MICROCHIMICA ACTA
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2025
·Vol. 192
·期 5
·1-13
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IF 5.3
Zhang Jing,Yin Zhaojiang,Xiong Wei,Fan QiQi,Yu Fengyao,Liao Fusheng,Fan Hao,Qu Fei,Yu Qiangqiang
A novel, low-toxicity Ru-Ni-BPY metal–organic framework (MOF) nanomaterial was developed and a simple and sensitive dual-mode "on–off" ferric ions (Fe 3+ ) sensing platform based on this material constructed. The dual-mode detection method enabled cross-validation of the electrochemiluminescence (ECL) and fluorescent (FL) signals, enhancing accuracy and effectively minimizing errors. In linear ranges of 0.005–10 μM and 0.078–10 μM, Fe 3+ can dramatically quench the ECL and FL signals of the Ru-Ni-BPY MOF, with quenching rates of 91.42% and 91.31%, respectively, and detection limits of 0.1 nM and 9.3 nM, respectively. This ECL method not only achieved efficient detection of Fe 3+ in rat brain microdialysis fluid but also successfully enabled real-time FL detection of Fe 3+ in nude mice. Therefore, this platform has great potential for applications in environmental protection, life sciences, and early disease diagnosis. Graphical abstract
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 6
·1-10
·
IF 5.3
Hou Waner,Liu Zhimin,Hao Xuanxuan,Lei Xun,Cheng Jintao,Li Yaxin,Hu Leqian,Li Peng
An electrochemiluminescence (ECL)-fluorescence (FL) dual-mode aptasensing system is proposed for estradiol detection. Firstly, ruthenium-based metal–organic framework nanosheets (RuMOFNSs) were synthesized by a simple one - pot method. RuMOFNSs exhibited both fluorescence (FL) and electrochemiluminescence (ECL) characteristics. After RuMOFNSs were immobilized on the electrode, complementary target DNA (cDNA), gold nanoclusters labeled aptamer (AuNCs-Apt) were successively assembled on the electrode to fabricate the aptasensor. The absorption spectrum of RuMOFNSs could be well overlapped with the fluorescence emission spectrum (or ECL spectrum) of AuNCs. When estradiol was absent, AuNCs-Apt hybridizes with cDNA to form double-stranded DNA. The close proximity between AuNCs and RuMOFNSs led to the efficient resonance energy transfer (RET) from AuNCs (donor) to RuMOFNSs (acceptor), thus the enhanced ECL (or FL) signals were achieved. In the presence of estradiol, the high affinity between Apt and estradiol led to the dissociation of double-stranded DNA; the increased distance between AuNCs and RuMOFNSs hindered the RET, and the decreased ECL (or FL) signals were obtained. The aptasensor demonstrates exceptional sensitivity for detecting estradiol, with FL and ECL detection limits of 97 pM and 20 fM, respectively. This innovative approach offers significant potential for endocrine-disrupting chemical determination. Graphical
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Liu Xue,Li Hang,Dai Jun-Xiang,Tian Guo-Qiang,Chen Si-Chong,Wu Gang,Wang Yu-Zhong
Poly(lactic acid) (PLA), a bio-based polymer, is considered to be a sustainable alternative to conventional petroleum-based plastics. However, owing to its widespread use and relatively slow degradation rate in water, PLA still poses potential environmental pollution risks after being discarded. The efficient chemical recycling of PLA represents an attractive approach to addressing both resource reuse and environmental pollution challenges caused by its waste. Hydrolysis is the predominant method of industrial recycling. However, because PLA is insoluble in water, efficient heterogeneous hydrolysis requires high-temperature and high-pressure conditions. In this study, an efficient homogenous hydrolysis method capable of simultaneously dissolving PLA and calcium hydroxide (Ca(OH) 2 ) was developed. Suitable solvents for this method were screened, and it was found that PLA hydrolysis using dioxane and 1,4,7,10,13-Pen-taoxacyclopentadecane as solvents achieved conversion rates of 93% and 90%, respectively, within 2 h at room temperature. Notably, the hydrolysis product, calcium lactate, precipitated as a solid from the solvent and therefore self-separated from the reaction solution. The solvent, acid/base conditions, water content, and depolymerization kinetics were investigated. Compared with previously reported hydrolysis methods, the enhanced efficiency observed in this study can be attributed to the concurrent solvation of PLA and Ca(OH) 2 , which maintains homogeneity throughout the reaction process. Additionally, this method facilitates closed-loop recycling of PLA and is compatible with the highly selective recovery of PLA from various types of PLA products.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Tong Zhou,Qingqing Chai,Man Zhang,Heping Cui,Ahmad Mohammad,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
Exogenous xylose (Xyl) could promote 2-furfural formation but inhibit pyrazines generation during its co-heating with alanine (Ala)-Xyl Amadori rearrangement product (AX-ARP). The activation energy of AX-ARP formation from Ala and Xyl was considerably lower than that of pyrazine formation from Ala and glyoxal (GO). Accordingly, the preferential interaction of exogenous Xyl with regenerated Ala triggered a continuous cycle of consumption and regeneration of Ala in AX-ARP-Xyl model. In this way, functioning as a catalyst, regenerated Ala facilitated the continuous conversion of AX-ARP into deoxyxylosones (DXs). However, exogenous Xyl accelerated the pH drop during the thermal treatment of AX-ARP, which favored the conversion of DXs into 2-furfural while limiting the transformation of their α-dicarbonyl fragments into pyrazines. Model reactions of AX-ARP-[ 13 C 5 -Xyl] further confirmed that exogenous Xyl was progressively converted into 2-furfural, while its downstream products, such as GO and methylglyoxal (MGO), did not exhibit an enhanced tendency to form pyrazines.
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TALANTA
·
2025
·
IF 6.1
Jiahui Huang,Siyi Wei,Maopu Tu,Weiqi Deng,Le Zhong,Fan Jiang,Zhixin Li,Ray P.S. Han,Xiaoyu Deng,Shaohua Xu,Yingzhou Tao
The measurement of total antioxidant capacity (TAC) is vital for evaluating the nutrient content of foods and beverages. The development of novel mimetic enzyme materials with high catalytic activity has led to the creation of highly sensitive methods for TAC assessment. In this study, we introduce a simple and efficient approach for preparing uniformly distributed Cu 2 O/Cu nanoparticles supported on graphite-phase carbon (g-C@Cu 2 O/Cu NPs). These g-C@Cu 2 O/Cu NPs demonstrate excellent peroxidase-like (POD-like) enzymatic activity and exhibit a strong binding affinity for TMB, with a K m value of 0.24 mM. A colorimetric analytical platform for TAC assessment was developed, utilizing g-C@Cu 2 O/Cu NPs, TMB, and H 2 O 2 as the chromogenic system. The method achieved a limit of detection for ascorbic acid as low as 0.15 μM, with a linear range from 0.5 to 100 μM. Furthermore, this method was successfully applied to evaluate TAC in real samples, highlighting its significant potential for food nutritional analysis.
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BIOELECTROCHEMISTRY
·
2024
·
IF 4.8
Haotian Xie,Zhaojiang Yin,Guobin Wei,Binghui Li,Hanfeng Cui,Hao Fan,Jing Zhang
This study developed a dual-mode “on-off-on” sensor based on a bipyridine ruthenium metal–organic framework (Ru-MOF) and dual enzyme cleavage technology for the sensitive detection of the K-ras gene. The sensor combines electrogenerated chemiluminescence (ECL) and fluorescence (FL) detection modes, achieving high sensitivity and specificity in detecting the K-ras gene through catalytic hairpin assembly (CHA) and dual enzyme cleavage reactions. Experimental results showed that the detection limits for the K-ras gene were 0.044 fM (ECL) and 0.16 fM (FL), demonstrating excellent selectivity and stability during detection. Through testing actual samples, the sensor has shown potential for application in complex biological environments. This method offers an efficient and reliable new tool for cancer diagnosis and treatment.
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Membranes
·
2025
·Vol. 15
·期 1
·26
·
IF 3.6
Rujing Hou,Junwei Xie,Yawei Gu,Lei Wang,Yichang Pan
Membrane technology is a promising methodology for carbon dioxide separation due to its benefit of a small carbon footprint. However, the trade-off relationship between gas permeability and selectivity is one obstacle to limiting its application. Herein, branched polyethyleneimine (BPEI) containing a rich amino group was successfully grafted on the surface of the metal–organic framework (MOF) of AIFFIVE-1-Ni (KAUST-8) through coordination between N in BPEI and open metal sites in the MOF and with the resultant maintained BET surface area and pore volume. Both the strengthened CO 2 solubility coefficients coming from the additional CO 2 adsorption sites of amino groups in BPEI and the reinforced CO 2 diffusivity coefficients originating from the fast transport channels created by KAUST-8 led to the promising CO 2 separation performance for KAUST-8@BPEI/Pebax-1074 MMM. With 5 wt.% KAUST-8@BPEI loading, the MMM showed the CO 2 permeability of 156.5 Barrer and CO 2 /N 2 selectivity of 16.1, while the KAUST-8-incorporated MMM (5 wt.% loading) only exhibited the CO 2 permeability of 86.9 Barrer and CO 2 /N 2 selectivity of 13.0. Such enhancement is superior to most of the reported Pebax-1074-based MMMs for CO 2 separation indicating a wide application for the coordination method for MOF fillers with open metal sites.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Wenjing Wang,Haobo Shi,Haoyang Huang,Hongying Liu,Chengxiang Li,Yongsheng Han
Hydrogen peroxide is a green oxidizing chemical with wide applications in industry. Its production heavily relies on the industrial anthraquinone process, which involves a large number of organic pollutants, challenging green and sustainable development. The recently developed pulsed electrochemical approach holds great potential for the green synthesis of hydrogen peroxide, but it is limited by the absence of highly efficient catalysts. Here, we report a strategy to improve the performance of Ni3S2 catalyst by tuning the content of Ni3+ species. The Ni3S2 catalyst exhibits good performance in oxygen evolution and oxygen reduction processes at the same time, leading to the formation of hydrogen peroxide. The enrichment of Ni3+ ensures the adsorption of reaction intermediates *O, *OH, and *OOH and promotes electron transfer during the reaction, thus facilitating hydrogen peroxide generation. By tuning the Ni3+ ratio in the Ni3S2 catalyst, the productivity of hydrogen peroxide was enhanced. The prepared hydrogen peroxide was used for propylene oxidation, resulting in pH-dependent products. This study highlights the significance of the design and rational synthesis of electrochemical catalysts for synthesizing hydrogen peroxide, which may be used for the electrochemical synthesis of chemicals.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-19
·
IF 15.7
Li Shaoyue,Yu Jifeng,Shen Yuting,Xiong Bing,Zhao De,Xu Weichen,Zhang Shen,Guan Xin,Liu Yunyun,Shan Xuexia,Zhu Anqi,Lyu Qi,Fang Yan,Chen Zitong,Yin Haohao,Sun Liping,Xu Huixiong
Obesity, a surging global health challenge, necessitates effective, accessible and innovative therapeutic models. Here we develop a spatiotemporally controllable microneedle (MN) drug delivery platform for sono-gene therapy to fight obesity. The platform delivers the methoxy polyethylene glycol-polyethyleneimine (mPEG-PEI) modified metal-organic frameworks (MOFs) sonosensitizer and the clustered regularly interspaced short palindromic repeats-activating (CRISPRa)/CRISPRa-uncoupling protein 1 (UCP1) system intradermally to adipocytes. Overall, this therapy platform is capable of achieving two major strategies of “annihilation” and “countermeasure”: one is to kill redundant white adipocytes by sonodynamic therapy, and the other is to promote the browning of white adipocytes through the controllable release of CRISPRa-UCP1 system and sonodynamic effect. Obese male mice treated with this sono-gene therapy shows significant ameliorate in glucose tolerance and insulin sensitivity, successfully achieves weight loss and restrains weight rebound. This study may enable a standard treatment paradigm for sono-gene therapy of obesity and other metabolic diseases.
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Small
·
2025
·
IF 12.1
Lijun Xu,Daohua Wang,Huang Ye,Hang Li,Chengshu Zhang,Qianwen Guan,Haiqing Zhong,Zhangtong Han,Junhua Luo
Organic–inorganic hybrid perovskites (OIHPs) have shown great potential for direct X-ray detection in security screening and medical diagnostics. However, their humidity stability is compromised due to the susceptibility of the structural components to water molecules, thereby limiting their practical application. In this work, stable and sensitive X-ray detection is achieved using high-quality bulk single crystals of the 3D perovskitoid (DMPZ)Pb 2 Br 6 ( DPB , DMPZ = N , N ′-dimethyl-pyrazinium), wherein N -acid protons are replaced with hydrophobic alkyl groups. Notably, the crystals maintain phase stability after 60 days of immersion in water at room temperature, demonstrating their significant potential for moisture-stable X-ray detectors. Based on the bulk crystals of DPB , the X-ray detectors are successfully fabricated, achieving a high sensitivity of 6437.2 µC Gy air −1 cm −2 at 70 V bias and a detection limit low to 46.7 nGy air s −1 , outperforming most low-dimensional perovskite detectors. Most strikingly, the detectors retain 79.6% of their initial sensitivity after 14 days of water immersion, highlighting exceptional moisture stability. This work is the first to construct moisture-stable high-performance X-ray detectors using 3D perovskitoid single crystals, advancing the development of stable X-ray detection.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Fei Guo,Lingfeng Wang,Huixin Dong,Pengyu Yan,Shishuo Wang,Qingquan Li,Shaohua Yin,Guoli Zhou,Ning Zhang,Xiao Wu,Yuandong Jia,Gaohong He,Xiaobin Jiang
High ion-selectivity and robust long-term stability are critical performance metrics for nanofiltration (NF) membranes targeting lithium extraction from high-salinity brines with impurities and high magnesium lithium ratios. Herein, a positive and negative heterostructure dual-layer NF membrane with sub-10 nanometer PA layer on 2D Zn-TCPP nanosheets through interfacial polymerization method coupled with vacuum assisted filtration was constructed. PA layer with positively charge on the top performed as the ‘shield’ that effectively retains Mg2+, while negatively charged Zn-TCPP coupled with uniform pores performed as the ‘accelerator’ to facilitate Li+ permeate. The addition of Zn-TCPP can increase the membrane free volume fraction and construct effective screening channels. An appropriate amount of Zn-TCPP nanosheets can construct PA layers as thin as 5 nm and lead to the best Li/Mg separation performance. (Water permeance of 6.79 L⋅m−2⋅h−1 bar−1 over 360 hours continuous operation when Mg/Li ratio is 50:1, and Li+/Mg2+ separation factor is 80.79). In the ternary metal ions solution tests (Li⁺, Mg²⁺, X⁺, where X = Na⁺ or K⁺ with doubled concentration), Li+/Mg2+ separation factor remains still above 40. The DFT simulations and molecular dynamics reveal The transmembrane energy barrier for Mg²⁺ significantly exceeds that for Li⁺ across the membrane. The adsorption heights of ions on Zn-TCPP in a stable state, the different ion perforation energy and ion diffusion rate furtherly explain the reason for the membrane with excellent separation performance.
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