JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Jinfan Zhou,Gaohua Li,Yunze Xu,Wenhui Ma,Xuehua Zhang,Haitao Yuan,Zilin Tan,Zhenghao Li,Hongwei Yu,Zhenzhao Xu,Zhiqiang Yu,Jiafei Xi,Chaoping Fu,Yanan Wang
The treatment of solid tumors with chimeric antigen receptor natural killer (CAR-NK) cell therapy confronts significant barriers, notably poor cellular infiltration and a highly immunosuppressive tumor microenvironment (TME). To overcome these challenges, we developed selenium-containing polymer nanoparticles (ManNAl-SeNPs) loaded with dibenzocyclooctyne (DBCO)-modified mannose. Metabolic glycoengineering metabolic glycoengineering (MGE) enabled efficient labeling of exogenous DBCO on azide (N 3 ) groups on CAR-NK cells, establishing a bioorthogonal click chemistry targeting strategy, significantly improving the anti-tumor activity of azide-CAR-NK (N 3 -CAR-NK) cells, including recognition specificity, migration efficiency, and cytotoxic activity. Herein, ManNAl-SeNPs with ultra-sensitive responsiveness of diselenide bonds, in the acidic TME, diselenide bond releases seleninic acid, acting as an immune checkpoint inhibitor while augmenting CAR-NK cells cytotoxicity. In vivo, the combination of ManNAl-SeNPs with N 3 -CAR-NK cells significantly increased targeting capacity and invasiveness. This study presents a TME-responsive nanoplatform with artificial bio-orthogonal combination strategy that effectively enhance the migratory ability and accumulation of CAR-NK cells for potent antitumor therapy.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 3
·84
·
IF 3.5
Fu AiWei,Liang Yaodong,He Yongjun
In the field of aqueous metal ion removal, conventional metal ion extraction methods often face limitations such as low separation efficiency and leaching of extractants, leading to secondary environmental contamination. This study used the Pickering emulsion templating method, with gelatin/sodium alginate complexes as stabilizing particles, to fabricate a Pickering emulsion hydrogel (PEHG) loaded with the zinc extractant di-(2-ethylhexyl) phosphoric acid (P204). The resulting hydrogel system not only improves emulsion stability but also effectively sequesters Zn 2 ⁺ ions from aqueous solutions. The structure of the materials was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The influence of pH, adsorbent dosage, initial zinc concentration, and contact time on adsorption capacity was investigated by the study. Results showed that at pH 4, the PEHG exhibited a maximum adsorption capacity of 13.47 mg g⁻ 1 for Zn 2 ⁺. The adsorption behavior follows pseudo-second-order kinetics and fits the Langmuir–Freundlich isotherm, suggesting a chemisorption-dominated mechanism. This corresponds to monolayer adsorption of a single solute from dilute solution onto heterogeneous surfaces. The adsorbent retains over 80% removal efficiency through five regeneration cycles, demonstrating excellent reusability. This study establishes a theoretical framework for preparing extractant-incorporated Pickering emulsion hydrogel microspheres using gelatin/sodium alginate composites. We developed an environmentally friendly and cost-effective adsorbent for heavy metal ions.
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Journal of Central South University
·
2026
·Vol. 33
·期 1
·144-159
·
IF 4.7
Yuan Rui,Tang Zhi-xing,Xiao Min-di,Cai Min-zhao,Zhao Zi-long,Gu Lin
Waterborne acrylic coatings are widely utilized due to their cost-effectiveness, high transparency, strong resistance to weather and chemicals, impressive mechanical properties, and excellent adhesion to various substrates. In these coatings, a reactive emulsifier containing phosphate groups can be integrated into the molecular chain during polymerization, which enhances the coating’s compactness and corrosion resistance. This work focuses on the synthesis of styrene-butyl acrylate (St-BA) latex and methyl methacrylate-butyl acrylate (MMA-BA) latex using the reactive phosphate emulsifier ANPEO 10 -P 1 through seed emulsion polymerization, achieving a conversion rate of approximately 99% and a solid content close to 50%. The resulting coatings from St-BA and MMA-BA latexes demonstrated long-term corrosion protection for carbon steel and aluminum alloy due to in-situ phosphatization, effectively preventing flash rust. Notably, the MMA-BA coating exhibited remarkable durability, enduring immersion for up to 1224 h (51 d) on Q235 carbon steel before reaching the failure threshold (∣ Z ∣ 0.01Hz ≤10 6 Ω·cm 2 ) on Q235 carbon steel. On 5052 aluminum alloy, the St-BA coating maintained ∣ Z ∣ 0.01Hz >gt;10 8 Ω·cm 2 for 480 h (20 d). Furthermore, the corrosion resistance of St-BA and MMA-BA coatings on Q235 steel sheet and 5052 aluminum alloy surpassed that of commercially available MMA-BA and St-BA coatings after immersion in a 3.5 wt% NaCl aqueous solution. This work also delves into the anticorrosion mechanism of MMA-BA and St-BA coatings.
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JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2026
·Vol. 56
·期 4
·65
·
IF 3.7
Chen Xue,Luo Qiufen,Zhang Hongfang
Developing a simple, rapid and sensitive rutin sensor is of great importance for the quality control or dietary guidance of some agriculture products. Herein, an electrochemical sensor for the quantification of rutin was developed based on the bimetallic nanoparticles with gold as core and platinum as shell. The nanoparticles were prepared by using MoS 2 nanosheets as heterogeneous substrate and reductant for the gold precursor. The morphology of the ultimate nanocomposite was tuned by the amount of gold precursor. With a relatively big amount of chloroauric acid, the nanocomposite exhibited a sea urchin-like core-shell morphology with monodispersity. Moreover, contributing to the large specific area and excellent conductivity of this nanocomposite, the modified electrode prepared with the bimetallic nanoparticles mediated with MoS 2 nanosheets exhibited a response almost twice that of the electrode modified with the single material. As results, the developed electrochemical sensor displayed a broad quantification range from 20 nM to 1 µM with a limit of detection of 3 nM and high sensitivity of 149.3 µA µM − 1 cm − 2 . In addition, the sensor exhibited excellent stability and reproducibility. The recovery results for onion samples demonstrated the application promise of the sensor in various agriculture products. Graphical abstract Adjusting the amount of HAuCl 4 results in two different materials. The performance of electrodes modified with MoS 2 -Au 100 @Pt or MoS 2 -Au 300 @Pt materials is compared. The electrochemical sensor developed by MoS 2 -Au 300 @Pt exhibits the highest sensitivity, and thus is applied to the determination of rutin in onion samples.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·145
·
IF 12.6
Zhao Jianguo,Lou Wanqing,Wang Yixin,Wang Lu,Jin Xiaoqian,Wang Chenyang,Yao Jiangmeng,Zhang Jinjin,Zhuang Wenjuan,Wei Jiayi,Lin Dajun,Guo Yishun,Shao Yi,Wang Bailiang,Jiang Zipei
During keratitis treatment, oxidative stress and inflammation often result in corneal neovascularisation, scarring, and reduced light transmittance. In this study, single-atom Pt/CeO 2 is synthesized, exhibiting significantly enhanced catalase-like and superoxide dismutase-like activities for the elimination of superoxide anions (•O 2 − ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (•OH). Doping single-atom Pt onto CeO 2 increases the Ce 3+ concentration in the Ce 3+ /Ce 4+ ratio from 39.12% to 58.66%, as confirmed by electron spin resonance, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. In vitro studies demonstrate that single-atom Pt/CeO 2 effectively reduces intracellular ROS levels in H 2 O 2 -activated human corneal epithelial cells. Additionally, it exerts an anti-inflammatory effect on LPS-stimulated RAW264.7 macrophages, significantly decreasing the expression of interleukin-1β, interleukin-6, and tumour necrosis factor-α. In vivo, in an LPS-induced keratitis animal model, single-atom Pt/CeO 2 accelerates corneal ulcer healing and preserves corneal light transmittance, attributed to its anti-inflammatory properties, enzyme-like activities, and ability to promote cell migration. This study offers a novel approach for treating various inflammatory and autoimmune diseases. Graphical
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高影响因子
CELLULOSE
·
2026
·
IF 4.6
Guo Yuqian,Cheng Yun,Zhao Yumeng,Qian Xinyu,Hou Leilei,Chen Linghua,Yang Shuo,Zhang Hongjie
The method of N-methyl-morpholine-N-oxide (NMMO) as a green and efficient solvent for dissolving fibers to prepare lyocell fibers is well known. Although we all know that the chemical composition, morphology, and pore structure of fibers determine the dissolution time of NMMO solution, it is difficult to evaluate the greatest impact factor on dissolution efficiency among the comprehensive factors. Herein, the relationship among the pore structure (specific surface area), swelling performance (maximum NMMO-retention value), and dissolution performance (dissolution time) of cellulose fibers in aqueous NMMO solution was quantitatively investigated. The novelty of this work is the quantitative evaluation of the impact of a single influencing factor (porous characteristics) on the swelling and dissolution properties. The porous characteristics of cellulose were effectively regulated without changing significant chemical structure using freeze-drying and hot-dried at 80 ℃ and 105 ℃ methods. Compared to hot-dried treatment, the freeze-dried cellulose fibers exhibited the high specific surface area (11.12 m 2 /g), highest NMMO-retention value (612%), the shortest dissolution time (40 min), which was shortened by 20 min. Higher specific surface area corresponded to the higher swell extent and dissolution efficiency by facilitating the diffusion of NMMO solution in cellulose fibers. Improving the porous characteristics of cellulose fibers not only effectively increased the NMMO retention value and swell extent but also shortened dissolution time without affecting the rheological properties of cellulose-NMMO solutions. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 9
·5804-5816
·
IF 3.9
Cheng Li-Qian,Wang Pengcheng,Li Qingna,Wang Zhiping,Jiang Yuqi,Zhu Dongze
The electrocaloric effect (ECE) has attracted considerable attention for its promising application in next-generation solid-state cooling systems due to its high efficiency, environmental friendliness, and potential for device miniaturization. In this study, rare-earth element Sm was introduced to dope in the relaxor ferroelectric ceramics based on 0.7 Pb(Mg 1/3 Nb 2/3 )O 3 –PbTiO 3 (PMN–30PT) to enhance the ECE response and broaden the working temperature range. The Sm doping effectively enhanced the breakdown strength, reduced leakage current, and refined grain morphology was also observed, contributing to improved electrical reliability. The Sm-doped sample achieved an adiabatic temperature change of 1.38 K under an electric field of 40 kV cm −1 . Moreover, an inferred broad effective temperature span ( T span ) of 62 °C was obtained, indicating excellent wide temperature reliability. These results demonstrate that appropriate Sm doping not only enhances the EC response but also broadens its operational temperature window, offering valuable insights for the design of high-performance electrocaloric ceramics for energy-efficient and environmentally friendly solid-state cooling applications.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2023
·Vol. 38
·期 6
·1311-1318
·
IF 1.6
Tong Yilin,Zhang Yu,Han Xuecai,Yu Kan,Bao Jiaqi
A novel fiber optic sensor based on hydrogel-immobilized enzyme complex was developed for the simultaneous measurement of dual- parameter, the leap from a single parameter detecting fiber optic sensor to a fiber optic sensor that can continuously detect two kinds of parameters was achieved. By controlling the temperature from high to low, the function of fiber sulfide sensor and fiber DCP sensor can be realized, so as to realize the continuous detection of dual-parameter. The different variables affecting the sensor performance were evaluated and optimized. Under the optimal conditions, the response curves, linear detection ranges, detection limits and response times of the dual-parameter sensor for testing sulfide and DCP were obtained, respectively. The sensor displays high selectivity, good repeatability and stability, which have good potentials in analyzing sulfide and DCP concentration of practical water samples.
研究领域:
光学传感
·
环境监测
·
生物传感器
·
分析化学
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 7
·4643-4651
·
IF 4.682
Bo Lin,Li Fujin,Hou Yangbo,Wang Lei,Wang Xinglong,Zhang Ruipeng,Zuo Min,Ma Yanzhen,Zhao Degang
The ternary Cu 3 SbSe 4 thermoelectric material with diamond-like structure exhibit good electrical properties in the middle-temperature region. Forming co-alloying solid solutions has long been considered as an effective strategy for decoupling electrical conductivity and Seebeck coefficient. In this study, the Cu 3- x Ag x Sb 1- y Te y Se 4 ( x = 0–0.1; y = 0–0.05) materials were fabricated by melting-ball milling-hot pressing process. The influences of configurational entropy on the microstructure and thermoelectric properties of Cu 3 SbSe 4 were evaluated. It was found that the electrical conductivity of Cu 2.9 Ag 0.1 Sb 0.95 Te 0.05 Se 4 was about 200% higher than that of pure sample due to the slightly configurational entropy tuning. Moreover, multiscale free path phonons of Cu 2.9 Ag 0.1 Sb 0.95 Te 0.05 Se 4 can be greatly scattered and the lattice thermal conductivity decreased from 3.0 to 2.1 Wm −1 K −1 at 300 K via lattice-distortion effect. The maximum zT value of 0.84 was obtained at 650 K for the Cu 2.9 Ag 0.1 Sb 0.95 Te 0.05 Se 4 sample. These results displayed the multiple effects on thermoelectric transport during the formation of co-alloying solid solutions. Graphical abstract
研究领域:
材料科学
·
热电学
·
固体化学
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 28
·期 2
·1620-1623
·
IF 1.798
Zhang Shuai,Li Lingxia,Lv Xiaosong
The Mg 3 (PO 4 ) 2 ceramics were prepared by using the conventional solid-state reaction method. And the samples sintered at 1025 °C showed high relative density with 96.51 %. The crystal structure and dielectric properties of Mg 3 (PO 4 ) 2 ceramics were investigated. Optimized dielectric properties tested at 1 MHz were obtained in Mg 3 (PO 4 ) 2 ceramic sintered at 1025 °C for 2 h (ε r ~ 5.9, tanδ ~ 0.0015 and τ ε ~ 40 ppm/°C). Meanwhile, Mg 3 (PO 4 ) 2 ceramic showed the chemical compatibility with Ag electrodes, which can be a promising candidate for multilayer components applications in high frequency.
研究领域:
材料科学
·
陶瓷
·
介电材料
·
电子材料
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高影响因子
ARCHIVES OF MICROBIOLOGY
·
2026
·Vol. 208
·期 8
·385
·
IF 3.4
Wang Jiahui,Zhu Yuzhang,Liu Tao,Hong Xiangyu,Liu Mi,Zhou Rui,Li Xianke,Jing Mingguo,Yang Lifang
The antibacterial strategy that utilizes ultraviolet-A (UVA)-irradiated natural photosensitizers is promising, being particularly effective against multidrug-resistant pathogens with high bactericidal efficiency and minimal resistance-inducing risk. Rutin is a natural flavonoid with wide availability, low cytotoxicity, and diverse pharmacological activities, making it a promising photosensitizer; however, its UVA-induced photodynamic antibacterial properties remain underexplored. The aim of this study is to systematically evaluate the antibacterial efficacy and mechanism of UVA-Rutin against foodborne Escherichia coli O157:H7 . In the study, Fourier transform infrared spectroscopy and Raman spectroscopy were used to characterize structural alterations in rutin post-UVA irradiation, focusing on functional groups relevant to photodynamic activity. Antibacterial efficacy was assessed via standardized assays including minimum inhibitory concentration (MIC) determination, while biocompatibility was evaluated using MTT cytotoxicity assays. To confirm the antibacterial effects, physiological/structural perturbations of bacteria were measured, including cell membrane integrity, DNA damage, motility, biofilm formation, and extracellular polysaccharide (EPS) production, as well as the generation of intracellular reactive oxygen species (ROS) measured using fluorescent probes. Reverse transcription quantitative polymerase chain reaction was used to analyze key virulence- and quorum sensing-related genes ( luxS , phoP , qseB , qseC ). Results showed that UVA-induced structural changes enhanced the photosensitizing activity of rutin. UVA-Rutin exhibited significant antibacterial activity (low MIC) and good biocompatibility, triggering the generation of massive intracellular ROS, disrupting cell membranes, inducing DNA damage, impairing motility, inhibiting biofilm/EPS production, and downregulating target genes. Collectively, UVA-Rutin exerts potent antibacterial effects via ROS-mediated structural/functional disruption and virulence gene regulation, highlighting its potential as a novel food industry antibacterial agent.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Lu Jiawei,Zhao Ziguang,Liao Xizhi,Liu Jiating,Chen Jin,Li Yuhong,Wang Yifan,Zhang Yinjun,Li Jie,Li Tao,Xiao Pengcheng,Wen Xin,Chen Yi
Conventional hydrogels typically exhibit limited elastic ranges due to heterogeneous crosslinking and restricted chain mobility. Achieving both ultraplasticity and hyperelasticity within the same hydrogel is challenging. Herein, we developed a zwitterionic hydrogel (PSM) based on a single poly ([2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide) (PSBMA). The hydrogel exhibits a reversible in situ transition from an ultraplastic state (PSM 2M , manual tensile strain ( λ ) ~ 120000%) to a hyperelastic state (PSM 6M , λ = 1200%, with full recovery within 2–10 s) by modulating chain conformation from free to entangled states through electrostatic and hydrophobic interactions. During the process, the PSM exhibits broadly tuneable mechanical properties with modulus of 700 Pa – 2 MPa and toughness of 15 – 8000 kJ/m 3 . Thus, this hydrogel provides adaptable mechanical responses and can accurately replicate the diverse mechanical properties of biological tissues, offering an option for materials used in cell and tissue engineering.
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高影响因子
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