DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 35
·15645-15652
·
IF 4.197
Hanxing Chen,Teng Tu,Ming Wen,Qingsheng Wu
New Cu2O-on-Cu nanowires (NWs) are constructed to develop the visible-light-driven activity of photocatalysts via the facile self-assembly of Cu2O nanoparticles (NPs) on a Cu NW surface assisted by a structure director, followed in situ reduction. In the resultant Cu2O-on-Cu NWs, the Cu2O NPs, with a diameter of 10 nm, show good distribution on the 50 nm-sized Cu single-crystal NWs. Owing to the band-gap adjusting effect and high electron transportation, the coupling of narrow-band-gap semiconductor Cu2O and excellent conductor Cu can lead to the markedly enhanced high visible light photocatalytic activity of Cu2O-on-Cu NWs toward the degradation of dye pollutants including Rhodamine B (RhB), methyl orange (MO) and methyl blue (MB). The as-designed Cu2O-on-Cu heterostructured NWs exhibit higher performance for the catalytic degradation of dye compounds than pure Cu2O. Nearly 60%, 100%, and 85% conversion with reaction rate constants (k) of 0.0137, 0.0746 and 0.0599 min−1 can be achieved for the degradation of RhB, MO and MB, respectively. Besides the highly efficient transportation of electrons, Cu NWs have a strong capacity for oxygen activation, which results in the gathering of negative charges and rich chemisorbed oxygen onto the surface. This may be responsible for the high catalytic efficiency of the Cu2O-on-Cu NWs toward the degradation of organic pollutants.
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高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 45
·8832-8841
·
IF 4.726
Huihui Wang,Hao Wu,Hujun Shen,Shaote Geng,Beibei Wang,Yanfang Wang,Xiaojun Ma,Guohui Li,Mingqian Tan
The combination of complementary MRI and NIR imaging methods evolved to provide an even more powerful bioimaging tool. Herein, a novel bimodal MRI/NIR nanoprobe GCF-HDA was prepared via a facile self-assembly approach of three types of amphiphilic structures in aqueous solution. The Stokes shift of the NIR moiety increased from 30 to 150 nm and fluorescence quantum yield increased from 1.5 to 8% after conjugation with electron-rich hexadecylamine (HDA) to organic dye Cy7. The photostability of the nanoprobe GCF-HDA was dramatically improved after involving the newly synthesized dye. Molecular dynamics simulation demonstrated that the GCF-HDA is composed of 2.0–3.5 nm clusters and in each cluster the head groups of the amphiphilic molecules assemble together and the tail groups point outwards. The r1 and r2 relaxivities of GCF-HDA were found to be 11.87 and 19.91 mM−1 s−1 per Gd(III) chelate at 0.5 T, respectively. In vitro cellular imaging with human glioma U-87 MG cells showed that the GCF-HDA was able to enter the cells and accumulate in the cytoplasm. The targeted GCF-HDA resulted in higher MR contrast enhancement and stronger fluorescence intensity than the corresponding non-targeted probe GC-HDA in the tumor tissue 96 hours post injection. Ex vivo fluorescence imaging and histological analysis of the tumor tissue further confirmed the specific binding ability of the GCF-HDA.
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高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 36
·7291-7299
·
IF 4.726
Yanfang Wang,Beibei Wang,Han Liao,Xiaojie Song,Hao Wu,Huihui Wang,Hujun Shen,Xiaojun Ma,Mingqian Tan
Mitochondrial dysfunctions cause numerous human disorders and the development of mitochondria-targeted nanocarriers for drug delivery has aroused great attention. Herein, we report the synthesis of a liposomal nanohybrid cerasome modified with triphosphonium (TPP) for drug delivery to the mitochondrial matrix. The cerasomes were observed to possess an average size of about 38 nm in diameter, and the theoretical simulation of GBEMP mapping demonstrated that the amphiphilic organotrialkoxysilanes were stable as a bilayer equilibrium conformation after self-assembly. The cerasomes showed good stability, excellent biocompatibility and sustainable drug release behavior. Moreover, the TPP-targeted cerasomes resulted in greater drug accumulation in mitochondria, thus leading to a greater antitumor effect as compared to non-targeted cerasomes by using doxorubicin as a modal drug. The specific accumulation of TPP-targeted cerasomes within mitochondria was also confirmed by using JC-1 as the fluorescent probe to analyze the mitochondrial transmembrane potential change.
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BIOCHEMICAL PHARMACOLOGY
·
2013
·
IF 4.576
Jing Han,Xun Huang,Lidan Sun,Zheng Li,Hai Qian,Wenlong Huang
A series of fatty chain conjugates of glucagon-like peptide-1(GLP-1) were designed and synthesized. First, eleven cysteine modified peptides ( 1 – 11 ) were prepared using Gly 8 -GLP-1(7-36)-NH 2 peptide as a starting point. Peptides 1 , 6 , 9 , and 11 which showed comparable GLP-1 receptor activate potency and glucose-lowering effect in vivo with Gly 8 -GLP-1(7-36)-NH 2 were selected for second step modifications to yield conjugates 12 – 23 . All conjugates retained significant GLP-1 receptor activate potency and more importantly exerted enhanced albumin-binding properties and in vitro plasma stability. The protracted antidiabetic effects of the most stable compound 14 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo. Furthermore, once daily injection of compound 14 to db/db mice achieved long-term beneficial effects on HbA1c lowering and glucose tolerance. Our results suggest that compound 14 is a promising type 2 antidiabetic agent deserving further investigation.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Xiaogan Li
Pure mesoporous TiO 2 microspheres based chemoresistive gas sensors showed response to several organic volatile compounds (VOCs) such as formaldehyde, methanol, ethanol, ammonia and acetone under the UV illumination in the humid air at room temperature . With the loading of NiO at the porous surface of TiO 2 microspheres, the sensor indicated a different sensing property. The sensor using 10 wt% NiO-wrapped mesoporous TiO 2 composite microspheres showed a good sensitivity to different concentrations of ammonia from 10 ppm to 100 ppm whereas almost no response to other VOCs indicating an excellent selectivity to detect ammonia in the humid air with UV illumination at room temperature.
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Nanoscale Research Letters
·
2014
·Vol. 9
·期 1
·1-13
·
IF 2.481
Li Chao,Ji Yang,Wang Can,Liang Shujing,Pan Fei,Zhang Chunlei,Chen Feng,Fu Hualin,Wang Kan,Cui Daxiang
Successful development of safe and highly effective nanoprobes for targeted imaging of in vivo early gastric cancer is a great challenge. Herein, we choose the CdSe/ZnS (core-shell) quantum dots (QDs) as prototypical materials, synthesized one kind of a new amphiphilic polymer including dentate-like alkyl chains and multiple carboxyl groups, and then used the prepared amphiphilic polymer to modify QDs. The resultant amphiphilic polymer engineered QDs (PQDs) were conjugated with BRCAA1 and Her2 monoclonal antibody, and prepared BRCAA1 antibody- and Her2 antibody-conjugated QDs were used for in vitro MGC803 cell labeling and in vivo targeted imaging of gastric cancer cells. Results showed that the PQDs exhibited good water solubility, strong photoluminescence (PL) intensity, and good biocompatibility. BRCAA1 antibody- and Her2 antibody-conjugated QD nanoprobes successfully realized targeted imaging of in vivo gastric cancer MGC803 cells. In conclusion, BRCAA1 antibody- and Her2 antibody-conjugated PQDs have great potential in applications such as single cell labeling and in vivo tracking, and targeted imaging and therapeutic effects' evaluation of in vivo early gastric cancer cells in the near future.
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ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Xueyan Wang,Mingshi Jin,Yuxiao Li,Lianhua Zhao
Anhydrous proton conducting membranes made of different ionic liquids (ILs), sulfonated poly (ether ether ketone) (SPEEK), and mesoporous silica (SiO 2 ) are successfully prepared. Influences of different ionic liquids on the properties of composite membranes doped with 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF 4 ]), 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([BMIm][Tfo]), 1-butyl-3-methylimidazolium chloride ([BMIm]Cl), diethylmethylammonium trifluoromethanesulfonate ([dema][Tfo]), and 1-ethylimidazolium trifluoromethanesulfonate ([EIm][Tfo]) ionic liquids are described. Fourier transform infrared spectroscopy (FT-IR) analysis showed that there were interactions between ionic liquids, SPEEK and mesoporous silica. IL leaching studies demonstrated that IL loss decreased significantly after doping with SiO 2 . The proton conductivity study showed that both anions and cations of IL influenced the proton conductivity of the composite membranes. Proton conductivity of composite membranes displayed a positive correlation with the number of hopping sites within IL cation structures. Of all the conducting membranes studied, SP/SiO 2 -7.5/[BMIm][BF 4 ]-50 showed the highest anhydrous proton conducting ability (15 mS cm −1 at 200 °C). Therefore, it is expected to find applications in proton exchange membrane fuel cells under medium temperature, anhydrous conditions.
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COMPOSITES SCIENCE AND TECHNOLOGY
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2017
·
IF 4.873
Lingyun Zhang,Shuhua Tu,Haitao Wang,Qiangguo Du
Pickering emulsion-templated polystyrene (PS)/graphene oxide (GO) composite microspheres were successfully prepared using surface-functionalized silica as the stabilizer . These preformed polymer/GO composite microspheres were then melt-blended into polymer matrix to prepare nanocomposite materials in a short minute using HAAKE torque rheometer . Transmission electron microscope (TEM) images of the nanocomposites demonstrate that GO is uniformly dispersed into PS matrix. A significant decrease of coefficient of thermal expansion (CTE) values from more than 150 to 50 ppm/K is realized with the introduction of well-dispersed GO nanosheets . The glass transition temperature (T g ) and the temperature of 5% weight loss (T 0.05 ) are increased by 5 and 17 °C, respectively. Furthermore, the impact energy of the composite sample with a GO loading of 0.86% is 64% greater than that of pure PS, and is nearly twice as high as that of the composite which was prepared by direct melt-blending of surface-modified GO and commercial PS. The tensile strength and elongation at break of the composites are also obviously improved. The work provides an economic and convenient method which eliminates the dispersion problem of GO in polymer matrix to prepare GO-based nanocomposite materials for industrial application on a large scale.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Xiaogan Li,Yangyang Zhao,Xueyan Wang,Jing Wang,Alexander M. Gaskov,S.A. Akbar
Reduced graphene oxide (rGO) decorated TiO 2 microspheres are prepared by using the hydrothermal method . The as-synthesized sample shows that TiO 2 particles are connected by the rGO nanosheets while some TiO 2 particles are found to be partly covered by rGO sheets. The rGO-decorated TiO 2 based chemoresistive-type sensor shows good sensitivity and excellent selectivity to different concentrations of ammonia from 5 ppm to 50 ppm at room temperature . However, the response and recovery speeds of the sensor to ammonia are sluggish and need further optimization.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Ye Zhang,Congjun Zhang,Jing Chen,Li Liu,Mengyue Hu,Jun Li,Hong Bi
Multidrug resistance (MDR) has been recognized as a major obstacle to successful chemotherapy for cancer in the clinic. In recent years, more and more nanoscaled drug delivery systems (DDS) are constructed to modulate drug efflux protein (P-gp) and deliver chemotherapeutic drugs for overcoming MDR. Among them, d-α-tocopheryl polyethylene glycol succinate (TPGS) has been widely used as a drug carrier due to its capability of inhibiting overexpression of P-gp and good amphiphilicity favorable for improving permeation and long-circulation property of DDS. In the present work, a novel kind of mitochondria-targeting nanomicelles-based DDS is developed to integrate chemotherapeutics delivery with fluorescence imaging functionalities on a comprehensive nanoplatform. The mitochondria-targeting nanomicelles are prepared by self-assembly of triphenylphosphine (TPP)-modified TPGS and fluorescent carbon quantum dots (CQDs) in an n-hexane/H2O mixed solution, named CQDs-TPGS-TPP. Notably, although the drug loading content of doxorubicin (DOX) in the as-prepared nanomicelles is as low as 3.4%, the calculated resistant index (RI) is greatly decreased from 66.23 of free DOX to 7.16 of DOX-loaded nanomicelles while treating both parental MCF-7 cells and drug-resistant MCF-7/ADR cells. Compared with free DOX, the penetration efficiency of DOX-loaded nanomicelles in three-dimensional multicellular spheroids (MCs) of MCF-7/ADR is obviously increased. Moreover, the released DOX from the nanomicelles can cause much more damage to cells of drug-resistant MCs. These results demonstrate that our constructed mitochondria-targeting nanomicelles-based DDS have potential application in overcoming MDR of cancer cells as well as their MCs that mimic in vivo tumor tissues. The MDR-reversal mechanism of the DOX-loaded CQDs-TPGS-TPP nanomicelles is also discussed.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Yanfeng Ji,Duanping Wang,Xulong Cao,Lanlei Guo,Yangwen Zhu
Hydrophobically modified polyacrylamidepolymers were synthesized by an aqueous micellar copolymerization, the N -benzyl- N - n -hexadecyl acrylamide being used as hydrophobic comonomer. The effect of the molecular weight (MW) and surfactant interactions on the rheological properties and oil-water interfacial activity were studied. The results indicate that increasing MW, the critical aggregation concentration of amphiphilic polymer will be decreased, and the network structural strength increased, which was measured by fluorescent probes, DLS and electron microscope. Mixing with the surfactant, sodium dodecyl sulfate (SDS), the solution viscosity increased at first and decreased later on with increasing the ratio of SDS concentration, and the dynamic interfacial tension between oil and water can be reduced by two orders of magnitude compared to the polymer solution only. The result of enhance oil recovery performance of the polymer/surfactant compound system is that it can significantly reduce the residual oil saturation due to the synergistic effect of the increasing viscosity and surface activity. The overall recovery efficiency was raised by 10–25% OOIP compared to the baseline polymers.
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RSC Advances
·
2016
·Vol. 6
·期 91
·88820-88825
·
IF 3.289
Liping Li,Qiuxia Zhang,Hong Huo,Jianjun Zhou,Lin Li
Organic gelators of glutamic acid derivative were synthesized, which have been successfully used to gel commercial electrolyte for lithium ion battery. The organic gelators self-assembled to form 3D fibrillar structures with very high porosity in the electrolyte solvent. Thermal stability of the gel electrolyte increased with the length of side chain and concentration of gelators. When the side chain length of gelator was 22 carbons, the gel electrolyte could endure temperature higher than 60 °C with the addition 2 wt% gelator. The most prominent advantage of gel electrolyte over liquid electrolyte was that it could broaden the electrochemical stable window, which has potential application in high voltage lithium ion batteries. With the addition of organic gelator, conductivity of the gel electrolyte would decrease a little, but it still showed the conductivity–temperature behavior of liquid electrolyte. The cells with gel electrolyte showed similar cycling performance as those with liquid electrolyte, which indicated that the organic gelators of glutamic acid derivatives could be used in lithium ion batteries, especially in high voltage lithium ion batteries.
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