accelerate the vulcanization at 120–140 °C without marked influences on crosslinking density and storage modulus at vulcanization equilibrium. The vulcanization of DES-containing gums at 120 °C is faster than that of the DES-free one at 140 °C while the DES-containing vulcanizates cured at 120 °C exhibit nonlinear rheological responses being similar to the DES-free one cured at 140 °C. The low-temperature vulcanization in general generates vulcanizates exhibiting higher tensile strength in comparison with those cured at 140 °C. Furthermore, DES could not influence the Mullins effect of the vulcanizates undergoing cyclic tension deformation. The results show that the non-volatile DES could be used to adjust the vulcanization kinetics without impact on the crosslinking density and Mullins effect, paving the way for developing energy-saving green vulcanization technologies.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Zelun Zhi,Yajuan Su,Yuewei Xi,Liang Tian,Miao Xu,Qianqian Wang,Sara Padidan,Peng Li,Wei Huang
In recent years, microbial colonization on the surface of biomedical implants/devices has become a severe threat to human health. Herein, surface-immobilized guanidine derivative block copolymers create an antimicrobial and antifouling dual-functional coating. We report the preparation of an antimicrobial and antifouling block copolymer by the conjugation of polyhexanide (PHMB) with either allyl glycidyl ether or allyloxy polyethylene glycol (APEG; MW 1200 and 2400). The allyl glycidyl ether modified PHMB (A-PHMB) and allyloxy polyethylene glycol1200/2400 modified PHMB (APEG1200/2400-PHMB) copolymers were grafted onto a silicone rubber surface as a bottlebrush-like coating, respectively, using a plasma-UV-assisted surface-initiated polymerization. Both A-PHMB and APEG1200/2400-PHMB coatings exhibited excellent broad-spectrum antimicrobial properties against Gram-negative/positive bacteria and fungi. The APEG2400-PHMB coating displayed an improved antibiofilm as well as antifouling properties and a long reusable cycle, compared with two other coatings, due to its abundant PEG blocks among those copolymers. Also, the APEG2400-PHMB-coated silicone coupons were biocompatible toward mammalian cells, as revealed by in vitro hemocompatibile and cytotoxic assays. An in vivo study showed a significant decline of Escherichia coli colonies with a 5-log reduction, indicating the APEG2400-PHMB coating surface worked effectively in the rodent subcutaneous infection model. This PHMB-based block copolymer coating is believed to be an effective strategy to prevent biomaterial-associated infections.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 16
·7810-7818
·
IF 3.3
Yanke Guo,Qiaoyun Qin,Jing Zhu,Baohe Wang
Propylene glycol methyl ether was directly synthesized from propylene and hydrogen peroxide under mild conditions via aluminum modified titanium silicalite-1 as a bifunctional catalyst. It has both active sites capable of epoxidation and active sites capable of ring opening reactions, thus realizing the one-pot preparation of propylene glycol methyl ether by propylene. The synergistic effect of Ti–Al on the catalytic performance and the distribution of propylene glycol methyl ether isomer were investigated in detail, and the synergistic catalysis between the two active sites was characterized. The gradual introduction of aluminum reduced the activation ability for hydrogen peroxide, but gradually increased the selectivity for propylene glycol methyl ether. Under the optimum conditions, the selectivity for propylene glycol methyl ether reached 91.53%. Combined with Density Functional Theory (DFT) calculations, the synergistic catalytic effect of doped Al and framework Ti in titanium silicalite-1 is discussed in detail from a microscopic perspective. Al increases the Lewis acid strength of Ti active sites and promotes the conversion of propylene to propylene oxide (PO), and simultaneously Ti increases the Brønsted acid strength of Al active sites and promotes the conversion of propylene oxide to propylene glycol ether.
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高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2013
·
IF 1.304
Likun Zhou,Jifeng Pang,Aiqin Wang,Tao Zhang
Jerusalem artichoke stalk (JAS) was employed as the feedstock for the production of ethylene glycol (EG) with a combined catalyst comprising commercial WO 3 and Raney Ni. The raw JAS contains 51.6 wt% cellulose, 10.3 wt% hemicellulose, 17.2 wt% lignin, 1.7 wt% ash, and 19.2 wt% water-soluble substances. It was found that the lignin component in the JAS had little effect on the conversion of hemicellulose while the water-soluble substances caused a negative effect, which led to an EG yield of only 29.9%. After a simple hot water pretreatment, most of the water-soluble substances were removed, and the EG yield was increased to 37.6%. Moreover, the hot water pretreatment also led to an improvement in the durability of the catalyst. The effects of reaction temperature and reaction duration were also investigated.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2010
·
IF 3.757
Xueqiao Xie,Yun Wang,Juan Han,Yongsheng Yan
Based on the poly(propylene glycol) 400 (PPG 400 )–salt aqueous two-phase system (ATPS), a green, economical and effective sample pretreatment technique coupled with high performance liquid chromatography was proposed for the separation and determination of sulfamethoxazole (SMX). The extraction yield of SMX in PPG 400 –salt ATPS is influenced by various factors, including the salt species, the amount of salt, pH, and the temperature. Under the optimum conditions, most of SMX was partitioning into the polymer-rich phase with the average extraction efficiency of 99.2%, which may be attributed to the hydrophobic interaction and salting-out effect. This extraction technique has been successfully applied to the analysis of SMX in real water samples with the recoveries of 96.0–100.6%, the detection limits of 0.1 μg L −1 , and the linear ranges of 2.5–250.0 μg L −1 .
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高影响因子
Science of Advanced Materials
·
2024
·Vol. 16
·期 1
·85-92
·
IF 0.9
Zhang Xuhui,Hu Wenjun,Wang Jinghua,Wang Xinlei,Wang Li,Fang Yong
This research was aimed to evaluate extension effect of poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA/PEG) thermosensitive hydrogel-encapsulated bupivacaine (BUP) on neuroblockade in cardiothoracic surgery and explore the potential adoption of this thermosensitive hydrogel
as a drug carrier for postoperative neuroblockade. An animal experimental design was adopted. First, PLGA/PEG thermosensitive hydrogel was prepared and BUP was encapsulated as the drug carrier and evaluated. Then, 40 rats were selected for thoracic surgery and randomly rolled into experimental
group (injection of hydrogel in the cardiothoracic region for neuroblockade after cardiothoracic surgery) and control group (conventional BUP injection). The neuroblockade effects (maximum possible effect (MPE), sensory and motor blockade duration) in the two groups of rats were compared and
analyzed. The Results showed that gel-microsphere (Gel-MS) composite drug delivery system was successfully prepared, which exhibited a complete 3D porous structure and favorable encapsulation effect for BUP. Rheological testing showed favorable hardness (G′) and viscosity (G″)
for Gel-MS/BUP (GMB). The experimental group exhibited a notably prolonged period of 100% MPE with a slower rate of decline versus controls. Sensory blockade and motor blockade durations in the experimental group rats were (22.4±3.8) h and (22.7±3.5) h, respectively, both markedly
longer than those in the control group rats (P <0.05). In Conclusion, Gel/MS-BUP demonstrated a remarkable extension effect on neuroblockade in cardiothoracic surgery, indicating its potential adoption value in prolonging anesthesia duration.
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高影响因子
RSC Advances
·
2015
·Vol. 6
·期 4
·2602-2610
·
IF 3.84
Yanna Zhao,Jing Zhao,Chunying Hao,Meihua Han,Mincan Wang,Yifei Guo,Xiangtao Wang
An amphiphilic dendron–drug conjugate was synthesized via oligoethylene glycol (OEG) dendrons coupled with anticancer drug doxorubicin (DOX). The amphiphilic conjugate OEG–DOX (GD) self-assembled into spherical nanoparticles in aqueous solution, with mean diameters of approximately 212.5 nm. As an effective drug carrier, DOX was entrapped into GD to form drug-loaded nanoparticles (GD/D) with high drug loading content (24%, wt%), due to the enhanced hydrophobic/aromatic interactions between the DOX moiety in GD and free DOX. Besides, GD nanoparticles exhibited thermo-induced collapse and aggregation, therefore, the temperature-dependent drug release profiles of DOX from GD/D nanoparticles were measured and the possible mechanism was proposed. Moreover, hemolytic activity of GD/D revealed the good blood compatibility, and the cytotoxicity of DOX in GD/D was enhanced significantly in vitro against HepG2 cells. Overall, amphiphilic conjugate GD was considered to be potentially feasible to overcome formulation challenges for drug delivery and to be used in clinic.
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ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Haotian Tang,Mengwei Guo,Rongrong Deng,Mingyuan Gao,Qibo Zhang
This study investigates the electrorefining of zinc derived from hot-dip galvanizing (HDG) slag, employing a deep eutectic solvent (DES) composed of choline chloride and ethylene glycol, commonly referred to as Ethaline DES. A thorough electrochemical analysis was carried out to examine the oxidative dissolution behaviors of metallic zinc and associated impurity metals, along with the reduction behavior of Zn(II) ions. These findings demonstrate that, in the Ethaline-ZnCl 2 DES system, zinc undergoes oxidation preferentially compared to impurities, enabling selective extraction of zinc from HDG slag. Furthermore, the reduction potential of Zn(II) is observed to be more positive than that of the impurity metal ions, favoring its preferential deposition at the cathode. Increasing the temperature and incorporating an appropriate quantity of water significantly reduce the viscosity and improve conductivity of the Ethaline DES system, thereby enhancing charge transfer and diffusion of Zn(II) ions while lowering the energy barrier for Zn(II) reduction. Under optimized electrorefining conditions, the resulting cathodic zinc achieves a purity of 99.967 %, with a current efficiency of 95.14 % and an energy consumption of 787 ± 26 kWh/t. This work proposes a sustainable and energy-efficient method for the electrorefining of zinc from HDG slag, presenting a viable pathway for the valorization of this metallurgical byproduct.
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产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 24
·3516
·
IF 4.7
Jia Li,Shu Li,Aozhen Zhong,Jun Xing,Ling Li,Cai Wang,Min Zheng
Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents, and wartime injuries. However, inadequate adhesion to bleeding wounds and poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostatic powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) for rapid hemostasis and effective antibacterial ability. When deposited on bleeding wounds, PPG powder can absorb interfacial liquid and rapidly swell into a physically cross-linked hydrogel in situ within 2 s to form a pressure-resistant physical barrier. Furthermore, the in vivo and in vitro results indicate that, as an effective sealant, the PPG powder possesses ease of use, excellent hemocompatibility, strong antibacterial abilities, and superior blood clotting abilities. The effective hemostatic sealing capability of the PPG powder is demonstrated in a variety of injury models in rats and rabbits. All of these factors show that, with its superior wound treatment abilities, PPG powder is a profound biomaterial for surgical applications.
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