Materials
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2018
·Vol. 11
·期 5
·791
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IF 2.467
Junping Ding,Huanchun Wang,Haomin Xu,Lina Qiao,Yidong Luo,Yuanhua Lin,Cewen Nan
High efficiency photocatalyst Bi2O2(CO3)1−xSxwas synthesized conveniently with chemical bath precipitation using Bi2O2CO3as the precursor. The microstructures of the samples are systematically characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), ultraviolet photoelectron spectroscopy (UPS) and UV-Vis spectroscopy; the optical and photocatalytic properties are carefully tested as well. The content ofS, which was tuned through the controlling of the precipitation process, was verified to have an intense effect over the photocatalytic properties. A nearly saturatedSratio and the best photocatalytic performance were observed in specimens with the mostScontent. Our study reveals that, with negligible influence of the morphology and crystal structure, Bi2O2(CO3)1−xSxpossessed a broadened optical absorption regionfromultraviolet to visible light, and enhanced photocatalytic activity in comparison to precursor Bi2O2CO3in photocatalytic degradation of Congo Red aqueous solution.Keywords:Bi2O2CO3;Bi2O2(CO3)1−xSx;broadband spectra;photocatalysis
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Molecular Medicine Reports
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2018
·Vol. 18
·期 2
·1789-1797
·
IF 1.922
Jian‑Xia Shi,Qin Huang
Glucagon‑like peptide‑1 (GLP‑1) is a gut incretin hormone that is considered to be a promising target for the treatment of patients with type 2 diabetes. However, the mechanisms underlying the protective effects of GLP‑1 on diabetic nephropathy are yet to be fully elucidated. Sirtuin (SIRT)1 encodes a member of the SIRT family of proteins that serves an important role in mitochondrial function and is reported to be associated with the pathogenesis of chronic kidney disease. The present study treated mouse podocytes with various concentrations of D‑glucose to establish a high glucose (HG)‑induced model of renal injury. The results of a 2',7'‑dichlorodihydrofluorescein diacetate assay, Annexin V/propidium iodide staining and ELISA demonstrated that treatment of podocytes with HG significantly enhanced the production of reactive oxygen species (ROS), promoted cell apoptosis and increased the secretion of proinflammatory cytokines, respectively. The cytokines increased following HG treatment included tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6. Notably, treatment with GLP‑1 attenuated HG‑induced increases in ROS production and podocyte apoptosis, which may occur via downregulation of the expression of caspase‑3 and caspase‑9, and increased expression of nephrin, podocin and SIRT1, as determined by reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Treatment with GLP‑1 led to protective effects in podocytes that were similar to those of resveratrol. Furthermore, SIRT1 knockdown using short hairpin RNA significantly enhanced the expression of caspase‑3 and caspase‑9 in mouse podocytes, compared with normal mouse podocytes. SIRT1 knockdown with or without GLP‑1 administration significantly decreased the expression of caspase‑3 and caspase‑9 in mouse podocytes, compared with SIRT1 knockdown mouse podocytes. In conclusion, the results of the present study indicated that GLP‑1 may be a promising target for the development of novel therapeutic strategies for HG‑induced nephropathy, and may function through the activation of SIRT1.
研究领域:
内分泌学
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肾病学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Weichen Zhu,Yu Huang,Bo Jiang,Rengui Xiao
The strong self-discharge reaction is one of the key factors limiting the practical use of dual-ion batteries, which leads to low coulombic efficiency and discharge capacity loss. It is of great significance to effectively reduce the self-discharge effect through redox reactions between organic electrodes and electrolytes. Herein, a dual-ion battery study that uses 1,4,5,8-naphthalenetetracarboxylic dianhydride as the anode and 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide as the electrolyte is conducted. Due to the introduction of organic materials, the storage mechanism of cations on the anode is changed, which weakens the self-discharge effect. The battery shows a low self-discharge rate of 6.12% h −1 and a high discharge capacity of 114 mAh g −1 . The voltage declines by only 0.14 V after resting for 15 h due to the strong redox reaction between Pyr 14 + cations and the C O groups of NTCDA. Meanwhile, a double-layer filter paper system with small porosity is used to improve the cycle performance of the battery.
研究领域:
能源存储
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电化学
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材料科学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2025
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IF 3.5
Yuan Li,Shengkai Sun,Hanfang Liu,Wenna Wang,Dehong Chen,Yu Yang,Feng Liu,Bin Yu,Jia Liu,Binjie Li,Lei Wang,Bin Li
Epoxidation of olefin catalyzed by titanium silicalite-1 (TS-1) can obtain important intermediate epoxides of industrial production in a green and pollution-free manner. However, due the problem of macromolecules transport path restraint, which cause the catalyst to fail in lifetime and activity. Strategically, to increase the transport channel of macromolecules and shorten the transport path, it is necessary to introduce mesoporous structures into zeolite. Here, we report a solid-state synthesis of hierarchical TS-1 zeolite by optimizing carbon black sequence. The texture property of hierarchical TS-1 can be optimized by carbon black. Most importantly, the addition sequence of carbon black can impact the porosity of hierarchical TS-1. The hierarchical zeolite is synthesized by incorporating 0.2 g carbon black into the seeds. When carbon black is firstly combined with seeds, the enhanced interaction facilitates the subsequent growth process, leading to large surface area from mesopores (121 m 2 /g) and abundant pores size (8–40 nm) and enhanced exposure of Ti active sites. The optimized hierarchical TS-1 possesses excellent catalytic performance with high conversion rate (24.4 %) and similar selectivity (93.8 %), which are 1.6 times higher than that of traditional TS-1 zeolites.
研究领域:
材料科学
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催化化学
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产品关联
DOI
高影响因子
CHEMICAL PAPERS
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2016
·Vol. 70
·期 5
·585-593
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IF 1.326
Lin Zhu,Fang-Fang Li,Ji-Qin Zhu,Zhi-Gang Lei
Olefins and paraffins are important basic chemical raw materials with so similar molecular structure and volatility that their separation is a difficult and energy-consuming process. Liquid–liquid equilibrium (LLE) data were determined for ternary systems of: 1-hexene + hexane + solvent at 25°C, 30°C, and 35°C, and N-formylmorpholine (NFM), N-methyl-2-pyrrolidone (NMP), 7-butyrolactone (GBL), and 1-methylimidazole (1-MEI) as the solvents studied. Liquid–liquid equilibrium data for each system were correlated to the NRTL (Non-Random Two Liquid) equation and the interaction parameters presented. The calculated results agree well with the experimental data.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
Cell Metabolism
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2020
·
IF 21.567
Wanfeng Xu,Yuan Che,Quan Zhang,Hai Huang,Chujie Ding,Yun Wang,Guangji Wang,Lijuan Cao,Haiping Hao
Summary Caspase-4 is an intracellular sensor for cytosolic bacterial lipopolysaccharide (LPS) and underlies infection-elicited pyroptosis. It is unclear whether and how caspase-4 detects host-derived factors to trigger pyroptosis. Here we show that mitochondrial permeability transition (MPT) activates caspase-4 by promoting the assembly of a protein complex, which we term the Apaf-1 pyroptosome, for the execution of facilitated pyroptosis. MPT, when induced by bile acids, calcium overload, or an adenine nucleotide translocator 1 (ANT1) activator, triggers assembly of the pyroptosome comprised of Apaf-1 and caspase-4 with a stoichiometry ratio of 7:2. Unlike the direct cleavage of gasdermin D (GSDMD) by caspase-4 upon LPS ligation, caspase-4 activated in the Apaf-1 pyroptosome proceeds to cleave caspase-3 and thereby GSDME to induce pyroptosis. Caspase-4-initiated and GSDME-executed pyroptosis underlies cholestatic liver failure. These findings identify Apaf-1 pyroptosome as a pivotal machinery for cells sensing MPT signals and may shed light on understanding how cells execute intrinsic pyroptosis under sterile conditions.
研究领域:
免疫学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
Cardiovascular Diabetology
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2024
·Vol. 23
·期 1
·1-19
·
IF 8.5
Tang Yuan-juan,Zhang Zhen,Yan Tong,Chen Ken,Xu Guo-fan,Xiong Shi-qiang,Wu Dai-qian,Chen Jie,Jose Pedro A.,Zeng Chun-yu,Fu Jin-juan
Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, a cleavage peptide off fibronectin type III domain-containing 5, has been shown to preserve cardiac function in cardiac ischemia–reperfusion injury. Whether or not irisin plays a cardioprotective role in DCM is not known. Methods and results T1DM was induced by multiple low-dose intraperitoneal injections of streptozotocin (STZ). Our current study showed that irisin expression/level was lower in the heart and serum of mice with STZ-induced TIDM. Irisin supplementation by intraperitoneal injection improved the impaired cardiac function in mice with DCM, which was ascribed to the inhibition of ferroptosis, because the increased ferroptosis, associated with increased cardiac malondialdehyde (MDA), decreased reduced glutathione (GSH) and protein expressions of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), was ameliorated by irisin. In the presence of erastin, a ferroptosis inducer, the irisin-mediated protective effects were blocked. Mechanistically, irisin treatment increased Sirtuin 1 (SIRT1) and decreased p53 K382 acetylation, which decreased p53 protein expression by increasing its degradation, consequently upregulated SLC7A11 and GPX4 expressions. Thus, irisin-mediated reduction in p53 decreases ferroptosis and protects cardiomyocytes against injury due to high glucose. Conclusion This study demonstrated that irisin could improve cardiac function by suppressing ferroptosis in T1DM via the SIRT1-p53-SLC7A11/GPX4 pathway. Irisin may be a therapeutic approach in the management of T1DM-induced cardiomyopathy.
研究领域:
内分泌学
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心脏病学
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分子生物学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Yuwei Zuo,Yue Sun,Wenzhong Yang,Kegui Zhang,Yun Chen,Xiaoshuang Yin,Ying Liu
The performance and mechanism of typical scaling inhibitors, i.e., 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDP) and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA), in inhibiting calcium carbonate scaling were investigated. Results of the static experiment at 30 °C and 80 °C revealed that at the optimal concentration, the scaling inhibition efficiency of PBTCA was superior to that of HEDP. Additionally, X-ray powder diffraction evaluation demonstrated that in comparison with HEDP, PBTCA inhibited the growth of the (1 0 4) crystal plane of calcite more evidently. Scanning electron microscopy analysis indicated that the addition of scaling inhibitors induced the crystal transformation of CaCO 3 from calcite to aragonite. Molecular dynamics simulation also confirmed that the interaction of PBTCA with the (1 0 4) crystal surface of calcite is more apparent than that of HEDP. This observation was a consequence of the PBTCA being more negatively charged, as determined via a quantum chemical calculation. The calculation further indicated that the spatial distance of PBTCA to the (1 0 4) face of calcite was less due to stronger chelating ability and better suitability of the structure. As a result, in the tested temperature range, PBTCA exhibited the more effective inhibitory effect against calcium carbonate scaling.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
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2014
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IF 5.71
Simin Yan,Xu Zhang,Haili Zheng,Danhong Hu,Yongtian Zhang,Qinghua Guan,Lifang Liu,Qilong Ding,Yunman Li
Proinflammatory cytokine TNF-α-induced adhesion of leukocytes to endothelial cells plays a critical role in the early stage of atherosclerosis . Oxidative stress and redox-sensitive transcription factors are implicated in the process. Thus, compounds that mediate intracellular redox status and regulate transcription factors are of great therapeutic interest. Clematichinenoside (AR), a triterpene saponin isolated from the root of Clematis chinensis Osbeck , was previously demonstrated to have anti-inflammatory and antioxidative properties. However, little is known about the exact mechanism underlying these actions. Thus we performed a detailed study on its effect on leukocytes–endothelial cells adhesion with TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) and cell-free systems. First, we found that AR reduced TNF-α-induced VCAM-1 and ICAM-1 expression and their promoter activity, inhibited translocation of p65 and phosphorylation of IκBα , suppressed IκB kinase-β (IKK-β) activity, lowered O 2 ∙− and H 2 O 2 levels, tackled p47 phox translocation, and decreased NOX4 NADPH oxidase expression. Second, we showed that AR exhibited no direct free radical scavenging ability in cell-free systems at concentrations that were used in intact cells. Besides, AR had no direct effect on the activity of IKK-β that was extracted from TNF-α-stimulated HUVECs. We also found that p47 translocation, NOX4 expression, and reactive oxygen species (ROS) levels were up-regulated before IκB phosphorylation in TNF-α-induced HUVECs. Moreover, TNF-α-enhanced IKK-β activity was also inhibited by (polyethylene glycol) PEG–catalase, N -acetylcysteine (NAC), and vitamin E. In conclusion, these results suggest that AR reduces VCAM-1 and ICAM-1 expression through NADPH oxidase-dependent IKK/NF-κB pathways in TNF-α-induced HUVECs, which finally suppress monocyte–HUVECs adhesion. This compound is potentially beneficial for early-stage atherosclerosis.
研究领域:
药理学
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免疫学
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心血管研究
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2014
·
IF 2.045
Guo-Min Yu,Li-Sheng Wang,Chao-Jun Du
A phosphorus flame retardant of 4-(hydroxymethyl)-1-oxido-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane (PEPA) was synthesized by pentaerythritol and phosphorus oxychloride at a certain condition. The structural features of PEPA were investigated with Fourier transform infrared spectroscopy and 1H NMR methods. The thermal behavior of PEPA was carried out with differential scanning calorimetry and thermogravimetric analysis instruments. A static analytic method was used to measure the solubilities of the PEPA in several organic solvents. The measurements were accurately acted in ethyl acetate, acetonitrile, isopropyl alcohol, ethanol, n-propyl alcohol, acetone, methanol, and chloroform at the temperature range from 292.75 K to 333.45 K. Using the Scatchard–Hildebrand methodology, the activity coefficients of the solute have been calculated, and the partial molar excess enthalpies at infinite dilution were also predicted.
研究领域:
化学
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材料科学
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Lixia Yang,Yuexia Han,Zhen Jiao
To obtain the basic data for the recovery of 1-methylimidazole from wastewater by extraction, the ternary liquid–liquid phase equilibrium data of the water (1) + 1-methylimidazole (2) + 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim][PF6]) (3) system were determined using an equilibrium autoclave at the temperatures of 303.15 to 323.15 K and 101.32 kPa. The solute distribution coefficient (D) and the selectivity (S) of the ternary system were calculated in accordance with the experimental data. Their values were up to 1.39 and 41.17, respectively, which showed that the ionic liquid can extract 1-methylimidazole effectively. The experimental results showed that the temperature had a slight effect on the liquid–liquid equilibrium behavior. Meanwhile, the calculated results revealed that the selectivity coefficient decreased with the enhancing concentration of 1-methylimidazole in the ternary system and the increasing temperature. In addition, the nonrandom two liquid (NRTL) model was used for correlation of the ternary systems. The root-mean-square deviation value of 0.0218 indicated that the calculated results using the model were in good agreement with the experimental data and were reliable to apply to practice.
研究领域:
化学工程
·
环境科学
✓ 已验证
DOI
高影响因子
Journal of Global Antimicrobial Resistance
·
2024
·
IF 3.7
Xiaoqian Long,Feng Lin,Biao Tang,Fengcheng Miao,Zhiyu Li,Yao Shen,Hua Yang,Jiangang Ma
Objectives Acinetobacter indicus is an important pathogen of nosocomial infection. The purpose of this study was to analyze the resistance and transmission of A. indicus strain AIBD14 isolated from slaughterhouse environment. Methods A total of 96 environmental samples were collected from slaughterhouse. The antimicrobial susceptibility test was carried out by microbroth dilution method and E -test. Whole genome sequencing and bioinformatics analysis of the AIBD14 were performed, then S1-PFGE and southern blot verified the location of bla NDM-1 and tet (X6). Results The AIBD14 is resistant to meropenem but susceptibility to tigecycline, and coharboring bla NDM-1 and tet (X6). The bla NDM-1 is located on the pAIBD14-NDM-1 that cannot be transferred by conjugation. Specifically, bla NDM-1 is located on the transposon Tn 125 , and bla NDM-1 can be transferred to other species with the help of transposon. The genetic background of bla NDM-1 is "IS Aba125 - bla NDM-1 - ble MEL - dsbD - cutA - groES - groEL -insE-IS Aba125 ". pAIBD14-NDM-1 is classified into the GR31 plasmid based on the homology of the repB . Meanwhile, there are two XerC/D-like binding sites on the plasmid, which can mediate the transfer of resistance genes. The tet (X6) gene is located on the chromosome of AIBD14, its downstream is accompanied by the neglected macrolide resistance gene estT , and there is a single copy of the insertion element IS CR2 around tet (X6) as the genetic background "IS Aba4 -IS 3 -hp-hp- tet (X6)- estT - guaA -IS CR2 ". Conclusions This is the first report of the coexistence of tet (X6) and bla NDM-1 in the A. indicus , and it has the risk of horizontal transfer across multiple species. So strict monitoring the multiple-resistant bacteria in the industrial chain is necessary based on the "One Heath".
研究领域:
微生物学
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传染病学
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基因组学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）