PHYSICAL REVIEW B
·
2024
·Vol. 109
·期 21
·214430
·
IF 3.2
Lei Yue,Ziyou Lu,Kun Yan,Le Wang,Shu Guo,Ruixin Guo,Peng Chen,Xiaobin Chen,Jia-Wei Mei
In our study, we conduct magnetization and heat capacity measurements to investigate field-induced magnetic phase transitions within the newly synthesized compound ${\mathrm{K}}_{2}{\mathrm{Ni}}_{2}{({\mathrm{SeO}}_{3})}_{3}$, a spin-1 dimer system arranged on a triangular lattice. From our first-principles simulations, we determine that the spin system in ${\mathrm{K}}_{2}{\mathrm{Ni}}_{2}{({\mathrm{SeO}}_{3})}_{3}$ can be represented as a two-dimensional triangular-lattice spin-1 dimer model, including an intra-dimer exchange of ${J}_{1}=0.32\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$, an inter-dimer exchange of ${J}_{2}=0.79\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$, and an easy-axis anisotropy of $D=0.14\phantom{\rule{0.16em}{0ex}}\mathrm{meV}$. The presence of easy-axis magnetic anisotropy explains the distinct magnetic phase diagrams observed under $c$-axis directional and in-plane magnetic fields. Notably, our investigation unveils a two-step phase transition with the magnetic field aligned with the $c$ direction. Our findings yield valuable insights into the magnetic phase transitions inherent to geometrically frustrated magnetic systems featuring dimer structures.
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Advanced Healthcare Materials
·
2026
·
IF 11
Xingxiu Jiang,Haoliang Shi,Binbin Chu,Yulan Gu,Yicheng Zhang,Li Wang,Yao He,Xiaofeng Zhang
Among working-age adults in the contemporary era, more than 30% of individuals with diabetes are at risk of developing diabetic retinopathy (DR), a progressive ocular disorder that is the leading cause of visual impairment and blindness. Despite its high prevalence, treatment options remain limited. Current therapeutic strategies only focus on the inhibition of neovascularization or prevention of vascular leakage. Additionally, the majority of conventional eye drop formulations fail to deliver drugs efficiently to the retina, further limiting clinical applicability. To address these issues, we herein designed and developed an eye drop formulation based on the chitosan-modified liposomes encapsulating epigallocatechin-3-gallate (EGCG), capable of transporting EGCG from the ocular surface to the retina. Mechanistic studies revealed that efficient retinal delivery of EGCG could protect Müller cells against high glucose (HG)-induced injury via SIRT1-BNIP3-mediated mitophagy. In vivo, the developed EGCG@CS-LIP showed enhanced fundus delivery and therapeutic efficacy compared with conventional liposomes or free EGCG systems, attributed to the transient modulation of corneal tight junctions. More importantly, the EGCG@CS-LIP eye drops could effectively increase the expression level of SIRT1 protein and inhibit the apoptosis and damage in retina, thus exerting significant in vivo therapeutic effects for the effective treatments of DR. Lastly, the constructed EGCG@CS-LIP indicated the excellent ocular biocompatibility, highlighting its promise for future clinical translation in DR therapy.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 15
·118583
·
IF 6.3
Qinghu Guo,Ting Wang,Jinglong Fan,Yimang Zhao,Xiangyu Meng,Xiaoyi Gao,Zhonghua Yao,Weiping Gong,Hanxing Liu,Hua Hao,Shujun Zhang
Electrostrictive ceramics are crucial for high-precision actuators due to their low hysteresis, fast response, and low heat dissipation. In this work, Nd 3+ was strategically employed to optimize the electrostrictive properties of x Nd-doped Pb(Ni 1/3 Nb 2/3 )O 3 -PbZrO 3 -PbTiO 3 (PNN-PZ-PT) ceramics. A phase transition from the morphotropic phase boundary to a cubic structure, accompanied by enhanced dielectric relaxor behavior was observed with increasing Nd content, which can be attributed to the disruption of long-range ordered ferroelectric domains caused by aliovalent Nd doping-induced local structural heterogeneities—thereby reducing strain hysteresis and enabling improved electrostrictive response. Notably, outstanding electrostrictive strain of 0.105% and high electrostrictive coefficient M 33 = 10.5 × 10 −16 m 2 /V 2 were obtained under a 10 kV/cm for the 3%Nd-doped PNN-PZ-PT ceramic, superior to other relaxor ferroelectric ceramics. Additionally, this composition exhibits outstanding cycling reliability with only 5% strain degradation over 10 6 electrical cycles, positioning it as a promising candidate for precision micro-actuators applications requiring ultra-stable, high-efficiency electromechanical responses.
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Cell Reports Medicine
·
2026
·
IF 14
Xiaoliang Dong,Mengwen Wang,Bingxin Wang,Hongli Li,Zeyun Cao,Binbin Li,Xun Zou,Xuan Kong,Huanxin Yang,Yufeng Zhou,Le Zhang,Li-Long Pan,Jia Sun
Neonatal necrotizing enterocolitis (NEC) is a severe inflammatory disease primarily affecting premature infants, characterized by high mortality and morbidity, with limited therapeutic options available. While emerging evidence links microbiota to NEC pathogenesis, the role of commensal metabolites in NEC and safe metabolite-based therapies remain unexplored. Metabolomic profiling reveals a significant reduction in 3-indoleacrylic acid (IA), a tryptophan-derived metabolite, in NEC infants and animal models. IA supplementation alleviates intestinal inflammation and tissue damage. Single-cell RNA sequencing analysis reveals the activation of STAT1 signaling as a necroptosis driver in intestinal epithelial cells, which is suppressed by IA. Protection is abolished by aryl hydrocarbon receptor (AhR) inhibitor CH-223191 or in intestinal epithelium-specific AhR knockout mice. Oral administration of Bifidobacterium longum subsp. infantis containing the IA-producing fldI gene prevents NEC in mice. Our study uncovers IA as a microbiota-derived therapeutic inhibiting STAT1-driven necroptosis via the AhR-SOCS5 axis, offering a targeted strategy for NEC management.
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Advanced Science
·
2026
·
IF 14.1
Dan Zhao,Lingling Zhang,Yue Wen,Lianghui Cheng,Sidan Tian,Fanling Meng,Liang Luo
Pyroptosis holds great promise for evoking robust anti‐tumor immunity, but many pyroptosis induction strategies rely on caspase‐3 (Casp‐3) activation and face challenges of the immunosuppressive nature of apoptosis and the frequent silencing of gasdermin E (GSDME), a substrate of Casp‐3, in tumors. Here, we report a strategy to rewire the pyroptotic pathway by bypassing Casp‐3 to directly activate gasdermin D (GSDMD). We identify a small‐molecule agonist, (E)‐2,3‐diiodobut‐2‐ene‐1,4‐diol (DIBDO), which undergoes deiodination to release iodide ions upon activation by the tumor‐abundant nucleophile glutathione, thereby catalytically generating singlet oxygen and molecular iodine. This cascade induces oxidative damage that downregulates key mediators of caspase‐9 and caspase‐8 pathways, thereby down‐regulating Casp‐3 activation. This mechanism selectively triggers GSDMD‐mediated pyroptosis, provoking robust immunogenic cell death and inflammatory cytokine release to reconfigure the tumor immune microenvironment. In murine tumor models, DIBDO enhances tumor infiltration of cytotoxic T cells and synergizes with checkpoint blockade therapy to suppress both primary and distal tumors. It can also serve as an in situ or exogenous vaccine to elicit potent and durable antitumor immunity. This work presents a paradigm‐shifting approach to cancer immunotherapy by decoupling pyroptosis from Casp‐3 dependence, offering a promising avenue to expand the scope of immunogenic cell death‐based treatments. This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death. This reconfigures the tumor microenvironment, transforms the tumor cells into in situ or exogenous vaccine, offering a novel paradigm for cancer immunotherapy.
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NEUROCHEMICAL RESEARCH
·
2026
·Vol. 51
·期 4
·226
·
IF 4.5
Qin Dani,Lei Yong,Le Meini,Cheng Mengke,Zhao Yingmin,Xia Lingyun,Li Xinyuan,Dong Xiaohua
Hypoxic-ischemic encephalopathy (HIE) is a severe perinatal brain injury that often leads to neurological impairments in survivors. Currently, effective therapeutic strategies for HIE remain limited and require further exploration. Emerging evidence indicates that microglia-mediated neuroinflammation plays a pivotal role in the pathophysiology of HIE. Nevertheless, clinically effective anti-inflammatory agents specifically targeting HIE are still lacking. Glycerol-3-phosphate (G3P) is a biologically significant metabolite involved in various cellular metabolic pathways. In this study, we investigated the neuroprotective effects of G3P against hypoxic-ischemic (HI)-induced brain injury by modulating microglial activation. In LPS-treated microglia, G3P suppressed the release of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α, reduced reactive oxygen species (ROS) levels, restored mitochondrial membrane potential (MMP), and promoted a shift toward an anti-inflammatory microglial phenotype. In addition, G3P treatment in zebrafish showed no toxicity and significantly mitigated HI-induced oxidative stress, while suppressing both the recruitment and pro-inflammatory activation of mpeg1⁺ macrophages and lyzc⁺ neutrophils. Moreover, administration of G3P dramatically reduced infarct volume and alleviated neuronal loss in rats with hypoxic-ischemic brain damage (HIBD). Y-maze and Morris water maze tests demonstrated that G3P treatment significantly enhanced spatial learning and memory in HIBD rats. Furthermore, G3P markedly reduced the hyperactivation of microglia and astrocytes in both cortical and hippocampal regions. Mechanistically, Immunofluorescence and Western blot analyses revealed that G3P exerted anti-inflammatory effects by inhibiting cyclic GMP-AMP synthase -stimulator of interferon genes (cGAS-STING) signalling pathway and its downstream TBK1/the nuclear factor kappa B (NF-κB) signaling pathway. These findings highlight G3P as a promising therapeutic candidate for HIE.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Liru Liu,Ping Cheng,Yingxiao Xiao,Sijin Chen,Yiping Zhang,Weizhu Chen,Fengfu Fu,Zhenyu Lin,Yongqiang Dong
(3 S ,3′ S )-astaxanthin ((3 S ,3′ S )-AST) with excellent physiological activity demands accurate chiral-selective detection, yet conventional methods have inherent limitations and SERS technology lacks relevant applications here. In this study, a chiral-selective hydrogel-based SERS chip was prepared by immobilizing aggregated silver nanocages (a-AgNCs) in polyvinyl alcohol (PVA) hydrogel for specific and sensitive (3 S ,3′ S )-AST detection. The hydrogel realized selective adsorption of (3 S ,3′ S )-AST, and a-AgNCs provided strong SERS enhancement via electromagnetic-chemical synergistic effect. The sensing system showed excellent stability (intra/inter-chip RSD < 4.22%, signal loss <5% in 6 weeks), a semi-logarithmic linear response for (3 S ,3′ S )-AST in 0.5–500 ng/g. Practical detection in Haematococcus pluvialis (HP) and Phaffia rhodozyma yeast (PRY) powders confirmed no (3 S ,3′ S )-AST in PRY, and the detected contents in HP samples were consistent with HPLC results. This chip establishes a rapid and reliable chiral-selective detection method for (3 S ,3′ S )-AST, and expands SERS application in chiral analysis of food-related natural products. Hydrogel SERS chips enable direct chiral-selective detection of (3 S ,3′ S )-astaxanthin with high sensitivity and reliable real-sample applicability. Download: Download high-res image (202KB) Download: Download full-size image
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ACS Synthetic Biology
·
2025
·
IF 3.9
Zhen Zong,Lianghua Xie,Jiaqi Fu,Zhongyang Liu,Wen-Wen Zhou,Wei Chen
Cyanidin-3-O-galactoside (C3Ga), a natural pigment, has various beneficial biological activities and is widely used as a food colorant. However, traditional plant extraction methods are time-consuming and unsustainable. Rapid and sustainable synthesis of C3Ga by engineered microorganisms offers a promising alternative to traditional plant-based methods and deserves to be explored. In this study, the bioproduction of C3Ga by Escherichia coli was achieved for the first time. The biosynthetic pathway of C3Ga from (+)-catechin was constructed by introducing anthocyanidin synthase (ANS) and UDP-galactose:cyanidin galactosyltransferase. Some strategies, including enhancement of the UDP-galactose biosynthesis pathway, identification of efficient ANS, overexpression of the C3Ga transporter, and modulation of multigene expression, were subsequently used to drive the metabolic flux toward C3Ga production. Next, the two-stage process for C3Ga production was optimized to mitigate limitations for further metabolic engineering. Combined with the knockout of β-phosphoglucomutase (ycjU), a newly identified competitive pathway for UDP-galactose, the production of C3Ga finally reached 217.9 mg/L. The strategies used in this study could be applied to the biosynthesis of other anthocyanins and galactosylated natural products.
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CANADIAN JOURNAL OF PLANT SCIENCE
·
2015
·Vol. 95
·期 5
·
IF 0.919
ZhaoLi-Xia,QuHai-Tao,FuYing,GaoShuang,YeFei
Zhao, L.-X., Qu, H.-T., Fu, Y., Gao, S. and Ye, F. 2015. Alleviation of injury from chlorimuron-ethyl in maize treated with safener 3-dichloroacetyl oxazolidine. Can. J. Plant Sci. 95: 897–903. The protective effects of herbicide safeners, including 3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine (R-28725), 3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (Racemate), and its two enantiomers (R)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (R-enantiomer) and (S)-3-dichloroacetyl-2,2-dimethyl-4-ethyl-1,3-oxazolidine (S-enantiomer), on reducing the phytotoxicity of chlorimuron-ethyl to maize were investigated. Soaking the seeds in safeners increased the endogenous glutathione (GSH) content and glutathione-S-transferase (GST) activity of maize. When induced by R-enantiomer, the GST activity in vivo and in vitro increased 180 and 192% compared with control, respectively. R-28725 and R-enantiomer also increased the acetolactate synthase (ALS) activity inhibited by chlorimuron-ethyl from 45 to 100 and 97% compared with the control, respectively. The kinetic parameter Vmax of GST in the maize treated with R-28725 and R-enantiomer increased by 103 and 92%, respectively, compared with the control. Our results suggest that R-28725 and R-enantiomer could significantly improve the GSH content, GST activity, and ALS activity of maize. Overall, maize could be protected from the injury caused by chlorimuron-ethyl.
研究领域:
植物科学
·
农业化学
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CHEMICAL ENGINEERING & TECHNOLOGY
·
2010
·Vol. 33
·期 12
·2082-2088
·
IF 1.266
F. Huang,W. Li,Q. Lu,X. Zhu
A homogeneous RuCl 2 (PPh 3 ) 3 catalyst was prepared for the hydrogenation of bio-oil to improve its stability and fuel quality. Experiments were first performed on three model aldehydes of acetaldehyde, furfural and vanillin selected to represent the linear aldehydes, oxygen heterocyclic aldehydes and aromatic aldehydes in bio-oil. The results demonstrated the high hydrogenation capability of this homogeneous catalyst under mild conditions (55–90 °C, 1.3–3.3 MPa). The highest conversion of the three model aldehydes was over 90 %. Furfural and acetaldehyde were singly converted to furfuryl alcohol and ethanol after hydrogenation, while vanillin was mainly converted to vanillin alcohol, together with a small amount of 2-methoxy-4-methylphenol and 2-methoxyphenol. Further experiments were conducted on a bio-oil fraction extracted by ethyl acetate and on the whole bio-oil at 70 °C and 3.3 MPa. Most of the aldehydes were transformed to the corresponding alcohols, and some ketones and compounds with C–C double bond were converted to more stable compounds.
研究领域:
化学工程
·
可再生能源
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INORGANIC CHEMISTRY
·
2026
·
IF 4.7
Hangwei Jia,Yaqi Jin,Junwei Feng,Bailin Chen,Feng Yu,Xueling Hou
Guanidine units have garnered significant attention in the study of ultraviolet (UV) nonlinear optical (NLO) materials due to their excellent microscopic optical properties, making them ideal systems for developing novel optical devices. A novel guanidinium-templated UV NLO crystal, [C(NH2)3]SbCl4 (GSC), was successfully synthesized via an aqueous solution method. GSC crystallizes in the orthorhombic chiral space group P212121, featuring a seesaw shaped [SbCl4]− anion. Remarkably, GSC exhibits a moderate second harmonic generation (SHG) response of 1.1 × KDP at 1064 nm and a large refractive index difference of 0.2 at 546 nm. This NLO effect originates from the synergistic interaction between the [C(NH2)3]+ unit and the stereochemically active [SbCl4]− unit. This work provides a candidate for the guanidine family of NLO materials.
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
·
2014
·
IF 2.235
Meng Lin,Xiaoke Hu,Weiwei Chen,Hui Wang,Chuanyuan Wang
A phenanthrene (PHE) degrading bacterium strain BZ-3 was isolated from the crude oil contaminated soil in Binzhou, China. The isolate was identified as Pseudomonas sp. BZ-3 on the basis of 16S rRNA gene sequence. Various experiments were conducted to investigate the effect of pH, salinity and PHE concentration on the degradation efficiency of PHE. The degradation efficiency and degradation metabolites of PHE were detected by using GC–MS and HPLC-MS analyses. The strain BZ-3 could degrade 75% of PHE at an initial concentration of 50 mg/L under 20 g/L salinity in 7 days. PHE degradation kinetics was estimated in a first-order degradation rate model and the rate coefficient was calculated as 0.108 d −1 . On the basis of the identified degradation metabolites, the strain BZ-3 could degrade PHE in the salicylate metabolic pathway. In a mixture system consisting of PHE and other PAHs including naphthalene (NA), anthracene (ANTH), and pyrene (PYR), the strain BZ-3 showed an efficiently degradation capability. Further study showed that the strain BZ-3 could also use NA, ANTH, PYR, xylene, 1-hydroxy-2-naphthoic acid, and hexane as the sole carbon and energy source, but did not grow on nitrobenzene-containing medium.
研究领域:
环境科学
·
微生物学
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