MICROBIAL PATHOGENESIS
·
2024
·
IF 3.3
Zhikun Zhang,Dawei Shi,Haiwei Dou,Ruijie Wan,Qing Yuan,Peng Tu,Deli Xin
In previous study, lower levels of serum GP130 were reported in children with MPP. GP130 is an important signal transducer, the down regulation of which may influence host immune responses. In this study, we aimed to analyze the regulatory mechanism of GP130 during MP infection. Firstly, the mRNA and protein levels of GP130 both decrease and then increase with increasing multiplicity of infection (MOI: 1 to 40) of MP. The lowest levels of GP130 were detected at MOI of 5. Then, heat treated MP but not trypsin treated MP or MP extracted proteins show regulatory effect to the expression of GP130. These indicate that the down regulation of GP130 is related to protein mediate adhesion process of MP. Gene expression analysis revealed that MP affected apoptosis and the TLR4 pathway in infected cells, and the mRNA level of IL-6 was correlated with that of GP130. Further, Z-VAD-FMK (pan-caspase inhibitor) can suppress the apoptosis induced by MP infection and restore GP130 at protein level. Further studies revealed that MP infection promoted TLR4 internalization but did not activate the NF-κB pathway. The levels of surface TLR4 showed correlation with the transcription of IL-6 and GP130. TAK242 (TLR4 inhibitor) and PS341 (proteasome inhibitor) can restore the decreased transcription of GP130, both of which were able to promote NF-κB pathway activation in MP-infected cells. These suggested that the regulation of TLR4/NF-κB pathway and induced apoptosis post MP infection are involved in the down-regulation of GP130 at transcription and protein levels, respectively.
研究领域:
微生物学
·
免疫学
·
细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Fei Yan,Gaosong Wang,Shengtao Dai,Qitao Huang,Guodong Su,Xibing Zhan,Liu Liu
Herein, a bio-based polyurethane (PU) was synthesized using L-lysine diisocyanate and castor oil as raw materials. Following the salt formation reaction and subsequent emulsification process, a waterborne sizing agent was successfully obtained. To enhance the adhesion strength between the carbon fibers (CF) and sizing agent, 3,4-dihydroxybenzoic acid containing a catechol group was chosen as the neutralizing agent and introduced into the PU. The particle size of the PU sizing agent was 124.3 nm, indicating its suitability for long-term storage. After treating with 1.0, 1.5, and 2.0 wt% concentrations of the sizing agent, the CF referred to as CF1, CF2, and CF3, respectively, were used to prepare CF/polyamide 6 (PA6) composites. The sizing agent considerably improved the interfacial bonding between the CF and the PA6 matrix, with the CF2/PA6 composites showing the greatest enhancement. Specifically, the flexural strength, interlaminar shear strength and interfacial shear strength of the treated composites were enhanced by 28.3%, 47.5%, and 52.3%, respectively, compared with those of the unsized composites. The interfacial failure mechanism of the composites under stress was elucidated via fracture morphology characterization. These findings offer a valuable reference for the future development of novel waterborne PU sizing agents.
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产品关联
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2013
·Vol. 23
·期 6
·1534-1539
·
IF 1.174
Yan Bianling,Zhou Xiaojun,Li Yuanyuan,Yin Fei,Zou Yang,Jiang Yinzhi,Wang Xing,Xie Jingli
A novel 3d–4f heterometallic coordination complex [Ce(H 2 O) 6 (CuL) 2 ]·NO 2 ·7H 2 O ( 1 ) (H 3 L = glycylglycine, N -[1-(2-hydroxy, phenyl)-propylidene]) was synthesized and characterized by IR, elemental analysis, TGA and single crystal X-ray diffraction. An octameric water cluster consisting of a planar tetrameric water ring and four dangling water molecules were observed in 1 . Variable-temperature magnetic data shows antiferromagnetic behavior for 1 .
研究领域:
化学
·
材料科学
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DOI
高影响因子
JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
·
2014
·Vol. 30
·期 3
·199-203
·
IF 0.827
Wei-Bin Ma,Jun-Tao Feng,Zhi-Li Jiang,Xing Zhang
We studied the knockdown activity and lethal toxicity of 6 essential oil compounds—methyl salicylate, linalool, 2-phenethyl alcohol, eugenol, β-citronellol, and trans-cinnamaldehyde—as fumigants against adult female Culex pipiens pallens in the laboratory. Of the 6 products tested, trans-cinnamaldehyde was the most toxic (LC50 = 0.26 µl/l air, 24 h) with a slow knockdown time (KT95 = 176.5 min at 0.5 µl/l air). Methyl salicylate displayed a lower toxicity (LC50 = 1.17 µl/l air, 24 h) but the fastest knockdown activity (KT95 = 16.8 min) at the sublethal concentration 0.5 µl/l air. Furthermore, the binary mixture of methyl salicylate and trans-cinnamaldehyde exhibited a combined effect of fast knockdown activity and high toxicity against Cx. p. pallens adults, showing potential for development as natural fumigants for mosquito control.
研究领域:
昆虫学
·
公共卫生学
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DOI
PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2022
·Vol. 147
·期 17
·9431-9450
·
IF 4.755
Liu Fu-Ya,Zhou Xue-Ling,Zhao He,Hu Wei-Dong,Xu Jian-Zhong,Jiao Yun-Hong,Qu Hong-Qiang
The synergistic effect and mechanism of the spherical CoSn(OH) 6 (T-CHS) and ammonium polyphosphate (APP) on epoxy resin (EP) were investigated by limiting oxygen index (LOI), vertical combustion test (UL-94), cone calorimeter, tensile machine, thermogravimetric analysis-coupled with a Fourier transform infrared spectrometer (TGA/FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy, and Raman spectrometer. The results indicate that when the mass ratio of APP and T-CHS is 5.9:0.1 and 5.5:0.5, respectively, there is a synergistic effect between APP and T-CHS, and the flame retardant EP samples could pass the V-0 level of UL-94 test and their tensile properties have little difference to that of the blank EP. Compared with the blank EP, the total heat release and total smoke production of EP/5.9APP/0.1 T-CHS are decreased by 25% and 26%, respectively. TGA/FTIR results of the EP samples under N 2 atmosphere indicate the NH 3 production of EP/5.9APP/0.1 T-CHS is decreased by 47% and the CO 2 and H 2 O production is increased by 991% and 210%, respectively, when compared with that of the blank EP. APP and T-CHS show a good synergistic effect on promoting the retention of C, Co, Sn, and N elements in the char residues. The char residues of EP/5.9APP/0.1 T-CHS and EP/5.5APP/0.5 T-CHS samples contain Co 3 O 4 , CoO, SnO, SnO 2 , oxides of phosphorus, and Sn element, which form a more compact physical barrier.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Pengcheng Qi,Zhenhao Xiao,Wenjing Song,Jiawei Xia,Weizuo Li,Xinmin Li,Guangyu He,Dafang He,Haiqun Chen
The escalating atmospheric CO 2 concentration necessitates its conversion into highvalue- added products like cyclic carbonates, yet existing catalysts face challenges such as poor recoverability (homogeneous ionic liquids, ILs) and insufficient activity (monometallic metal–organic frameworks, MOFs). To address this, a series of bimetallic Ni x /Zn 1-x -PTA MOFs with different Ni/Zn molar ratios were synthesized via a solvothermal method, and then composite catalysts (Ni x /Zn 1-x -PTA@Mim-6) were prepared by impregnating the MOFs with Mim-6 ILs. This work provides a promising approach for efficient and sustainable CO 2 capture and conversion by integrating the advantages of bimetallic MOFs (high porosity, recyclability) and ILs (high catalytic activity). Characterizations via FT-IR, XRD, TEM, STEM-EDS, and TGA confirmed the successful synthesis, well-defined structure (e.g., nanoflower-like morphology of Ni 0.2 /Zn 0.8 -PTA MOFs), homogeneous elemental distribution, and good thermal stability of the composites. Catalytic tests showed that Ni 0.2 /Zn 0.8 -PTA@Mim-6 exhibited optimal performance: under solvent-free and co-catalyst-free mild conditions, the yield and selectivity of styrene carbonate both exceeded 99%, which was significantly superior to monometallic Ni-PTA@Mim-6 (46% yield) and Ni 0.2 /Zn 0.8 - PTA MOFs with co-catalyst (76% efficiency). The catalyst also demonstrated excellent recyclability (no significant activity loss after 5 cycles, conversion 69% and selectivity 99%) and universality for various epoxides (e.g., high yields for 1,2-butylene oxide and epichlorohydrin). Mechanistic studies revealed that the synergistic effect of multiple active sites—Lewis acid sites (unsaturated Ni/Zn) for epoxide activation, Lewis base sites (O in Ni-O/Zn-O) for CO 2 activation, and Br - from Mim-6 for ring opening—lowered the reaction energy barrier (activation energy 35.80 kJ/mol) and enhanced catalytic efficiency.
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Fengping Ruan,Degang Deng,Ming Wu,Bowen Chen,Lei Lei,Ruoshan Lei,Shiqing Xu
A novel dual-emitting Ca 8 ZrMg(PO 4 ) 6 (SiO 4 ): (Eu 3+ , Eu 2+ ) phosphors with ultrahigh-sensitive optical temperature sensing are prepared by a conventional solid-state method. The Eu 2+ /Eu 3+ co-activated Ca 8 ZrMg(PO 4 ) 6 (SiO 4 ) phosphors exhibit efficient dual-mode emissions with an intense, broad blue emission peaked at 414 nm and a relative bright red-emitting centered at 614 nm under 297 nm UV-light excitation, respectively. Furthermore, the fluorescence intensity ratio (FIR) technology is applied to analyse the optical temperature sensing performance of Ca 8 ZrMg(PO 4 ) 6 (SiO 4 ): (Eu 3+ , Eu 2+ ) phosphors. Based on different thermal quenching behavior of Eu 2+ and Eu 3+ dual-emitting centers, linear temperature-dependent FIR between Eu 2+ and Eu 3+ is obtained. The maximal absolute sensitivity reaches as high as 5.94% K −1 , which is superior to that for the other luminescent temperature sensing materials reported previously. Analyses of the temperature-dependent photoluminescence spectra and configurational coordinate diagrams for Ca 8 ZrMg(PO 4 ) 6 (SiO 4 ): (Eu 3+ , Eu 2+ ) phosphors indicate that the temperature-sensitive variation in FIR of Eu 2+ to Eu 3+ is originated from the difference in thermal quenching activation energy for 5d→4f transition of Eu 2+ and 5 D 0 → 7 F J (J = 1, 2, 4) transitions of Eu 3+ . These results reveal that the Ca 8 ZrMg(PO 4 ) 6 (SiO 4 ): (Eu 3+ , Eu 2+ ) phosphors show glorious potential in high temperature optical thermometry.
研究领域:
材料科学
·
无机化学
·
光学传感
·
功能材料
·
固体物理
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DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Chao Chen,Haijian Li,Zhao Qin,Changjian Wang,Yi Xu,Zhihua Sun,Siyu Xu,Jianhua Yi,Fengqi Zhao
Hexanitro complex K 2 Ba[Ni(NO 2 ) 6 ] was prepared via the co-precipitation method, and its composition and morphology were characterized by XRD , SEM , XPS and FT-IR techniques. The catalytic performances of K 2 Ba[Ni(NO 2 ) 6 ] for CL-20, FOX-7 and TKX-50 thermolysis were also discussed and studied by using DSC and TG-DTG-MS. After K 2 Ba[Ni(NO 2 ) 6 ] were mixed with CL-20, the activation energy ( E a ) of thermolysis reaction was increased, while the heat release was greatly improved, and the transformation from NH 3 to NO occurred. It is attributed to that the decomposition products of K 2 Ba[Ni(NO 2 ) 6 ] have strong effects on the oxidation of the radicals and the electrons transfer . Besides, the thermolysis E a of FOX-7 by addition of the K 2 Ba[Ni(NO 2 ) 6 ] was increased by 81.03 kJ mol −1 , and the heat release was greatly increased. In addition to that the two-step separate thermolysis processes of pure FOX-7 was almost replaced by a one-step exothermic reaction for the FOX-7/K 2 Ba[Ni(NO 2 ) 6 ] mixture, which was due to that Ni 2+ cations could effectively increase the activity of amino groups in the FOX-7 thermolysis process. Finally, K 2 Ba[Ni(NO 2 ) 6 ] scarcely has the thermolysis catalytic activity of TKX-50 owing to the influence of metal cations on the decomposition of the hydroxylamine . Furtherly, the characteristics of ignition and flame propagation on the three energetic mixtures were strongly correlated to their thermolysis pathway and mechanism. The comparative study on the effects of K 2 Ba[Ni(NO 2 ) 6 ] to the CL-20, FOX-7 and TKX-50 thermolysis and ignition showed that the hexanitro complex has great significance on promoting the heat release efficiency of solid propellants for future study.
研究领域:
材料科学
·
化学动力学
·
含能材料
·
催化化学
·
热分析
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DOI
高影响因子
Acta Crystallographica Section E-Crystallographic Communications
·
2017
·Vol. 73
·期 6
·871-875
·
IF 0
Fu W.-W.,Li Y.-Q.,Liu Y.,Chen M.-S.,Li W.,Yang Y.-Q.
A new complex, namely bis[4′-(furan-2-yl)-2,2′:6′,2′′-terpyridine]nickel(II) dichloride decahydrate, [Ni(C19H13N3O)2]Cl2·10H2O, has been crystallized by solvent evaporation and characterized by single-crystal X-ray diffraction. The coordination environment of the NiII cation is distorted octahedral with slight deviations from an idealized geometry. The most intriguing structural feature is an infinite two-dimensional hybrid water–chloride network parallel to (011) constructed by O—H⋯O and O—H⋯Cl hydrogen bonds involving two independent chloride ions and ten independent solvent water molecules with an l-shaped pattern. One of the furyl rings is disordered with a refined occupancy ratio of 0.786 (13):0.214 (13)
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DOI
ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 32
·43974-43984
·
IF 7.8
Zhang Chuyi,Sun Zhi,Kong Weiqian,Wu Wenzhuo,Zheng Xiaoli,Xu Qun
The enhancement of photocatalytic efficiency is limited by exciton dynamics, where photogenerated electrons and holes rapidly recombine due to strong Coulomb attraction. The manipulation of electron spin, involving the control of electron spin and spin states, has emerged as a promising strategy to improve photocatalytic performance via spin-polarization-facilitated charge separation. In this work, we demonstrate a spin-polarization effect achieved by treating ZnSn(OH) 6 (ZHS) with supercritical CO 2 (SC CO 2 ), which accelerates exciton dissociation and spin-dependent electron migration, thereby enhancing the efficiency of photocatalytic CO 2 reduction to CO. Mechanistic investigations reveal that SC CO 2 treatment induces oxygen vacancies in ZHS, generates spin-polarized electrons, and selectively exposes highly active {111} crystal facets. Experimentally, it reveals that the oxygen vacancies, together with adjacent hydroxyl groups, construct frustrated Lewis pairs (FLPs). Through enhanced quantum spin exchange interactions (QSEIs), the recombination of photogenerated charge carriers is significantly suppressed, and then their lifetime is prolonged, and CO 2 adsorption and activation are simultaneously enhanced. It was found that, under treatment at 16 MPa of SC CO 2 , the CO production rate of ZHS reaches 144.82 μmol·g –1 ·h –1 , which is 29.37 times that of the untreated sample. Therefore, this study demonstrates that manipulating spin-polarized electrons in photocatalytic semiconductors is an effective strategy to boost CO 2 RR efficiency, offering new insights for the design of efficient spin-dependent photocatalysts toward solar energy conversion.
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产品关联
DOI
高影响因子
BMC PLANT BIOLOGY
·
2026
·
IF 5.6
Yang Ping,Yang Qian,Chang Yingying,Li Jihua,Chen Rupei,Gelaye Yohannes,Liu Nian,Huang Li,Zhou Xiaojing,Chen Weigang,Yu Bolun,Ding Yingbin,Jiang Huifang,Liao Boshou,Lei Yong,Luo Huaiyong
Peanut ( Arachis hypogaea L.) is an important oil and economic crop, and its production has long been severely threatened by soil-borne bacterial wilt (BW) disease. However, the molecular mechanism of host resistance to it has not yet been systematically elucidated. In this study, the highly resistant peanut variety Zhonghua 6 was used as the research object. Through transcriptomic analysis, a total of 1,122 differentially expressed genes (DEGs) were identified between carefully designed treatment and control groups. WGCNA analysis led to the discovery of 14 hub genes, including two cytochrome P450 genes and a UGDH gene. Through metabolomic analysis, 1,614 differentially accumulated metabolites (DAMs) were identified, and 6-methylcoumarin, erucamide, and piceatannol were confirmed to inhibit the growth of R. solanacearum. Integrative transcriptomic and metabolomic analyses uncovered a comprehensive immune regulatory network consisted of genes involved in key pathways associated with R. solanacearum infection such as MAPK signaling, plant hormone signal transduction, phenylpropanoid biosynthesis, flavonoid biosynthesis, and ABC transporter. Overall, these results provide new insights into the molecular mechanisms governing peanut resistance to R. solanacearum , which might assist in the mining of resistance-related genes, developing of new disease control measures as well as breeding of novel disease-resistant cultivars in peanut.
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DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2026
·
IF 2.5
Jiarui Zhang,Sijia Tong,Si Cheng,Jiale Liu,Shuang Feng,Yue Deng,Xinyue Zhou,Yalin Xi,Meiyun Shi,Lei Yin
A green and highly selective Ultra-Performance Convergence Chromatography with MS 3 (UPC 2 -MS 3 ) method was developed for the quantification of M-PEG₆-OH in rat plasma. • The MS 3 detection provided exceptional specificity by effectively eliminating matrix interferences and offered a superior signal-to-noise ratio compared to conventional MRM. • Utilizing supercritical CO₂ as the primary mobile phase enabled a 1.5 min analysis, significantly reducing organic solvent consumption and aligning with green chemistry principles. • The fully validated method was successfully applied to characterize the pharmacokinetic profile of M-PEG₆-OH in rats. The quantification of hydrophilic polyethylene glycol (PEG) derivatives in biological matrices is often hindered by poor chromatographic retention and severe matrix effects in conventional reversed phase systems. This study addresses these challenges by developing a novel, green analytical platform integrating ultra-performance convergence chromatography (UPCC) with triple mass spectrometry (MS 3 ) detection. The method leverages the orthogonal separation mechanism of UPCC to achieve superior resolution within an ultra-short 1.5 min analytical cycle. Notably, the MS 3 acquisition strategy effectively eliminated background chemical noise, resulting in a 4.7-fold enhancement in the signal to noise ratio compared to standard MRM modes at the lower limit of quantification (LLOQ) level. The methodology was rigorously validated according to FDA guidance (adopted from the ICH M10 guidelines) over a range of 10–1000 ng/mL, demonstrating an LLOQ of 10 ng/mL. Quantitative greenness evaluation via AGREE (0.75) and BAGI (77.5) metrics confirmed the environmental sustainability of the approach. Successfully applied to a pharmacokinetic study in rats, this robust UPCC-MS 3 platform provides a high performance, compliant, and ecofriendly tool for the biological disposition assessment of PEG based therapeutics. In conclusion, the established platform successfully harmonizes high-throughput bioanalytical efficiency with green chemistry principles, demonstrating outstanding technical superiority and structural compliance for seamless integration into standardized laboratory workflows within the pharmaceutical industry. Download: Download high-res image (260KB) Download: Download full-size image
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PubMed
高影响因子
危险品化学品经营许可证（带存储）