JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 13
·136513
·
IF 3.721
Nannan Dou,Jianying Qu
Herein, a hybrid nanomaterial of copper-nickel bimetal and reduced graphene (rGO) was simply and quickly synthesized by hydrothermal method, which was characterized by transmission electron microscope, field emission scanning electron microscopy, fourier transform infrared spectroscopy, electrochemical impedance and X-ray diffractometry. A new type of electrochemical sensor was constructed by fixing this hybrid on the glassy carbon electrode (GCE). Square wave voltammetry and cyclic voltammetry indicate that this Cu-Ni/rGO/GCE sensor has highly sensitive electrocatalytic activities to 4-aminophenol (4-AP) and acetaminophen (AC). The linear detection ranges were 0.10∼50.00 μM for AC and 0.10∼30.00 μM for 4-AP, with the detection limits of 2.13 nM for AC and 2.19 nM for 4-AP, respectively. The Cu-Ni/rGO/GCE was successfully used for the determination of 4-AP and AC simultaneously of paracetamol tablets, and satisfactory results were obtained.
研究领域:
材料科学
·
分析化学
·
生物医学
✓ 已验证
DOI
高影响因子
Drug Design Development and Therapy
·
2017
·
IF 2.822
Jingrun Chen,Junjie Liu,Dongxiao Cui,Chaoqun Yan,Liqiang Meng,Liqian Sun,Shurong Ban,Rui Ge,Taigang Liang,Qingshan Li
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis. All the derivatives were subjected to in vitro cytotoxicity screening against HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), and LS174T (human colon carcinoma), by using the MTT assay. The results revealed that several of the 4-methoxy-substituted compounds exhibited potent cytotoxicity. Among these, compound 12e showed the highest activity against cancer cells which 50% inhibitory concentration (IC50) values were in the range of 6.1–9.2 μM with low toxicity on normal human hepatocyte. Preliminary investigation of possible mechanisms of action of compound 12e against HEPG-2 cells indicated possible induction of apoptosis, as determined by morphological observations and Annexin V/propidium iodide (PI) double staining, in addition to apparent dissipation of mitochondrial membrane potential (MMP), as measured by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1) staining in combination with the activation of caspase-9 and caspase-3 by Western blot analysis. Overall, the data suggest that compound 12e may be a promising potential anti-cancer agent that could act primarily by inducing apoptosis through the mitochondria-mediated intrinsic pathway in human hepatoma cells.
研究领域:
药理学
·
肿瘤学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2020
·
IF 4.006
Qian Wu,Kuoquan Zhao,Yuanyuan Chen,Jinsong Xiao,Mengzhou Zhou,Dongshen Li,Nianjie Feng,Chao Wang
In this study, a glucose-lysine (G-L) model was selected to simulate the dietary system (cooking of alcohol-cured steak) to study the effect of alcohol concentration on the formation of advanced glycosylation products (AGEs) in Maillard reaction . It was first reported that higher alcohol concentrations accelerated the formation of AGEs as well as their intermediates glyoxal (GO) and methylglyoxal (MGO). The contents of GO and MGO increased from 11.74 ± 2.55 to 50.18 ± 0.16 μg/mL and 19.04 ± 1.25 to 58.51 ± 2.56 μg/mL with increasing ethanol concentration, respectively. High-alcohol samples produced higher levels of Nε-(carboxymethyl) lysine (CML) and Nɛ-carboxyethyl lysine (CEL) detected by U-HPLC-MS/MS. The capacity of catechin to inhibit the formation of AGEs and intermediates were significantly related to the concentration of ethanol, which may be due to ethanol accelerated catechin degradation and weakened the ability of catechin to trap GO and MGO. Our study strongly suggests that although we cannot completely avoid the AGEs produced by the Maillard reaction , in daily life, we try to avoid adding alcohol, especially high-concentration alcohol, when cooking and processing ingredients.
研究领域:
食品科学
·
化学
·
营养学
✓ 已验证
DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2022
·Vol. 64
·期 5
·688-698
·
IF 1.023
Wentao Zhang,Liu Yonggang,Liu Zhaogang,Li Shuai,Hao Wei,Hu Yanhong,Wu Jinxiu
Abstract Novel rubber antioxidants, cysteine lanthanum and cysteine cerium, were applied in natural rubber composites. The anti-aging behavior of the composites with rare-earth complexes was systematically investigated via mechanical properties retention after aging, Fourier transform infrared spectroscopy-attenuated total reflection, thermo-oxidative stability and thermo-oxidative degradation kinetics. The results showed that rare-earth complexes could improve the mechanical properties of composites, decrease the formation of thermo-oxidative products and increase activation energy of the thermo-oxidative degradation. Compared with commercial antioxidant N -isopropyl- N '-phenyl- p -phenylenediamine, the vulcanizates with cysteine lanthanum performed better resistance to thermal oxidation aging. The outstanding anti-aging behavior of rare-earth complexes was attributed to not only the anti-oxidative effect between amino and sulfhydryl groups, but the trapping effect of rare-earth ions on free radicals.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 2
·1-12
·
IF 5.7
Niu Xiaohui,Yan Simeng,Zhao Rui,Han Sha,Cao Kunjie,Li Hongxia,Wang Kunjie
Chirality plays a key role in many fields of natural sciences as well as life sciences. Chiral materials are widely developed and used for electrochemical chiral recognition. In recent years, carbon quantum dots (CQDs) have been widely used as a novel carbon nanomaterial due to their excellent charge transfer properties, good biocompatibility, and low cost. The special structure of π-conjugated porphyrin attracts attention. Supramolecular self-assembly shows a way to construct chiral materials by self-assembling simple molecules into chiral composites. Herein, we demonstrate the self-assembly of achiral porphyrins induced by chiral carbon quantum dots assembled from L- and or D-tryptophan (L- and or D-Trp) with carbon quantum dots, resulting in 5,10,15,20-tetrakis (4-carboxyPheyl) (TCPP) self-assembled structure. The electrochemical chiral recognition of chiral self-assembled materials was studied using Phenylalanine (Phe) enantiomer as a chiral analyte. Electrochemical chiral recognition results showed that the chiral self-assembled materials induced by chiral templates have a good ability to discriminate Phe enantiomers. Therefore, this research provides a new idea for the synthesis of chiral composites and further expands applications to electrochemical chiral recognition. Graphical
研究领域:
材料科学
·
电化学
·
纳米技术
·
超分子化学
·
手性传感
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2011
·Vol. 175
·期 1
·39-46
·
IF 2.578
Yin Huanshun,Shang Kun,Meng Xiaomeng,Ai Shiyun
A differential pulse voltammetric method was developed for the simultaneous determination of paracetamol, 4-aminophenol and dopamine at pH 7.0 using a glassy carbon electrode (GCE) coated with gold nanoparticles (AuNPs) and a layered double hydroxide sodium modified with dodecyl sulfate (SDS-LDH). The modified electrode displays excellent redox activity towards paracetamol, and the redox current is increased (and the corresponding over-potential decreased) compared to those of the bare GCE, the AuNPs-modified GCE, and the SDS-LDH-modified GCE. The modified electrode enables the determination of paracetamol in the concentration range from 0.5 to 400 μM, with a detection limit of 0.13 μM (at an S/N of 3). The sensor was successfully applied to the stimultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively, in pharmaceutical tablets and in spiked human serum samples.
1. Gold nanoparticles and organophillic layered double hydroxide modified glassy carbon electrode was fabricated. 2. The modified electrode displayed excellent redox activity towards paracetamol. 3. This electrode was successfully applied to the simultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively
研究领域:
分析化学
·
生物传感器
·
药物分析
·
电化学检测
✓ 已验证
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 22
·3977
·
IF 4.329
Chenglong Wang,Luyang Qiao,Qiang Zhai,Kai Yan,Lili Wang,Jinhuan Zheng
Herein, a polyurethane acrylate-based TiO2(PU-TiO2) was fabricated using a two-step method. First, a polyurethane prepolymer was prepared. Second, PU-TiO2was prepared using amino-modified TiO2(A-TiO2). The best synthesis process of the polyurethane prepolymer was when the reaction temperature was 80 °C, the reaction time was 3 h and theR-value of the polyurethane acrylate was 2. Next, the influence of the A-TiO2content on the structure and performance of PU-TiO2was examined. The analysis of the rheological properties of the PU-TiO2ink indicated that its viscosity gradually increased as the A-TiO2content increased. The tensile performance of film improved because of the presence of A-TiO2. The photo-polymerisation and photo-rheological performance indicated that the PU-TiO2structure changed from a hyperbranched structure with TiO2as the core to a segmented structure, as the A-TiO2content was 3%.Keywords:polyurethane acrylate-based TiO2;polyurethane prepolymer;A-TiO2;hyperbranched structures;blue light-curable ink
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2016
·Vol. 74
·期 7
·2719-2739
·
IF 1.371
Fan Xinjian,Zhang Zhiying,Yue Shujing,Xiao Changfa
A series of novel covalently linked waterborne polyurethane/3-aminopropyltriethoxysilane/multiwalled carbon nanotube (WPU/Si/MWCNT) nanocomposites were synthesized through an optimized copolycondensation of hydroxyls. A multiwalled carbon nanotube (MWCNT) as the inorganic filler was pretreated with a successive two-step modification route for its surface function with hydroxyl groups. 3-Aminopropyltriethoxysilane (APTES) was embedded into the backbone of the WPU molecules, hydrolysis of which generates silanol groups in the polyurethane (PU) matrix at the emulsification stage. Meanwhile, the silanol groups could condense with the hydroxyl groups on the surface of the modified MWCNT, generating the covalent bond between the modified MWCNT and the APTES-embedded PU matrix. The change of surface composition of the MWCNT during surface modification process was characterized by using both Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The transmission electron microscope (TEM) was utilized to image morphology of the modified MWCNT. The field emulsion scanning electron microscopy (SEM) micrographs and particle size distribution curves showed that the modified MWCNT was well dispersed in the PU matrix. The thermal stability, water resistance, mechanical properties and dynamic mechanical thermal behaviors of the WPU/Si/MWCNT films were characterized by thermogravimetric analysis, swelling test, tensile test, and dynamic mechanical thermal analysis, respectively. These results revealed that compared to the pristine WPU, the WPU/Si/MWCNT system with APTES and the modified MWCNT possesses outstanding water resistance, high thermal stability and excellent mechanical properties.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Yuman Zhang,Yao Yu,Qi Wang,Wenjun Shi,Hanying Hu,Danqing Hou,Zhi Li
Non-alcoholic fatty liver disease (NAFLD) was a pathological syndrome characterized by excessive lipid deposition in the liver. Excessive lipid in the liver produced reactive oxygen species (ROS), the occurrence of oxidative stress and lipid peroxidation was accelerated, which aggravated liver function damage. Based on these, resveratrol, a natural antioxidan, was encapsulated in liposoluble interior by amphiphilic phosphatidylserine, and then self-assembled with chitosan oligosaccharide complexed with zinc ions to form Zn-Cos/Res@Ps nanoparticles. The size of the Zn-Cos/Res@Ps was about 168.57 ± 4.35 nm, and the zeta potential was about 17.45 ± 1.79 mV. Furthermore, Zn-Cos/Res@Ps could significantly inhibition of lipid deposition, decreased the contents of reactive oxygen species (ROS) and synergistically decreased the levels of malondialdehyde (MDA) in HepG2 cells. Zn-Cos/Res@Ps could also reduce the content of serum total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), improved the liver injury and reduced the degree of liver fibrosis in mice. The Zn-Cos/Res@Ps group showed better results than the single-drug nanoparticle group. In conclusion, Zn-Cos/Res@Ps nanoparticles could effectively alleviate the disease progression by inhibiting oxidative stress and lipid peroxidation, promoted fatty acid catabolism, and effectively reverse and prevent the progress of nonalcoholic steatohepatitis.
研究领域:
纳米技术
·
药理学
·
肝病学
·
分子生物学
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2015
·
IF 1.173
Ben Zhang,Juan Li,Xiaogai Lv,Yuanchen Cui,Ying Xu
Polyaspartic acid/2-amino-2-methyl-1,3-propanediol graft copolymer, a novel non-phosphorus scale and corrosion inhibitor, was synthesized and characterized by infrared spectroscopy. Its performance was evaluated by static scale inhibition method and dynamic corrosion testing. It was found that the graft copolymer showed excellent inhibition ability against CaCO3, CaSO4, and Ca3(PO4)2 scales and a definite inhibition corrosion performance as well. The inhibition efficiency was close to 99.9% against CaCO3, CaSO4, and Ca3(PO4)2 when the inhibitor was at an appropriate concentration. The inhibitor had still possessed higher antiscale efficiency against CaCO3 with increasing concentration of Ca2+ and heating time. In addition, The graft copolymer could change the structure of crystals CaCO3, CaSO4, and Ca3(PO4)2 by observation of scanning electron microscopy.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CEREAL SCIENCE
·
2022
·
IF 4.075
Yan Du,Zhengxing Chen,Feng Liang,Wenju Zhou,Tingyu Li,Zhaoxin Tu,Youjin Tan,Juan Li
The aim of this study was to explore the impact of hypoxia stress germination on qualities of highland barley (HB). The main functional components, physicochemical properties, and cooking qualities of HB were investigated after hypoxia stress germination. Results showed that γ-aminobutyric acid, total phenols, total flavonoids , essential amino acids , and fragrance components of HB were significantly increased ( P < 0.05) after germination. The relative crystallinity, pasting viscosity, breakdown, setback and enthalpy of hypoxia stress germinated highland barley was decreased as compared to ungerminated HB. However, gelatinization temperature, onset temperature, peak temperature and conclusion temperature of HB increased after germination. The micro-cracks presented on the surface of kernel might be the main reason for improvement of cooking characteristics of HB. To conclude, hypoxia stress germination improved the functional nutrients, physicochemical properties, texture, flavor and taste of HB, which might be an effective method to improve the cooking and edible quality of whole grains .
研究领域:
食品科学
·
植物生理学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Boyin Yan,Songxue Wang,Zhiquan Liu,Da Wang,Wenxin Shi,Fuyi Cui
In this work, the UV 254 /H 2 O 2 process was utilized to remove β-N-methylamino- l -alanine (BMAA), a kind of cyanobacteria neurotoxin, and the influence of reaction parameters and environmental factors on the degradation of BMAA has been systematically investigated. The results showed that BMAA could be effectively removed in the UV 254 /H 2 O 2 system compared to UV or H 2 O 2 alone and OH was confirmed as the main ROS to degrade BMAA. The degradation rate of BMAA increased first and then decreased with the increase of pH and the maximum k obs was 0.1545 min −1 obtained at pH 9. The removal of BMAA in the UV 254 /H 2 O 2 system was inhibited in actual water, while the degradation rate of BMAA in actual water could still exceed 90% by appropriately extending the reaction time. The decrease in the degradation efficiency of BMAA in actual water was primarily due to the ultraviolet light absorption and competition effects of NOM, and anions (Cl − and HCO 3 − ) would also inhibit the degradation of BMAA. Five by-products ([M − H] - = 118, 103, 88, 87 and 59) were identified in this study and the degradation pathways of BMAA were proposed. The production of by-products was attributed to the fracture of the C–N bond and hydroxylation reaction. This study is worthwhile to deepen the understanding of the degradation mechanism of BMAA in the UV 254 /H 2 O 2 system.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）