NEUROCHEMICAL RESEARCH
·
2018
·Vol. 43
·期 7
·1439-1453
·
IF 2.772
Jia Jingjing,Zhang Ting,Chi Jieshan,Liu Xiaoma,Sun Jingjing,Xie Qizhi,Peng Sijia,Li Changyan,Yi Li
CeO 2 nanoparticles (nanoceria) have been used in many studies as a powerful free radical scavenger, and LXW7, a small-molecule peptide, can specifically target the integrin αvβ3, whose neuroprotective effects have also been demonstrated. The objective of this study is to observe the neuroprotective effect and potential mechanism of CeO 2 @PAA-LXW7, a new compound that couples CeO 2 @PAA (nanoceria modified with the functional group of polyacrylic acid) with LXW7 via a series of chemical reactions, in H 2 O 2 -induced NGF-differentiated PC12 cells. We examined the effects of LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 on the viability of primary hippocampal neurons and found that there was no significant difference under control conditions, but increased cellular viability was observed in the case of H 2 O 2 -induced injury. We used H 2 O 2 -induced NGF-differentiated PC12 cells as the classical injury model to investigate the neuroprotective effect of CeO 2 @PAA-LXW7. In this study, LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 inhibit H 2 O 2 -induced oxidative stress by reducing the production of reactive oxygen species (ROS) and regulating Bax/Bcl-2, cleaved caspase-3 and mitochondrial cytochrome C (cyto C) in the apoptotic signaling pathways. We found that the levels of phosphorylation of focal adhesion kinase (FAK) and of signal transducer and activator of transcription 3 (STAT3) increased significantly in H 2 O 2 -induced NGF-differentiated PC12 cells, whereas LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 suppressed the increase to different degrees. Among the abovementioned changes, the inhibitory effect of CeO 2 @PAA-LXW7 on H 2 O 2 -induced changes, including the increases in the levels of p-FAK and p-STAT3, is more obvious than that of LXW7 or CeO 2 @PAA alone. In summary, these results suggest that integrin signaling participates in the regulation of apoptosis via the regulation of ROS and of the apoptosis pathway in H 2 O 2 -induced NGF-differentiated PC12 cells. LXW7, CeO 2 @PAA, and CeO 2 @PAA-LXW7 can play neuroprotective roles by counteracting the oxidative stress and apoptosis induced by H 2 O 2 in NGF-differentiated PC12 cells. CeO 2 @PAA-LXW7 exerting a more powerful synergistic effect via the conjunction of LXW7 and CeO 2 @PAA.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Qu Zhengquan,Zhang Baozhong,Liu Xihong,Cui Xiaoying,Zhao Ke,Li Ying,Xie Lingling,Zhu Huina,Chen Hanyu,He Baoshan
Fumonisin B1 (FB1) is a secondary metabolite generated by Fusarium verticillioides , which can widely contaminate crops. Herein, an electrochemical aptamer sensor with high sensitivity and selectivity was constructed for FB1 detection, leveraging the specific recognition capability of aptamers. Polyethylenimine-functionalized cerium dioxide-supported platinum nanoparticles (PEI-CeO 2 @PtNPs) were used for the modification of electrodes. The nanocomposite enhanced electrical conductivity on the electrode, and provided more attachment sites to increase the loading capacity of aptamer chains. Additionally, polyethylenimine-functionalized melamine-cyanuric acid condensation polymers (PEI-MCA) were used as carrier for the signal probe. Because of the unique porous structure and abundant functional groups on the surface of MCA, the loading efficiency of methylene blue (MB) was significantly enhanced, and the complementary DNA (cDNA) strand of aptamers was effectively loaded on PEI-MCA by strong electrostatic interaction to construct signal probes. The cDNA was captured by aptamers through complementary base pairing, and PEI-CeO 2 @PtNPs amplified electrical responses cooperatively with PEI-MCA. In the presence of FB1, the aptamers preferentially bound to FB1, and the signal probes were detached from the electrode surface, resulting in a decrease in the electrochemical response. Under optimal conditions, the dynamic range of the constructed aptasensor was 1 × 10 −1 to 1 × 10 4 pg/mL, with a detection limit of 89 fg/mL. Additionally, the sensor had high selectivity, reproducibility, and stability, and could detect FB1 in milk and corn flour samples.
研究领域:
分析化学
·
食品安全
·
生物传感器
·
纳米材料
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Guangzhao Zhou,Ziyu Wang,Xiaochao Wang,Yiran Zhang,Xuteng Zhao,Qi Chen,Ting Chen,Zhen Huang,He Lin
Nonthermal plasma catalysis offers the potential to synthesize ammonia on a distributed scale under ambient pressure by consuming renewable electricity. Clarifying the relationship between plasma discharge and the role of catalysts is beneficial to the performance improvement of nonthermal-plasma-catalytic ammonia synthesis (NTPCAS). In this study, the plasma discharge was enhanced using CeO2 and Fe2O3/CeO2 (Fe/Ce) mechanically mixed with dielectric Al2O3, recorded as Ce@Al and Fe/Ce@Al, respectively, and the promoting effect of plasma discharge enhancement on the catalytic role of Fe/Ce and CeO2 in NTPCAS was investigated in a dielectric barrier discharge reactor under atmospheric pressure. The results indicate that the concentration of ammonia synthesized using Fe/Ce was only 2.7% higher than that synthesized using CeO2 and that synthesized using Fe/Ce@Al was 36.5% higher than that synthesized using Ce@Al and 102.6% higher than that synthesized using Fe/Ce at maximum. In addition, the ammonia production rate of Fe/Ce in Fe/Ce@Al with the optimum Al2O3 mixing ratio was 8.8 times that in pure Fe/Ce. U–I curves, U–Qc curves, and self-luminous optical imaging results of the discharge region packed with the catalysts indicated that Al2O3 mixing effectively strengthened the plasma discharge. Catalyst characterization showed that Fe/Ce had better catalytic properties than CeO2, explaining the better performance of Fe/Ce@Al than that of Ce@Al in the NTPCAS. In situ N2 and H2 adsorption, desorption, and reaction behaviors over catalysts revealed that significantly improved N2 adsorption and activation over Fe/Ce@Al under plasma conditions were the key to NTPCAS. The strategy of mixing highly active ammonia synthesis catalysts with discharge-enhanced materials can significantly improve the performance of NTPCAS catalysts, thus providing a novel approach to designing catalysts for NTPCAS.
研究领域:
化学工程
·
催化
·
等离子体科学
·
材料科学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Feifei Li,Mingyue Wang,Jinming Zhang,Xingtao Lin,Dazhi Wang,Weijie Cai
The design of highly efficient catalysts for CO 2 reforming with ethanol is of great interest due to the serious coke deposition and the sintering of active metal. In this work, sandwich-type Co core@shell catalyst (SiO 2 @Co@CeO 2 ) with Co nanoparticles between SiO 2 core and CeO 2 shell was synthesized by strong electrostatic adsorption method. Interestingly, SiO 2 @Co@CeO 2 catalyst exhibited the outstanding activity/stability toward CO 2 reforming of ethanol in comparison with Co-SiO 2 catalyst. A bi-functional mechanism involving active sites on CeO 2 shell was proposed. Indeed, cobalt nanoparticles between SiO 2 core and CeO 2 shell maintained the high dispersion because of the confinement effect, which supplied a stable Co-ceria interface area where the reaction occurred. In addition, CO 2 could readily react with the O vacancies in CeO 2 shell to form surface oxygen species and CO, which allowed a continuous cleaning of coke. These positive factors could make it as an attractive candidate for dry reforming process.
研究领域:
催化
·
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Haoyuan Zheng,Yuxiao Jia,Chen Jin,Hang Che,Chia-TseLee,Guang Liu,Li Wang,Yuyuan Zhao,Shixuan He,Haizhen Liu,Xinhua Wang,Yifeng Yu,Mi Yan
The magnesium based metal hydrogen storage composite system Mg(NH 2 ) 2 -2LiH has a theoretical hydrogen storage capacity of 5.6 wt.% and is a promising hydrogen storage material for vehicles. However, its application is limited due to serious thermodynamic and kinetic barriers. Introducing efficient catalysts is an effective method to improve the hydrogen storage performance of Mg(NH 2 ) 2 -2LiH. This article investigates for the first time the use of nano rare earth oxide CeO 2 (∼44.5 nm) as an efficient modifier, achieving comprehensive regulation of the hydrogen storage performance of Mg(NH 2 ) 2 -2LiH composite system through oxygen vacancy driven catalysis. The modification mechanism of nano CeO 2 is also systematically studied using density functional theory (DFT) calculations and experimental results. Research has shown that the comprehensive hydrogen storage performance of the Mg(NH 2 ) 2 -2LiH-5 wt.% CeO 2 composite system is optimal, with high hydrogen absorption and desorption kinetics and reversible performance. The initial hydrogen absorption and desorption temperatures of the composite system were significantly reduced from 110/130°C to 65/80°C, and the release of by-product ammonia was significantly inhibited. Under the conditions of 170°C/50 min and 180°C/100 min, 4.37 wt.% of hydrogen can be rapidly absorbed and released. After 10 cycles of hydrogen release, the hydrogen cycle retention rate increased from 85% to nearly 100%. Further mechanistic studies have shown that the nano CeO 2− x generated in situ during hydrogen evolution can effectively weaken the Mg–N and N–H bonds of Mg(NH 2 ) 2 , exhibiting good catalytic effects. Meanwhile, oxygen vacancies provide a fast pathway for the diffusion of hydrogen atoms in the composite system. In addition, nano CeO 2− x can effectively inhibit the polycrystalline transformation of the hydrogen evolving product Li 2 MgN 2 H 2 in the system at high temperatures, reducing the difficulty of re-hydrogenation of the system. This study provides an innovative perspective for the efficient modification of magnesium based metal hydrogen storage composite materials using rare earth based catalysts, and also provides a reference for regulating the comprehensive hydrogen storage performance of hydrogen storage materials using rare earth catalysts with oxygen vacancies.
研究领域:
材料科学
·
催化
·
氢气存储
·
纳米技术
✓ 已验证
DOI
高影响因子
ENERGY
·
2024
·
IF 9
Tao Tan,Yushu Chen,Yongyue Wang,Zuhao Li,Zhige Zhang,Jun Xie,Yong Chen
The use of green biogas as a raw material for producing methanol-friendly syngas (H 2 /CO ≈ 2) for one-step methanol synthesis has gained significant attention. However, developing efficient catalysts with high activity and stability remains challenging, as they often face issues with stability and carbon deposition. This study presents a Ni/CeO 2 /HT catalyst designed for high activity and long-term stability by leveraging the Ce redox cycle and strong interactions between Ni-CeO 2 and hydrotalcite (HT). The catalyst benefits from abundant oxygen vacancies generated by the Ce 3+ - Ce 4+ pathway, enhancing its ability to activate CO 2 and H 2 O and providing excellent coke resistance. Comprehensive analyses of CO 2 /H 2 O adsorption and carbon elimination mechanisms were conducted using techniques such as in situ H 2 -TPR, CO 2 /H 2 O-TPSR, in situ CH 4 -TPSR, CO 2 /H 2 O-TPO, and FTIR. The Ni/CeO 2 /HT catalyst outperformed others in CO 2 /H 2 O adsorption and CH 4 activation capacity, promoting the generation of active oxygen species and effectively removing coke precursors, thereby improving resistance to Ni sintering and carbon deposition. At 750 °C and a weight hourly space velocity (WHSV) of 32,400 mLg Cat −1 h −1 , it achieved CH 4 and CO 2 conversions of 93 % and 66 %, respectively, with long-term stability exceeding 200 h.
研究领域:
催化化学
·
可再生能源
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Zhenxing Wang,Hongli Zhao,Qianmei Gao,Kaicha Chen,Minbo Lan
Here we presented a new facile strategy to fabricate ultrathin two-dimensional (2D) metal oxide nanosheets , by using polydopamine-coated graphene (rGO@PDA) as a template under simply wet-chemical conditions. Based on the strategy, graphene-like CeO 2 –TiO 2 mesoporous nanosheet ( MNS-CeO 2 -TiO 2 ) was prepared and was loaded with dispersive Ag nanoparticles (AgNPs) to obtain effective electrocatalysts (denoted as Ag/MNS-CeO 2 -TiO 2 ) for electrochemical detection of superoxide anion (O 2 •− ). Characterizations demonstrated that MNS-CeO 2 -TiO 2 exhibited ultrathin thickness, larger specific surface area, and pore volume in comparison with its bulk counterpart. The above properties of MNS-CeO 2 -TiO 2 shorten electron transmission distance, promotes mass transfer, and is conducive to the dispersion of post-modified AgNPs. Therefore, the recommended Ag/MNS-CeO 2 -TiO 2 sensors (denoted as Ag/MNS-CeO 2 -TiO 2 /SPCE ) exhibited satisfactory properties, including the sensitivity of 737.1 μA cm −2 mM −1 , the detection limit of 0.0879 μM (S/N = 3), and good selectivity. Meanwhile, the sensors also successfully realized in the online monitoring of O 2 •− released from HepG2 cells, meaning the prepared sensors had practical application potential towards the analysis of O 2 •− in biological samples.
研究领域:
材料科学
·
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Tiancheng Li,Mengmeng Shu,Cheng Zhu,Yixin Li,Qicheng Liu,Zhiyu Zhu,Yangyang Jiang,Peng Mei,Yu Jin,Bing Fang,Lunguo Xia
In osteoarthritic chondrocytes, dysregulation of mitochondrial dynamics due to excessive intracellular reactive oxygen species (ROS) under inflammatory conditions is a significant contributory factor to poor treatment outcomes, because it leads to a reduced cell response to chondrogenic drugs during this state. The aim of this study was to develop a multifunctional Au@CeO 2 yolk-shell nanozyme (YSN) as a novel therapeutic nanomaterial and drug delivery system. Under photothermal conditions, Au@CeO 2 nanozymes neutralized excessive ROS, enhanced antioxidant capacity, and maintained mitochondrial homeostasis of osteoarthritic chondrocytes, thereby restoring cellular responsiveness to external stimuli. Furthermore, bioactive peptide CK2.1 loaded in YSNs (Au@CeO 2 -CK2.1) achieved ordered release under photothermal conditions, effectively promoting chondrocyte anabolic activity. In a mice osteoarthritis (OA) model, local Au@CeO 2 -CK2.1 photothermal therapy effectively enhanced cartilage repair and regeneration in vivo . Mechanically, our research uncovers that decreased chondrogenic drug response is associated with activation of extracellular regulated kinase-1 and -2 (ERK1/2) pathway, and Au@CeO 2 -CK2.1 YSNs regulates mitochondrial dynamics through inhibiting ERK1/2 and dynamin-1-like protein (DRP1) phosphorylation. The results of this study demonstrated an effective therapeutic strategy that rescued chondrogenic drug response in osteoarthritic chondrocytes, achieving anti-inflammation and cartilage regeneration.
研究领域:
纳米技术
·
生物材料
·
药物递送系统
·
再生医学
·
骨科
·
细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Tiping Wei,Liguo Wang,Jiajun Zhang,Yan Cao,Xiang Hui,Jianhui Shi,Shuang Xu,Liyan Zhao,Peng He,Huiquan Li
Bio-based pentamethylene dicarbamate (PDC) belongs to N-substituted carbamates, which are important fine chemicals and organic intermediates. In this work, well-defined CeO2 rods, cubes, and octahedrons were successfully prepared to catalyze the synthesis of PDC by carbonylation of 1,5-pentanediamine (PDA) with methyl carbamate (MC). Among them, CeO2 rods with higher amounts of acid–base sites and abundant oxygen vacancies showed superior intrinsic activity in the PDA carbonylation reaction. In situ FTIR results showed that intermediate polyureas were readily formed in the reaction, and then, CeO2 rods promoted the alcoholysis of polyureas to PDC. In situ DRIFTS results indicated that the surface of CeO2 rods is more favorable for the adsorption and activation of the reactants. CeO2 rods can also be used for the efficient synthesis of a series of N-substituted carbamates. We believe that this work will contribute to the efficient, green, and sustainable production of N-substituted carbamates.
研究领域:
催化
·
化学工程
·
绿色化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2021
·Vol. 17
·期 43
·2101393
·
IF 13.281
Shiyin Zhao,Yangke Long,Yiping Su,Shubin Wang,Zuotai Zhang,Xuanjun Zhang
Antibiotics discharge has been a critical issue as the abuse in clinical disease treatment and aquaculture industry. Advanced oxidation process (AOPs) is regarded as a promising approach to degrade organic pollutants from wastewater, however, the catalysts for AOPs always present low activities, and uncontrollable porosities, thus hindering their further wider applications. In this work, an aliovalent-substitution strategy is employed in metal-organic framework (MOF) precursors assembly, aiming to introduce Co(II/III) into Ce-O clusters which could modify the structure of the clusters, then change the crystallization, enlarge the surface area, and regulate the morphology. The introduction of Co(II/III) also enlarges the pore size for mass transfer and enriches the active sites for the production of sulfate radicals (SO 4 • − ) in MOF-derived catalysts, leading to excellent performance in antibiotics removal. Significantly, the CeO 2 •Co 3 O 4 nanoflowers could efficiently enhance the generation of sulfate radical SO 4 • − and promote the norfloxacin removal efficiency to 99% within 20 min. The CeO 2 •Co 3 O 4 nanoflowers also present remarkable universality toward various antibiotics and organic pollutants. The aliovalent-substitution strategy is anticipated to find wide use in the exploration of high-performance MOF-derived catalysts for various applications.
研究领域:
环境科学
·
材料科学
·
化学工程
·
催化
·
废水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Yicheng Wei,Xiaojian Li,Xu Sun,Hongmin Ma,Yong Zhang,Qin Wei
Combining dual-signal channels of differential pulse voltammetry (DPV) and amperometric i–t curve, we developed an amplified sandwich-type electrochemical immunosensor for ultrasensitive detection of prostate specific antigen (PSA). Due to the large specific surface area and good adsorption property, 3-aminopropyltriethox functionalized CeO 2 mesoporous nanoparticles (NH 2 -M-CeO 2 ) was used for supporting toluidine blue (TB) as the electron transfer mediator and anti-PSA as the signal response. To prevent the leak of TB and facilitate the electron transfer property of NH 2 -M-CeO 2 , ionic liquids doped carboxymethyl chitosan (CMC/ILs) were incorporated and TB/M-CeO 2 /CMC/ILs complex was gotten to act as the label of anti-PSA (Ab 2 ). Meanwhile, Au-CoS/graphene was as the matrix materials modifying the electrode to immobilize anti-PSA (Ab 1 ). Specifically, Au-CoS/graphene cannot produce electrochemical signals through DPV method but can provide an obviously electrochemical signal towards catalysis hydrogen peroxide (H 2 O 2 ) through amperometric i–t curve method. At the time of detection, with the increase of concentrations of PSA, the DPV signals from TB/M-CeO 2 /CMC/ILs were increased and the amperometric i–t curve signals from the Au-CoS/graphene were decreased. Under the optimum conditions, the immunosensor demonstrated remarkable analytical performance of a linear range of 0.5 pg/mL to 50 ng/mL with a detection limit of 0.16 pg/mL for quantitative detection of PSA (S/N=3).
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Ran Tao,Feifei Mu,Jérome Chauvin,Serge Cosnier,Xue-Ji Zhang,Dan Shan
Rational design of highly dispersed CeO 2 nanozymes with abundant oxygen vacancies is critical for achieving efficient and sensitive H 2 O 2 detection. Herein, we report a deep eutectic solvent (DES)-guided engineering strategy to construct an N-doped carbon (NC) framework integrated with mussel-inspired, uniformly dispersed CeO 2 nanoparticles. The DES acts both as a green C/N source and a self-templating medium, regulating heteroatom distribution and graphitization degree to yield a conductive carbon scaffold. Dopamine undergoes oxidative self-polymerization under mild alkaline conditions, and its catechol–amine functionalities strongly chelate Ce 3+ ions, directing homogeneous nucleation and suppressing nanoparticle aggregation. This molecularly engineered architecture produces an oxygen-vacancy-rich interface enriched with redox-active Ce 3+ /Ce 4+ sites, enabling rapid electron transfer and accelerated H 2 O 2 redox kinetics. The optimized CeO 2 /NC electrode delivers a diffusion-controlled amperometric response with dual linear ranges (0.05–60 and 60–300 μM), a low detection limit of 0.036 μM, and sensitivities of 94.8 and 49.3 mA M -1 cm -2 , respectively, surpassing most reported CeO 2 -based sensors. Furthermore, the sensor exhibits excellent selectivity and retains 89 % of its initial response after prolonged operation. This work provides a scalable, eco-friendly pathway for constructing bioinspired, oxygen-vacancy-rich nanozymes, offering broad applicability in advanced electrocatalytic sensing platforms.
研究领域:
材料科学
·
电化学
·
纳米技术
·
传感器与生物传感器
·
环境化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）