FOOD CHEMISTRY
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2026
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IF 10.4
Jingbin Shi,Hongyuan Guo,Hao Wu,Xuedong Jia,Runying Chai,Yujue Feng,Suozhu Wu
Norfloxacin (NOR) is a fluoroquinolone antibiotic, and its long-term intake poses serious threats to human health. Therefore, sensitive determination of NOR is of great significance. This work develops a molecularly imprinted electrochemical sensor (MIES) for detecting NOR based on molecularly imprinted polypyrrole/carboxylated multi-walled carbon nanotubes-chitosan/glassy carbon electrode (MIP/cMWCNT-CS/GCE). The cMWCNT-CS serves as a conductive layer for signal amplification, while MIP acts as the recognition element for specific identification of NOR. NOR is indirectly detected by the reduction peak current of potassium ferricyanide probe . This MIES exhibits an ultra-wide linear range (1.00 × 10 −13 –1.00 × 10 −5 M) and an ultra-low detection limit (1.78 × 10 −14 M) with rapid response (adsorption time 4 min), high selectivity, and excellent reproducibility. Furthermore, the MIES is successfully applied to determine NOR in honey, milk, and tap water samples with satisfactory recoveries (87.30% ∼ 121.00%). This work provides a promising analytical avenue for rapid and ultrasensitive monitoring of NOR in food and environmental samples.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
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IF 5.6
Chengsi Li,Jing Li,Chengyingjie Yang,Zhenghao Zhu,Yachen Zhang,Yin Xiang
Chronic kidney disease (CKD) is a condition characterized by progressive loss of kidney function. Vascular calcification is not only a common late-stage complication of CKD but also serves as an independent predictor of cardiovascular events and mortality in CKD patients. This study investigates the mechanism by which vericiguat (VER), a soluble guanylyl cyclase (sGC) sensitizer, attenuates CKD-associated vascular calcification. The hypothesis that vericiguat alleviates the decrease of sGC activity mediated by calcium and phosphorus metabolism was verified in both in vitro and in vivo experimental models. The calcium levels were increased in the aorta of CKD rats and VSMCs in vitro, and the expression of osteogenic differentiation-related markers, eNOS and PKG was upregulated. Nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) levels were downregulated, while VER significantly improved calcification by activating the NO/cGMP/PKG pathway. Meanwhile, L-NAME antagonized the positive effects of VER in either CKD rats or calcified VSMCs.
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Nature Communications
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2026
·Vol. 17
·期 1
·1909
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IF 15.7
Yang Bin,Li Deyang,Deng Renren,Zhao Jian,Wang Yubin,Xu Shiqing,Lei Lei
Persistent luminescence materials are promising for night-vision displays, background-free medical diagnostics, and high-resolution radiography, yet achieving efficient violet, yellow, and red emission within a single robust and scalable host remains a longstanding challenging. Here, we overcame this limitation by constructing Gd 3+ -mediated cluster traps within alkaline-earth fluorochlorides to minimize energy loss during electron migration. These clusters serve as both intrinsic emitters and efficient energy transfer platforms for various activators, including Eu 2+ , Sm 2+ , Tb 3+ , and Mn 2+ , enabling bright and spectrally tunable multicolor persistent luminescence upon X-ray irradiation. The persistent luminescence intensity of Eu 2+ is enhanced by up to 32.7-fold upon Gd 3+ codoping. Moreover, violet persistent luminescence from Eu 2+ is employed to excite perovskite quantum dots for full-color time-domain dynamic displays, while Sm 2+ emission facilitates low-dose, high-resolution delayed X-ray imaging. These findings establish a generalizable strategy for designing efficient multicolor persistent materials for advanced multifunctional optical technologies.
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DESALINATION
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2026
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IF 9.9
Narendra Basel,Jianquan Luo,Guozhu Wang,Yinhua Wan
Oilfield-produced water (OFPW), a major byproduct of hydrocarbon extraction, is highly saline and contains elevated concentrations of divalent ions, such as calcium (Ca 2+ ), posing significant challenges for its treatment, transportation, and reuse. Nanofiltration (NF) membranes offer an energy-efficient solution for OFPW treatment by selectively rejecting multivalent ions while allowing monovalent ion transport; however, conventional NF membranes often suffer from limited Ca 2+ rejection and severe fouling. In this study, a polyamide NF membrane with an engineered spatial charge distribution was fabricated via mixed-monomer interfacial polymerization using piperazine and polyethyleneimine, assisted by a dodecyl phosphate (DDP) surfactant. The resulting membrane features a negatively charged front surface and a positively charged rear surface, forming a dual-charged configuration. This structure integrates Donnan repulsion from the positive sublayer and size-sieving effects, leading to enhanced ion selectivity and antifouling performance. Compared with commercial NF270 and DL membranes, the fabricated membrane achieved significantly higher Ca 2+ rejection (98.95%) and Na + /Ca 2+ selectivity (21.44), while maintaining competitive water permeability and reduced fouling during treatment of both simulated and real OFPW. These results demonstrate that tailoring spatial charge distribution in NF membranes is an effective strategy for improving ion selectivity and fouling resistance in high-salinity water treatment applications.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Shanshan Tao,Ruijia Hu,Xinyi Zhang,Chang Liu,Suqin Wang,Hongbo Li,Ruqin Yu
The residues of organophosphorus pesticides (OPs) in the environment and crops, resulting from irrational use will cause irreversible damage to the human nervous system by hindering acetylcholinesterase (AChE) activities. This study developed a novel proportional fluorescence sensing system based on UiO-66-NH 2 coated MnO 2 and Ampliflu Red (AR). In this sensor system, manganese dioxide nanosheets have both fluorescence quenching and catalytic functions. Based on the core mechanism of selective decomposition by reducing agents, it can respond to various OPs and enable multi-target detection of reducing biomolecules such as glutathione (GSH), cysteine (Cys), and ascorbic acid (AA). By means of principal component analysis (PCA), the sensor can effectively distinguish among GSH, Cys, and AA, achieving specific recognition of multiple targets. Under optimal conditions, the detection linear range for parathion is 1×10 -6 to 9×10 -1 mg/mL, with a detection limit as low as 0.33×10 -6 mg/mL; The linear ranges for GSH, Cys, and AA detection are 1–100 μM, 30–90 μM, and 1–50 μM, respectively, with detection limits of 0.33 μM, 10 μM, and 0.33 μM, respectively. This method exhibits high accuracy, facile operation, and favorable stability. It has been successfully implemented for the detection of tap water and 1% human serum samples. This makes the research findings more intuitive and clear. In addition, this research provides a feasible approach for developing diversified sensors based on functionalized metal-organic frameworks (MOFs), demonstrating strong potential for applications in environmental monitoring and bioanalysis.
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Food Bioscience
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2026
·
IF 6.2
Haoyu Liu,Yuxin Wang,Yan Li,Xiaoyan Liu,Pan Yue,Xiaodong Li,Lu Liu
s: Calcium is essential for bone health, but its bioavailability is limited by its poor solubility in the intestinal environment. To overcome these challenges, this study developed a novel calcium delivery system through the self-assembly of lactoferrin and casein phosphopeptides, followed by chelation with calcium to form an LF-CPP-Ca ternary complex. The product was characterized using intrinsic fluorescence spectroscopy, Fourier transform infrared spectroscopy, and Zeta potential techniques. Results demonstrated that LF and CPP form complexes through hydrogen bonding and electrostatic interactions, inducing conformational changes in LF. The incorporation of calcium ions further drove the formation of the ternary chelate, resulting in reduced particle size, homogeneous distribution, and enhanced structural stability. In vitro simulated digestion experiments demonstrated that LF-CPP-Ca showed significantly lower calcium release rate (89.43%) during the intestinal phase compared to CPP-Ca (97.91%), demonstrating its superior capability to deliver calcium to absorption sites. In the Caco-2 cell model, LF-CPP-Ca demonstrated exceptional calcium transport efficiency. Particularly in the presence of oxalic acid and phytic acid, the reduction in calcium absorption rate of LF-CPP-Ca (PA: 32.99%; OA: 38.36%) was much lower than that of CaCl 2 (PA: 45.71%; OA: 57.33%) and CPP-Ca (PA: 41.65%; OA: 45.43%), demonstrating excellent anti-interference capacity. This work establishes a new paradigm for designing mineral delivery systems based on protein-peptide co-assembly and multi-ligand chelation.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Yumo Zhao,Hao Lu,Huachen Liu,Yuanhao Wang,Ziye Ling
Ionic liquids (ILs) are attractive CO₂ capture media but their deployment is constrained by high viscosity, slow gas–liquid mass transfer and solvent-handling issues. Here, we show that these limitations can be substantially relaxed by architecting the IL phase inside sodium alginate microcapsules using an all-aqueous Ca 2+ crosslinking and freeze-drying route. A simple dripping process produces SA–IL capsules with compact shells, whereas introducing a controlled emulsification step generates ESA–IL capsules with hierarchically porous shells and percolated transport channels, without resorting to microfluidic hardware or sacrificial templates. Structural and thermal analyses confirm that [BMIM][BF₄] is physically confined in amorphous alginate networks and that emulsification/freeze-drying reshapes the shell into a mechanically robust, multi-scale porous framework.Under high-pressure CO₂, ESA–IL reaches a capacity of 60.99 cm 3 (STP) g −1 at 298 K and 50 bar on a dried-capsule mass basis, exceeding the dense-shell SA–IL and the neat [BMIM][BF₄] tested under the same protocol. For solvent-level comparison, the corresponding IL-normalized capacities (per gram of [BMIM][BF₄]) are reported in parallel. This improvement is consistent with the process-generated porous shell increasing accessibility and thereby promoting more effective utilization of the confined IL.Isosteric heats derived from 298/323 K isotherms fall in the range of 12–18 kJ mol −1 for both microcapsule types, indicating physisorptive interactions; ESA–IL shows modestly higher values at intermediate and high loadings, consistent with strengthened IL/alginate microenvironments rather than a change in adsorption mechanism. ESA–IL also displays pronounced CO₂/N₂ discrimination, with CO₂ uptakes exceeding N₂ by more than an order of magnitude at elevated pressures, and retains over 98% of its initial capacity after 20 pressure-swing cycles at 298 K. These results indicate that a low-cost emulsification–crosslinking–drying route can produce hierarchically structured IL microcapsules with enhanced CO₂ uptake in the encapsulated format, rapid uptake–release kinetics, and favourable CO₂/N₂ separation-related characteristics, while maintaining good regenerability—thereby offering a practical and scalable platform for CO₂ capture from N₂-rich flue gases.
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SEPARATION SCIENCE AND TECHNOLOGY
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2026
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IF 2.3
Wenqiang Wang,Fang Wang,Zhen Jia,Chunhui Li,Aili Wang,Shubo Shang
Water pollution from phosphonates is receiving increasing attention and adsorption is a promising treatment method. In this work, CaLa – layered double hydroxide (CaLa – LDH) was used to adsorb phosphonates (1-hydroxyethane-1,1-diphosphonic acid, HEDP) from water, demonstrating an excellent theoretical maximum adsorption capacity of 89.41 mg-P/g at pH 3.0. The pseudo-second-order kinetic model accurately describes the adsorption process of CaLa – LDH for HEDP, implying that the adsorption process was governed by chemisorption. The heterogeneous adsorption of the CaLa – LDH was confirmed by the Sipes model. Among co-existing ions (SO42−, Cl−, NO3−, CO32−, PO43−, Ca2+, and Mg2+), CO32− and PO43− hindered adsorption. Characterization analysis showed that the adsorption mechanisms may involve electrostatic attraction, chemisorption, ion exchange, and complexation. Additionally, the CaLa – LDH adsorbent can be reused up to four times, with adsorption capacity recovering to over 90%. During the fifth cycle, adsorption capacity decreased to 41%. The CaLa – LDH was applied to remove phosphorus from the actual leachate concentrate, with satisfactory results confirming its potential for actual wastewater treatment.
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Small
·
2026
·
IF 11.8
Zhiwei Liu,Guoheng Xu,Binbo Li,Yaohui Gu,Yuhui Hu,Fangfang Xu,Bo Wang,Zhengguo Hu,Jinglai Duan
Nanofluidic ionic memristors have garnered considerable attention for their operational principles that emulate biological synapses, positioning them as promising candidates for neuromorphic systems. However, simultaneously achieving non-volatility and function-tunability in ionic memristors remains a significant challenge. Here, we demonstrate the successful emulation of key neuromorphic functions, including neural activation and synaptic plasticity, using a nanofluidic memristor integrated with sub-nanometer (sub-nm) channels within ion-track membranes. Unlike unipolar resistive switching, which is predominantly driven by concentration polarization in symmetric ion solution system, we demonstrate a reversible transport switching mechanism, triggered by multivalent ions (e.g., Ca 2+ and La 3+ ), that toggles between fast and slow modes. This mechanism induces a transition to bipolar resistive switching, significantly enhancing the device's non-volatility while preserving its reversibility. Furthermore, the memristive response can be effectively tuned by varying the doping concentration and external voltage. These findings provide new insights and design strategies for developing tunable bio-synapse emulation platforms operating in ionic aqueous media.
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Advanced Science
·
2026
·
IF 14.1
Manxuan Liu,Zhongcheng Li,Qian Ren,Ziqian Lu,Yubing Zhang,Yili Guo,Ruomeng Li,Die Hu,Linglin Zhang
The chronic and refractory infected wounds of diabetes are primarily attributed to the persistent bacterial infection and the inhibition of wound healing caused by hypoxia. Hydrogel with intelligent drug delivery systems hold significant potential in the treatment of diabetic wounds. Herein, we have developed an glucose-responsive intelligent hydrogel named as CF-CPGaMPN, which incorporates polyvinylpyrrolidone-coated calcium peroxide (PVP@CaO 2 ) nanoparticles, catalase, and gallium-polyphenol (GaMPN) nanoparticles. The borate ester bonds in the CF-CPGaMPN hydrogel break under high glucose conditions, releasing GaMPN nanoparticles, thereby achieving glucose-triggered on-demand drug release. The CF-CPGaMPN hydrogel not only inhibits various microorganisms but also continuously releases oxygen, thereby promoting the healing of diabetic infection wounds. Furthermore, the multicellular ecosystem surrounding the CF-CPGaMPN hydrogel is also explored, and the diverse cellular heterogeneity is analyzed by single-cell RNA sequencing, highlighting the critical roles of Neutrophils, Fibroblasts, and Epidermal cells in diabetic infected wound. In addition, CF-CPGaMPN hydrogel inhibits the Neutrophil extracellular trap (NET) formation and alleviates the cellular hypoxic environment to improve diabetic wound healing. In conclusion, the CF-CPGaMPN hydrogel not only provides a promising drug release strategy for the healing of diabetic infected wounds, but also contributes to the rational design of customized hydrogels for biomedical use targeting different cellular functions.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Lisha Gong,Jiming He,Zhijuan Li,Jinru Liu,Xinquan Yang,Rong Yin,Jing Xie,Bitao Lu,Kun Yu,Fei Lu,Guangqian Lan,Enling Allen Hu,Xiangjun Wang,Ruiqi Xie,Dahua Shou,Wentao Lin,Shengsheng Pan
The management of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is severely hampered by the inability of existing therapies to achieve conformal fitting and sustained drug release within the dynamic, moist vaginal environment. Herein, we report a novel Janus-structured microneedle (MN) system engineered from a poly(vinyl alcohol)/silk fibroin (PVA/SF) hybrid that overcomes these critical limitations through intelligent, hydration-triggered shape adaptation. A facile one-pot process induces spontaneous spatial segregation, forming an asymmetric bilayer architecture with a PVA-rich upper layer and an SF-enriched lower layer. This unique structure enables the device to be pre-programmed into a compact coil for minimally invasive insertion, which subsequently unfurls upon vaginal moisture exposure to achieve conformal contact with irregular wound surfaces. Crucially, we decipher the shape memory mechanism through 2D correlation spectroscopy and molecular dynamics simulations. These analyses reveal a sequential disruption of hydrogen bonds, while hydrophobic interactions from SF β-sheets provide exceptional mechanical stability in the hydrated state. In a rat model of severe vaginal injury, the arbutin-loaded MN (ARMN) scaffold orchestrates a holistic healing process—effectively scavenging ROS, suppressing IL-6-mediated inflammation, promoting VEGF-driven angiogenesis and PCNA-enhanced proliferation, and mitigating surgery-induced dysbiosis. This work establishes a pioneering paradigm of stimuli-responsive, self-adapting medical devices for transformative therapy in complex mucosal tissue regeneration.
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POLYMER ENGINEERING AND SCIENCE
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2026
·
IF 3.6
Yuxin Luo,Wenyi Yang,Zhanpeng Xie,Hang Zheng,Wanfen Pu,Feng Jiang
The viscosity and elasticity of water-soluble polymers are critical in the petroleum industry, particularly under high-temperature and high-salinity conditions. In this study, a multi-armed hydrazide-POSS (HPOSS) and a carbonyl-functionalized hydrophobic association polymer (CFHAP) were developed to create dual networks (CFHAP/HPOSS). Unlike conventional binary cross-linkers, HPOSS promoted the formation of dense and stable covalent cross-linked structures. Even at low concentrations of both CFHAP and HPOSS, CFHAP/HPOSS exhibited robust network formation with exceptional thickening properties, achieving a significantly higher viscosity of 3927 mPa·s at 2 g/L compared to the polymer's 410 mPa s and the binary cross-linking system's 2453 mPa s. Under a 40 g/L Na + solution, CFHAP/HPOSS exhibited salt responsiveness by enhancing their hydrophobic network, resulting in a viscosity of 5325 mPa s and a modulus G′ > G″. These enhanced rheological properties were further utilized to improve aqueous foam stability. The results revealed improved foam stability with an extended half-life time (8248 s), low drainage rate (0.0064 g/s maximum), and minimal bubble size distribution variation. SEM images also reveal a fully formed polymer film network, which effectively inhibits foam drainage and coarsening. Our strategy provides valuable insights into developing new materials with adjustable thickening and elastic properties. Highlights A multi-armed hydrazide-POSS is synthesized and used as a crosslinking agent. Dynamic acylhydrazone bond is used to fabricate a network with enough stability. Hydrophobic interaction is used to fabricate a network with salt responsiveness. The prepared polymer exhibits improved viscosity and elasticity.
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危险品化学品经营许可证（带存储）