Polymer Chemistry
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2015
·Vol. 6
·期 36
·6529-6542
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IF 5.52
Jinxia An,Xiaomei Dai,Yu Zhao,Qianqian Guo,Zhongming Wu,Xinge Zhang,Chaoxing Li
To improve the pharmacokinetic and pharmacodynamic profiles of clinical anticancer drugs for cancer therapy, the development of effective drug delivery systems with precise biological functions is critically required. In the current study, we developed a PEGylated and core-cross-linked polymeric nanovehicle, LA-pDAGEA/pPEGA-b-p(DMDEA-co-BADS), with reduction- and pH-dependent degradation and fluorescence imaging function for tumor-targeted delivery of hydrophobic drugs. The multifunctional copolymers were synthesized using RAFT polymerization. By utilizing the intrinsic fluorescence of nanovehicles resulting from the boron–dipyrromethene dye-conjugated chain transfer agent (BODIPY), the cellular internalization process was exhibited. Cellular uptake and the competition inhibition assay show that the nanovehicles could be internalized into HepG2 cells via receptor-mediated endocytosis. Moreover, the drug-loaded nanovehicles were capable of significantly inhibiting cancer cell proliferation. Our newly developed multifunctional nanovehicles may thus facilitate the development of efficient drug delivery systems for application in diagnosis and therapy of cancer.
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CARBON
·
2015
·
IF 6.196
Jiangru Zhang,Xiang Wang,Guicun Qi,Binghai Li,Zhihai Song,Haibin Jiang,Xiaohong Zhang,Jinliang Qiao
A novel carbon microspheres composed of N-doped hollow carbon nanospheres was prepared by a newly developed three-step method. Firstly, poly(styrene-co-butyl acrylate)/polypyrrole (PSBA/PPy) latex particles with core–shell structure were synthesized by the chemical oxidative polymerization of pyrrole in poly(styrene-co-butyl acrylate) (PSBA) emulsion, then PSBA/PPy core–shell latex was dried by spray drying process . Finally, the dried PSBA/PPy particles were pyrolyzed under nitrogen atmosphere at 500–800 °C without activation process . It was found that nitrogen content could reach 7.62 wt% and large amount of micro-, meso- and macro-pores existed in this kind of carbon microsphere. The application of this carbon microsphere in CO 2 capture was also explored.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2015
·
IF 2.729
Bowen Zhang,Yishu Wang,Meng Li,Lili Cui,Xingquan He
A novel composite consisting of poly[iron (II) tetraphenylporphyrin] (PFeTPP) and poly(sodium- p -styrenesulfonate) (PSS) modified graphene (Gr), denoted as PFeTPP/PSS-Gr, was obtained by a solvothermal method and used for the voltammetric determination of dopamine (DA). Compared with either pristine PFeTPP or PSS-Gr, the fabricated composite exhibits superior electrocatalytic activity towards the oxidation of DA. Its oxidation peak current shows a linear dependence over the DA concentration in the range from 0.1 to 40 μM, with a detection limit of 5.73 nM ( S / N = 3). Furthermore, the fabricated PFeTPP/PSS-Gr composite can detect DA in the presence of a large excess of ascorbic acid (AA) and uric acid (UA). Our proposed sensor conceivably represents a promising material for bioanalytical applications.
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ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Wei Feng,Xiaojun Zhou,Wei Nie,Liang Chen,Kexin Qiu,Yanzhong Zhang,Chuanglong He
Construction of multifunctional nanocomposites as theranostic platforms has received considerable biomedical attention. In this study, a triple-functional theranostic agent based on the cointegration of gold nanorods (Au NRs) and superparamagnetic iron oxide (Fe3O4) into polypyrrole was developed. Such a theranostic agent (referred to as Au/PPY@Fe3O4) not only exhibits strong magnetic property and high near-infrared (NIR) optical absorbance but also produces high contrast for magnetic resonance (MR) and X-ray computed tomography (CT) imaging. Importantly, under the irradiation of the NIR 808 nm laser at the power density of 2 W/cm2 for 10 min, the temperature of the solution containing Au/PPY@Fe3O4 (1.4 mg/mL) increased by about 35 °C. Cell viability assay showed that these nanocomposites had low cytotoxicity. Furthermore, an in vitro photothermal treatment test demonstrates that the cancer cells can be efficiently killed by the photothermal effects of the Au/PPY@Fe3O4 nanocomposites. In summary, this study demonstrates that the highly versatile multifunctional Au/PPY@Fe3O4 nanocomposites have great potential in simultaneous multimodal imaging-guided cancer theranostic applications.
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2015
·
IF 1.295
Bi-Yi Yang,Fei-Fei Qi,Xiao-Qing Li,Jing-Jing Liu,Fei Rong,Qian Xu
A novel solid-phase extraction (SPE) system, based on a new sorbent of Nylon6/Polypyrrole (PA6/PPy) core–shell nanofibres mat and a new packing format of SPE disks, is presented in this paper. A series of related parameters that may affect the efficiency, such as the kind of eluent and its volume, the amount of nanofibres mat, ionic strength, pH of the sample, flow rate of the sample and volume of the sample, have been investigated systematically. Under the optimised conditions, the target analyte in 10 mL water samples can be completely extracted by a 3.0 mg PA6/PPy nanofibres mat and easily eluted by 400 µL acetonitrile. Around 20 µL elution was injected directly to HPLC-UV for determination, without further concentration. Besides, the nanofibres mat could be repeatedly used up to six cycles. Satisfactory linearity was achieved in the range of 0.1–40.0 ng/mL with a correlation coefficient of 0.9999. The limit of detection (LOD) (3 S/N) was 0.03 ng/mL, which could meet the determination requirements of atrazine as per the European Union legislation, US. Safe Drinking Water Act and the State Environmental Protection Administration of China. The simple, effective and economic method was proposed for the determination of atrazine in environmental water at trace level. The recoveries ranged from 94.73 to 114.92%, with relative standard deviations (RSDs) of 2.5–4.2%, and were obtained from tap water and lake water samples with atrazine at 2.0 ng/mL, suggesting the actual feasibility of the proposed method in environmental water samples.
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APPLIED SURFACE SCIENCE
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2015
·
IF 2.711
Shaoqiang Cao,Hongyang Zhang,Yuanqing Song,Jianling Zhang,Haigang Yang,Long Jiang,Yi Dan
Polypyrrole/polyvinyl alcohol–titanium dioxide (PPy/PVA–TiO 2 ) composite films used as photo-catalysts were fabricated by combining TiO 2 sol with PPy/PVA solution in which PPy was synthesized by in situ polymerization of pyrrole (Py) in polyvinyl alcohol (PVA) matrix and loaded on glass. The prepared photo-catalysts were investigated by X-ray diffraction (XRD), ultraviolet–visible diffuse reflection spectroscopy (UV–vis DRS), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectra and photoluminescence (PL). The results indicate that the composites have same crystal structure as the TiO 2 and extend the optic absorption from UV region to visible light region. By detecting the variation ratio, detected by ultraviolet–vis spectroscopy, of model pollutant rhodamine B (RhB) solution in the presence of the composite films under both UV and visible light irradiation, the photo-catalytic performance of the composite films was investigated. The results show that the PPy/PVA–TiO 2 composite films show better photo-catalytic properties than TiO 2 film both under UV and visible light irradiation, and the photo-catalytic degradation of RhB follows the first-order kinetics. The effects of the composition of composite films and the concentration of RhB on the photo-catalytic performance, as well as the possible photo-catalytic mechanism, were also discussed. By photo-catalytic recycle experiments, the structure stability of the PPy/PVA–TiO 2 composite film was investigated and the results show that the photo-catalytic activity under both UV and visible light irradiation have no significant decrease after four times of recycle experiments, suggesting that the photo-catalyst film is stable during the photo-catalytic process, which was also confirmed by the XRD pattern and FT-IR spectra of the composite film before and after photo-catalytic.
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BIOSENSORS & BIOELECTRONICS
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2015
·
IF 6.409
Wenjing Lian,Shuang Liu,Lei Wang,Hongyun Liu
A new strategy for the sensitive detection of kanamycin (KA) and other antibiotics based on molecularly imprinted polymer (MIP) and bioelectrocatalysis was developed in the present study. The KA-polypyrrole MIP films were electropolymerized on the surface of pyrolytic graphite (PG) electrodes, with pyrrole (PY) serving as the monomer and KA as the template. Because KA is electro-inactive, electroactive K 3 [Fe(CN) 6 ] was used as the probe in the cyclic voltammetric (CV) measurements. The difference of the CV reduction peaks of K 3 [Fe(CN) 6 ] at electrodes between the MIP films after KA removal and KA-rebinding MIP films could thus be used to determine KA quantitatively. When horseradish peroxidase (HRP) and H 2 O 2 were added into the testing solution, the detection sensitivity of the system was greatly amplified because the electrochemical reduction of H 2 O 2 could be catalyzed by HRP and mediated by K 3 [Fe(CN) 6 ]. With the bioelectrocatalysis amplification, the limit of detection (LOD) for KA fell as low as 28 nM, approximately two orders of magnitude lower than that for the MIP films in the absence of enzymatic catalysis. The strategy demonstrated the generality. Not only KA but also other antibiotics, such as oxytetracycline (OTC), could be determined by this method. More significantly, in addition to the K 3 [Fe(CN) 6 ]–HRP–H 2 O 2 system, other bioelectrocatalysis systems, such as Fc(COOH) 2 –GOD–glucose (Fc(COOH) 2 =ferrocenedicarboxylic acid, GOD=glucose oxidase), could also be used to amplify the CV signal and realize the sensitive detection of KA for the MIP film system, thereby illustrating the great potential and prospects of the strategy.
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CHEMICAL ENGINEERING JOURNAL
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2015
·
IF 4.321
Qian Yao,Lujiang Xu,Zheng Han,Ying Zhang
Furfural, an abundant biomass derived compound, was converted into indoles via thermo-catalytic conversion and ammonization with zeolites. The effect of reaction temperature, catalyst, weight hourly space velocity (WHSV) and ammonia to furfural molar ratio on the product distribution was investigated systematically. They all played important roles on indoles production. The maximal carbon yield of indoles (20.79%) was achieved by using HZSM-5 (Si/Al = 25) catalyst at 650 °C with WHSV as 1.0 h −1 and NH 3 to furfural molar ratio as 2. The HZSM-5 (Si/Al = 25) catalyst was recycled for five times and showed slight deactivation. Three possible aldehyde group of furfural conversion pathways were proposed and one possible reaction pathway from furfural to indoles was verified based on the experimental and quantum calculation results, that is, furfural firstly reacted with ammonia to form furfural-imine, and then furfural-imine underwent a cracking reaction to form furan. Thereafter, furan was converted to pyrrole and finally to indoles.
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SENSORS AND ACTUATORS B-CHEMICAL
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2015
·
IF 4.097
Xueping Zhang,Dong Liu,Bin Yu,Tianyan You
A novel nonenzymatic electrochemical sensor for the detection of hydrogen peroxide (H 2 O 2 ) was developed based on free-standing nitrogen-doped carbon nanoparticles-embedded carbon nanofibers (NCNPFs) film, which were prepared by the carbonization of electrospun polypyrrole nanoparticles/polyacrylonitrile (PPy NPs/PAN) composite nanofibers. A series of NCNPFs- x samples with different mass concentration of PPy NPs to PAN (wt.%) were prepared. When the PPy NPs precursor is 12 wt.%, large amount of resulting NCNPs are embedded uniformly in NCNFs substrate without obvious aggregation. The as-obtained NCNPFs-12 wt.% has smaller diameter, higher content of pyrrolic-N and more defective sites, which result in high electrocatalytic activity for H 2 O 2 reduction. The NCNPFs-12 wt.%-based H 2 O 2 sensor shows a fast amperometric response within 2 s, and a wide linear range of 5.0 × 10 −6 to 2.7 × 10 −2 M with a high sensitivity of 383.9 μA μM −1 cm −2 . In addition, this nonenzymatic sensor displays good selectivity, high reproducibility and long-term stability. Because of the remarkable analytical performances, the NCNPFs-12 wt.%-based electrochemical sensor shows potential applications for the detection of H 2 O 2 in human serum and disinfectant samples with satisfactory results.
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CATALYSIS LETTERS
·
2015
·Vol. 145
·期 10
·1913-1921
·
IF 2.307
Wu Jing,Zhi Yunfei,Shan Shaoyun,Su Hongying,Wu Shuisheng,Jia Qingming
Abstract Polypyrrole(PPy) supported Cr(III)(salen)Cl catalyst was prepared for alternating copolymerization of cyclohexene oxide and carbon dioxide. The supported catalyst and the copolymerization products were characterized by FTIR, XRD, XPS, ICP-MS, SEM, TEM, NMR, gel permeation chromatography, thermogravimetric analysis and differential scanning calorimetry. After the study, we concluded that the homogeneous Cr(III)(salen)Cl is successfully supported on the PPy, and its catalytic performance is much better than the homogeneous one. Moreover, the copolymerization product catalyzed by PPy-Cr(III)(salen)Cl exhibits higher molecular weight, narrower molecular weight distribution, superior thermal stability and selectivity. Graphical Abstract
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CHEMISTRY-A EUROPEAN JOURNAL
·
2014
·Vol. 20
·期 37
·11826-11834
·
IF 5.696
Yang Wang,Yun Xiao,Ruikang Tang
Graphical Undercover double agent : Spindle-like polypyrrole hollow nanocapsules (PPy HNCs) can load and deliver anticancer drugs with high efficiencies; meanwhile, the polypyrrole (PPy) shells are an excellent agent for organic photothermal therapy (see figure; DOX=doxorubicin). Two cancer therapy methods were successfully combined to significantly improve the effect of tumor therapy in vitro and in vivo. The monodispersed spindle-like polypyrrole hollow nanocapsules (PPy HNCs) as the multifunctional platforms for combining chemotherapy with photothermal therapy for cancer cells are reported. Whereas the hollow cavity of nanocapsules can be used to load the anticancer drug (i.e., doxorubicin) for chemotherapy, the PPy shells can convert NIR light into heat for photothermal therapy. The release of the drug from the spindle-like PPy HNCs is pH-sensitive and near-infrared (NIR) light-enhanced. More importantly, the spindle-like PPy HNCs can penetrate cells more rapidly and efficiently in comparison with the spherical PPy HNCs. Both in vitro and in vivo experiments demonstrated that the combination of DOX-loaded spindle-like PPy HNCs and NIR light provide a highly effective and feasible chemo-photothermal therapy cancer method with a synergistic effect. Owing to their high photothermal conversion efficiency, large hollow cavity, and good biocompatibility, the spindle-like PPy HNCs could be used as a promising new cancer drug-nanocarrier and photothermal agent for localized tumorous chemo-photothermal therapy.
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ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Xuemei Yao,Li Chen,Xiaofei Chen,Zhe Zhang,Hui Zheng,Chaoliang He,Jingping Zhang,Xuesi Chen
For drug delivery systems, the most important factors are biocompatibility and stability. To achieve excellent biocompatibility, learning from naturally occurring systems may be the best choice. Herein, a series of pH-sensitive metallo-supramolecular nanogels (MSNs) were prepared by the metallo-supramolecular coordinated interaction between histidine and iron-meso-tetraphenylporphin, which mimicks the way that hemoglobin carries oxygen. With the excellent biocompatibility and special supramolecular pH sensitivity, MSNs had been exploited to load and release anticancer drug doxorubicin (DOX). In vitro drug release profiles showed that only a small amount of the loaded DOX was released in PBS solution at pH 7.4, while up to about 80% of the loaded DOX could be quickly released at pH 5.3 due to the pH-dependent disassembly of MSNs. Confocal laser scanning microscopy (CLSM) and flow cytometry were used to verify the cellular uptake and intracellular drug release behaviors of DOX-loaded MSNs toward MCF-7. Efficient cellular proliferation inhibition against MCF-7 and HeLa cells was also observed by a 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. These features suggested that MSNs could be of great potential as intelligent drug delivery systems.
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