FOOD CHEMISTRY
·
2015
·
IF 3.391
Xueke Liu,Zhigang Shen,Peng Wang,Chang Liu,Guojun Yao,Jiayuan He,Donghui Liu,Zhiqiang Zhou
Isomerization of chiral pesticides in residue analysis has not drawn much attention which can cause wrong decisions on the enantioselective environmental behavior. A residue analysis method for α-cypermethrin and its three acid metabolites, cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethyl cyclopropanecarboxylic acid (cis/trans-DCVA) and 3-phenoxybenzoic acid (3-PBA), in foods such as chicken, honey, milk and pork has been established, in which the isomerization of α-cypermethrin was minimized. The target compounds were determined by GC–ECD after a derivatization reaction with 1,1,1,3,3,3-hexafluoroisopropanol. The conditions of the method were optimized by Taguchi orthogonal experiment. Under the optimized conditions, good linearity was obtained with correlation coefficients ranging from 0.9964 to 0.9998. The limits of detection were 0.001–0.005 mg kg −1 . The recoveries were 70.9–114.9% with relative standard deviations of 0.6–15%. In addition, ratios of isomerization ranged only from 2.3% to 7.0%. This method was applied in commercial animal food products.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2024
·
IF 2.3
Deli Zou,Lei Liu,Fangshen Liu,Dahong Li,Huiming Hua
From Garcinia pedunculata Roxb. fruits, two undescribed aromatic compounds including a benzofuran and a depsidone derivative, and a new natural product, together with four known compounds were isolated. Through the analysis of spectroscopic data, high resolution mass spectrum and calculated nuclear magnetic resonance, their structures were determined. The α-glucosidase inhibitory activity of the isolates was evaluated. And compound 3 exhibited a moderate inhibitory effect on α-glucosidase. The molecular docking of compound 3 was performed to elucidate the interaction with α-glucosidase.
研究领域:
植物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Ke Zhao,Shiwei Sun,Hui Wang,Lin Wang,Guoqing Qin,Jiahe Fan,Mengru Guo,Wei Wang
α -Glucosidase plays an important role in catalyzing the hydrolytic cleavage of disaccharides into monosaccharides. In this study, a phytochemical investigation of the potential α -glucosidase inhibitory fraction from the aerial parts of Euonymus fortunei led to the isolation and identification of two new tetracyclic triterpenoids , fortunenones A and B ( 1 – 2 ), together with 11 known triterpenoids ( 3 – 13 ). Fortunenones A and B are rare C 32 triterpenoids possessing a 24,24-dimethyl group. The partial isolated compounds were evaluated their effects on α -glucosidase, of which echinochlorin D ( 5 ), lupenone ( 7 ), wilforlide B ( 12 ), and wilforlide A ( 13 ) exhibited remarkable inhibitory effects with the half inhibitory concentration ranged from 207.2 × 10 −6 M to 388.3 × 10 −6 M compared with the positive control, acarbose. An enzyme kinetics analysis by Lineweaver-Burk plots revealed that the inhibition types of the four active compounds were all mixed inhibition. Molecular docking further revealed that hydrophobic interactions and hydrogen bonds play an important role in the inhibition of α -glucosidase activity. Our results demonstrate the potential of E. fortunei extract and its constituents to inhibit α -glucosidase.
研究领域:
植物化学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Maiquan Li,Yunxia Dong,Mangjun Kang,Tiantian Tao,Wenlan Li,Sheng Zhang,Wei Quan,Zhonghua Liu
Hyperglycemia can cause early damage to human bady and develop into diabates that will severely threaten human healthy. The effectively clinical treatment of hyperglycemiais is by inhibiting the activity of α-amylase. Black tea has been reported to show inhibitory effect on α-amylase and can be used for hyperglycemia treatment. However, the mechanism underlying is unclear. In this study, in vivo experiment showed that black tea theaflavins extract (BTE) effectively alleviated hyperglycemia. In vitro experiment showed that the effects may be caused by the interation between theaflavins and α-amylase. While TF1 and TF3 were mixed type inhibitors of α-amylase, TF2A and TF2B were competitive inhibitors of α-amylase. Molecular docking analysis showed that theaflavins monomers interacted with the hydrophobic region of α-amylase. Further study verified that monomer-α-amylase complex was spontaneously formed depending on hydrophobic interactions. Taken together, theaflavins showed potential anti-hyperglycemia effect via inhibiting α-amylase activity. Our results suggested that theaflavins might be utilized as a new type of α-amylase inhibitor to prevent and cure hyperglycemia.
研究领域:
营养学
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药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Mengting Ni,Xing Hu,Deming Gong,Guowen Zhang
Vitexin, a C-glycosylated flavonoid , is abundant in numerous foods . In this study, vitexin was determined as an uncompetitive α-glucosidase inhibitor and its binding site was different from the active site. It possessed a remarkably higher inhibitory activity than acarbose with its IC 50 value of 52.80 ± 1.65 μM. Interestingly, the combination of acarbose with vitexin showed a strong synergistic inhibition effect. The stable complex between vitexin and α-glucosidase was mainly formed by hydrogen bonds and hydrophobic forces. The presence of vitexin induced a looser conformation of α-glucosidase and decreased its surface hydrophobicity. Computational docking and chemical modification of α-glucosidase found that residues Glu, Asn, Lys, and Thr were essential for the binding course and their importance order was Glu, Asn > Lys > Thr. Molecular dynamics simulation results revealed the molecular mechanism of the interaction between vitexin and α-glucosidase and verified the above experimental results. This work proposed rewarding findings in functional research of vitexin as a potential α-glucosidase inhibitor.
研究领域:
食品科学
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生物化学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2019
·Vol. 48
·期 7
·4653-4659
·
IF 1.676
Lei Dongling,Ma Shiyu,Lu Youcai,Liu Qingchao,Li Zhongjun
A rechargeable Li-CO 2 battery has been considered to be a promising battery system due to its high-energy density and the utilization of carbon dioxide (CO 2 ). However, the high overvoltage caused by the discharge product Li 2 CO 3 hinders the development of Li-CO 2 batteries. In this work, α-MnO 2 nanowires obtained via a redox reaction have been employed as the cathode catalyst in the Li-CO 2 battery, which can provide sufficient catalytic sites for CO 2 evolution and tune the cathode structure for the uniform distribution of Li 2 CO 3 and C on the cathode. The Li-CO 2 battery with an MnO 2 /carbon nanotube (CNT) cathode exhibits significantly reduced overpotential, and could be operated for 50 cycles with a fixed capacity of 1000 mAh g −1 and 6 cycles of full discharge–charge tests at a current density of 100 mA g −1 .
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 7
·6829-6834
·
IF 1.798
Su Chang,Li Yu,Li Shouchun,Liu Li,Guo Xuexin,Lian Hongwei,Guan Xiulong
Pure and Pr-doped α-Fe 2 O 3 nanotubes are successfully synthesized via electrospinning and following calcined method. The crystal, morphologies structures and composed of the as-prepared samples are investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), respectively. The researches of the gas sensing properties of the samples show that Pr-doped α-Fe 2 O 3 nanotubes possess excellent sensitive to ethanol, and the response value of Pr-doped α-Fe 2 O 3 nanotubes to 10 ppm ethanol is 21.3 at the operating temperature 240 °C, which is much higher than that of pure α-Fe 2 O 3 nanotubes (1.5). That is to say that the ethanol sensitive of α-Fe 2 O 3 nanotubes is improved remarkably by doping Pr. Moreover, Pr-doped α-Fe 2 O 3 nanotubes show good selectivity and long-term stability.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Yanan Gao,Xuejing Qi,Yiping Zheng,Hongyu Ji,Linhua Wu,Nannan Zheng,Jingling Tang
The vitamin E analogue, α-tocopherol succinate (α-TOS), has a broad anti-tumor effect. α-TOS can induce cancer cells apoptosis and suppress tumor growth by targeting mitochondria. Low bioavailability of α-TOS is the major problem encountered with formulation development. In our study, α-TOS nanoemulsion (α-TOS-NE) was demonstrated as a new drug delivery system of α-TOS to increase the bioavailability. MTT-based cytotoxicity assay and mitochondrial membrane potential (ΔY) were performed on human breast cancer cell lines MCF-7 and human oral epithelial cancer cell lines KB to evaluate in vitro anticancer efficacy of α-TOS-NE. In comparison with free α-TOS, α-TOS-NE exhibited a stronger cytotoxicity and decreased ΔΨ. Pharmacokinetic profiles of I.V. α-TOS-NE group, I.P. α-TOS-NE group, and I.P. free α-TOS group (7% DMSO/93% PEG) were drawn. First of all, nanoemultion (NE) enables the I.V. injection of α-TOS, make it possible to be an I.V. preparation. Second, compare to the I.P. free α-TOS group, I.P. α-TOS-NE group had a higher bioavailability. Thus, NE improved the strong anti-cancer efficacy of α-TOS while increasing its in vivo bioavailability in rats. In conclusion, our laboratory-made NE was a safe drug delivery system for clinical trials and could be a promising formulation for α-TOS by I.V administration.
研究领域:
药剂学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Juan Liu,Yanyi Liu,Yuxiang Shen,Xudong Wei,Wenhuan Yuan,Jianying Qi,Jielong Cao,Pengyuan Deng,Haiyao Hu,Liang Wang,Jin Wang
Thallium (Tl) is an untraditional toxic metal. Emerging Tl pollution has received increasing concerns. Despite its extreme biotoxicity, Tl is an irreplaceable element for specific high-tech fields (e.g., superconductors, semiconductors, and optical fibers) due to its peculiar physio-chemical properties. Besides, Tl has been also regarded as critical strategic metal owing to its low abundance and scarcity in the earth’s crust. Herein, a novel composite of α-FeOOH@BC was facilely synthesized via biochar modification with environmentally abundant iron oxides (α-FeOOH) to separate Tl(I) from wastewater. The results showed that overall large distribution coefficient values ( K d > 5000 mL/g) of Tl separation by α-FeOOH@BC in a wide pH range (5.0–11.0) were achieved, suggesting a generally promising Tl separation capacity. Multiple characterizations with Scanning Electron Microscope-Energy Dispersive Spectrometer (SEM-EDS), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD) and X-ray Photoelectron Spectroscopy (XPS) indicate that the dominant Tl separation mechanisms included electrostatic attraction, ion exchange and complexation. These findings indicate that the α-FeOOH@BC material may have important application in Tl separation from industrial wastewaters, which are usually moderately acidic with pH values ranging from 5.0 to 7.0. This study offers novel perspectives on using environmental abundant iron oxides modified biochar for easy and fast separation of Tl from industrial wastewater. All these findings can facilitate to develop waste-to-resources strategy for recycling Tl in the loop of circular economy and industrial symbiosis.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Jingyang Liu,Jihang Hou,Zhiyi Zhang,Yongkang Liu,Rong Liu,Zeyuan Deng,Ting Luo
Ulcerative colitis (UC) is a chronic, recurring gastrointestinal disease that not only threatens human health but also increases the risk of colon cancer. Camellia oil has potential for the treatment of colitis. However, bioactive compounds, namely squalene and α-tocopherol, vary greatly in Camellia oil from different regions, and their therapeutic efficacy in colitis varies. We therefore investigated the effect of Camellia oil with different concentrations of squalene and α-tocopherol on colitis. Our results showed that Camellia oil attenuated the weight loss, decreased disease activity index (DAI), increased colon length, improved colon histology in DSS-induced colitis in mice, and reduced the gene expression and serum concentrations of TNF-α and IL-6. Camellia oil supplemented with squalene (final concentration of 375 mg/kg of Camellia oil) and α-tocopherol (final concentration of 600 mg/kg of Camellia oil) had the most potent effects on the alleviation of colitis symptoms. In conclusion, the intake of Camellia oil relieved DSS-induced colitis, and the modulation of squalene and α-tocopherol contents in Camellia oil further impacted its efficacy, which provides a theoretical basis for the development of novel Camellia oil with potent therapeutic potential to lower the risk of colitis.
研究领域:
医学
·
营养学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Wang-Wei Liao,Lei Yang,Jie Chen,Da-Li Zhou,Xian-lin Qu,Kun Zheng,Guang Han,Jia-Bei Zhou,Min Hong,Zhi-Gang Chen
Copper selenide (Cu 2 Se) has been extensively studied as an eco-friendly thermoelectric candidate owing to the outstanding thermoelectric performance of its high-temperature β-phase. In this study, we propose that α-Cu 2 Se is also a promising thermoelectric material at near-room-temperature. We synthesize nanostructured Cu 2-x Se via a facile solvothermal method, and densify the samples using Spark Plasma Sintering to maintain the small grain sizes. Although the as-prepared α-Cu 2 Se has intrinsically low lattice thermal conductivity , its high Cu deficiency leads to a high carrier concentration, therefore, a low thermoelectric performance. As an electron donor, bismuth can effectively compress the Cu vacancies of the as-prepared α-Cu 2 Se and in turn reduce its carrier concentration from 4.1 × 10 20 to 2.0 × 10 20 cm −3 at room temperature, achieving a significantly enhanced power factor and a reduced carrier thermal conductivity. Consequently, a zT of 0.43 at 373 K is obtained in Cu 1.982 Bi 0.006 Se, showing great potential in developing high-performance near-room-temperature α-Cu 2 Se-based thermoelectric materials.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2021
·Vol. 57
·期 1
·67-77
·
IF 3.713
Mengqing Zhang,Ruijin Yang,Shuhuai Yu,Wei Zhao
Summary α-Glucosidase inhibitors, which can inhibit α-glucosidase to reduce the release of glucose after a mixed carbohydrate diet, has become a key tool in the management of type 2 diabetes mellitus (T2DM). SFP-1, an α-glucosidase inhibitor derived from Sargassum fusiforme ( S . fusiforme ), was studied as a food-derived hypoglycaemic agent. By binding α-glucosidase and then changing the conformation of the enzyme, SFP-1 with a mixed inhibition type exerted an excellent inhibitory effect (IC 50 value: 0.681 mg mL −1 ). Structural analyses suggested that the average molecular weight of SFP-1 was 1.61 × 10 5 Da, mainly composed of glucuronic acid, fucose, galactose, glucose, mannose and xylose, and the relative molar ratio was 23.07: 15.17: 7.72: 4.92: 4.04: 1.99. FTIR and NMR analysis suggested that SFP-1 was an acidic polysaccharide with both α-type and β-type glycosidic bonds. S . fusiforme polysaccharide (SFP-1) has the potential to develop as functional foods and nutraceuticals in T2DM management.
研究领域:
食品科学
·
药理学
·
海洋生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）