Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yayuan Guan,Yuling Su,Lili Zhao,Fancui Meng,Quanxin Wang,Yongchao Yao,Jianbin Luo
Polyurethane micelles with disulfide linkage located at the interface of hydrophilic shell and hydrophobic core (PU-SS-I) have been shown enhanced drug release profiles. However, the payloads could not be released completely. The occurrence of aggregation of hydrophobic cores upon shedding hydrophilic PEG coronas was considered as the reason for the incomplete release. To verify the above hypothesis and to develop a new polyurethane based micelles with dual stimuli respond properties and controllable location of pH and reduction responsive groups in the PU main chains, a tertiary amine was incorporated into the hydrophobic core PU-SS-I, which resulted polyurethane with both reduction and pH sensitive properties (PU-SS-N). Biodegradable polyurethane with only disulfide linkages located between the hydrophilic PEG segment and the hydrophobic PCL segments (PU-SS-I) and polyurethane with only pH sensitive tertiary amine at the hydrophobic core (PU-N-C) were used as comparisons. Paclitaxel (PTX) was chosen as mode hydrophobic drug to evaluate the loading and redox triggered release profiles of the PU micelles. It was demonstrated that PU-SS-N micelles disassembled instantly at the presence of 10 mM GSH and at an acidic environment (pH = 5.5), which resulted the nearly complete release (~ 90%) of the payloads within 48 h, while about ~ 70% PTX was released from PU-SS-I and PU-SS-N micelles at neutral environment (pH = 7.4) with the presence of 10 mM GSH. The rapid and complete redox and pH stimuli release properties of the PU-SS-N nanocarrier will be a promising anticancer drug delivery system to ensure sufficient drug concentration to kill the cancer cells and to prevent the emergency of MDR. The in vitro cytotoxicity and cell uptake of the PTX-loaded micelles was also assessed in H460 and HepG2 cells.
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Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Li Lei,Ran Yan,Shougang Chen,Xiangping Hao,Wenwen Dou,Hu Liu,Zhanhu Guo,Dan Kilula,Ilwoo Seok
An intelligent narrow pH-triggered multilayer film was prepared on magnesium alloys, aiming to solve the implant infections during the implantation period and improve the corrosion resistance of magnesium alloys. The encapsulation of ibuprofen by chitosan (IBU@CS) makes the release of IBU sensitive to narrow pH (pH 6.8–7.4). Positive charged IBU@CS was assembled with heparin (Hep) to fabricate (Hep/IBU@CS) 10 film on AZ31 alloys using layer-by-layer method. The microstructure, composition and anticorrosion properties of the film were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and electrochemical experiments. Cellular activity was studied by MTT cell viability assay. The results showed that the Hep/IBU@CS multilayer films improved the corrosion resistance of magnesium alloys. The in vitro test demonstrated that the release of IBU in the film presented narrow pH sensitivity. The films showed no obvious signs of cytotoxicity conformed by the MTT assay and presented antibacterial properties. These preliminary results demonstrate the potential use of the Hep/IBU@CS multilayer films on magnesium-based implants.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Chongchong Liu,Panping Yang,Jingguo Li,Shaokui Cao,Jun Shi
Remotely multi-responsive chitosan (CS) hydrogels holds great promise in the design of anticancer drug carriers. In this paper, near-infrared (NIR)-/pH-dual responsive CS/β-GP/Ti 3 C 2 @AuNRs hybrid hydrogel was prepared based on CS/β-glycerol phosphate disodium salt (β-GP) crosslinking system embedded with NIR-responsive Ti 3 C 2 @gold nanorods (AuNRs) nanosheets . Excess β-GP promoted the formation of massive electronegative cavities, which endowed hybrid hydrogels with high drug loading efficiency for electropositive DOX (around 88.5 %). The collapse of chitosan network in acidic medium gave the hybrid hydrogel with distinct pH response. In addition, the distinct temperature increase owing to the strong NIR responsiveness of Ti 3 C 2 @AuNRs nanosheets would accelerate the DOX release dramatically. Therefore, NIR-, pH- and thermal-multi-responsiveness would synergistically endow CS/β-GP/Ti 3 C 2 @AuNRs hybrid hydrogel with notable NIR-triggered photothermal effect and remotely controllable drug delivery properties.
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Materials
·
2020
·Vol. 13
·期 18
·3950
·
IF 3.057
Minmin Chen,Jinxia Hu,Cancan Bian,Chenghao Zhu,Chen Chen,Zhijun Guo,Zhimin Zhang,Godfred Amfo Agyekum,Zhuoqi Zhang,Xichuan Cao
As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca2+and PO43−into the MSNs’ framework. The in vitro doxorubicin hydrochloride (DOX) release was inhibited at neutral pH 7.4 but triggered significantly at pH 5.0 due to the dissociation of ZnO caps. The internalization behavior and cytotoxicity of 4T1 cells indicated MSCNs-ZnO could efficiently deliver DOX into the cells with significant antitumor activity. Such a DDS with pH-responsive biodegradation and controlled drug release has promising potential for cancer therapy.Keywords:mesoporous silica composite nanoparticles (MSCNs);ZnO QDs;pH-responsive biodegradability;pH-responsive drug delivery
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2020
·
IF 4.872
Teng Xu,Feng Nan,Xiaofeng Jiang,Yuling Tang,Yunhang Zeng,Wenhua Zhang,Bi Shi
This work was conducted to study the effect of soil pH (4.0, 6.0, and 8.0) on the transport, fractionation, and oxidation of trivalent chromium [Cr(III)]. Variation in pH altered soil chemical and mineralogical properties such as zeta potential, cation exchange capacity and redox potential of natural soil. Breakthrough curves and batch sorption experiments coupled with fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses demonstrated that the easy mobility of Cr(III) in pH 4.0 soil was dominated by the limited coordination effect. The high retention of Cr(III) in pH 8.0 soil was mainly ascribed to the hydrolysis. Incubation experiments indicated that the proportions of Cr in exchangeable fraction decreased with increasing of soil pH and incubation time, and kinetics analysis revealed that the time dependent transformation was controlled by mass transfer and chemical processes (e.g., hydrolysis, ion association). The XPS confirmed the oxidation of Cr(III) in pH 8.0 soil during the incubation period. Furthermore, the content of toxic hexavalent chromium [Cr(VI)] was positively associated with time and initial concentration of Cr(III) released. These results revealed the hazardousness of Cr(III) in soil contaminated simultaneously by inorganic acid and alkali.
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MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 6
·2100055
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IF 4.979
Peihong Li,Yanlong Sui,Xueyan Dai,Qiangsheng Fang,Haofei Sima,Chunling Zhang
Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self-healing properties. In this paper, tannic acid is combined with lysine-containing F127 through Schiff base. A series of FLaT hydrogels cross-linked by hydrogen bonds and dynamic chemical bonds is prepared, and the influence of Schiff base amount on the performance is discussed. The FLaT hydrogel exhibits reversible sol–gel transition, self-healing, injectability, and pH sensitivity. Increasing the amount of Schiff base can improve the strength, stability, and self-healing ability of the hydrogel. Owing to their low cytotoxicity, linear release pattern, and pH-controlled release rate, the FLaT hydrogels show potential use in drug delivery systems for cancer treatment.
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MACROMOLECULAR RAPID COMMUNICATIONS
·
2025
·
IF 4.3
Chunhui Li,Maohang Huang,Huan Yu,Qing Yang,Lijing Hao,Yunhua Chen
The synthesis of high-performance hydrogel adhesives often relies on complex, multi-component systems, complicating their preparation and application. To overcome these limitations, we report a thermosensitive nanogel adhesive (NGA) via a facile one-step precipitation polymerization of N -isopropylacrylamide (NIPAM) and 3-acrylamidophenylboronic acid (AAPBA). This NGA functions as a simple adhesive, forming stable bonds with hydroxyl-rich substrates without requiring additional curing steps. The resulting nanogel exhibits dual sensitivity to temperature and pH, undergoing reversible changes and gelation under specific conditions. Mechanical interfacial bonding tests of hydrogel substrates reveal that a minimal volume of 15 µL of the NGA dispersion achieves a shear strength of 7.0 ± 1.4 kPa and a tensile strength of 15.7 ± 4.2 kPa. Furthermore, the adhesion performance can be precisely tuned by controlling the nanogel particle size, dispersion pH, and concentration. Biocompatibility assessments confirm excellent hemocompatibility and cell viability. This work not only presents a robust and tunable nanogel adhesive platform but also establishes a general model for the design of functional nanogel-based adhesives, significantly expanding their potential applications.
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MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Keyi Long,Tiao Han,Wenxi Hu,Fuping Nie,Mei Yang,Jun Li,Changjun Hou,Danqun Huo
Loop-mediated isothermal amplification (LAMP) has been used as one of the tools for nucleic acid detection. The pyrophosphoric acid (PPi) produced by LAMP leads to a change in the pH value of the solution, and acid-base indicators can be used to distinguish positive from negative. However, the microliter reaction system and low concentration target cause small changes in pH, sensitive pH indicators are urgently needed. Herein, we developed a one-step solvothermal approach to synthesize biomass-derived carbon dots named FA-bioCDs. Compared with hydrothermal synthesis, the solvothermal approach red-shifted the emission maximum to 535 nm, and made FA-CDs pH-sensitive in the range of 8.16–9.12, so it can be used for LAMP endpoint detection. The relatively alkaline LAMP buffer reduces the fluorescence of FA-bioCDs. Rapid LAMP accumulates hydrogen ions, lowering the pH and “turning on” FA-bioCDs fluorescence. Thus, LAMP acts as a pH-mediated fluorescence switch for FA-bioCDs. The strategy was used for human papillomavirus DNA detection, and the detection limit was as low as 2.450 copies·μL −1 in about 30 min. LAMP ensures rapid and sensitive detection, and the relatively long emission wavelength of FA-bioCDs may reduce interference in practical detection scenarios. The development of LAMP-FA-bioCDs not only offers a rapid and environmentally friendly tool for nucleic acid detection in clinical settings but also bridges the gap between agriculture and medicine.
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Precision Chemistry
·
2025
·
IF 6.2
Er-Fei Zhen,Bing-Yu Liu,Meng-Ke Zhang,Lu−Lu Zhang,Chen-Yu Zhang,Jun Cai,Marko M. Melander,Jun Huang,Yan-Xia Chen
Understanding how the electrolyte pH affects electrocatalytic activity is a topic of crucial importance in a large variety of systems. However, unraveling the origin of the pH effects is complicated often by the fact that both the reaction driving forces and reactant concentrations in the electric double layer (EDL) change simultaneously with the pH value. Herein, we employ the hydrogen evolution reaction (HER) at Au(111)-aqueous solution interfaces as a model system to disentangle different pH-dependent factors. In 0.1 M NaOH, the HER current density at Au(111) in the potential range of −0.4 V < ERHE < 0 V is up to 60 times smaller than that in 0.1 M HClO4. A reaction model with proper consideration of the local reaction conditions within the EDL is developed. After correcting for the EDL effects, the rate constant for HER is only weakly pH-dependent. Our analysis unambiguously reveals that the observed pH effects are mainly due to the pH-dependent reorganization free energy, which depends on the electrostatic potential and the local reaction conditions within the EDL. Possible origins of the pH and temperature dependence of the activation energy and the electron transfer coefficients are discussed. This work suggests that factors influencing the intrinsic pH-dependent kinetics are easier to understand after proper corrections of EDL effects.
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Current Drug Delivery
·
2025
·Vol. 22
·期 10
·1469-1480
·
IF 3
Haifeng Zhang,Qiuhui Wang,Shangdong Wang,Ruiyao Zhou,Jianwu Cai,Xiao Hu
BackgroundPancreatic cancer is a highly malignant tumor with a poor prognosis, and current treatment methods have limited effectiveness. Therefore, developing new and more effective therapeutic strategies is crucial. This study aims to establish pH-responsive silk fibroin (SF) nanoparticles encapsulating β-hydroxyisovalerylshikonin (SF@β-HIVS) to enhance the therapeutic effects against pancreatic cancer.MethodsSF@β-HIVS nanoparticles were prepared using a self-assembly technique and characterized under different pH conditions using scanning electron microscopy (SEM) and dynamic light scattering (DLS). The effects of SF@β-HIVS on the viability, apoptosis, and migration of PANC-1 cells were assessed through in vitro experiments. Additionally, in vivo experiments using a PANC-1 xenograft mouse model evaluated the antitumor activity and biosafety of SF@β-HIVS.ResultsSF@β-HIVS nanoparticles exhibited a uniformly distributed spherical structure under pH 7.4 conditions and rapidly disintegrated in acidic environments, releasing the drug. In vitro experiments demonstrated that SF@β-HIVS significantly inhibited PANC-1 cell proliferation, induced apoptosis, and suppressed cell migration. In vivo, experiments confirmed the significant antitumor activity and good biosafety of SF@β-HIVS.ConclusionThis study successfully developed pH-responsive SF@β-HIVS nanoparticles and validated their potential in treating pancreatic cancer. These findings provided a foundation for the clinical application of SF@β-HIVS in pancreatic cancer treatment.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jing Wang,Guanghui An,Dongmei Hong,Yinggang Zheng,Hui Zhang,Xinwei Huang,Enduo Feng
Helicobacter pylori ( H. pylori ) infection poses a significant global health burden and is implicated in various chronic gastric diseases. However, current antibiotic therapies are limited by non-specific bacterial targeting, which often results in antimicrobial resistance and disruption of gut microbial homeostasis. To overcome these limitations, we developed a pH-responsive, self-sacrificing cascade nanozyme platform, ZnO 2 -CuNiS@G-Ch, for the targeted eradication of H. pylori . In the highly acidic gastric environment, ZnO 2 rapidly decomposes to release Zn 2+ and H 2 O 2 , initiating selective bacterial killing. Furthermore, the generated H 2 O 2 triggers the cascade activation of CuNiS@G-Ch nanozyme, exhibiting multiple enzyme-like activities-peroxidase (POD), catalase (CAT), and oxidase (OXD) to locally generate reactive oxygen species (ROS) and O 2 , thereby amplifying the bactericidal effect. Notably, upon transiting to the neutral intestinal milieu, the degradation of ZnO 2 was completely suppressed, effectively halting downstream nanozyme activity and preserving the gut microbiota. Comprehensive in vitro and in vivo studies confirmed the robust anti- H. pylori efficacy of ZnO 2 -CuNiS@G-Ch, alongside potent anti-inflammatory effects, gastric mucosal protection, and excellent biocompatibility. This work provides a selective, efficient, and microbiota-friendly strategy for H. pylori therapy, offering a promising alternative to conventional broad-spectrum antibiotics.
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RSC Advances
·
2014
·Vol. 4
·期 90
·48943-48951
·
IF 3.708
Bing Liu,Hongying Chen,Xiao Li,Chaonan Zhao,Yakun Liu,Lijuan Zhu,Hongping Deng,Jichen Li,Guolin Li,Fulin Guo,Xinyuan Zhu
A new type of pH-responsive flower-like micelle based on backbone-cleavable triblock copolymer polycaprolactone-oxime-poly(ethylene glycol)-oxime-polycaprolactone (PCL-OPEG-PCL) was developed for anticancer drug delivery. Firstly, PCL-OPEG-PCL was synthesized by ring-opening polymerization. The structure of PCL-OPEG-PCL was confirmed by 1H NMR and Fourier transform infrared spectroscopy (FTIR). Benefiting from the amphiphilic character and unique molecular architecture with the hydrophilic PEG and hydrophobic PCL segments, PCL-OPEG-PCL could self-assemble into flower-like micelles in aqueous solution, which has been demonstrated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The cytotoxicity of the flower-like micelles was evaluated by MTT assay against NIH/3T3 normal cells. Doxorubicin (DOX), a model anticancer drug, was encapsulated into these flower-like micelles with high efficiency. The in vitro study showed that DOX-loaded flower-like micelles possessed high stability at physiological pH of 7.4, whereas the DOX release from the flower-like micelles was significantly accelerated at mildly acidic pH of 5.0, demonstrating the pH-responsive feature of the drug carrier with oxime linkages. DOX-loaded flower-like micelles were investigated for proliferation inhibition of Hela cells in vitro, and the DOX dose required for 50% cellular growth inhibition was found to be 1.81 μg mL−1. All of these results demonstrate that flower-like micelles self-assembled from PCL-OPEG-PCL triblock copolymers can be used as effective and promising drug nanocarriers.
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