SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Ming Wang,Xingliang Cheng,Yuling Hu,Gongke Li
Conventional meat products are susceptible to bacterial toxin contamination, posing serious risks to food safety. This study presents a portable surface-enhanced Raman scattering (SERS) platform integrated with stimuli-responsive DNA hydrogels and trimetallic nanozymes for the detection of botulinum neurotoxin type A (BoNT/A). The system employs Cu/Au/Pt trimetallic nanozymes immobilized on a steel mesh alongside DNA anchor strands that initiate hydrogel film formation. Through sequential assembly of BoNT/A aptamers and crosslinked DNA strands, a stimuli-responsive hydrogel encapsulating the nanozymes is constructed. In the presence of BoNT/A, the aptamer triggers hydrogel cleavage facilitated by exonuclease I, releasing the nanozymes to catalyze the oxidation of TMB. This reaction generates a visible colorimetric change for rapid visual screening, while the concurrently enhanced SERS signals provide the basis for highly sensitive and quantitative detection. The platform achieves an exceptionally low detection limit of 1 ng/L for BoNT/A within 45 minutes, with a linear SERS response between 5.0 and 400.0 ng/L. Successful application in real meat samples confirms its practicality as a robust, on-site tool for food safety monitoring.
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高影响因子
ACS Applied Polymer Materials
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2026
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IF 5.2
Zhenyang Yin,Yitong Jiang,Fengyu Meng,Xiaoming Qi,Jiangsheng Chen,Hongbo Dai,Chen Qian,Yaqin Fu
Flexible polyurethane foam (FPUF) suffers from high flammability and environmental concerns, necessitating sustainable fire protection strategies. This work highlights a nacre-inspired, halogen-free flame-retardant coating with a hierarchical multicomponent “brick–mortar” architecture. Ammonium polyphosphate (APP) and sodium montmorillonite (MMT) act as rigid multiscale “bricks”, while Schiff base-modified chitosan (DCS) cross-linked with gelatin (GEL) forms the adhesive “mortar”, constructing a hydrogen-bonded, organic–inorganic hybrid network with robust interfacial compatibility on FPUF. The resulting FPUF/3A@M-D/G composite demonstrates remarkable fire safety, achieving a limiting oxygen index (LOI) of 32.6% and a UL-94 V-0 rating. Cone calorimetry shows significant reductions in pHRR1 (−46.1%) and pHRR2 (−67.7%), and THR (−16.8%), along with prolonged ignition time (from 4 to 6 s) and increased char yield (from 8.2 to 26.3 wt %). Meanwhile, the coating improves compressive strength (from 7.96 to 9.32 kPa) without compromising elasticity. Mechanistic analyses (SEM, FTIR, Raman, XPS, and Py-GC/MS) reveal a dual flame-retardant action of condensed-phase char reinforcement and gas-phase radical inhibition. This scalable bioinspired strategy provides a halogen-free pathway to simultaneously improve flame retardancy and mechanical robustness of FPUF for applications in transportation, furniture, and energy systems.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Jingyi Qu,Yunbo Lei,Hao Zhang,Weixing Peng,Haotian Yu,Zunyuan Xie,Lingxiang Gao
This study demonstrates an electric-field-induced self-assembly strategy for fabricating smart iron complex-gelatin hydrogels. By applying a direct current (DC) electric field during the gelation process, gelatin/polyvinyl alcohol (PVA) interpenetrating network hydrogels containing organic iron complexes (EDTA-Fe and COS-Fe) were fabricated. The results reveal that an external electric field effectively polarizes the functional groups within the hydrogel, thereby transforming its microscopic network from a disordered state into an ordered, anisotropic structure aligned along the electric field direction. This structural ordering induces the formation of abundant heterogeneous interfaces, which significantly enhances dielectric loss via Maxwell-Wagner interfacial polarization and improves impedance matching. Consequently, the hydrogels exhibit reinforced mechanical properties and excellent microwave absorption performance. Specifically, the COS-Fe-loaded hydrogel (PGC) exhibits superior electromechanical responsiveness (Δ G = 4.13 kPa, ρ = 20%), whereas the EDTA-Fe-loaded hydrogel (PGE) demonstrates stronger tunable microwave absorption, achieving an optimal minimum reflection loss ( RL ) of −33.0 dB at 2.86 GHz under an electric field of 1.6 kV/mm.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Shuang Sun,Wen Bao,Huaqin Zhang,Xieraili Maimaitiyiming
Recent advances in flexible electronics technology have heightened demand for safe, long-life energy storage devices. This paper employs a functionally oriented and component-synergistic approach to design and prepare multifunctional hydrogel electrolytes (HEs) for constructing long-life flexible zinc-ion hybrid supercapacitors (ZHICs). The study utilized biomass gelatin as a scaffold, incorporating carboxymethyl chitosan (CMCs) and zwitterionic materials to form a physicochemical dual network. This approach constructed a multi-layered dynamic bonding network, endowing the hydrogel with self-adhesive and self-healing intelligent properties, significantly enhancing its mechanical strength and electrical conductivity. Ultimately, sodium alginate (SA) was incorporated to confer 2D printing adaptability, successfully identifying the optimal formulation composite hydrogel as the printing ink. The introduction of SA enabled the composite hydrogel to form a stable, interpenetrating network with both rigidity and toughness, exhibiting high mechanical properties (toughness is 100 MJ m −3 ), zinc plate interfacial adhesion energy is 13.96 J m −2 , alongside self-healing capabilities upon injury (10 min self-healing rate: 22.3%). Rapid ion-crosslinked HEs formed by immersing composite hydrogels in Zn 2+ solutions exhibit a conductivity of 0.34 S m −1 . The ZIHCs devices assembled from HEs have a thickness of 2 mm, operate stably under certain pressure and temperature variations, and demonstrate stable cycling characteristics exceeding 11,000 cycles. This research provides inspiration for designing flexible hydrogel electrolytes with excellent environmental adaptability.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Shumaila Ijaz,Jia Wan,Mingzhou Yuan,Meifang Yin,Jun Wu,Yongzhi Liang
In the realm of flexible electronics, eutectogels have emerged as a highly promising material, outperforming hydrogels in environmental tolerance and surpassing ionogels in biosafety and economic affordability. These attributes have positioned eutectogels as a burgeoning choice for the development of multifunctional flexible devices. However, as a relatively new material, achieving optimal mechanical and electrical properties in eutectogels through conventional preparation methods has proven challenging, primarily due to the extensive hydrogen bonding present in deep eutectic solvents. To address this challenge, we incorporated natural macromolecules, specifically gelatin and carrageenan, into a polyacrylamide matrix to create a double-network eutectogel. The addition of carrageenan significantly enhanced the mechanical properties of the gel by promoting the formation of a robust hydrogen bond network among gelatin molecules. This innovation dramatically enhanced in the gel's performance, with a tensile strength of 2.58 MPa and toughness of 17.6 MJ/m 3 , representing increases of 32.3 times and 17.9 times, respectively, compared to the gel without carrageenan. Moreover, these eutectogels achieved high electrical conductivity (2.29–3.62 mS/cm) through hydrogen bonding interactions. The critical role of carrageenan in strengthening the mechanical network highlights its potential as a key component in the development of mechanically robust, ionic-conducting, and anti-freezing high-performance wearable sensors. This work not only overcomes the limitations of existing materials but also paves the way for the next generation of wearable sensors with enhanced durability and functionality.
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PubMed
高影响因子
Nano Materials Science
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2026
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IF 20.5
Meili Xia,Yongju Gao,Jianqiang Gao,Dingxin Yin,Ruibo Tian,Wenjing Guo,Pengmin Liu,Fuqin Wu,Duxia Cao,Hao Zhang,Yang Li,Songfang Zhao,Jong-Hyun Ahn
Natural material-based conductive hydrogels are promising candidates for wearable electronics due to their excellent biocompatibility, high softness, and stable adhesion. However, it remains challenging to integrate high environmental tolerance, low interfacial impedance, high ionic conductivity, and switchable modulus and adhesion into a single platform for practical applications. Herein, we propose a material and structure concept of temperature-mediated multiple dynamic interactions and ion-electron hybrid conduction to fabricate high-performance multifunctional biogels with desired features. Skin temperature-mediated phase transition of gelatin and reversible dissociation-association of dynamic interactions allow the biogels to possess a high self-healing efficiency (95%) and reversible adhesion strength (44.96 kPa) with a switching ratio of 8.72. Ion-electron hybrid conduction facilitates the capacitive coupling process of ionic and electronic current, resulting in low interfacial impedance (56.63/29.68 k Ω at 10/100 Hz) and high electrical conductivity (ionic conductivity: 0.74 S m −1 and electronic conductivity: 0.059 S m −1 ). Benefiting from these superior properties, the multifunctional biogels demonstrate important applications in strain/pressure sensors, epidermal electrodes, and triboelectric nanogenerators. Intelligent gesture control and recognition systems are developed with the assistance of a convolutional neural network. This concept offers new opportunities for fabricating multifunctional and high-performance conductive biogels, paving the way for the development of intelligent flexible electronics.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Yanze Zhu,Yuanqing Ma,Zhihaote Yu,Peicheng Chen,Changxin Shi,Shubin Li,Weli Xu,Xiaojun Han
The bacterial infection is a major issue in the field of chronic wound healing. It is important to design a hydrogel material with good biocompatibility, water retention and antibacterial properties for the problem of bacterial infection. In this work, a dual-network antibacterial hydrogel (GSAH) with Ag+, thiolized gelatin (Gel-SH) and sodium alginate (SA) was prepared. Gel-SH formed the first network of the hydrogel through metal coordination bonds with Ag+. The metal coordination bonds between SA and Ag+ formed the second network. The compressive stress of GSAH was 660.95 KPa, and the swelling equilibrium was reached at 12 h with a swelling rate of 10.4%. The complete degradation of the hydrogel within 24 h indicated its biodegradability. The antibacterial results showed that the inhibition zones of GSAH against E. coli and S. aureus were 17.2 ± 1.6 mm and 9.5 ± 0.5 mm, respectively. GSAH holds potential for antibacterial dressing in the biomedical field.
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高影响因子
Small
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2026
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IF 11.8
Yitian Zhang,Dianji Li,Minhao Liu,Ziqing Tang,Hui Yu,Min You,Qiang Chen,Xi Ding
Highly wet, dynamic, inflammatory, and fouling environments were significant challenges in the healing of diabetic oral ulcers. Inspired by the oral mucosa, a wet-adhesion Janus hydrogel (WAJH) with asymmetric bifunctionalities of antifouling/antioxidant was proposed for diabetic oral ulcer treatment. In the WAJH, the antifouling layer was composed of the agar/polyacrylamide double-network (Agar/PAAm DN) hydrogel, and the wet-adhesive layer was constructed by the poly(acrylic acid-co-2-phenoxyethyl acrylate)/tannic acid (PAEA/TA) hydrogel. The antifouling layer mimicked the oral epithelium to prevent pollutant invasion, and the adhesive layer imitated the basement membrane of oral mucosa to adhere firmly to wet diabetic oral ulcers. Importantly, the adhesion energies of the two layers were distinctly different, measuring 15 J m −2 for the antifouling layer and 316 J m −2 for the adhesive layer, respectively. Notably, TA not only significantly enhanced the toughness and wet adhesion but also endowed the WAJH with reactive oxygen species (ROS) scavenging and antioxidant capabilities. The WAJH remarkably accelerated the healing of oral ulcer by inhibiting inflammation at the ulcer, promoting angiogenesis, and promoting re-epithelialization in vivo. Consequently, the WAJH with antifouling and antioxidant exhibited promising prospects in the clinical treatment of diabetic oral ulcer.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2026
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IF 13.8
Ben Niu,Yineng Liu,Ruiling Liu,Xiangjun Fang,Weijie Wu,Hangjun Chen,Chuan Tong,Huizhi Chen,Haiyan Gao
Fresh walnuts are highly susceptible to microbial spoilage and oxidative browning, primarily due to their elevated moisture and fat content. To address this, an active Janus film (C film), fabricated from gelatin-sodium alginate and zein, was developed. This film provides a sustainable unidirectional moisture barrier and bacteriostatic properties. The active ingredient in C film is cinnamaldehyde (CIN). CIN showed 94.8% encapsulation efficiency in tannic acid nanoemulsions (CIN-Tas). Morphological analysis revealed hydrogen bonding between CIN-Tas and gelatin without significantly altering the film structure. The developed Janus film incorporating CIN-Tas exhibited enhanced thermal stability, antioxidant capacity, and mechanical properties. Water vapor permeability (WVP) values were 4.23×10 -7 and 1.49×10 -7 gPa -1 s -1 m -1 on either side, enabling external moisture barrier and internal moisture absorption. The CIN loaded films exhibited antimicrobial activity (inhibition zones: 3.19 cm against Penicillium cynodontis , 4.77 cm against Penicillium citrinum ). CIN release followed the Korsmeyer-Peppas model, sustaining release for 180 hours. A significant preservation effect was observed in fresh walnut storage experiments using C film coating. The decay rate was decreased by 20.34%. A decrease of 9.68% in malondialdehyde (MDA) content accumulation was recorded. Additionally, the rise in acid value (AV) and peroxide value (POV) was decreased by 25.21% and 7.99%, respectively. These results indicated that this packaging technology effectively inhibits microbial growth and maintains storage humidity, prolonging walnut freshness. It offers promising potential for extending food shelf life.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Hong-Xiang Chu,Run-Ze Shao,Zhi-Wei Zhang,Yue-Han Sun,Ling-Yun Li,Yun-Ze Long,Jun Zhang
Burns and scalds heal slowly due to tissue loss at the wound site and the susceptibility to bacterial infection. Stem cell therapy can compensate for the missing cells at the wound site and promote wound healing. However, the activity of stem cells is easily affected by solvents and high-molecular-weight polymers, which limits the efficacy of stem cell therapy. Here, we developed a compact and portable in situ dual-channel composite electrospinning device. For the first time, this device allowed mesenchymal stem cells (MSCs) to be attached to the surface of polycaprolactone(PCL)/chitosan fibers. The dual-channel design prevents MSCs from contacting the spinning solution directly, thereby overcoming the negative impact of solvents on cell activity and broadening the range of solvents. This advantage is not achievable with conventional electrospinning methods that incorporate MSCs into the spinning precursor solution. The experimental results confirmed that our method combining electrospray and electrospinning enabled uniform dispersion of MSCs among the fibers, and enhanced stem cells survival, promoting their function of stem cells in the wound healing. Further experiments have confirmed that MSCs incorporation endows nanofiber dressings with antibacterial properties and promotes wound healing by inducing the secretion of epidermal growth factor. This combination of stem cell therapy and nanofibers offered a promising new approach for treating burns and scalds, suitable for both outdoor and home emergency handling.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Bo Li,Kaixuan Ma,Tao Yuan,Haoran Wu,Yiming Huo,Haojue Wang,Xiao Xu,Yang Liu,Lei Yang,Kai Chen
Repairing spinal cord injury (SCI) remains hindered by two major unmet challenges: the inability to precisely reconstruct irregular lesion cavities, where tissue contraction and collapse disrupt anatomical continuity, and the lack of effective platforms for stable and localized delivery of fragile therapeutics such as exosomes, whose rapid clearance severely limits efficacy. Addressing these bottlenecks requires biomaterials that can simultaneously rebuild three-dimensional structure and orchestrate a pro-regenerative microenvironment. Here, we present a morphology-adaptive injectable microporous annealed particle scaffold (MS) for localized and long-term release of human umbilical cord MSC-derived exosomes (hucMSC-Exo). GelMA/SFMA microspheres were fabricated via solvent-free microfluidic electrospraying combined with liquid nitrogen-assisted cryo-processing, preserving exosome bioactivity. This “disassemble-and-reassemble” approach enables minimally invasive injection of microspheres into irregular lesion cavities, followed by body temperature-induced annealing and in situ photocuring to form a mechanically stable, interconnected three-dimensional scaffold, which supports cell infiltration, nutrient diffusion, and sustained exosome release. In vivo , MS@Exo suppressed inflammation and scar formation, enhanced angiogenesis, and promoted neuronal survival, axonal regeneration, and myelination, ultimately achieving superior functional recovery over MS or Exo alone, demonstrating a clear synergistic effect. Transcriptomic profiling further revealed that MS@Exo reprogrammed gene expression by downregulating extracellular matrix- and collagen-related pathways while upregulating neuronal, synaptic, and ion channel signaling networks, thereby shifting the repair process from an inflammatory-proliferative phase toward a differentiation-remodeling phase. Collectively, MS@Exo acts as an intelligent multifunctional scaffold that couples advanced fabrication with exosome-based therapy to overcome fundamental limitations in SCI repair, offering a broadly applicable strategy for reconstructing irregular tissue defects in regenerative medicine.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Guoqiang Ren,Jingyun Ma,Qiuyue Peng,Pengfei Liu,Xiaobo Wang,Da Li,Yuesheng Zhang,Chaonan He,Chen Huang,Honghua Ye,Yavuz Nuri Ertas,Qingbo Xu,Jiangfang Lian,Mingming Hao
Chronic wounds of diabetes present critical challenges with impaired healing, high infection risk, and poor compatibility of conventional dressings. Effective management requires dressings integrating tissue-matched mechanics, antioxidative/anti-inflammatory activity, and bioelectronic functionalities. Herein, we report a mechanoadaptive and conductive hydrogel (denoted as GPGQ) composed of gelatin, polyvinyl alcohol (PVA), grape seed extract (GSE), and quaternary ammonium chitosan (QAC). GPGQ exhibits state-dependent mechanoadaptability via enhanced hydrogen bonding: in the hydrated state, it shows a tensile strength of 0.10 MPa and compressive strength of 0.20 MPa (matching soft tissue mechanics); upon dehydration, strengths increase to 0.25 MPa and 2.3 MPa (resisting external pressure); rehydration restores >90% flexibility, ensuring long-term adaptability to tissue microenvironments. Its adhesion to porcine skin reaches 60 kPa, facilitating stable contact between the dressing and tissue. GPGQ's 3D porous network (20–80 μm) facilitates cell integration, electrolyte transport, and low-impedance conduction. Electrochemical impedance confirms low skin-electrode impedance (<10 3 Ω, 0.1 Hz–100 kHz), while signal tests validate stable sEMG acquisition and resolve 0–300 Hz bands. Biologically, GPGQ promotes fibroblast migration, angiogenesis, and collagen deposition. Grape seed proanthocyanidins suppress IL-1β, IL-6, and TNF-α, elevate IL-10 and TGF-β, and scavenge DPPH radicals and reactive oxygen species (ROS), while stabilizing the glutathione (GSH)/glutathione disulfide (GSSG) ratio. In vivo studies demonstrate that GPGQ accelerates diabetic wound closure through synergistic mechanical support and biochemical modulation. These findings suggest that GPGQ holds promise as a multifunctional dressing for managing chronic wounds associated with diabetes, integrating mechanical adaptability, bioelectronic compatibility, and pro-healing bioactivity.
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高影响因子
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