Nature Communications
·
2026
·
IF 18.1
Yan Jiao,Liu Lai,Chen Zhihao,Zhao Qian,Han Xiaoqing,Wang Yanjing,Mu Zhengzhi,Wang Xingbo,Song Panpan,Kang Yaqing,Lu Weijie,Guo Ai-Min,Sun Qing-Feng,Zhang Haiyuan
Electron-spin dynamics represent an additional dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices ( C Au) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and C Au, we demonstrate that left-handed C Au (Lh- C Au) enhances, whereas right-handed C Au (Rh- C Au) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we engineer molecularly imprinted C Au ( C Au@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model (male DBA/1 J mice). Treatment with Rh- C Au@MIP significantly reduces prostaglandin E 2 secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Li Yahong,Wang Shiwen,Tang Xuedong,Chen Qiaolin,Wang Hang,Lin Houwei
Vulvar squamous cell carcinoma (VSCC) is a rare malignancy, which accounts for only 2–5% of cancers related to the female reproductive system. Current histopathological diagnoses rely on the subjective interpretation of immunohistochemical staining, highlighting the need for more objective and comprehensive analytical techniques. Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometric imaging (MSI) using dual-polarity matrices has emerged as a powerful tool for identification and spatial mapping of diverse metabolites in tissue because it can broaden the molecular coverage and acquire two ion images, but most are restricted in brain or kidney tissue. MSI-based research on VSCC remains scarce and research on the distribution patterns of the metabolites is necessary in order to investigate the molecular mechanisms in their physiological and pathological functions. In this study, bis(4-(1,3-benzoxazol-2-yl)) phenyl analogues including N , N -bis(4-(1,3-benzoxazole-2-yl) phenyl)aniline (BPA), N , N -bis(4-(1,3-benzoxazole-2-yl)phenyl)-1-naphthylamine (BPNA), N , N -bis(4-(1,3-benzoxazole-2-yl)phenyl)-9-aminoanthracene (BPAA), and N , N -bis(4-(1,3-benzoxazol-2-yl)phenyl)-6-(phenanthren-9-yl) naphthalen-2-amine (BPYA) were synthesized and evaluated as matrices for MALDI-Fourier transform ion cyclotron resonance (FT ICR)-MSI of lipid metabolites in VSCCs in both positive and negative ion modes. Among the four candidate matrices, BPYA exhibited superior performance in dual-polarity MALDI-MSI, including higher detection sensitivity, lower laser power, and lower background noise, when compared with commonly used MALDI matrices. The use of BPYA enabled the detection of 402 and 107 lipids in VSCC tissue in positive and negative ion modes, respectively. Various VSCCs were analyzed using MALDI-MSI and co-registered with haematoxylin and eosin (H&E) stained images; 140 lipids were found to be different. The difference analysis results of MSI were also validated using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis and 18 lipids were consistent in our MALDI-MSI and UPLC-MS results. This approach allowed the investigation of lipid distribution in these gynecological tissues and may broaden the molecular coverage. The technology may have potential to provide faster and user-independent tissue diagnoses using the tissue’s spatial lipidomic distributions. The characteristic distribution patterns of different lipids provide useful insights into investigating the molecular mechanisms of the physiological and pathological functions of VSCC. This method can also be extended to the other widely used benchmark tissues, such as mouse brain. Graphical abstract
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 4
·172
·
IF 3.5
Lin Lei,Zhao Xiaofen,Zhao Yuzhen,He Zemin,Niu Lichun,Feng Xiangbo,Miao Zongcheng,Hang Cai
As industrialization has developed rapidly, the issue of organic pollutants in water and the atmosphere has become increasingly severe. In this study, a P(BAB-NIPAM)/CS@H-MWCNT adsorption material was synthesized by introducing MWCNT during free radical polymerization using BAB and NIPAM as monomers. Dual anchoring was achieved through π-π stacking and electrostatic attraction, which enhanced the stability between the polymer matrix and MWCNT and significantly improved the material’s broad-spectrum adsorption potential for pollutants with different charges. The structure of the material was analyzed and characterized using FTIR, XRD, and SEM. At a pH value of 4.0, with a reaction time of 200 min and a temperature of 298 K, the removal rate of CR reached as high as 92.2%, and the adsorption process conformed to the Langmuir model. P(BAB-NIPAM)/CS@H-MWCNT combines the strong hydrophilicity imparted by BAB monomers with the unique thermosensitivity of NIPAM monomers. The swelling and contraction behavior of hydrogels can be precisely controlled by regulating the environmental temperature to achieve pollutant desorption, thereby establishing a controllable cycle system of “adsorption-desorption” and effectively improving the reuse efficiency of materials. It provides new materials and technical ideas for the low-cost and sustainable treatment of organic pollutants.
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高影响因子
FIBERS AND POLYMERS
·
2026
·
IF 3.1
Hu Yale,Song Xiaodi,Li Yuanyuan,Cheng Meijia,Jing Hao,Qian Neng,Fan Shuo
Polyamide 6 (PA6) fabric is widely used in textile applications owing to its excellent physical and mechanical properties. However, its high flammability and severe melt-dripping behavior during combustion significantly limit its application in fire-sensitive fields. In this study, a phosphorus–nitrogen-containing polysiloxane flame retardant (NPSi) was synthesized and synergistically combined with thiourea (TU) to enhance the flame retardancy of PA6 fabric. The thermal stability, combustion behavior, mechanical properties, and flame-retardant mechanisms of the treated PA6/TU/NPSi fabric were systematically investigated. Owing to the synergistic interaction between TU and NPSi, the flame retardancy of PA6 fabric was markedly improved, particularly with respect to melt-dripping suppression. The PA6/TU/NPSi fabric achieved a UL-94 V-0 rating and exhibited a limiting oxygen index (LOI) of 29%. Compared with pristine PA6 fabric, the peak heat release rate (PHRR) and total heat release (THR) of the PA6/TU/NPSi-3 fabric decreased by 80.0% and 47.8%, respectively. This enhanced fire safety performance was primarily attributed to the formation of a dense and continuous char layer in the condensed phase, together with the release of non-combustible gases in the gas phase.
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Nature Communications
·
2026
·
IF 18.1
Zhang Shixiong,Cai Yongli,Wen Hong,Liu Liang,Yu Lei,Zhang Peng,Guo Jianping,Chen Ping
The activation and valorization of inert molecules (e.g., dinitrogen (N 2 ), alkanes, and alkenes) for the synthesis of nitrogen-containing organic compounds have long been a highly sought-after goal in chemistry. However, it remains a formidable challenge, stemming from the inherent chemical inertness of the robust N ≡ N and C-H bonds, as well as the competitive adsorption and activation of reactants. Consequently, examples of direct C-N bond formation using N 2 and alkanes/alkenes as feedstocks remain exceptionally scarce. Herein, we report that sodium hydride supported on magnesium oxide (NaH/MgO) possesses unique multiple reactive sites, which enable the conversion of N 2 and unactivated arenes and facilitate C-N bond formation. The synergistic interplay between sodium, magnesium, and hydride species at the NaH/MgO interface plays a pivotal role in the reduction of N 2 to NH x species. These reactive NH x intermediates then deprotonate the aryl C-H bond, attack the alkali-interacted aryl ring, and drive the formation of sodium anilide on the surface. Subsequent protonation of sodium anilide yields aniline with high selectivity (>90%). This work demonstrates the feasibility of transforming N 2 and simple arenes into key nitrogen-containing organic compounds via a solid surface-mediated process, thereby opening ample room for developing heterogeneous catalysts for the transformation of N 2 and organic substrates.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Liu Lei,Xiang Shengxin,Shi Qiongfeng,Duan Shengshun,Wei Xiao,Yu Gang,Chen Zhishui,Zhang Huiyun,Hong Jianlong,Zheng Tong,Xiong Yu-an,You Yu-Meng,Wu Jun
Molecular ferroelectrics—hybrid organic-inorganic architectures that exhibit piezoelectric coefficients comparable to classic oxide ceramics while offering rich compositional and structural tunability—have emerged as promising materials for human-interfaced high-frequency acoustic sensing. Nevertheless, the inherent brittleness and relatively high modulus hinder their practical deployment on dynamically deformable interfaces. Here, we report stretchable molecular ferroelectric acoustic fibers fabricated by incorporating molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium (TMCM-CdCl 3 ) crystals into flexible thermoplastic polyurethane (TPU) via electrospinning. Intermolecular interactions between TMCM-CdCl 3 and TPU, along with the interlocked layered architecture between electrodes and fibers, endow the fiber acoustic sensor with high stretchability (tensile strain >100%), high force sensing sensitivity (4.36 V/kPa), and wide-frequency acoustic sensing (30–5000 Hz). Crucially, a strain-induced sensitivity enhancement effect is proposed and verified, where the acoustic sensitivity of the sensor increases from 15.03 mV/dB to 30.16 mV/dB under strain. Furthermore, we demonstrate that the acoustic fiber can maintain a high speech recognition accuracy (97.05%) even for mixed speech data obtained using the acoustic fiber in original and 20% tensile strain states. This work establishes a route for acoustic sensing at dynamic deformable interface and advances human-interfaced acoustic applications such as robotic interaction, biomedical engineering, and virtual reality.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Yifei,Duan Peiyang,Liao Yingqi,Wang Hao,Li Beibei,Zhang Hangyuan,Yang Hao,Cheng Tao,Sun Jingyu
Electrocatalytic oxygen reduction reaction (ORR) for H 2 O 2 production represents a sustainable alternative route to the energy-intensive anthraquinone process. Nevertheless, under industrially-relevant acidic conditions, excessive protons at the reaction interface exacerbate low H 2 O 2 selectivity and severe H 2 O 2 reduction. Herein, we propose a universal alkali metal cation (AMC: Li + , Na + , K + , or Cs + ) dosing strategy to markedly boost the acidic H 2 O 2 electrosynthesis. Upon Cs + addition, 2e − ORR selectivity increases from 20% to 80%, concurrently suppressing an H 2 O 2 reduction current by 50% and achieving an H 2 O 2 production rate of 9.2 mol g −1 h −1 at 500 mA cm −2 . Microelectrode hydrogen evolution measurements witness impeded proton diffusion in AMC-dosed acidic electrolytes, directly restricting proton supply to catalytic active sites. In situ spectroscopic analysis combined with molecular dynamics simulation demonstrate AMCs help reconfigure interfacial water networks via cation hydration shells, thereby disrupting proton-hopping pathways. The efficacy trend (Li +
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高影响因子
Molecular Horticulture
·
2026
·Vol. 6
·期 1
·71
·
IF 10
Ma Yue,Li Hongyu,Sun Hongmei
Genotypic recalcitrance limits efficient somatic embryogenesis (SE). In this study, an SE induction system for the recalcitrant species Lilium amabile Palib. was established by modulating redox homeostasis. The first SE in this species was achieved by supplementing MS medium containing 1.0 mg·L −1 picloram (PIC) with 150.0 mg·L −1 glutathione (GSH), which increased SE induction rate from 0 to 33.3%. Physiological analysis revealed that GSH treatment upregulated endogenous GSH and key antioxidant enzymes, glutathione peroxidase (GPX) and glutathione S-transferase (GST). Specifically, their activities were elevated 1.9- and 9.8-fold higher, respectively, than those of control. This synergistic action scavenged hydrogen peroxide (H₂O₂), thereby alleviating oxidative stress. Furthermore, LaGSTU6 was identified as a core regulator of SE. In the SE-efficient lily Lilium martagon var. pilosiusculum Freyn, transient silencing of LaGSTU6 delayed embryogenesis initiation, caused severe browning, induced H₂O₂ accumulation, and reduced the antioxidant capacity, yielding a significant decrease in both the SE induction rate and efficiency. These findings preliminarily confirm that LaGSTU6 is a critical regulator of SE competence in lilies. Thus, we overcame genotypic recalcitrance and established the first SE induction system in Lilium amabile Palib. Our findings provide insights into the study of totipotency and inform strategies for regenerating recalcitrant germplasms.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·686
·
IF 5.4
Zhang Li,Xiong Shuiying,Jiang Liting,Qiu Jiaxin,Jin Qian,Lv Xinding,Tu Xinman
A novel electrochemical sensor for determination of vanillin based on carbon black and NiCo 2 O 4 nanocomposite (CB@NiCo 2 O 4 ) was established. The nanocomposite was immobilized onto electrode surface, the carbon black can selectively adsorb vanillin via π-π stacking interactions between the aromatic domains and the benzene ring of vanillin. Concurrently, the NiCo 2 O 4 with cage-structure enhances the electrochemical signal response of the adsorbed vanillin by the high specific surface area and favorable ion-exchange capability. Under optimized experimental conditions, the sensor exhibits a linear range of 0.1 ~ 60 µM with a limit of detection of 30 nM, and the selectivity and signal stability were confirmed to be satisfactory. In real-sample analysis, the results are agreement with the contrast testing results of high-performance liquid chromatography, and the spike recovery experiment values ranged from 95.35% to 103.80%, with relative standard deviations (RSDs) of 3.77%~4.59% ( n = 3). The proposed electrochemical sensor possesses a favorable application prospect in product quality control. Graphical abstract
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·700
·
IF 5.4
Zhao Xinyuan,Xu Bingxin,Zhang Wei,Wei Haiyan,Zhang Yu,Chen Wenwen,Shang Ming,Wang Cuijuan
A portable ozone detection strategy is reported based on derivatization-assisted surface-enhanced Raman spectroscopy (SERS). The strategy integrates active sampling, chemical derivatization, and signal enhancement using high-index gold trisoctahedrons embedded in a porous hydrogel (Au TOHs/hydrogel), assembled into a 48-well microdevice. Ozone is selectively captured by eugenol and converted to formaldehyde, which reacts with 3-methyl-2-benzothiazolinone hydrazone (MBTH) to form a Raman-active azo compound, enabling sensitive detection. The SERS signal at 1270 cm − 1 exhibited a strong linear correlation with the logarithm of analyte concentration (R 2 = 0.996). The limit of detection under simulated air conditions is 5.80 × 10 − 6 mg/m 3 . The SERS sensor demonstrated high stability, spatial uniformity, and reproducibility (RSD < 10%), along with good selectivity against common volatile organic compounds. Validation with air samples and comparison with ultraviolet-visible UV-vis spectrophotometry further supports its applicability. This cost-effective and user-friendly platform shows potential for point-of-use detection of trace ozone. Graphical abstract
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高影响因子
Food and Bioprocess Technology
·
2026
·Vol. 19
·期 10
·502
·
IF 5.6
Zhou Jianxin,Liu Yiping,Feng Mingfeng,Mo Yalan,Li Chaonan,Liu Chunlai,Li Xiaogang
Kiwifruit soft rot is one of the most destructive postharvest diseases, causing substantial economic losses during storage. In this study, carboxymethyl-β-cyclodextrin (CM-β-CD) nanospheres were synthesized through carboxymethylation with chloroacetic acid. Carvacrol (CAR) was subsequently incorporated into the nanospheres through impregnation to produce CAR@CM-β-CD. Scanning and transmission electron microscopy revealed that CAR@CM-β-CD predominantly formed spherical or quasi-spherical particles with relatively smooth surfaces. Dynamic light scattering analysis showed an average hydrodynamic diameter of 278.9 nm and a polydispersity index of 0.128. The formulation showed sustained release for 112 h, indicating favorable controlled-release performance. Thermogravimetric analysis showed that CAR@CM-β-CD in TGA was enhanced char residue at 800 °C, indicating improved high-temperature stability through carbonization. CAR@CM-β-CD exhibited improved but incomplete wettability and spreading on the tested surface. In vitro plate antifungal assays revealed strong antifungal activity, with a half-maximal effective concentration (EC 50 ) of 54.8 mg/L. The drug-loading (DL) capacity reached 13.46%. Cytocompatibility tests using human bronchial epithelial BEAS-2B cells showed high cell viability (> 81.59%) at 100 mg/L and a much lower apoptosis rate than carbendazim. Through morphological analyses and staining assays of the hyphae, we elucidated the antifungal mechanism of CAR@CM-β-CD. Collectively, these results suggest that CAR@CM-β-CD is a promising and effective controlled-release antimicrobial formulation for postharvest preservation of kiwifruit.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 43
·34240-34255
·
IF 4.4
Han Qianyue,Sun Youping,He Jiangmei,Zhang Kaifei,Liang Ting,He Chengwei
This study investigated the effects of rolling speed on the microstructure, mechanical properties, and corrosion behavior of Mg–2Zn–0.4Ca magnesium alloy in SBF. The results indicate that rolling speed strongly controls dynamic recrystallization (DRX), grain size, and dislocation density. Although the sample rolled at 768 mm/s showed a relatively high fraction of DRXed grains, retained coarse deformed grains and high GND density caused pronounced microstructural inhomogeneity. At 1024 mm/s, the alloy obtained the finest average grain size (3.51 μm) and the lowest dislocation density, achieving a good balance between grain refinement and defect regulation. Consequently, its ultimate tensile strength (UTS) and elongation (EL) reached 291.39 MPa and 9.9%, respectively. When the rolling speed increased to 1280 mm/s, DRX was suppressed, while the fractions of deformed grains and unindexed regions increased, leading to degraded mechanical properties. Corrosion tests revealed that the 1024 mm/s sample had the lowest corrosion rate, hydrogen evolution volume, and corrosion current density, owing to its homogeneous microstructure, reduced local distortion, and dense, stable corrosion product layer. Overall, moderate rolling speed can synergistically improve microstructural uniformity, mechanical properties, and corrosion resistance, providing guidance for plastic processing of biodegradable Mg alloy sheets.
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