Materials Research Express
·
2018
·Vol. 5
·期 6
·065906
·
IF 1.151
Dong Mao,Lishan Zhu,Xiaofeng Fei,Xinyu Zheng,Dong Fang
The fabrication of indium sulfide/graphene oxide composites (In2S3@GO) via a novel hydrothermal method was reported. The morphology of the composites showed that the daisy-like In2S3 structures were dispersed evenly on GO with large specific surface area. The photocatalytic performance of In2S3@GO was evaluated through photodegradation Rhodamine B. In2S3@GO exhibits higher photodegradation performance than that of pure In2S3. In addition, the composites showed great adsorption-desorption ability and stability. The solution pH value also has a significant influence on photocatalytic activity of In2S3@GO. This work may provide new insights to construct carbon-based semiconductor photocatalyst for organic dye pollution degradation.
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Frontiers in Bioengineering and Biotechnology
·
2024
·
IF 4.3
Rongyi Wang,Hongsen Li,Lu Han,Boao Han,Yiting Bao,Hongwei Fan,Chaoyue Sun,Ruijie Qian,Liying Ma,Jiajing Zhang
The mitochondria act as the main producers of reactive oxygen species (ROS) within cells. Elevated levels of ROS can activate the mitochondrial apoptotic pathway, leading to cell apoptosis. In this study, we devised a molecular prodrug named CTT 2 P, demonstrating notable efficacy in facilitating mitochondrial apoptosis. To develop nanomedicine, we enveloped CTT 2 P within bovine serum albumin (BSA), resulting in the formulation known as CTT 2 P@B. The molecular prodrug CTT 2 P is achieved by covalently conjugating mitochondrial targeting triphenylphosphine (PPh 3 ), photosensitizer TPPOH 2 , ROS-sensitive thioketal (TK), and chemotherapeutic drug camptothecin (CPT). The prodrug, which is chemically bonded, prevents the escape of drugs while they circulate throughout the body, guaranteeing the coordinated dispersion of both medications inside the organism. Additionally, the concurrent integration of targeted photodynamic therapy and cascade chemotherapy synergistically enhances the therapeutic efficacy of pharmaceutical agents. Experimental results indicated that the covalently attached prodrug significantly mitigated CPT cytotoxicity under dark conditions. In contrast, TPPOH 2 , CTT 2 , CTT 2 P, and CTT 2 P@B nanoparticles exhibited increasing tumor cell-killing effects and suppressed tumor growth when exposed to light at 660 nm with an intensity of 280 mW cm −2 . Consequently, this laser-triggered, mitochondria-targeted, combined photodynamic therapy and chemotherapy nano drug delivery system, adept at efficiently promoting mitochondrial apoptosis, presents a promising and innovative approach to cancer treatment.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2012
·
IF 2.289
Peng Gao,Shaoqiang Yang,Zhu Xue,Guangbo Liu,Guoli Zhang,Longqiang Wang,Guobao Li,Yuzeng Sun,Yujin Chen
As a new type hydrogen storage material, Co–B hydrogen storage alloy was a hot research topic and has been paid increasing attention in recent years. In this work, a series of Co–B alloys with molar ratio of 1:1, 2:1 and 3:1 were synthesized by high energy ball-milling method. The phase, structure and morphology of the samples have been characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM), which demonstrated that the samples ball-milled more than 5 h were mainly amorphous phase. Their electrochemical performance as electrochemical hydrogen storage material was investigated by galvanostatic charge–discharge process and cyclic voltammetry (CV) techniques. Electrochemical measurements showed that the Co–B alloys had excellent electrochemical hydrogen storage capacities and exhibited remarkable high rate discharge performance. Their electrochemical hydrogen storage capacity was 771 mAh/g, which was much higher than previous reports (238 mAh/g). Based on XRD and CV results, the exceptional electrochemical performances were suggested to arise from the electrochemical hydrogen storage reaction on the Co–B materials, which was brought about by the special amorphous structure and high chemical reactivity of the Co–B particles.
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Nano Research
·
2024
·
IF 9.5
Liu Fang,Zou Lingyun,Chen Yongcheng,Liu Zuolong,Huang Yue,Jin Qiao,Ji Jian
Biofilm-associated bacterial infection brings serious threats to global public health owing to serious antibiotic resistance. It is urgently needed to develop innovative strategies to combat biofilm-associated bacterial infections. Polymyxins stand out as the last line of defense against Gram-negative bacteria. However, serious nephrotoxicity of polymyxins severely limits their clinical utility. Herein, a hypoxia-responsive liposome is designed as the nanocarrier of polymyxin B (PMB) to combat biofilms developed by Gram-negative bacteria. A metronidazole modified lipid (hypoxia-responsive lipid (HRLipid)) is synthesized to fabricate hypoxia-responsive liposomes (HRLip). PMB loaded hypoxia-responsive liposomes (HRL-PMB) is then prepared to mitigate the nephrotoxicity of PMB while preserving its excellent bactericidal activity. HRL-PMB shows very low hemolysis and cytotoxicity due to liposomal encapsulation of PMB. PMB can be readily released from HRL-PMB in response to hypoxic biofilm microenvironment, exerting its bactericidal activity to realize biofilm eradication. The excellent in vivo antibiofilm ability of HRL-PMB is confirmed by a Pseudomonas aeruginosa infected zebrafish model and a P. aeruginosa pneumonia infection model. Meanwhile, HRL-PMB can greatly reduce the nephrotoxicity of PMB after intravenous injection. The hypoxia-sensitive liposomes held great promise to improve the biosafety of highly toxic antibiotics while preserving their intrinsic bactericidal ability, which may provide an innovative strategy for combating biofilm-associated infections.
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Nanomaterials
·
2025
·Vol. 15
·期 5
·410
·
IF 4.3
Yongxin Lu,Shangjie Gao,Teng Ma,Jie Zhang,Haixia Liu,Wei Zhou
The construction of heterojunctions can effectively inhibit the rapid recombination of photogenerated electrons and holes in photocatalysts and offers great potential for pollutant degradation. In this study, a Z-scheme heterojunction g-C3N4/WO3photocatalyst was synthesized using a combination of hydrothermal and calcination methods. The photocatalytic degradation performance was tested under visible light; the degradation efficiency of Rh B reached 97.9% within 15 min and that of TC-HCl reached 93.3% within 180 min. The excellent photocatalytic performance of g-C3N4/WO3composites can be attributed to the improved absorption of visible light, the increase in surface area, and the effective separation of photogenerated electron–hole pairs. In addition, after four cycles of experiments, the photocatalytic performance of g-C3N4/WO3did not decrease obviously, remaining at 97.8%, which proved that the g-C3N4/WO3heterojunction had high stability and reusability. The active radical capture experiment confirmed that h+and ·O2−played a leading role in the photocatalytic degradation. The Z-scheme heterojunction g-C3N4/WO3designed and synthesized in this study is expected to become an efficient photocatalyst suitable for environmental pollution control.
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Small Methods
·
2025
·
IF 9.1
Xiaoying Han,Juxin Yin,Yu Wang,Jianjian Zhuang,Kai Hu,Yehong Gui,Haohua Mei,Jizhi Tong,Ying Mu
The rapid, precise, and automated diagnosis of infectious diseases is crucial for effective disease management and control. Herein, the integrated portable and automatic digital detection system (IPADS), a novel diagnostic platform for nucleic acid detection is introduced. The device employs the hybrid magnetic system (HMS), which uses an electromagnet and a movable permanent magnet to modulate the magnetic field and control bead movement, increasing nucleic acid extraction efficiency to over 80%, while simplifying the traditional labor-intensive process and enabling quick, low-risk sample processing. Additionally, a disposable cartridge is designed for integrated HMS based preprocessing, with detection performed using digital RPA-Cas12a, enabling rapid, enclosed, and automation-friendly detection across a dynamic range spanning five orders of magnitude, with a sensitivity as low as 100 copies mL −1 in serum samples. An automated platform further optimizes workflow. As a proof of concept, IPADS is applied to detect hepatitis B virus (HBV) DNA in 20 clinical serum samples, demonstrating high concordance with gold-standard quantitative PCR (qPCR) methods. These results validate the potential of IPADS as a reliable point-of-care testing solution.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Jianhua Liu,Junzhi Li,Liqun Xu,Yajuan Qiao,Jiucun Chen
In this work, multifunctional B,N codoped carbon dots (B/N–C-dots) were synthesized from a facile hydrothermal treatment of branched polyethylenimine and 4-formylphenylboronic acid. The obtained B/N–C-dots had a very narrow size distribution and showed excitation-wavelength-dependent photoluminescence properties with a high fluorescence quantum yield (QY) of 15.85%. The B/N–C-dots showed temperature and pH (3–13) dual responses. Additionally, the B/N–C-dots showed a good sensitivity and selectivity to Fe3+ with a detection limit of 1.62 μM. What is more, the as-prepared B/N–C-dots exhibited low toxicity and good biocompatibility and could be used for cell imaging. Considering these good properties, the obtained B/N–C-dots have good potential for temperature, pH, and ion sensors and cellular imaging.
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ANALYTICAL BIOCHEMISTRY
·
2017
·
IF 2.334
Xuan Ni,Bing Xia,Lumei Wang,Jing Ye,Gaoshang Du,Haiwei Feng,Xiaotong Zhou,Tong Zhang,Wenhao Wang
In this paper, we developed a fluorescent aptasensor for 17β-estradiol (E2) determination in aqueous solution using label-free E2-specific aptamer, gold nanoparticles (AuNPs) and Rhodamine B (RhoB) as sensing probe, fluorescent quencher and fluorescent indicator respectively. In the absence of E2, AuNPs were wrapped by E2 aptamer and maintained dispersed in NaCl solution basically. These dispersed AuNPs could effectively impair the originally high fluorescence of RhoB. Contrarily, in the presence of E2, E2 aptamer could specifically combine with E2 to form E2-aptamer complex, so the AuNPs were released by E2 aptamer and aggregated under the influence of NaCl. The aggregated AuNPs have a weak influence on RhoB fluorescence. Therefore, the E2 concentration can be determined by the change of fluorescence intensity of RhoB. This fluorescent assay has a detection limit as low as 0.48 nM, a linear range from 0.48 to 200 nM, and high selectivity over other disrupting chemicals. It was applied to determine E2 in water samples with recoveries in the range of 94.3–111.7%. The fluorescent aptasensor holds great potential for E2 detection in environmental water samples.
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yongli Shi,Zhaomin Liu,Yaxing Yang,Xiaojie Xu,Yan Li,Tong Li
To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA- co -MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH 1.2, 6.8, and 7.4 buffers. The final MLX-NPs@hydrogel preparation was obtained by immersing the hydrogels in the MLX-NPs suspensions (pH 7.4) for 48 h. The thermodynamic properties and cytotoxicity of the MLX-NPs@hydrogel preparation were also studied. TEM images illustrated that mPEG-b-PCL NPs had a uniform size distribution. The poly(mPEGMA- co -MAA) hydrogels showed an excellent pH-sensibility. Thermal gravity analysis (TGA) data suggested that the protection of hydrogels improved the stability of mPEG-b-PCL NPs. The release studies revealed that MLX-NPs@hydrogel could deliver the MLX-NPs into alkalescent environment ( e.g. intestinal tract). Then, the medicated NPs released MLX at a sustained release profile. Such preparation could overcome the drawbacks of oral MLX, and enhance its therapeutic effects. Therefore, the NPs@hydrogel was a promising sustained-controlled release matrix.
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Nanomaterials and Nanotechnology
·
2016
·
IF 1.109
JiaDong Chen,WeiSha Liao,Ying Jiang,DanNi Yu,MeiLing Zou,Han Zhu,Ming Zhang,MingLiang Du
In this study, novel titanium dioxide (TiO2) and zinc oxide (ZnO) hybrid photocatalysts in the form of nanofibres were fabricated by a facile method using electrospinning followed by a calcination process. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were employed to investigate the morphology and structure of the heterogeneous nanofibres. The photocatalytic performances were evaluated via the photodegradation of Rhodamine B (RhB) under irradiation with UV light. Due to the low recombination rate of photo-induced charge carriers, the high utilization efficiency of UV light and the large contact area with the target molecules, the ZnO/TiO2 hybrid nanofibres exhibited high catalytic activity towards the Rhodamine B, and the amount of Zn(OAc)2 in the precursor of these nanofibres played an important role in determining the photo decomposition performance.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2017
·
IF 1.9
Peizong Deng,Fangfang Teng,Feilong Zhou,Zhimei Song,Ning Meng,Runliang Feng
Ketoconazole is a broad spectrum imidazole antifungal drug. For the treatment of superficial fungal infections with ketoconazole, it needs to be permeated to deep skin layers. In order to develop topical formulation of ketoconazole for improving its skin deposition and water-solubility, ketoconazole-loaded methoxy poly (ethylene glycol)-b-poly (δ-valerolactone) micelles were developed through thin-film hydration method. Particle size, drug loading capacity, infrared spectrum and X-ray diffraction of drug-loaded micelles were characterized. The optimal drug formulation was selected for skin delivery and deposition investigation performed by use of mice skin, and its in vitro release and antifungal activity were also investigated. Penetration and distribution in the skin were also visualized using fluorescein-loaded micelles and fluorescence microscopy. The drug-loaded micelles were obtained with encapsulation efficiency of 86.39% and particle diameter of about 12 nm. The micelles made ketoconazole aqueous solubility increase to 86-fold higher than crude one. Ketoconazole-loaded micelles showed no skin permeation of ketoconazole, obviously enhance skin deposition and demonstrated similar antifungal activity as compared with marketed ketoconazole cream. Fluorescein-loaded micelles displayed higher skin deposition than fluorescein water solution. These results demonstrate that the MPEG-PVL micelle is a potential delivery system for ketoconazole in the field of skin delivery.
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Polymer Chemistry
·
2014
·Vol. 5
·期 10
·3346-3351
·
IF 5.368
Shusheng Zhang,Wenxin Fu,Zhibo Li
A poly(ethylene glycol)-b-poly(γ-(2-methoxyethoxy)esteryl-L-glutamate) (PEG-b-poly-L-EG2Glu) diblock was prepared by the ring-opening polymerization (ROP) of L-EG2Glu N-carboxyanhydride (NCA) using PEG–NH2 as the macroinitiator. When the average degree of polymerization (DP) for poly-L-EG2Glu was below 40, the PEG-b-poly-L-EG2Glu diblock could spontaneously form hydrogels in water. For the different diblocks, a thermally-induced increase in mechanical strength was observed for the PEG-b-poly-L-EG2Glu diblock between 20–45 °C. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) revealed that continuous networks of nanoribbons were formed in these hydrogel samples. Circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) characterization suggested that the formation of sufficient β-sheet content accounted for the nanoribbon assemblies and hydrogel networks. The minimal gelation concentration and gel mechanical properties were found to strongly depend on the composition of the PEG-b-poly-L-EG2Glu diblocks.
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