JOM
·
2023
·Vol. 75
·期 3
·701-707
·
IF 2.6
Yao Qiang,Guo Jing,Guan Fucheng,Zhao Miao,Zhang Sen,Tuo Xiaohang,Yang Qiang
As a transition metal dichalcogenides (TMDCs), molybdenum disulfide (MoS 2 ) comprises individual sheets stacked into a bulk-phase structure. Compared with bulk-phase MoS 2 , the few-layer MoS 2 presents a two-dimensional nanostructure similar to graphene, which has the advantages of large specific surface area and many unsaturated vacancies in the edge layer and has broad application prospects in the fields of photoelectricity and catalysis. Here, a simple and practical method of exfoliating bulk-phase MoS 2 is proposed. The bulk-phase MoS 2 was sonicated using chitosan/acetic acid (CS/HAc) solution to obtain oligomeric MoS 2 . The raw materials used in this method have good biocompatibility, the preparation process and operation are simple, and the pollution caused to the environment is small, which meets the green chemical standard. The method provides a new idea and way for the peeling treatment of other laminated materials. The results show that the stacking of (002) crystal plane of MoS 2 samples after treatment with CS/HAc solution is reduced and the crystalline phase is changed from polycrystalline to single-crystal structure, which has great potential for applications in optical and electrical fields.
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Desalination and Water Treatment
·
2024
·
IF 1
Yongjun Sun,Jianwen Liu,Wenquan Sun,Huaili Zheng,Kinjal J. Shah
The water solubility and polymerizability of maleoyl chitosan (MCS) was significantly improved by introducing a maleoyl group into the chitosan chain and MCS is a promising monomer for preparing chitosan-based flocculants with good water solubility. In this study, MCS was grafted with acrylamide and diallyldimethylammonium chloride to prepared a cationic chitosan modified flocculant chitosan-graft-poly (acrylamide diallyldimethylammonium chloride) (PMAD) with excellent solubility by ultraviolet (UV)-induced copolymerization techniques. The effects of monomer concentration, the percentage of maleated chitosan, photoinitiator concentration and illumination time on the intrinsic viscosity, grafting efficiency and dissolution time of PMAD were investigated by single factor experiments. The optimal synthesis conditions were determined with monomer concentration 12.5%, MCS percentage 10%, cationicity 11.25%, photoinitiator concentration 0.3% and illumination time 120 min, proving that UV initiated method was benefited to improve water solubility of PMAD. PMAD prepared at the optimized condition has the optimal viscosity of 4,823.2 mg L –1 , the grafting efficiency of 70.7% and the dissolution time of 75 min. At the same time, the synthesized products PMAD were characterized by infrared spectroscopy, scanning electron microscopy, H-nuclear magnetic resonance, thermogravimetric and X-ray diffraction techniques. The flocculation experiments of PMAD on algae-containing water showed that the flocculation performance of PMAD was remarkably higher than that of commercially available polyacrylamide and polyaluminum ferric chloride. The optimal removal rate of Chl a (81.2%), turbidity (94.9%), and algae cell concentration (99.7%) by PMAD was obtained at dosage of 40 mg L –1 , pH value 8 and G value 500 s –1 . The obtained zeta potential results proved that the main flocculation mechanism of PMAD was the function of adsorption bridging.
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JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
·
2015
·Vol. 18
·期 2
·155-170
·
IF 1.856
Ke Z,Guo H,Zhu X,Jin Y,Huang Y.
Purpose We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus. Methods TMC and TMC-VB12 were synthesized and insulin loaded TMC/TMC-VB12 nanoparticles were prepared and characterized. Modified and unmodified nanoparticles were studied with Caco-2/HT29-MTX cell model and ligated rat ileum loop. Results Compared with unmodified NPs, VB12 modified NPs showed significantly higher drug internalization in Caco-2/HT29-MTX cell model. The internalization mechanism via VB12 mediation included caveolae and clathrin-mediated endocytosis pathway. Meanwhile, an increased transportation of drugs was observed for VB12 modified NPs, possibly due to the ligand-receptor interaction via an intrinsic factor-dependent fashion. Although the uptake and transport of VB12 modified NPs could be partially influenced by mucus, they still showed higher drug permeation through Caco-2/HT29-MTX co-cultured cells than unmodified NPs in the presence or absence of mucus. Moreover, in situ study in ligated rat ileum loop demonstrated that VB12 modified nanoparticles could reduce the residual insulin in intestinal lumen (0.59 times) and increase their absorption in epithelial tissue (4.8 times) compared with the unmodified ones. Conclusion VB12 modified trimethyl chitosan nanoparticle is a promising carrier for peroral delivery of insulin.
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CELLULOSE
·
2026
·
IF 4.6
Wang Qing,Huang Zhenyang,Chen Zijian,Zhong Yingying,Mo Qijie,Zhang Wei,Yu Mingguang,Wang Hongwu
The development of novel food packaging materials that are both eco-friendly and highly oil-resistant has been identified as a critical challenge in the food packaging industry. Herein, a facile strategy for fabricating food packaging paper with oil and water resistant properties is reported. Specifically, filter paper was used as the substrate, chitosan was employed as the film-forming matrix, and phytic acid was utilized as a crosslinking agent to modify chitosan, resulting in the successful preparation of functional paper with excellent oil and water resistance. The effects of chitosan coating concentration and phytic acid crosslinking time on the oil and water resistance were systematically investigated. The optimal oil and water resistance was achieved when the chitosan coating amount was set at 30 g/m 2 and cross-linked with a 5% wt phytic acid solution for 10 min. The material exhibited oil resistance lasting beyond 24 h and water resistance exceeding 30 min, demonstrating its ability to effectively block oil for prolonged periods and withstand water exposure, suggesting potential utility in food-contact packaging applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yumiao Lang,Mingru Wang,Shasha Zhou,Dandan Han,Peng Xie,Cuiping Li,Xiaoxi Yang
Polysaccharides are employed to modify proteins, forming complexes that enhance the functional properties of proteins, such as emulsification and stability. In this study, myofibrillar protein (MP)-chitosan (CS) complexes were formed between CS and MP under acidic conditions (pH 3.0–6.0). Results showed that CS can improve the solubility and emulsifying properties of MP, and the MP-CS complexes at pH 3.0 and 6.0 had better emulsifying properties. Concurrently, the particle size results indicated that better the emulsifying properties of the complex, the smaller the particle size. Consequently, the characteristics of the MP-CS complexes (at pH 3.0 and 6.0) were investigated. Our analysis using Fourier transform infrared spectroscopy revealed that the amide I band of MP was blue-shifted with the addition of CS, signifying a decrease in hydrogen bonding within MP. The endogenous fluorescence spectra showcased that the hydrophobicity surrounding the tryptophan residues in the protein changed, leading to enhanced polarity. Thermogravimetric analysis and differential scanning calorimetry further confirmed that the addition of CS improved the thermal stability of MP. These findings provide valuable insights into the interactions between MP and CS. Furthermore, the MP-CS complex can be leveraged to create a Pickering emulsion system for the efficient delivery of bioactive substances.
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JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Yang Yang,Li Yinan,Yang Yufen,Fang Min,Zhu Weiju,Li Cun
Hypochlorite and nitrite are commonly utilized in the food industry. Therefore, it is important to develop a low-cost, efficient, and rapid method to detect hypochlorite (ClO − ) and nitrite (NO 2 − ). In this study, a novel fluorescent probe, CS-BP, was developed from chitosan (CS) by chemically incorporating phenothiazine derivatives (BP) through a Schiff base linkage. The probe exhibited a specific “turn-off” fluorescence response to ClO − or NO 2 − with a color change from bright yellow to colorless. The detection limits of ClO − and NO 2 − were 0.54 µM and 0.83 µM. By adjusting the pH of the CS-BP aqueous solution, ClO − and NO 2 − could be effectively distinguished. A smartphone-based detection method was developed for rapid and portable analysis. Furthermore, CS-BP was successfully loaded onto test strips, cotton swabs, and fluorescent films, demonstrating excellent selectivity and versatility for detecting ClO − and NO 2 − in complex samples. The results showed that CS-BP holds great potential for practical applications.
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Polymers
·
2026
·Vol. 18
·期 13
·1677
·
IF 5.8
HanJiong Ji,Shengqiang Liao,Shibo Wu,Sijia Chen,Xue Guan,Chenlong Li,Dawei Zhang
The skin is the largest organ of the human body and, due to its direct contact with the external environment, is one of the most vulnerable tissues. Traditional medical bandages and gauze exhibit limited efficacy in wound management, often neglecting the control of wound inflammation and the promotion of skin regeneration. Hydrogels, as an emerging material, possess appropriate swelling capacity, oxygen permeability, and the ability to absorb wound exudates, thereby facilitating wound healing, making them an ideal choice for functional applications in skin tissue engineering. In this study, dual-treated balsa wood (BWSM) was used as the hydrogel substrate, with polyvinyl alcohol (PVA), chitosan (CS), and zinc gluconate (ZnG) used as the primary raw materials. The BWSM/PVA/CS/ZnG hydrogel was prepared via gamma-ray irradiation. Balsa wood treated with alkaline solutions, hydrogen peroxide solutions, and microwave treatment processing exhibited enhanced transparency, increased porosity, improved thermal stability and swelling rates, while retaining adequate mechanical strength. Gamma-ray irradiation of the BWSM/PVA/CS/ZnG hydrogel wound dressing demonstrated sustained drug release and antibacterial efficacy through release and antimicrobial tests. Animal experiments showed that the BWSM/PVA/CS/ZnG composite hydrogel promoted wound healing in mice and effectively prevented scar formation. The aforementioned results demonstrate that the PVA/CS/ZnG composite hydrogel loaded with balsa wood exhibits durable antibacterial properties and high mechanical strength and promotes wound healing, making it suitable for applications in biomedical materials such as wound dressings.
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International Journal of Nanomedicine
·
2026
·
IF 8.7
Qin Yu,Xue-Ying Tan,Xian Liu,Hai-Bo Mao,Zhao-Gui Chen
Background Acute kidney injury (AKI) is a critical clinical syndrome with high morbidity and mortality, primarily driven by mitochondrial oxidative stress and tubular epithelial cell apoptosis. Current antioxidant therapies are limited by poor bioavailability and lack of renal specificity. To address this, we developed a dual-targeting nanomedicine based on ultrasmall chitosan oligosaccharide-functionalized ruthenium-curcumin nanodots (LMWC/Ru-Cur).Methods Ru-Cur coordination polymer nanodots were synthesized and subsequently coated with low-molecular-weight chitosan (LMWC). The nanoparticles were characterized for size, surface charge, stability, and antioxidant capacity. In vitro studies using HK-2 cells assessed cytocompatibility, cellular uptake, and protection against H2O2- or cisplatin-induced injury via measurements of viability, mitochondrial ROS, membrane potential, and apoptosis. In vivo efficacy and biodistribution were evaluated in murine models of ischemia-reperfusion- and cisplatin-induced AKI.Results The resulting LMWC/Ru-Cur nanodots exhibited uniform size (~7.6 nm), good aqueous stability, and potent broad-spectrum radical scavenging ability. They were efficiently internalized by renal tubular cells via megalin receptor-mediated endocytosis, leading to significantly enhanced renal accumulation. Treatment with LMWC/Ru-Cur attenuated oxidative stress, restored mitochondrial function, reduced apoptosis in injured HK-2 cells, and improved renal function (serum creatinine and blood urea nitrogen), histopathology, and inflammatory cytokine levels in both AKI models, outperforming free curcumin or unmodified Ru-Cur. The nanodots also demonstrated favorable short-term biocompatibility and in vivo biosafety.Conclusion LMWC/Ru-Cur nanodots represent a promising targeted nanotherapeutic strategy for AKI, integrating passive glomerular filtration with active receptor-mediated tubular delivery to effectively mitigate oxidative stress and mitochondrial damage, thereby preserving renal function. This work provides a rational design for metal-polyphenol based nanomedicines in the treatment of acute organ injury.
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Biomedical Materials
·
2026
·Vol. 21
·期 3
·035017
·
IF 3.9
Lixia Fan,Xinren Xu,Huimin Luo,Yuke Xiang,Baixian Huang,Jun Wang,Ruixue Wang
Although chemotherapy remains a cornerstone of oncological treatment, its clinical application is severely hindered by the systemic toxicity and poor targeting efficiency inherent in conventional drug delivery systems. Given the relatively low levels of reactive oxygen species (ROS) in pathological tissues (<100 μM), there is an urgent need to develop stimuli-responsive carriers with superior sensitivity. In this study, we developed ditelluride-bridged carboxymethyl chitosan nanoparticles (DTeC NPs) as an innovative, ROS-triggered doxorubicin (DOX) release platform, using disulfide-crosslinked nanoparticles (DSC NPs) as a comparative control. Both nanocarriers exhibited a uniform particle size of approximately 200 nm and achieved high drug loading (∼25%) via electrostatic interactions with the polysaccharide backbone. Owing to the exceptional sensitivity of ditelluride bonds to oxidative environments, DTeC NPs demonstrated significantly accelerated degradation and drug release; notably, the cumulative DOX release reached 98.1% within 48 h in the presence of 100 μM H2O2. Furthermore, in vitro assays confirmed that DTeC/DOX NPs effectively enhanced cellular uptake. At a DOX concentration of 8 μg Ml−1, DTeC/DOX NPs reduced the viability of HepG2 and H22 cells to 27.4% and 33.9%, respectively, demonstrating significantly higher cytotoxicity compared to DSC/DOX NPs (35.9% for HepG2 and 45.8% for H22). In vivo studies further revealed that DTeC/DOX NPs achieved a tumor growth inhibition (TGI) rate of 72.29% in H22 tumor-bearing mice, markedly outperforming both free DOX (42.19%) and the disulfide-crosslinked control (60.81%). In summary, these findings underscore the immense potential of the ditelluride-crosslinking strategy for enhancing the precision and therapeutic efficacy of cancer chemotherapy.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Wenlu He,Jingtong Zhang,Qihao Sun,Ying Hao,Jingjing Yang,Jing Yang,Daming Wu,Jingyao Sun
To meet high-efficiency thermal management demands in agricultural greenhouses, bio-based chitosan (CS) and polyethylene glycol (PEG) composite hydrogel films (P1–P3) were prepared. By incorporating PEG into the chitosan matrix, the limitation of traditional CS hydrogels—which offer passive insulation but lack active energy storage—was effectively addressed. Experimental results demonstrated that the composite hydrogels possess exceptional thermal stability; after being heated at 60°C for 30 min, the PEG remained firmly locked within the CS network without any leakage. In thermal insulation tests, when exposed to a 200°C heat source, the P3 sample (containing 21% PEG) took the longest time (313 s) for its top surface to reach 60°C, significantly outperforming the neat P0 sample (188 s). In greenhouse simulation experiments, after 2 h of light-induced heating, the P3 group achieved an indoor temperature rise of 15.1°C, exhibiting the strongest thermal storage and release capacity. Regarding mechanical properties, P3 showed the highest mean compressive stress of 75.19 ± 1.60 kPa. Additionally, the transparency of the hydrogels increased with higher PEG content, which is beneficial for greenhouse lighting. This study proves that CS/PEG composite hydrogels offer significant advantages in thermal management and structural durability for agricultural greenhouse film applications.
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Molecular Catalysis
·
2026
·
IF 4.3
Shuo Wang,Jing Ding,Yichang Pan,Hui Wan,Guofeng Guan
Chitosan-supported pyridinium ionic-liquid catalysts were prepared. • Halide, DD, and ionic-liquid loading effects were systematically studied. • Br-IL2Cs-90DD gave 95% cyclic carbonate yield at 0.5 MPa CO 2 . • The catalyst retained high activity over five consecutive cycles. • DFT revealed cooperative activation by N⁺, Br⁻, and chitosan –OH sites. Developing recyclable heterogeneous organocatalysts with clearly identifiable cooperative active sites is important for the mild and solvent-free cycloaddition of CO2 with epoxides. Herein, a chitosan-supported pyridinium ionic-liquid catalyst was constructed by covalently immobilizing bifunctional ionic-liquid moieties onto renewable chitosan through Schiff-base chemistry. The catalyst integrates pyridinium cations, Br⁻ nucleophiles, Schiff-base linkages, and chitosan hydroxyl groups into a cooperative heterogeneous catalytic environment. Among the investigated structural variables, the bromide-containing catalyst prepared from high-deacetylation chitosan (Br-IL2Cs-90DD) showed the best performance, affording 96% epichlorohydrin conversion, 99% cyclic carbonate selectivity, and 95% cyclic carbonate yield at 80 °C and an initial CO 2 pressure of 0.5 MPa within 4 h under solvent-free conditions. This performance is competitive with representative heterogeneous ionic-liquid and biomass-supported catalysts operating under mild-pressure conditions. The recovered catalyst retained 94% conversion, 98% selectivity, and 93% yield after five consecutive cycles, and post-reaction FT-IR/XPS characterization further supported the structural retention of the immobilized ionic-liquid catalyst. Characterization and density functional theory calculations support the proposed cooperative catalytic mechanism, in which the pyridinium cation and Br⁻ promote epoxide activation and ring opening, while chitosan hydroxyl groups help stabilize alkoxide and carbonate-related species. This work provides a biomass-derived immobilized ionic-liquid catalyst for metal-free CO 2 -to-carbonate conversion and offers molecular-level insight into cooperative active-site design. Download: Download high-res image (271KB) Download: Download full-size image
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JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Yanling Liang,Weikun Li,Xin Tan,Nuoya Chen,Diyi Feng,Yinghua Tao,Xiaojing Wu,Ling Liu,Liqin Ge
Thromboembolic diseases are a major global health threat. Yet current thrombolytic therapies remain limited by systemic off-target effects, short drug half-life, and poor thrombus penetrability. Herein, we report a self-sacrificing template strategy that enables simultaneous microcapsule assembly and template degradation, resulting in the formation of hollow chitosan microcapsules (CSMs) without the need for post-assembly template removal. The microcapsules obtained are then employed to cure thrombosis-related diseases. Using CaCO 3 microparticles (CMPs) as templates, water-soluble chitosan (CS) is assembled onto porous CMP preloaded with recombinant tissue plasminogen activator (rt-PA) under controlled conditions, which triggers CMP dissolution while retaining rt-PA within the CSMs. Subsequently, CSMs are modified with fibrin-targeting CREKA peptides to produce rt-PA@CSMs-CREKA, which possess an optimal microscale size for overcoming margination effects. These microcapsules exhibit high drug loading, favorable biocompatibility, and prolonged circulation time. Both in vitro and in vivo studies demonstrate that rt-PA@CSMs-CREKA achieves superior thrombus targeting, site-specific drug accumulation, and enhanced penetration, effectively degrading fibrin networks and dissolving thrombotic clots. Compared with free rt-PA, rt-PA@CSMs-CREKA possesses significantly enhanced thrombolytic efficacy while downregulating key coagulation factors (FXa and PAI-1). This study presents a promising targeted delivery platform for thrombolytic therapy and offers a novel approach for fabricating CS-related polymeric microcapsules.
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