FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Haifeng Mai,Xinqi Liang,Baoyi Zhang,Weijuan Huang
Emulsion gels are typically prepared via a two-step process involving emulsification followed by gelation. However, this approach is complex, as emulsion droplets may aggregate before gelation, and harsh gelation conditions may disrupt the emulsion structure and degrade encapsulated bioactive components. Recently, one-step methods have emerged, particularly under high oil content or by inducing a transition from emulsion to gel. In this study, we propose a facile one-step method to prepare uniform and stable low-oil emulsion gels. A carboxymethyl chitosan (CMC) solution and an oil phase containing cinnamon essential oil (CEO) were homogenized using a high-speed disperser at 10,000 rpm for 2 min under 23 °C, inducing a transition from solution to gel. Schiff base reactions between the amino groups of CMC and the aldehyde groups of cinnamaldehyde occurred simultaneously at the oil-water interface and in the aqueous phase, enabling concurrent emulsification and gelation. Increasing CMC concentration (1–2 wt%) and CEO content significantly reduced droplet size, accelerated gelation, and improved structural uniformity. Confocal laser scanning microscopy (CLSM) and cryo-scanning electron microscopy (cryo-SEM) analyses revealed that higher CMC concentrations promote denser gel networks, while increased CEO concentrations yield smaller and more uniformly dispersed oil droplets. Stability assessments demonstrated that emulsion gels prepared with 2 wt% CMC exhibited superior storage stability, freeze-thaw resistance, and centrifugal stability. This facile one-step method for preparing low-oil emulsion gels holds promise for applications in low-fat substitutions development and the encapsulation of sensitive bioactive compounds.
✓ 已验证
产品关联
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Yongjun Sun,Jianwen Liu,Wenquan Sun,Huaili Zheng,Kinjal J. Shah
The water solubility and polymerizability of maleoyl chitosan (MCS) was significantly improved by introducing a maleoyl group into the chitosan chain and MCS is a promising monomer for preparing chitosan-based flocculants with good water solubility. In this study, MCS was grafted with acrylamide and diallyldimethylammonium chloride to prepared a cationic chitosan modified flocculant chitosan-graft-poly (acrylamide diallyldimethylammonium chloride) (PMAD) with excellent solubility by ultraviolet (UV)-induced copolymerization techniques. The effects of monomer concentration, the percentage of maleated chitosan, photoinitiator concentration and illumination time on the intrinsic viscosity, grafting efficiency and dissolution time of PMAD were investigated by single factor experiments. The optimal synthesis conditions were determined with monomer concentration 12.5%, MCS percentage 10%, cationicity 11.25%, photoinitiator concentration 0.3% and illumination time 120 min, proving that UV initiated method was benefited to improve water solubility of PMAD. PMAD prepared at the optimized condition has the optimal viscosity of 4,823.2 mg L –1 , the grafting efficiency of 70.7% and the dissolution time of 75 min. At the same time, the synthesized products PMAD were characterized by infrared spectroscopy, scanning electron microscopy, H-nuclear magnetic resonance, thermogravimetric and X-ray diffraction techniques. The flocculation experiments of PMAD on algae-containing water showed that the flocculation performance of PMAD was remarkably higher than that of commercially available polyacrylamide and polyaluminum ferric chloride. The optimal removal rate of Chl a (81.2%), turbidity (94.9%), and algae cell concentration (99.7%) by PMAD was obtained at dosage of 40 mg L –1 , pH value 8 and G value 500 s –1 . The obtained zeta potential results proved that the main flocculation mechanism of PMAD was the function of adsorption bridging.
✓ 已验证
DOI
高影响因子
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
·
2015
·Vol. 18
·期 2
·155-170
·
IF 1.856
Ke Z,Guo H,Zhu X,Jin Y,Huang Y.
Purpose We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus. Methods TMC and TMC-VB12 were synthesized and insulin loaded TMC/TMC-VB12 nanoparticles were prepared and characterized. Modified and unmodified nanoparticles were studied with Caco-2/HT29-MTX cell model and ligated rat ileum loop. Results Compared with unmodified NPs, VB12 modified NPs showed significantly higher drug internalization in Caco-2/HT29-MTX cell model. The internalization mechanism via VB12 mediation included caveolae and clathrin-mediated endocytosis pathway. Meanwhile, an increased transportation of drugs was observed for VB12 modified NPs, possibly due to the ligand-receptor interaction via an intrinsic factor-dependent fashion. Although the uptake and transport of VB12 modified NPs could be partially influenced by mucus, they still showed higher drug permeation through Caco-2/HT29-MTX co-cultured cells than unmodified NPs in the presence or absence of mucus. Moreover, in situ study in ligated rat ileum loop demonstrated that VB12 modified nanoparticles could reduce the residual insulin in intestinal lumen (0.59 times) and increase their absorption in epithelial tissue (4.8 times) compared with the unmodified ones. Conclusion VB12 modified trimethyl chitosan nanoparticle is a promising carrier for peroral delivery of insulin.
✓ 已验证
DOI
PubMed
高影响因子
CELLULOSE
·
2026
·
IF 4.6
Wang Qing,Huang Zhenyang,Chen Zijian,Zhong Yingying,Mo Qijie,Zhang Wei,Yu Mingguang,Wang Hongwu
The development of novel food packaging materials that are both eco-friendly and highly oil-resistant has been identified as a critical challenge in the food packaging industry. Herein, a facile strategy for fabricating food packaging paper with oil and water resistant properties is reported. Specifically, filter paper was used as the substrate, chitosan was employed as the film-forming matrix, and phytic acid was utilized as a crosslinking agent to modify chitosan, resulting in the successful preparation of functional paper with excellent oil and water resistance. The effects of chitosan coating concentration and phytic acid crosslinking time on the oil and water resistance were systematically investigated. The optimal oil and water resistance was achieved when the chitosan coating amount was set at 30 g/m 2 and cross-linked with a 5% wt phytic acid solution for 10 min. The material exhibited oil resistance lasting beyond 24 h and water resistance exceeding 30 min, demonstrating its ability to effectively block oil for prolonged periods and withstand water exposure, suggesting potential utility in food-contact packaging applications.
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Wenxu Zhang,Zirui Ma,Mengyue Zhang,Zhanpeng Yu,Liangliang Wu,Ying Tang,Lianchun Zhao,Guofu Ma,Ziqiang Lei
The persistent coexistence of heavy metals and organic pollutants in aquatic systems has emerged as a critical challenge in global environmental remediation strategies. The study of materials for simultaneous and efficient removal of multiple pollutants is particularly important. In this study, a three-dimensional reticulated multifunctional adsorbent material, ADS-Gel-1 (α-CD/CMS-P(AA- co -SS)) was constructed based on free radical polymerization using α-cyclodextrin (α-CD) and carboxymethyl chitosan (CMS) as the dual raw materials. Performance tests showed that the material exhibited rapid adsorption kinetics ( t ≤ 150 min) for a wide range of pollutants including antibiotics, dyes and heavy metal ions in a complex aqueous environment (pH 3–9), and the adsorption of norfloxacin (NOR), tetracycline hydrochloride (TC), procaine (Pr), methylene blue (MB), Mn(II) and Cu(II) followed the Langmuir model. The adsorption process is a spontaneous reaction, and the adsorption process is exothermic. The maximum adsorption amounts of NOR, TC, Pr, MB, Mn(II) and Cu(II) reached 861.48, 617.08, 829.84, 1667.52, 1054.87 and 1226.00 mg/g, respectively. The adsorption mechanism involves multiple synergistic effects such as host-guest inclusion, π-π stacking, metal coordination and hydrogen bonding networks. In addition, ADS-Gel-1 maintained the removal rate above 49.06 % in five reusable cycles. It provides a novel functional material design strategy for environmental remediation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yixiu Ni,Ting Feng,Shengye You,Aokang Zhang,Feng Liang,Wei Dong,Yizhong Bao
Current treatments for diabetic wounds affecting the oral mucosa frequently yield insufficient results. Key challenges complicating recovery include bacterial colonization, oxidative damage, and impaired blood vessel formation during tissue repair. To bridge this substantial therapeutic void, our research introduces an injectable hydrogel (named as SQD1) engineered specifically to promote healing within diabetic oral ulcers. This innovative biomaterial combines a polysaccharide network derived from dialdehyde scleroglucan and quaternized chitosan, further enhanced by incorporating shikonin nanoparticles. Upon local injection, SQD1 rapidly transitions into a protective hydrogel layer. The dressing demonstrates robust antimicrobial efficacy alongside potent scavenging of reactive oxygen species. These combined actions effectively transition the lesion environment away from chronic inflammation toward a productive proliferative healing state. A significant advantage involves the material's inherent biodegradability following therapy completion, guaranteeing total bodily assimilation once its wound-healing functions conclude. Collectively, results from both laboratory and animal studies confirm that SQD1 markedly hastens repair processes in oral mucosal injuries. Representing a significant stride forward, this hydrogel technology offers a highly promising approach for managing diabetic oral ulcerations, ultimately aiming to enhance patient prognoses associated with this difficult pathology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yitong Chen,Chuying Zhang,Jiajia Xue,Na Zhang,Shuyang Zhou,Hao Teng,Jinbo Bai,Hang Zhao
Dielectric polymers are crucial basic materials for capacitive energy storage in power systems and electronic devices. However, the inherent performance degradation of conventional polymers at elevated temperatures greatly restricts their application in emerging energy storage fields. It is a key challenge to prepare polymer-based dielectrics that maintaining high energy storage density ( U e ) under elevated temperatures and high fields. In this work, the positively-charged chitosan (CS) and the negatively-charged hydroxylated boron nitride nanosheets (BNNS-OH) were self-assembled as the surface-charged BNNS-OH@CS hybrid nanostructure. Then it was filled into the polyetherimide (PEI) matrix to obtain the BNNS-OH@CS/PEI composite dielectrics. This hybrid nanostructure can construct trap energy levels in PEI matrix to capture charges, thereby restricting the charge migration. Furthermore, the localized reverse electric field formed at the interface between CS and BNNS-OH can reduce the kinetic energy of high-energy electrons within the composites, consequently disrupting charge transport pathways and mitigating space charge accumulation. Such features endow the composite dielectrics with significantly reduced leakage current and conduction loss under elevated temperatures and high fields. It is noteworthy that the highest U e of the 0.3 wt% BNNS-OH@CS/PEI composite with the charge-discharge efficiency ( η ) above 90 % is 4.2 J/cm 3 at 150 °C, which is 289 % higher than that of pure PEI (~ 1.08 J/cm 3 ). Consequently, this work provides a simple and feasible method for developing polymer dielectrics with high energy storage density under high temperatures and high fields.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Dandan Li,Jiepeng Zhao,Sai Huang,Zijian Li,Zhuo Cai,Zhaomin Tong,Liantuan Xiao,Suotang Jia,Xuyuan Chen,Yifei Ma,Mei Wang
Conductive MXene-based fibers hold great promise in the field of flexible wearable electromagnetic interference (EMI) shielding, but their poor spinnability, disordered layer stacking, and weak interfacial interactions severely limit their performance. To overcome these challenges, we develop a synergistic material-structure strategy to fabricate coaxial chitosan@MXene/graphene oxide (GO) composite fibers with chitosan (CS) as the outer shell. The introduction of GO significantly improves the dispersibility and interfacial compatibility of MXene, thereby resolving its inherent poor spinnability. The outer CS layer not only serves as a mechanical support layer but also forms an antioxidant protective shell, effectively inhibiting the degradation of MXene in aqueous and oxygenated environments. Furthermore, we propose a facile post-processing immersion-drying strategy, the immersion process induces slip and rearrangement of MXene and GO layers. Subsequent drying and shrinkage processes further compact the layers, thereby “locking” a tightly ordered conductive structure to yield CS@Mx-G-1 fibers. In this strategy, the fiber conductivity increases from 6.56 × 10 3 S/m to 1.55 × 10 4 S/m, while the electromagnetic interference shielding effectiveness enhances from 30 dB to 45 dB. The fibers maintain stable conductivity and flexibility after two immersion cycles. This approach provides a novel strategy for constructing high-performance flexible EMI shielding fibers.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Yanling Liang,Weikun Li,Xin Tan,Nuoya Chen,Diyi Feng,Yinghua Tao,Xiaojing Wu,Ling Liu,Liqin Ge
Thromboembolic diseases are a major global health threat. Yet current thrombolytic therapies remain limited by systemic off-target effects, short drug half-life, and poor thrombus penetrability. Herein, we report a self-sacrificing template strategy that enables simultaneous microcapsule assembly and template degradation, resulting in the formation of hollow chitosan microcapsules (CSMs) without the need for post-assembly template removal. The microcapsules obtained are then employed to cure thrombosis-related diseases. Using CaCO 3 microparticles (CMPs) as templates, water-soluble chitosan (CS) is assembled onto porous CMP preloaded with recombinant tissue plasminogen activator (rt-PA) under controlled conditions, which triggers CMP dissolution while retaining rt-PA within the CSMs. Subsequently, CSMs are modified with fibrin-targeting CREKA peptides to produce rt-PA@CSMs-CREKA, which possess an optimal microscale size for overcoming margination effects. These microcapsules exhibit high drug loading, favorable biocompatibility, and prolonged circulation time. Both in vitro and in vivo studies demonstrate that rt-PA@CSMs-CREKA achieves superior thrombus targeting, site-specific drug accumulation, and enhanced penetration, effectively degrading fibrin networks and dissolving thrombotic clots. Compared with free rt-PA, rt-PA@CSMs-CREKA possesses significantly enhanced thrombolytic efficacy while downregulating key coagulation factors (FXa and PAI-1). This study presents a promising targeted delivery platform for thrombolytic therapy and offers a novel approach for fabricating CS-related polymeric microcapsules.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Qianqian Ouyang,Hongjiao Qu,Weiyan Quan,Yongkai Tang,Xufeng Zhu,Luming Deng,Xian Xie,Kefeng Wu
Microneedle patches have emerged as promising tools for wound repair. However, their clinical utility is limited by poor adhesion and insufficient interfacial stability, which often lead to secondary wound separation and inefficient drug delivery. Here, we report a seaweed-derived bioadhesive microneedle patch that integrates robust tissue adhesion with sustained drug release for effective skin regeneration. The hydrogel patch, composed of chitosan and poly(vinylpyrrolidone) (PVP), absorbs wound exudates and forms mechanically stable adhesion on tissue surfaces. As such, it maintains long-term fixation and protects the wound site. The microneedle array, fabricated via electrostatic interactions between seaweed-derived polysaccharides (contained α -D-Glcp-1→, →4,6)- α -D-Glcp-(1→, and →4)- α -D-Glcp-(1 → units, with a molecular weight of 27,476 Da, named SFP) and chitosan, exhibits rigid, sharp conical tips that enable efficient skin penetration while ensuring strong interfacial adhesion through conformal contact and hydrogen bonding. This intimate microneedle–tissue integration facilitates localized, continuous release of the antibacterial polysaccharide at the wound interface, thereby ensuring sustained therapeutic efficacy. Furthermore, in vivo studies demonstrated accelerated wound closure, enhanced collagen deposition, promoted angiogenesis, and reduced inflammation. Together, these findings establish the seaweed-derived microneedle patch as a multifunctional platform that stabilizes the wound interface, enhances therapeutic delivery, and holds broad potential for diverse biomedical applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Jingyang Shi,Xianbo Fang,Jieliang Wang,Zhao Cao,Jing Lv,Yongdan Cao,Xiaoping Wang,Na Luo,Fang Zhou,Aiqing Wang,Burdonov Alexander Evgenievich
In rare earth flotation, the separation of bastnaesite and parisite from fluorite is challenging by the similarity of their surface properties and solubility. This study utilized carboxymethyl chitosan (CTS) as a green organic inhibitor for the flotation separation of bastnaesite and parisite from fluorite. The inhibitory effect and mechanism of CTS on fluorite were studied through flotation tests and modern detection methods. The flotation tests results indicate that CTS can effectively inhibit fluorite under the conditions: CTS concentration of 20 mg/L, octyl hydroxamic acid (OHA) concentration of 1×10 –4 mol/L, and at pH 9.8, whereas it only slightly affects the flotation recovery of bastnaesite and parisite. The mechanism analysis results indicate that CTS selectively adsorbs on fluorite surface and reduces the contact angle from 27.25° to 20.38°, while significantly delaying the adhesion process of bubbles on the fluorite surface and reducing its ultimate adhesion angle. CTS undergoes strong chemical adsorption on the surface of fluorite, hindering the subsequent adsorption of OHA, but has weak adsorption on the rare earth minerals. CTS chelates with Ca 2+ on the fluorite surface through its –COO – molecule, forming a hydrophilic Ca(COOR) adsorption cover on the fluorite surface to increase its steric hindrance and inhibit fluorite flotation. Therefore, CTS can be used as a green, environmentally friendly, and highly selective inhibitor to achieve efficient flotation separation of bastnaesite and parisite from fluorite.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2026
·
IF 3.2
Xi Su,Wei Xu,Lulu Liu,Qingxiang You,Wenchang Yi,Siyu Chen,Zhenying Wan,Shuya Huang
A novel ethyl cellulose-sodium alginate/chitosan/curcumin (EC-SA/CS/Cur) composite microgel system was developed through a one-step emulsion method. Optimized homogenization at 1,300 rpm for 2 min enabled consistent fabrication of EC-SA/CS/Cur microgels with a mean particle size of 2.85 μm. The microstructural morphology, particle size distribution, and chemical composition of the optimized EC-SA/CS/Cur microgels were characterized by microscopy, laser particle size analysis, and Fourier-transform infrared spectroscopy. The microgels exhibited a curcumin encapsulation efficiency of 54.4 ± 6.8% and a drug loading capacity of 0.032 ± 0.004%. The microgels exhibited excellent stability under enzymatic and physiological pH environments while displaying a unique sustained-release profile in ethanol-containing media; under agitated conditions, a cumulative release of 3.2 μg/mL was achieved within 6 h, representing a 28.0% increase in cumulative release compared to static conditions. The minimum inhibitory concentration of EC-SA/CS/Cur microgels was determined as 675 μg/mL; after 3 h of exposure, their antimicrobial efficacy significantly outperformed free curcumin. These results confirm that the EC-SA/CS microgel system acts as an effective delivery vehicle, markedly enhancing curcumin’s antimicrobial performance. This study provides a promising strategy for developing stable, high-efficiency curcumin delivery systems with improved therapeutic potential, particularly for oral/throat protection against alcohol-induced irritation via on-site curcumin release to alleviate local inflammatory damage.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）