Solar RRL
·
2025
·
IF 4.7
Xinyu Zhao,Songlin Lu,Keyu Cui,Ye Zhang,Jing Luo,Chunbo Liu,Huaqiao Tan
The exciton binding energy ( E b ) is recognized as a pivotal parameter governing charge separation in polymeric photocatalysts. Reducing E b in polymers enhances carrier generation, thereby boosting photocatalytic activity. Rationally constructing donor–acceptor (D–A) architectures in heptazine-based polymers offers an effective strategy to overcome intrinsic excitonic limitations. In this work, CN x ( x = 0.015, 0.025, 0.05) materials with intramolecular D–A configurations were developed by integrating electron-donating units with heptazine acceptor motifs. The optimized material CN 0.025 exhibits a 29% reduction in E b (97 → 69 meV) and extended visible-light absorption, attributable to enhanced π-conjugation and modulated electronic structures. Remarkably, under visible-light irradiation, CN 0.025 achieves 97.7% degradation of 2,4-dichlorophenol (10 ppm) within 50 min. Moreover, CN x exhibits a 29.8-fold higher CO yield than pure g-C 3 N 4 in photocatalytic CO 2 reduction. Electrochemical photocurrent measurements reveal a remarkable enhancement in the photocurrent response of CN 0.025 relative to g-C 3 N 4 , which suggests more efficient exciton dissociation and increased carrier availability at the catalytic surface for subsequent redox reactions. This work establishes a paradigm for exciton dissociation in polymeric photocatalysts through engineered D–A nanoarchitectures.
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CRYSTENGCOMM
·
2017
·Vol. 19
·期 17
·2349-2358
·
IF 3.474
Yu-Peng Zhou,Zhang-Wen Wei,Zhuo-Jia Lin,Hui-Tao Ling,Zhengang Guo,Mei Zhang,Chi-Keung Lam,Bao-Hui Ye,Hsiu-Yi Chao
With the idea of supramolecular hosts encircling monoanions, a series of urea-containing trinuclear cationic copper complexes were designed, prepared and structurally analyzed. Copper(I) acetylides [Cu3(μ-dppm)3(μ3-η1-CCC6H4-4-NHC(O)NHC6H4-4-R)2]+ (dppm = bis(diphenylphosphino)methane; R = NO2 (1), CF3 (2), Cl (3), H (4), tBu (5), and OCH3 (6)) were prepared with F−, BF4−, or NO3− present as the anion. Eight 1-D anion coordination polymers (ACPs), 1·F, 2·F, 3·BF4, 4·F, 5·F, 5·BF4, 5·NO3 and 6·0.5F·0.5BF4, were clearly determined by X-ray diffraction. Diversity in the polymeric architecture is generated by both the choice of R-group used and anion present. 2·F, 3·BF4, 4·F, and 5·F show linear 1-D structures; 5·BF4 and 5·NO3 feature single-stranded helical structures; 1·F and 6·0.5F·0.5BF4 exhibit meso-helical structures. Solid state UV-vis absorption and luminescence properties are also discussed.
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高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 44
·17972-17977
·
IF 5.101
Pengtao Shao,Hongzhi Wang,Qinghong Zhang,Yaogang Li
Mn-doped ZnSe nanocrystals (Mn:ZnSe d-dots) that emit white light were synthesized in aqueous media in microfluidic reactors. White light emission from Mn:ZnSe d-dots was a result of combined emission of blue light (emission from non-coordinated surface selenium sites) and yellow light (4T1 → 6A1 emission from Mn2+ ions). Emission from non-coordinated surface selenium sites was realized by adjusting the ratio of the flow volumes of [Zn]/[Mn] and the mass of stabilizer added. Photoluminescence from the Mn:ZnSe d-dots was easily tuned from 580 to 602 nm by regulating flow volume. Under the optimal experimental conditions, Mn:ZnSe d-dots that emit white light with a quantum yield of about 10.2% were fabricated.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Zhiyong Zhou,Lichao He,Yu Mao,Wenshuai Chai,Zhongqi Ren
Enantioseparation of racemic tryptophan is very important for pharmaceutical production. Conventional separation methods are high costly, energy intensive and environmentally unfriendly. Permeation separation based on membrane separation technique is a promising technology with advantages of energy efficient, clean and no additives. However, lots of organic compounds are commonly used for the traditional preparation of various membranes for enantioseparation of racemic tryptophan. Thus, we developed a totally green and clean preparation method using nature polymer sodium alginate as functional polymer, water as solvent and CaCl 2 as crosslinking agent. Besides, polyvinylidene fluoride membrane was selected as supported membrane. Molecularly imprinted technology with d -Tryptophan as template molecule was introduced to enlarge mass transfer flux. Various methods were used in characterization of molecularly imprinted composite membrane (MICM) and non-imprinted composite membrane (NICM). Effects of preparing conditions, permeation conditions and concentration polarization on permeation performance of MICM by pressure-driven were investigated. High enantiomeric excess ( ee % > 98%) of the permeation solution could be obtained under mild conditions. Reducing the presence of concentration polarization was beneficial to maintaining high ee % (>98%). Moreover, the thermo and chemical stability of MICM were studied too. Comparison with previous studies indicated that the proposed totally green and clean method was not only low costly and environment friendly but also beneficial to significantly increasing ee .
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BIOMATERIALS
·
2025
·
IF 12.9
Qingzhou Kong,Yinuo Zhao,Haifan Gong,Luoyao Kang,Jialu Fu,Lixiang Li,Boyao Wan,Peizhu Wang,Xiaojuan Li,Yue Wang,Jinghui Zhang,Yanbo Yu,Xiaoyun Yang,Xiuli Zuo,Haina Wang,Yanqing Li
Antimicrobial peptides (AMPs) offer a route to counter resistant pathogens but are often hampered by proteolysis, whereas D-peptides resist proteases yet remain underexplored due to data scarcity and design challenges. Here, we present PeptiD-Agent, a purely agent based framework that predicts D-peptide antimicrobial activity with extremely limited data, enabling rapid discovery of potent candidates. Using this approach, we identified DA2, a D-enantiometric AMP lead with broad-spectrum activity against drug-resistant bacteria and minimal hemolytic toxicity. DA2 showed high stability under physiological conditions, including resistance to enzymatic degradation and serum. Mechanistic studies indicate that DA2 exerts bactericidal effects by disrupting the integrity of the bacterial membrane in concert with multiple synergistic mechanisms. In murine models of skin wounds and intraperitoneal infection, DA2 conferred significant protection against drug-resistant pathogens and, when delivered via hydrogel, accelerated wound healing. These findings establish a computational route to potent, stable D-peptide antimicrobials and provide a general strategy for AMP design in data-scarce settings.
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PubMed
高影响因子
Catalysts
·
2018
·Vol. 8
·期 10
·468
·
IF 3.465
Lu Zheng,Yining Sun,Jing Wang,He Huang,Xin Geng,Yi Tong,Zhi Wang
In this present study, we proposed a smart biomineralization method for creating hybrid organic–inorganic nanoflowers using a Co2+-dependent enzyme (D-psicose 3-epimerase; DPEase) as the organic component and cobalt phosphate as the inorganic component. The prepared nanoflowers have many separated petals that have a nanometer size. Under optimum conditions (60 °C and pH of 8.5), the nanoflower can display its maximum activity (36.2 U/mg), which is about 7.2-fold higher than free DPEase. Furthermore, the immobilized DPEase presents enhanced pH and thermal stabilities. The DPEase-nanoflower maintained about 90% of its activity after six reaction cycles, highlighting its excellent reusability.Keywords:nanoflower;immobilization;metal-dependent enzyme;D-psicose;DPEase
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高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yue Wang,Xiliang Yu,Weiping Zhao,Shiyi Liu,Sangeeta Prakash,Xiuping Dong
This study developed a functional gel system based on cod protein, incorporated with vitamin D-loaded bilayer microcapsules, to achieve both texture softening and nutritional enhancement through controlled moisture regulation and composite ingredients. Results demonstrated that the incorporation of microcapsules (5%-30%) significantly reduced cooking loss, gel strength, hardness, and gumminess, while improving whiteness ( p <0.05). Composite gels with 5%-15% microcapsules met the Level 6 (soft & bite-sized) criteria according to the International Dysphagia Diet Standardisation Initiative (IDDSI) testing, indicating their suitability for individuals with dysphagia. Particularly, the microcapsule content of 15% was identified as optimal. Microscopic observations confirmed that the microcapsules remained intact and demonstrated improved protein cross-linking, attributable to the addition of microcapsules enhancing hydrophobic interactions. However, excessive incorporation (30%) disrupted the three-dimensional network architecture of the gel. In vitro digestion results indicated that the soft gels with 15% microcapsules achieved a high protein digestibility of 91.83% and enhanced vitamin D bioaccessibility, compared to the free-form vitamin D with release rate of 57.46%. Furthermore, the composite gels with 15% microcapsules exhibited improved oral processing properties, including lower friction coefficient and reduced masticatory force, fulfilling both swallowing safety and nutritional requirements for populations with special dietary needs.
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
·
2024
·
IF 2.3
Jun Meng,Bo Yang,Chang Shu,Shuai Jiang
Background Prostate cancer (PCa), a prevalent malignancy worldwide, is frequently identified in advanced stages due to the absence of distinctive early symptoms, thereby culminating in the development of chemotherapy-induced drug resistance. Exploring novel resistance mechanisms and identifying new therapeutic agents can facilitate the advancement of more efficacious strategies for PCa treatment. Methods Bioinformatics analysis was employed to investigate the expression of FOXG1 in PCa tissues. Subsequently, qRT-PCR was utilized to validate FOXG1 mRNA expression levels in corresponding PCa cell lines. FOXG1 knockdown was performed, and cell proliferation was assessed using CCK-8 assays, while cell migration and invasion capabilities were evaluated through wound healing and Transwell assays. Western blot and Seahorse analyzer were used to measure oxidative phosphorylation (OXPHOS) levels. Additionally, to explore potential approaches to alleviate PCa drug resistance, this study assessed the impact of biologically active saikosaponin-d (SSd) on PCa malignant progression and resistance by regulating FOXG1 expression. Results FOXG1 exhibited high expression in PCa tissues and cell lines. Knockdown of FOXG1 inhibited the proliferation, migration, and invasion of PCa cells, while FOXG1 overexpression had the opposite effect and promoted OXPHOS levels. The addition of an OXPHOS inhibitor prevented this outcome. Finally, SSd was shown to suppress FOXG1 expression and reverse docetaxel resistance in PCa cells through the OXPHOS pathway. Conclusion This work demonstrated that SSd mediated FOXG1 to reverse malignant progression and docetaxel resistance in PCa through OXPHOS.
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PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Wenyi Hou,Zhaoyi Lin,Xinling Chen,Yu Sun,Yao Lin,Mengran Peng,Feng Zhou,Huamin Jiang,Yan Li,Yue Zheng
There have been various interventions for photoaging skin, such as retinoic acid treatment and laser therapy. However, more precise, secure, and effective technologies and materials were still need to be explored. Cathepsin D (CTSD) repairs the epidermal barrier in chronic photodamaged skin through increasing TGase-1 expression and activity. Cathepsin K (CTSK) affects the metabolism of skin elastic fibers. Therefore, gelatin/alginate composite hydrogel microspheres loaded with CTSD or CTSK were fabricated. The microspheres with an average size of 79.8 ± 30.4 μm were stable in PBS (pH 7.4) for 5 days and then disintegrated in vitro . 0.1 mg/mL of microspheres continuously released 12-13 ng/mL CTSD or CTSK for the first three consecutive days. In vivo , the microspheres were almost completed degraded on day 7 after the subcutaneous injection. The biosafety and efficacy of CTSD- and CTSK- microspheres were confirmed in vitro and in vivo . They reduced ROS and inhibited the degradation of skin collagen and elastic fibers by upregulating Nrf2 and downregulating MMP-1 and MMP-3, which reversed photodamage of skin induced by UV. In conclusion, the gelatin/alginate composite microspheres loaded with CTSD or CTSK showed a great potential for chronic photodamaged skin.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Chaowei Luo,Jie Xiong,Hongyan Zeng,Mengchen Liao
Heterointerface engineering is an effective strategy to design and construct high-performance photocatalysts. Herein, polyaniline (PANI) nanoparticles and ZnTi layered double hydroxide (ZnTi-LDH) nanosheets were integrated to form organic–inorganic heterostructure (PANI/LDH) via d – π electronic coupling using in-situ polymerization for photocatalytic oxidation/reduction towards tetracycline (TC) and Cr(VI). The photocatalytic activity was closely related to feed amount of aniline (Ani) in the polymerization process, which the abundant PANI nanoparticles were evenly distributed on the surface of ZnTi-LDH nanosheets at the proper Ani feed amount, and thus reinforced d –π electronic coupling at the organic–inorganic interfaces more efficiently. Density functional theory calculations further verified the existence of d –π overlap at the PANI/LDH heterointerface. The strong d –π coupling boosted charge separation and transfer to improve photocatalytic efficiency. As a result, the optimal PANI/LDH (0.3) exhibited outstanding photocatalytic activities with 97.8 % Cr(VI) reducing rate and 87.8 % TC removal rate in the single Cr(VI) and TC system, as well as high simultaneous removal rate of Cr(VI) and TC in TC/Cr(VI) coexistence system, respectively. Subsequently, the photocatalytic enhanced mechanisms were put forward to remove Cr(VI) and TC under visible-light. Finally, the aquatic toxicity of the photolytic products was evaluated using Chlorella sp. as an ecological indicator, showing that the PANI/LDH had a notable detoxification efficiency of TC and Cr(VI).
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PubMed
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2017
·
IF 0.828
Shan Bai,Zhenzhong Ouyang
Direct graft copolymerization of maleic anhydride (MAH) onto poly(D,L-lactide-co-glycolide) (PLGA) was performed by use of benzoyl peroxide (BPO) as initiator. Fourier transform infrared spectra, nuclear magnetic resonance, titration analysis of maleation extent and water contact angle were employed to characterize the obtained MPLGA. The effects of monomer concentration, initiator concentration and reaction temperature on the degree of maleation were investigated. The MPLGA scaffold was obtained by using NaCl as the porogen. The results showed that maleic anhydride was successfully grafted onto the PLGA chains. The monomer and initiator concentrations played an important role in the graft copolymerization; the extent of maleation first increased with increasing content of MAH and BPO and then declined. The extent of maleation continuously increased with increasing temperature to 100°C, and then the rate of increase decreased. The extent of maleation could be controlled in the range from 0.15 to 0.71% by adjusting the graft copolymerization conditions. The introduction of anhydride enhanced the water contact angle of PLGA. The MPLGA scaffold showed a network of interconnected pores ranging from 50 to 300 μm.
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Journal of Materials Chemistry C
·
2013
·Vol. 1
·期 30
·4556-4564
·
IF 0
Liang Pan,Benlin Hu,Xiaojian Zhu,Xinxin Chen,Jie Shang,Hongwei Tan,Wuhong Xue,Yuejin Zhu,Gang Liu,Run-Wei Li
Two donor–acceptor (D–A) polyazothines (PAs), incorporating the oxadiazole entity either acting as an electron acceptor (A) to form D–A structured PA-1 with the triphenylamine donor (D), or acting as a donor to form D–A structured PA-2 with the 3,3′-dinitro-diphenylsulfone acceptor, have been successfully synthesized via a polycondensation reaction. The variation in the role of the oxadiazole moiety in the D–A polymers, together with the use of different top electrode metals, leads to interesting electronic transport properties and various resistive switching behaviors of the present polyazothines. Pt-electrode devices based on a PA-1 active layer show a rewritable memory effect with poor endurance (less than 20 cycles), whereas the PA-2 based Pt devices exhibit write-once read-many-times (WORM) memory behavior. For the Al-electrode devices, both PAs demonstrate a much improved resistive switching effect, and the endurance of the PA-2 devices is better than that of the PA-1 devices. The difference in the electronic transport and memory properties of the four devices may originate from the different charge injection/extraction and electron transfer processes of the sandwich systems, and will provide guidelines for selecting both the proper D and A moieties in D–A polymers and electrode metals for high-performance resistance random access memories (RRAMs).
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