SENSORS
·
2024
·Vol. 24
·期 11
·3623
·
IF 3.4
Arif Ullah Khan,Muhammad Tahir,Fazal Ul Nisa,Mizna Naseem,Iqra Shahbaz,Zeyu Ma,Zilu Hu,Abdul Jabbar Khan,Muhammad Sabir,Liang He
Metal-oxide-based gas sensors are extensively utilized across various domains due to their cost-effectiveness, facile fabrication, and compatibility with microelectronic technologies. The copper (Cu)-based multifunctional polymer-enhanced sensor (CuMPES) represents a notably tailored design for non-invasive environmental monitoring, particularly for detecting diverse gases with a low concentration. In this investigation, the Cu-CuO/PEDOT nanocomposite was synthesized via a straightforward chemical oxidation and vapor-phase polymerization. Comprehensive characterizations employing X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), X-ray diffraction (XRD), and micro Raman elucidated the composition, morphology, and crystal structure of this nanocomposite. Gas-sensing assessments of this CuMPES based on Cu-CuO/PEDOT revealed that the response current of the microneedle-type CuMPES surpassed that of the pure Cu microsensor by nearly threefold. The electrical conductivity and surface reactivity are enhanced by poly (3,4-ethylenedioxythiophene) (PEDOT) polymerized on the CuO-coated surface, resulting in an enhanced sensor performance with an ultra-fast response/recovery of 0.3/0.5 s.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Hongyang Zhang,Rui-Hong Gong,Yu−Shan Lin,Tao Wang,Dou Luo,Jiahua Li,Li-Sha Shen,Wai-Yeung Wong,Sibao Chen,Guo-Qing Chen
Supramolecular polymers driven by the metal-ligand coordination possess reversible bonds, making them promising candidates for integrating the therapeutic functions of metal ions and small-molecule drugs, and subsequently releasing these components within cells after endocytosis. In this study, a kind of supramolecular polymer, SHICU, is developed, composed of Shikonin ligand and Cu(II) ion. Upon reduction by intracellular glutathione (GSH), SHICU dissociates to release Shikonin, Cu(II), and SHICU fragments. The released Shikonin and Cu(II) exhibit a synergistic antitumor effect through the reactive oxygen species (ROS)-dependent necrosis. Meanwhile, the released SHICU that remains structural integrity induces a distinct antitumor mechanism by triggering cuproptosis in tumor cells. This dual functionality, combining ROS-dependent necrosis and cuproptosis, highlights the potential of SHICU in advancing antitumor therapies, while the integration of supramolecular polymers with the emerging cell death mechanism of cuproptosis facilitates the development of innovative cancer drugs.
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Battery Energy
·
2024
·
IF 9
Xiangchao Xu,Fen Qiao,Yanzhen Liu,Wenjie Liu
Cu(OH) 2 has the advantages of ease of structural regulation, good conductivity, and relatively low cost, making it a suitable candidate material for use as an electrocatalyst. However, its catalytic efficiency and stability still need to be improved further. Therefore, Cu(OH) 2 /Cu 2 S was successfully prepared on copper foam (CF) using the in situ growth and hydrothermal method. The structural characterization showed that sulfidation treatment induced transformation of Cu(OH) 2 /CF from smooth nanorods into a coral-like structure, which exposed more active sites of Cu(OH) 2 /Cu 2 S and enhanced the performance of electrocatalytic hydrogen evolution reaction (HER). Compared with Cu(OH) 2 , Cu(OH) 2 /Cu 2 S showed better alkaline HER performance, especially when the vulcanization concentration was 0.1 M, the overpotential of Cu(OH) 2 /Cu 2 S was 174 mV, and the reaction kinetics was 64 mv dec −1 at a current density of 10 mA cm −2 . In this work, the morphology and electronic structure of copper-based metal sulfide electrocatalysts were adjusted by sulfide treatment, which provided a new reference for improving HER performance.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zhenyao Li,Wei Wei,Xuli Hu,Zhen Zhang,Yangshun Hu,Yushan Wu,Yao Wang,Junchen Xu,Mingyue Ding
While engineering lattice strain has been proven effective in enhancing the electrochemical CO 2 reduction performance of a catalyst, the correlation between strain effect and the intrinsic catalytic mechanism has remained elusive. Herein, a photolithography-inspired method is proposed to regulate Cu(111) lattice strain. By irradiating the photosensitive Cu(Acac) sol–gel, Acac chelate bond undergoes π→π * electronic transition, and the ring-closed Cu(Acac) decompose into the stabilized Cu(Acac) mesh which presents as nanospots embedded onto the surface of the Cu cluster. The photoinduced nanospots serve to exert compressive strain to the Cu(111) lattice in which the lattice distance is reduced by 5.7–11.4%. Herein, the catalyst with 11.4% lattice compression exhibits enhanced C 2 H 4 production capabilities, reaching a maximal Faradaic efficiency of 57.00%, and a high partial current density of 456.01 mA cm −2 . Theoretical calculations reveal that the compressed Cu(111) lattice exhibits reduced surface energies, leading to a significant drop in the C─C coupling reaction free energy from 1.16 eV over the pristine lattice, to 0.57 eV over the 10% compressed lattice. Additionally, the 10% compressed lattice facilitates spontaneous *O splitting immediately after OC─CHO coupling which leads to the generation of C 2 H 4 -favoring *CCH intermediate.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Zhongqiu Zhao,Zixuan Zhou,Lei Wang,Ying Zhang,Yaguang Sun,Mingchang Zhu,Shuangyan Wu
Riboflavin was first isolated from milk and widely used in food, biological and pharmaceutical fields. Accurate detection of riboflavin content is of great significance for the treatment of related diseases and the supervision of food/drug quality. In this paper, a 1D chain copper-based coordination polymer with excellent water stability was synthesized by hydrothermal method using rigid ligand 1,10-phenanthroline and flexible ligand 1,4-phenylenedioxydiacetic acid, named Cu-phen-PEDA. Based on the Förster resonance energy transfer (FRET) and dynamic quenching detection mechanism, the emission spectrum of Cu-phen-PEDA overlaps with the absorption spectrum of riboflavin. As an energy donor in this case, Cu-phen-PEDA significantly increases the fluorescence intensity of riboflavin (energy acceptor), while simultaneously decreasing its own fluorescence intensity, which is an effective proportional-building strategy. In the lower concentration range, riboflavin can be specifically recognized by ratiometric fluorescence with a good linear relationship, and the detection limit is as low as 23 nM. The potential aspects of its specificity, stability, reusability and practical application were explored.
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Nanoscale Horizons
·
2025
·
IF 6.6
Xiao Wan Han,Xu Chen,Tianle Yang,Ying Yi Luo,Rui Xue Liang,San Qi An,Xinli Liu
Cuproptosis has recently received much attention in cancer treatment. However, copper ionophores don’t show the obvious clinical efficacy. Although some Cu-based and copper ionophores-loaded nanomaterials have been applied to induce cuproptosis, it is difficult to achieve the clinical translation limited by the complicated composition, harsh synthesis condition, external stimulus, and potential biotoxicity. Phytic acid, a naturally occurring organic phosphorus carbohydrate, possesses distinct antineoplastic effect on multiply types of cancer and high biocompatibility. Based on metal-phosphonate coordination, a novel Cu-phytic acid nanozyme (denoted as CP) with pH/GSH dual-response was fabricated by a “one-spot” method. CP with three enzyme-mimicking activities enhanced cuproptosis therapy through GSH depletion, reactive oxygen species augment, hypoxia relief and the attenuation of glycolysis. As a proof of concept, Elesclomol (a copper ionophore)-resistant A549 cells were used to investigate CP- induced cuproptosis for inhibition of tumor growth in vitro and in vivo.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Zhao Xin,Li Changzhi,Wen Jie,Qiang Qian,Shen Zirong,Yu Haipeng,Zhou Xin,Yue Fengxia,Fang Ruiqi,Li Yingwei,Zhang Tao
Lignin refining still suffers from great challenges of selective depolymerization and cleavage of stubborn C‒C linkages. Here, a robust atomically dispersed Cu/Ni-SA@HNC catalyst is fabricated for super-selective hydrogenolysis of lignin and model compounds via an unusual “preferential C α –C β bond cleavage in β-O-4 linkages” pathway, affording toluene in yield up to 75.7% from β-O-4 model compounds, and up to 33.7 ± 1.6 wt% (nine parallel experiments) from poplar lignin. The catalyst exhibits high stability, and the scale-up potential is demonstrated by the high space-time yield of toluene (33.7 g·g cat −1 ·h −1 ) in continuous flow reaction of β-O-4 model compound. The origin of the extraordinary selectivity towards C α –C β bond cleavage rather than C‒O bond cleavage in β-O-4 model compounds is uncovered. This work conquers the major challenges in lignin valorization by using non-noble dual-metal single-atom catalyst, not only showcasing the application perspective of atomically dispersed catalysts in biopolymer refinery, but also providing a cost-efficient, petroleum independent solution to valuable commodity chemicals.
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ACS Nano
·
2024
·
IF 15.8
Minglei Lu,Zhuoyu Zheng,Weiwei Lu,Haiping Zhu,Junwei Liao,Yuxin Ge,Xueer Huang,Qian Zhang,Jiajin Li,Yiyuan Zhou,Xiaoping Wu,Baozhu Chen,Chunxiao Yang,Xitang Qian,Minhua Shao,Tiejun Wang
Aqueous-phase reforming of methanol represents a promising avenue for hydrogen (H2) production. However, developing highly efficient and low-cost nonprecious catalysts remains challenging. Here, we report the synthesis of Cu-based catalysts with Cu, Cu2O, and CuN3 nanoparticles anchored on the nitrogen-doped carbon, forming Cu0/Cu+/Cu-N3 active sites. This catalyst achieves a H2 production rate of 140.1 μmol/gcat/s at 210 °C, which is several times to 2 orders of magnitude higher than that of Cu-, Ni-, even Pt-based catalysts, demonstrating excellent long-term stability over 350 h at 210 °C. A mechanism investigation reveals that the Cu-N3 site facilitates water dissociation into *OH and improves *CO and *OH conversion, leading to enhanced CO conversion and H2 production kinetics.
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Energy & Environmental Science
·
2024
·
IF 32.4
Liqun Wang,Jingting Jin,Wenzhi Li,Cunshuo Li,Leyu Zhu,Zheng Zhou,Lulu Zhang,Xia Zhang,Liang Yuan
Direct conversion of methane into high value-added products is of great practical significance. The synergistic effect in catalysts with dual-active components show potential to increase the methanol yield and selectivity. In this work, Cu–Pd/anatase is in situ generated and exhibits a relatively high methanol yield rate of ∼31 800 μmol gcat−1 h−1 and near-exclusive selectivity of liquid products (methanol). The reaction mechanism behind the heterogeneous catalysis process has been investigated. It is confirmed that copper ions hold the ability to produce hydrogen peroxide which can be further promoted by anatase. Chlorine ions can promote the stable adsorption of CO and the formation of *CH3 intermediates, facilitating high activity and selectivity for methanol production. Pd and Cu cooperatively dissociate methane, which promotes the formation of key configuration metal-CH3. The ˙CH3 intermediate desorption will be facilitated on Cu–Pd/anatase through the manner of electron regulation, which is proved by the combination of density functional theory calculations and in situ infrared spectroscopy. Methanol is formed when a ˙CH3 is desorbed from a copper site and combines with a hydroxyl radical.
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COMPOSITES COMMUNICATIONS
·
2025
·
IF 7.7
Ke Zhang,Minghui Ou,Yujie Xiao,Zhiwei Wei,Li Yang,Yi Xie,Changsheng Zhao
Copper-based nanozymes have emerged as promising therapeutic agents for oxidative stress-related diseases due to their enzyme-mimicking properties. However, their development is still limited by poor biocompatibility, insufficient broad-spectrum free radical scavenging ability, and potential toxicity from Cu 2+ leakage. To address these challenges, we developed Cu@EA-BTC, a broad-spectrum antioxidant material, by integrating ellagic acid (EA) into copper-based metal-organic frameworks (Cu@BTC). The Cu@BTC serves as a stable copper source, while the EA endows the Cu@EA-BTC with broad-spectrum ROS scavenging and enhanced catalase (CAT)-like activity via facilitating the reduction of Cu 2+ to Cu + . As a result, the Cu@EA-BTC exhibits superior antioxidant properties and excellent biocompatibility, including both cellular and blood compatibility. Meanwhile, the Cu@EA-BTC effectively protects immune cells from oxidative damage, which indicates its potential for oxidative stress-related therapies. This study provides a promising strategy for developing safe and efficient nanozyme-based antioxidant materials for biomedical applications.
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JACS Au
·
2025
·
IF 8.7
Xuan Bie,Yukun Pan,Xiaowei Wang,Shiyu Zhang,Jiahui Hu,Xiaoxiao Yang,Qinghai Li,Yanguo Zhang,Robert E. Przekop,Yayun Zhang,Hui Zhou
Gas sources rich in CO2 derived from biomass/waste gasification, anaerobic digestion, or industrial carbon capture often contain impurities such as H2S, H2O, and NH3, which can significantly hinder catalyst performance. Here, we show the role of NH3 on the reverse water–gas shift (RWGS) reaction over a commercial Cu/ZnO/Al2O3 catalyst, examining its effects on both the catalytic activity and the catalyst structure. We found that NH3 reversibly decreases CO2 conversion immediately by suppressing carbonate hydrogenation and CO desorption. This effect intensifies with an increase in NH3 concentration but decreases at higher temperatures. However, prolonged exposure (over 100 h) to RWGS conditions in the presence of 1.4% NH3 leads to near-total and irreversible deactivation of the Cu/ZnO/Al2O3 catalyst. Under NH3 exposure, the catalyst loses Cu+ sites on the surface, causing a spatial separation of Cu and ZnO. Finally, to address this challenge, we propose a novel strategy to mitigate NH3 inhibition by decomposing NH3 into N2 and H2.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Chenxu Guo,Miao Li,Wenming Guo,Jiawei Xie,Hang Qin,Moyu Liao,Yi Zhang,Pengzhao Gao,Hanning Xiao
Methanol steam reforming (MSR) is considered as a promising approach to provide hydrogen for proton-exchange membrane fuel cells. However, it is challenging to develop effective and durable Cu-based catalysts. Herein, Cu-ZnO catalysts are prepared by facile quenching of ZnO in copper nitrate solution followed by reduction to obtain the desired metal loading and induce the doping of surface metal heteroatoms for producing more vacancies. Catalysts enriched with oxygen vacancies can efficiently activate H 2 O and rapidly transform C-containing intermediates, resulting in higher methanol conversion and lower CO selectivity. As a result, the quenched optimal catalyst achieves 100 % methanol conversion and 0.05 % CO selectivity at 280 ℃, exhibiting the excellent catalytic performance in MSR reaction. In practical applications, structured catalysts are more attractive for large-scale catalytic reactions owing to the low pressure drop and high utilization efficiency. Therefore, ZnO-Cu 3 catalyst is coated on cordierite honeycomb ceramics with 100 % methanol conversion and 0.04 % CO selectivity at 280 ℃. After 100 h of the reaction, the structured catalyst remains ∼ 92.3 % with CO selectivity varying from 0.02 to 0.06 %, demonstrating the good catalytic stability in the long-term experiment. In addition, the evolution of reactants and intermediates on the catalyst surface are briefly described by FTIR spectra. This study offers a novel and efficient approach to obtain highly active and durable catalysts with great potential for industrial-scale preparation and application.
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