JOURNAL OF CHROMATOGRAPHY A
·
2011
·Vol. 1218
·期 48
·8664-8671
·
IF 4.194
L.Y. Kong,B.G. Su,Z.B. Bao,H.B. Xing,Y.W. Yang,Q.L. Ren
A simple and direct reversed-phase high performance liquid chromatography (RP-HPLC) method with UV detection was developed and validated for the determination of mono- and di- d -α-tocopherol polyethylene glycol 1000 succinate (TPGS 1000) in TPGS mixture. Before the HPLC analysis, mono- and di-TPGS 1000 were separated by simulated moving bed (SMB) chromatography system and characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The mass spectrometric results confirmed that the molar mass distribution of TPGS prepared in our laboratory was very close to that of the product of Eastman Chemical Company with similar n ¯ (average polymerization degree), M n ¯ (number-average molecular weight) and M w ¯ (weight-average molecular weight). The HPLC analysis was carried out on a C30 analytical column with mobile phases comprised of acetonitrile (A) and isopropanol (B) in gradient conditions. Validation of the analytical method was done on the following parameters: system suitability, linearity, limits of detection and quantification, accuracy and precision, method robustness and solution stability. The linearity of the calibration curves for mono- and di-TPGS 1000 from both sources was found to be good ( r 2 > 0.9996). The recovery values were from 94.6% to 103.3% for mono-TPGS, and 93.5% to 103.3% for di-TPGS. This method could be successfully used in the direct quantification of mono- and di-TPGS in TPGS 1000 mixture using TPGS standards with similar molecular mass distributions although derived from different sources.
研究领域:
分析化学
·
药学
·
色谱学
·
质谱分析
✓ 已验证
DOI
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Zhang Wen,Zhang Qiong,Zhang Ruixue,Liu Zhihao,Li Hongdong,Wu Zexing,Zhang Yang,Xu Guang-Rui,Wang Lei
The demand for Cl 2 is increasing globally, and the chlorine evolution from seawater is a promising technique in the chlor-alkali field to generate chlorine gas. Here, we constructed a novel hollow porous CoNiSe 2 /NiSe 2 nanosheet array for the electrosynthesis of chlorine in seawater-like solution. The CoNiSe 2 /NiSe 2 heterostructures were generated by ion exchange and calcination, which can improve their stability. Moreover, the formed porous hollow nanostructures show an ultra-high specific surface area due to the unique morphology and crystal structure, which can provide channels for mass transfer between the electrolyte and the surface of catalysts and expose more catalytically active sites for accelerating the reaction process. What is impressive is that the hybrid coupling of the Se 4p orbital and the Co/Ni 3d orbital in the heterointerface further reduces the reaction energy barrier of the chlorine evolution reaction (CER). The hollow porous CoNiSe 2 /NiSe 2 nanosheet arrays only exhibit an overpotential of 108 mV to reach the current density of 100 mA cm −2 in an acidic medium containing 4.0 M NaCl. Furthermore, the hollow porous CoNiSe 2 /NiSe 2 nanosheet arrays showed excellent stability and Cl 2 selectivity. The designed transition metal selenides provide a choice for the further development of non-noble metal-based catalysts in the chlor-alkali industry.
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Mengmeng Ji,Jinwei Li,Liuping Fan,Liang Wang,Shengquan Huang
Pseudomonas aeruginosa , a significant opportunistic pathogen, poses a serious threat to food safety due to its antibiotic resistance and strong biofilm-forming ability. In this study, quercetagetin (Que) was identified as a novel quorum sensing (QS) inhibitor. Reporter strain assays, molecular docking, and dynamic simulation indicated that Que acts as an antagonist of the QS receptors. Que attenuated QS-regulated virulence phenotypes in a dose-dependent manner but showed insufficient antibiofilm activity ( p >0.05) at sub-minimum inhibitory concentration (sub-MIC) levels. In contrast, the combination of 0.5 mmol/L Que with 20 mmol/L D-leucine or D-tryptophan exhibited additive effects on planktonic cells, reducing its survival by 2.19–3.97 log compared to the control. For biofilm cells, the combined treatment potentiated the reduction in cell density by 0.48–1.42 log. Notably, these effects were strain-dependent but were equal to or outperformed those of the ε-polylysine (ε-PL) control. Mechanistically, this enhancement was driven by the disruption of biofilm matrix and cell membrane integrity. This was evidenced by the greater suppression of Acyl-homoserine lactones (AHLs) synthesis and virulence phenotypes, alongside substantial reductions in biofilm biomass and roughness and increased in membrane permeability compared to Que. Furthermore, the combination resulted in repression of key enzymes activities (Na + -K + -ATPase and succinate dehydrogenase) by 29%–38%. These changes indicated a promising strategy to control P. aeruginosa and enhance food safety.
✓ 已验证
产品关联
DOI
高影响因子
ChemistrySelect
·
2022
·Vol. 7
·期 45
·e202203721
·
IF 2.307
Weihua Yu,Jianhua Kuang,Qingqing Hu,Zhonghua Wang,Yunwen Liao,Zhengjun Cheng
Graphical A new ratio fluorescent probe (RF-probe) based on the mixing of red-emitting D-penicillamine (DPA) stabilized copper nanoclusters (DPA-CuNCs) with pyridoxal 5’-phosphate (PLP) was designed for sensitive and selective determination of Al 3+ . The excess accumulation of nonessential Al 3+ in the human body can cause serious health problems, thus there is significant interest in the detection of Al 3+ . A new ratio fluorescent probe (RF-probe) based on the mixing of red-emitting D-penicillamine (DPA) stabilized copper nanoclusters (DPA-CuNCs) with pyridoxal 5’-phosphate (PLP) was designed for sensitive and selective determination of Al 3+ . The −CHO group of PLP is expected to form an imine linkage with the free −NH 2 group available of the DPA on the surface of DPA-CuNCs. The content of Al 3+ could be mensurated by the as-prepared RF-probe with a linear response in the range of 1.33–46.67 μmol ⋅ L −1 , and corresponding limit of detection (LOD) was calculated to be 0.33 μmol ⋅ L −1 . Moreover, the RF-probe was successfully extended to the assay of Al 3+ in aluminum carbonate chewing tablets, baking powder, pond water and drink water with satisfactory results compared to the standard atomic absorption spectroscopy (AAS).
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2023
·
IF 3.1
Kai Wang,Yunfei Xiao,Changchun Wu,Yimo Feng,Zhipeng Liu,Xi Zhu,Hongjun Zang
3-Acetylamino-5-acetylfuran (3A5AF) is an important nitrogen-containing fine chemical with broad application prospects and high research value. Herein, we report a novel method for the conversion of N-acetyl- d -glucosamine (NAG) to 3A5AF in the choline chloride-based deep eutectic solvents (DESs). The catalytic activities of various DESs have been smoothly screened, and DES 2 (choline chloride/PEG-200/boronic acid = 1/1/0.5) displayed the best catalytic performance. In the absence of any additional solvent, catalyst and additive, product 3A5AF was obtained in 18.3% yield after reacting at 180 °C for 15 min under atmospheric condition. In addition, DES 2 showed a good reusability. The possible reaction pathway was elucidated on the basis of the results of LC-MS and 13 C NMR spectra. This study provided a new perspective for the application of DES in the conversion of chitin biomass.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2022
·Vol. 32
·期 2
·572-582
·
IF 3.518
Liu Tingting,Zhou Zhiping,Zhang Liming,Zhang Wenwen,Yang Wenming
In this study, we introduced molecular imprinting combined with electrochemical method to determine trace 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide in standard solution and actual samples. For this purpose, we synthesis of vinyl silica coated MWCNTs in alkaline environment with surfactant, molecularly imprinted polymers were prepared on the surface of MWCNTs by free radical polymerization, following the composite materials were dissolved in chitosan solution and dropped on the glassy carbon electrode. The functionalized materials were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetry and nitrogen adsorption desorption. Electrochemical performance of molecularly imprinted membrane was characterized by cyclic voltammetry, electrochemical impedance spectroscopy and differential pulse voltammetry. Selectivity, stability and reproducibility of the sensors were also studied and discussed. A good linear relationship for supervising 2,4-D from 1.0 × 10 −4 to 1.0 × 10 −8 mol L −1 with the correlation coefficient of 0.994 and a low LOD of 4.270 nmol L −1 (S/N = 3). The electrochemical sensor has been successfully applied to detect 2,4-D with a recovery rate ranges from 96.2 to 102.4% and a relative standard deviation of less than 4.74%. This work provides potential ideas for detection of trace 2,4-D in real samples.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 21
·10062-10066
·
IF 3.925
Yongrui He,Bing Zheng,Meiling Qi,Lijun Huo
This work reports the separation performance of a new π-conjugated copolymer (PBDB-T) with alternating electron-donor and electron-acceptor units as the stationary phase for capillary gas chromatography (GC). To date, they have not been explored in the field of chromatography. The PBDB-T column exhibited a column efficiency of 3850 plates m−1 determined by n-dodecane at 120 °C and high-resolution performance toward a wide range of aromatic isomers, particularly halobenzenes, phenols, anthracene and phenanthrene. Moreover, it showed excellent separation repeatability and reproducibility in terms of run-to-run, day-to-day and column-to-column and good thermal stability. This work demonstrates the good potential of the indicated D–A copolymer as a new class of stationary phase for chromatographic analyses.
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 17
·8029-8036
·
IF 3.925
Qingju Liu,Saixue Tang,Hui Wang,Ping Han
The current luminescent metal–organic framework (MOF) based fluorescence detection mostly focuses on achiral molecules. The stereospecific recognition and determination of MOF-based detection remain challenging. A novel luminescent terbium-based MOF (Tb-MOF) based biosensing system with excellent performance for stereoselective detection of D-amino acids (D-AAs) was introduced in this paper. D-Amino acid oxidase catalyzes stereospecific oxidative deamination of D-AAs, producing H2O2. The generated H2O2 effectively quenches the fluorescence of Tb-MOF. Under optimum conditions, the D-AAs were detected with excellent efficiency. The linear working range was 0.5–100 μM for D-Alanine (D-Ala) and 0. 5–5 μM for D-Proline (D-Pro), respectively. The limit of detection (Ksv detection) for D-Ala and D-Pro was 0.09 μM and 0.14 μM, respectively. The detection can be performed within 30 min with high selectivity and long-term stability. The fluorescent sensing platform required simple fabrication and operation and was free from complicated reaction processes and expensive reagents. The present sensing system was successfully applied in D-AA detection in human serum with good recovery, indicating its potential application in detection in biological samples.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Haijun Sun,Baohao Zhang,Lu Lu,Ziyan Chen,Yaqing Huo,Wenqing Li,Bao Zhang,Jian Song
Eutectogel-based soft materials demonstrate great potential for application in the field of wearable devices. However, the development of multifunctional eutectogel materials as versatile sensors for wearable devices with excellent stretchability, self-healing, stability over a wide temperature range, and adhesion remains a challenge. In this study, we construct a novel dual-network (DN) eutectogel comprising a d -gluconic acetal-based supramolecular network and a polymer network in a deep eutectic solvent. The DN eutectogel exhibited excellent comprehensive properties, such as remarkable stretchability (elongation at break over 4300 %, tensile fracture strain of 0.21 MPa), self-recovery and fatigue resistance, rapid self-healing, outstanding stability over a wide range of temperatures (−20–100 ℃), robust adhesion, and good conductivity. Based on these comprehensive properties and thermosensitive capacity, a temperature sensor based on the DN eutectogel was developed with a high sensitivity of 8.1–65.0 % °C −1 . In addition, wearable strain and pressure sensors based on this eutectogel with high sensitivity, wide monitoring range, and excellent stability were fabricated for precise real-time monitoring of human activities. This study paves the way for the design of multifunctional wearable devices in the future.
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2022
·Vol. 19
·期 10
·e202200648
·
IF 2.745
Xiao-San Li,Mao-Xun Yang,Yu-Hao Luo,He-Hui Zhan,Mei-Fang Chen,Yong-Mei Huang,Li Liu,Xue-Mei Yang
A series of novel D-ring fused or substituted steroidal N-heterocycles were synthesized, and their chemical structures were characterized by spectroscopic analysis. The anticancer activity of these compounds against four human cancer cell lines (MCF-7, H1299, HeLa and HepG2) were evaluated and the structure-activity relationship (SAR) was also investigated. Compound 3c displayed significant inhibitory activity on the four cancer cells with IC 50 values ranging from 3.88 to 10.05 μM. Overall, these studies indicated that construction of N-heterocyclic system with D-ring substituted containing a double bond at C-16 and C-17 or D-ring fused with [17,16-d]azolo[1,5-a]pyrimidine could be a promising strategy to improve antitumor activity for steroids deserved further investigation. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Dongbo Wang,Ying Wang,Yuan Li,Ting Shi,Dandan Han,Junbo Gong
Impurity sugars produced in upstream process of functional sugars are significantly impacting the product quality. In this work, the effect of congeners ( d -maltose ( d -MAL), d -fructose ( d -FRU), d -glucose ( d -GLU)) on primary and secondary nucleation of d -tagatose ( d -TAG) crystals was investigated. The impurity sugars showed an inhibition on primary nucleation of d -TAG crystals, while a promotion on the secondary nucleation of d -TAG. Interestingly, the impact of impurity sugars on d -TAG crystal growth was similar to that on primary nucleation. The diffusion ability, hydrogen bonding forming ability, interaction energy of d -TAG crystal surfaces and impurity sugars were evaluated by molecular dynamics (MD) simulations to reveal the nucleation and growth behavior. Based on the above findings, we designed the d -TAG crystallization experiments, and obtained d -TAG crystals with uniform particle size distribution and regular morphology. This study helps to understand the influence of impurity sugars on crystallization, guiding the industrial manufacturing of functional sugars.
✓ 已验证
DOI
PubMed
高影响因子
Polymer-Plastics Technology and Materials
·
2022
·
IF 2.439
Wenqiang Wang,Yiming Gong,Qingxia Huang,Liuzemu Li,Airong Xu,Rukuan Liu
Green polyvinyl alcohol/poly(D,L-lactide-co-glycolide) (PVA/PLGA) composite materials were developed by dissolving PVA and PLGA in hexafluoroisopropanol (HFIP), followed by the subsequent layout of PVA/PLGA/HFIP liquid film and the removal of HFIP. Interestingly, the PVA/PLGA composite materials display remarkedly enhanced tensile strength, elongation at break, biodegradability and biocompatibility. Systematic investigations have been completed to reveal the effects of PVA/PLGA mass ratio on the tensile strength, elongation at break, biodegradability and biocompatibility. Meanwhile, the morphology, crystallinity and chemical structure of the PVA/PLGA material and possible interaction between PVA and PLGA are also investigated using scanning electron micrograph, infrared spectra and X-ray diffraction techniques.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）