Materials Science & Engineering C-Materials for Biological Applications
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2020
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IF 5.88
Junjie Yuan,Baoxin Wang,Chen Han,Xiaoyan Huang,Haijun Xiao,Xiao Lu,Jianxi Lu,Dong Zhang,Feng Xue,Youzhuan Xie
The treatment of infectious or potentially infective bone defects remains a major problem in clinical practice. Silver has the ability to potentiate antibiotics against resistant bacterial strains. In order to reduce the risk of long-term infections, it is necessary for the biomaterial scaffold to release Ag + in a controlled manner during the entire healing process. In this study, given the antimicrobial characteristics of nanosized Ag (NSAg), we synthesized β-tricalcium phosphate (β-TCP) doped with 5 and 10 wt% NSAg (5 wt% NSAgTCP and 10 wt% NSAgTCP, respectively). The NSAgTCP composites exhibited similar macroporous structures to pure β-TCP. The NSAgTCP samples were examined by scanning electron microscopy at 10,000-times magnification, which revealed that silver was still present at the nanometer scale. X-ray diffraction revealed that silver does not change the crystalline properties of β-TCP. In addition, we observed that the mechanical strength of NSAgTCP increased with increasing amounts of added Ag. The antibacterial, physical, and chemical properties of NSAgTCP were investigated in vitro. We found that NSAgTCP is effective at inhibiting the growth of Staphylococcus aureus and Escherichia coli and is not cytotoxic to human bone marrow mesenchymal stem cells. Moreover, it does not hinder liver or kidney function when tested in vivo. As the bioceramic degrades, Ag ions are slowly released and new bone is formed. No significant cytotoxic effects were observed even when 10 wt% NSAgTCP was used. NSAgTCP has the ability to simultaneously repair bone defects and act as an anti-infective agent; hence, we expect that this material, with its good bone-repairing and anti-infective properties, will find wide spread use as a novel bone substitute.
研究领域:
生物材料学
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医学
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骨科
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DOI
PubMed
高影响因子
ANALYST
·
2017
·Vol. 142
·期 19
·3699-3706
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IF 3.885
Linwei Li,Chengjun Wu,Yang Ma,Shuhao Zhou,Zhen Li,Tiemin Sun
Rational engineering of native β-CD as an ideal chiral selector for a definite analyte in capillary electrophoresis represents a challenge in separation science. Herein, a rational and systematic strategy that combines the de novo design and molecular modeling is firstly described to expedite the manipulation and selection of effective selector for enantioseparation in capillary electrophoresis. Using β-adrenoreceptor agonists as model analytes, we demonstrate how this strategy efficiently improves the enantiorecognition in chiral discrimination sites of inclusion complexes. The evolved β-CD derivative could be utilized as a chiral receptor to achieve the effective enantioseparation (Rs > 1.5) of racemic β-adrenoreceptor agonists. We highlight a novel strategy for efficiently and rapidly manipulating native CD based on the characteristics of analyte so as to gain an excellent chiral selector.
研究领域:
分析化学
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分离科学
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药物化学
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DOI
PubMed
高影响因子
MOLECULES
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2022
·Vol. 27
·期 15
·4954
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IF 4.927
Chengqi Bao,Yan Lu,Jiawei Liu,Yansha Gao,Limin Lu,Shuwu Liu
In this work, β-cyclodextrin (β-CD)/mesoporous carbon (CMK-8) nanocomposite was synthesized and used as an electrochemical sensing platform for highly sensitive and selective detection of Cu2+. The morphology and structure of β-CD/CMK-8 were characterized by scanning electron microscope (SEM) and X-ray diffraction (XRD). In addition, the dates from electrochemical impedance spectroscopy (EIS) and Cyclic voltammetry (CV) demonstrated that the β-CD/CMK-8 possessed a fast electronic transfer rate and large effective surface area. Besides this, the β-CD/CMK-8 composite displayed high enrichment ability toward Cu2+. As a result of these impressive features, the β-CD/CMK-8 modified electrode provided a wide linear response ranging from 0.1 ng·L−1to 1.0 mg·L−1with a low detection limit of 0.3 ng·L−1. Furthermore, the repeatability, reproducibility and selectivity of β-CD/CMK-8 towards Cu2+were commendable. The sensor could be used to detect Cu2+in real samples. All in all, this work proposes a simple and sensitive method for Cu2+detection, which provides a reference for the subsequent detection of HMIs.Keywords:copper ion;β-cyclodextrin;mesoporous carbon;electrochemical sensor
研究领域:
分析化学
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材料科学
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DOI
PubMed
高影响因子
RSC Advances
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2011
·Vol. 1
·期 2
·282-289
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IF 0
Xueying Qiu,Yuhong Yang,Liping Wang,Shanling Lu,Zhengzhong Shao,Xin Chen
Time-evolved gelation behavior of a chitosan-β-glycerophosphate (CS/β-GP) system was elucidated from rheological investigation, NMR analysis, fluorescence measurement, and morphology observation. Urea and isobutanol were selected to assess the interactions between the two components during the gelation process of the CS/β-GP system. Urea was found to be detrimental to the gelation process by both disrupting hydrogen bonding and retarding the formation of hydrophobic domains. On the contrary, the addition of isobutanol accelerated the sol–gel transition by strengthening the hydrophobic interactions. These results reveal that both hydrogen bonding and hydrophobic interactions within chitosan or between chitosan and β-glycerophosphate molecules are the main reasons for gel formation. The results also indicate that firstly the formation of hydrogen bonds makes the hydrophobic sites more accessible, and then the synergistic hydrogen bonding and hydrophobic interactions lead to the final formation of CS/β-GP gel network. This work demonstrates the possibility of tuning the gelling ability as well as the mechanical properties of CS/β-GP hydrogels. Thus, it gives the opportunities to optimize the performance of this promising natural thermosensitive material for practical applications in the future.
研究领域:
材料科学
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生物医学工程
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DOI
RSC Advances
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2015
·Vol. 5
·期 130
·107670-107679
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IF 3.84
Shoulian Wei,Jianwen Li,Yong Liu
Magnetic mesoporous nanoparticles of Fe3O4@mSiO2 were prepared through co-precipitation and tetraethoxysilane hydrolysis at 60 °C and pH 10 with hexadecyl trimethyl ammonium bromide as the template. Hydroxypropyl β-cyclodextrin was modified onto Fe3O4@mSiO2 under sodium citrate and N2 protection via an ultrasound process to increase the catalytic efficiency. The prepared nanoparticles were characterized by Fourier transform infrared spectrometry, X-ray diffraction, scanning electron microscopy and a peroxidase-like activity assay. The results showed that the prepared nanoparticles have magnetic properties, peroxidase-like activity and a loose spherical cluster structure. Compared with Fe3O4@mSiO2 nanoparticles, Fe3O4@mSiO2@HP-β-CD nanoparticles exhibit higher catalytic ability toward both H2O2 and 3,3′,5,5′-tetramethylbenzidine. Fe3O4@mSiO2@HP-β-CD nanoparticles can catalyse β-estradiol (β-E2) oxidation in the presence of H2O2 and be used as a colourimetric sensor for indirect detection of β-E2. A good linear relationship was obtained from 0.8 μM to 16 μM. The limit of detection of the proposed method was 0.2 μM. The visual method was successfully used in the analysis of β-E2 in commercial tablets and animal feeds, with recovery ranging from 92.6% to 110%.
研究领域:
生物化学
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分析化学
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材料科学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Hang Li,Sen-Lin Chang,Tan-Ran Chang,Ying You,Xiao-Dong Wang,Li-Wei Wang,Xiao-Fan Yuan,Ming-Hui Tan,Pei-Dong Wang,Peng-Wei Xu,Wei-Bo Gao,Qing-Sheng Zhao,Bing Zhao
Cannabidiol (CBD), which has a wide variety of biological activities, is one of the phytocannabinoids from Cannabis sativa L. However, due to the poor aqueous solubility, its applications in food, cosmetic, and pharmaceutical fields are limited. Moreover, the previous researches on the improvement in the solubility of CBD are rare. Cyclodextrins (CDs) are useful materials to improve the solubility of poorly water-soluble molecules. Therefore, this work was aimed to study the physicochemical properties, water solubility, and dissolution rate of the inclusion complexes of CBD with β-cyclodextrin (β-CD) and 2, 6-di-O-methyl-β-cyclodextrin (DM-β-CD), and to determine the influence of complexation on the antioxidant activity of CBD. Job’s plot and phase solubility study revealed that CBD formed inclusion complexes with β-CD and DM-β-CD at a 1:1 stoichiometric ratio. The thermodynamics analysis demonstrated that the inclusion process was spontaneous and endothermic. Then, the inclusion complexes of CBD with β-CD or DM-β-CD were prepared and characterized by PXRD, FT-IR, DSC, SEM, and 1 H NMR. The loading efficiency (LE) of the two inclusion complexes was 20.4% and 17.7% respectively, while the complexation efficiency (CE) was 92.4% and 90.8% respectively. Moreover, the results of molecular docking further showed that CBD was encapsulated successfully. The results also displayed that the water solubility of CBD in CBD/β-CD inclusion complex (IC) and CBD/DM-β-CD IC was significantly increased to 0.395 and 14.118 μg/mL, which was enhanced by 17-fold and 614-fold respectively at such a high LE, and the in vitro dissolution rate of CBD was also promoted after complexation. Besides, the antioxidant activity of CBD was improved after encapsulation with β-CD and DM-β-CD. Significantly, the ABTS free radical scavenging ability of the two inclusion complexes was better than that of Vitamin C (Vc).
研究领域:
药学
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食品科学
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材料科学
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DOI
高影响因子
Applied Nanoscience
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2022
·Vol. 12
·期 9
·2683-2693
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IF 3.869
Chi Yu,Ye Zhenghe,Su Xianyan,Li Zhao,Ren Xuexiang
In this work, a compound was fabricated using β-cyclodextrin (β-CD) and propithiumazole (PTC). FTIR and TG were used to analyze the intermolecular force and thermal stability of the compound and results indicated. The intermolecular forces were van der Waals forces. According to previous research, the seed coat agent and suspension concentrate (SC) were prepared using this compound and auxiliary. The inhibitory effect on Fusarium graminearum was studied with a bioassay. The data suggested inhibition rate of microencapsulated PTC are about 7.8% and 5% higher than PTC at 72 h and 192 h, respectively. In addition, results of pot experiments suggested dry weight of crops were increased after using seed coat agent contained microencapsulated prothioconazole which indicates that the seed coat agent may be beneficial to protein synthesis. Compared to commercial PTC, field experiments were conducted to investigate the preventive effects of SC against fusarium head blight (FHB). The results of toxicity test and field experiment showed that this compound can improve the utilization efficiency about 5% of PTC and reduce pesticide injury to wheat seeds.
研究领域:
植物保护
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农药科学
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DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
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2023
·
IF 4.1
Zekang Wang,Haiyan Chen,Yuyue Qin,Tianqing Lan
In this study, the Fenton oxidized lignin was prepared to investigate the effect of Fenton oxidation modification on the activity of lignin immobilized β-glucosidase (β-GL). The results demonstrated that Fenton oxidation could significantly improve the activity and stability of immobilized β-GL. This is because the Fenton oxidation increased the electrostatic, hydrogen bonding, and hydrophobic forces between lignin and β-GL, resulting in increased lignin adsorption onto β-GL. The Fenton oxidation also changed the chemical structure of lignin, altering the lignin-β-GL binding site and reducing the negative effect of lignin on the β-GL catalytic domain . This research will improve understanding of the effect of Fenton lignin oxidation on immobilized β-GL activity and expand the use of lignin in enzyme immobilization .
研究领域:
生物化学
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酶工程
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DOI
PubMed
高影响因子
HYDROMETALLURGY
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2021
·
IF 4.156
Licheng Zhang,Lianmin Ji,Lijuan Li,Dong Shi,Taoshan Xu,Xiaowu Peng,Xuexue Song
A method of recovering cobalt, nickel, and lithium from mixed solutions was proposed based on β-diketone solvent extraction using benzoyltrifluoroacetone (HBTA), trioctylphosphine oxide (TOPO), and green kerosene. The effective metal recovery and separation parameters such as solution pH, saponification degree, extraction time, and phase ratio were evaluated experimentally. The results indicated that cobalt and nickel were recovered through 2-stage cross-current extraction at different phase ratios and that lithium was recovered through three-stage countercurrent extraction. The metal-loaded organic phase was stripped using an inorganic acid solution to obtain cobalt-, nickel-, and lithium-concentrated solutions. The Co/Ni and Ni/Co molar ratios in the cobalt- and nickel-concentrated solutions were 54.4 and 164, respectively, and the lithium concentration reached 1.78 × 10 4 mg L −1 in the lithium-enriched solution. The extraction mechanism was studied, and the results revealed that Co 2+ and Ni 2+ were extracted by ion exchange in which two moles of H + or Na + had been replaced by divalent metal ions . The Li + extraction stoichiometry was studied by cultivating single crystals. Because cobalt, nickel, and lithium were recovered by single extraction, no other organic substances were required. This work provides a sustainable, environmentally friendly, and versatile method of recovering valuable metals from spent lithium batteries .
研究领域:
化学工程
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环境科学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Yuan Bian,Yongjin Ma,Yanyang Shang,Pengfei Tan,Jun Pan
Bi 2 O 2 CO 3 with a narrow band gap ( Eg ∼ 2.93 eV) was self-assembled by Bi 2 O 2 CO 3 nanosheets via a hydrothermal method, and the β-Bi 2 O 3 /Bi 2 O 2.33 @Bi 2 O 2 CO 3 composites were further fabricated using Bi 2 O 2 CO 3 as template by slow thermal decomposition for 4 h, described as: Bi 2 O 2 CO 3 → β-Bi 2 O 3 /Bi 2 O 2.33 @Bi 2 O 2 CO 3 (300 °C) → β-Bi 2 O 3 /Bi 2 O 2.33 (320 °C) → β-Bi 2 O 3 (350 °C). Deep investigation towards the generation and existence of β-Bi 2 O 3 and Bi 2 O 2.33 on the surfaces and interfaces of Bi 2 O 2 CO 3 were also carefully conducted by XRD, HRTEM and XPS analysis. In comparison with pure Bi 2 O 2 CO 3 , β-Bi 2 O 3 /Bi 2 O 2.33 @Bi 2 O 2 CO 3 displayed superior photocatalytic degradation efficiency and stability to cationic dyes under visible-light irradiation. Especially, the as-prepared BOC–300 °C with relatively high specific surface area (12.11 m 2 g −1 ) could entirely remove Rh-B and MB in 45 min and 60 min, which were approximately 4.7 and 6.6 times as high as that of pure Bi 2 O 2 CO 3 , respectively. Further study demonstrated that the enhanced photocatalytic degradation efficiency of β-Bi 2 O 3 /Bi 2 O 2.33 @Bi 2 O 2 CO 3 is surely owing to the well matched band gap and p - n heterojunction, which made it possible for much faster charge transfer rather than electron-hole pairs recombination process.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
BMC Veterinary Research
·
2024
·Vol. 20
·期 1
·1-11
·
IF 2.3
Ding Yili,Zhang Zhiyuan,Ding Charles,Xu Shufeng,Xu Zhe
As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to prevent and treat parasites, but also shows anti-cancer effects against several types of cancer, exhibits anti-cancer effects in paclitaxel and doxorubicin-resistant cancer cells. However, fenbendazole’s poor in water solubility (0.3 µg/mL), limits its clinical applications. Even great efforts were made toward increasing its water solubility, the results were not significant to reach anti-cancer drug delivery requirement (5–10 mg/mL). Through single factor and orthogonal strategy, many complex conditions were designed and used to prepare the complexes, the inclusion complex with methyl- β -cyclodextrin with 29.2 % of inclusion rate and 89.5% of inclusion yield can increase drug’s water solubility to 20.21 mg/mL, which is the best result so far. Its structure was confirmed by differential scanning calorimetry, scanning electron microscopic image, 1D and 2D NMR spectra in D 2 O. In its in vitro pharmacokinetic study, fenbendazole was 75% released in 15 min., in its in vivo pharmacokinetic study, the bio-availabilities of fenbendazole, its major metabolic anthelmintic agent oxfendazole and its minor metabolic anthelmintic agent oxfendazole were increased to 138%, 149% and 169% respectively, which would allow for fewer drug doses to achieve the same therapeutic effect and suggest that the complex can be used as a potential anticancer agent.
研究领域:
药剂学
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药物化学
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生物医学
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DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2020
·Vol. 78
·期 6
·2993-3008
·
IF 2.014
Chen Yuying,Chen Juan,Li Jianping,Jiang Jingzhe,Fang Ziang,Lin Xing,Jiang Yan,Zhang Hongwen,Liu Hongbo
In this study, a macroinitiator of β-CD-ONa was prepared by a substitution reaction of β-cyclodextrin (β-CD) with sodium (Na). The macroinitiator was then used in the ring-opening polymerization of octamethylcyclotetrasiloxane (D 4 ) to obtain a star polymer, in which β-CD is the core and polysiloxane is the arm. FTIR, NMR, TGA, CA, etc., were used to characterize the structure and properties of star polymers. The results indicated that there were four polysiloxane arms attached to each β-CD core, and the star polymer had good thermal stability. With the increase in D 4 monomer dosage, the hydrophobicity of the star polymer slightly improved, but the reaction time had no significant effect on hydrophobicity. When the star polymer was coated onto polyethylene terephthalate membrane, the transmittance increased from 87.6% to 92.8%, and the haze did not change significantly. Furthermore, the surface of star polymer porous membranes was prepared by the static breath-figure method using n -hexane as solvent at 30 °C. The results showed uniform pore distribution and increased hydrophobicity.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）