ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Qian Zhang,Qian Wang,Guangyu Wang,Zilu Zhang,Shan Xia,Guanghui Gao
With good flexibility and biocompatibility, hydrogel-based sensors have been widely used in human motion detection, artificial intelligence, human–machine interface, and other fields. Previous research on hydrogel-based sensors has focused on improving the mechanical properties and signal transmission sensitivity. With the development of human smart devices, there is an increasing demand for hydrogel sensor comfort and more application functions, such as ultrathin structures and recognition functions for contact surfaces, which are realized with higher requirements for the thickness, flexibility, friction resistance, and biocompatibility of hydrogels. Inspired by the ultrathin and flexible characteristics of human organ biofilms, we constructed conductive hydrogel films by using the flim-casting and glycerol–H2O secondary hydration methods. This ultrathin structure enables the hydrogel films to have a high elongation at break of 523.3%, a stress of 3.5 MPa, and a good friction resistance. Combined with the excellent sensing properties (gauge factor = 2.1 and a response time of 200 ms), the hydrogel film-based sensor can not only record human motion signals but also recognize the surface texture and roughness of objects, such as glass, brushes, wood, and sandpaper with mesh sizes of 80, 50, and 24, accurately. In addition, this hydrogel film has a series of excellent properties such as UV shielding, antiswelling ability, and good biocompatibility. This research provides a novel way for the development of emerging soft-material smart devices, such as hydrogel-based electronic skin and soft robots.
研究领域:
材料科学
·
传感器
·
软体机器人
·
生物医学工程
·
电子皮肤
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-20
·
IF 10.6
Liu Lisha,Deng Dashi,Li Chenchen,Huang Guixiao,Zhang Wenjuan,Liang Ting,Liang Rui,Liang Mingkang,Su Yilin,Lin Chongyang,Li Guangzhi,Wu Song
Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in acupuncture needles, and premature or untargeted drug release. Here, we designed a new type of tubular acupuncture needles, with an etched hollow honeycomb-like structure to enable the high loading of therapeutics, integrating the traditional acupuncture and drug repository into an all-in-one therapeutic platform. In these proof-of-concept experiments, we fabricated injectable hollow honeycomb electroacupuncture needles (HC-EA) loaded with melittin hydrogel (MLT-Gel), enabling the combination treatment of acupuncture stimulation and melittin therapy in a spatiotemporally synchronous manner. Since the RA microenvironment is mildly acidic, the acid-responsive chitosan (CS)/sodium beta-glycerophosphate (β-GP)/ hyaluronic acid (HA) composited hydrogel (CS/GP/HA) was utilized to perform acupuncture stimulation and achieve the targeted release of injected therapeutics into the specific lesion site. Testing our therapeutic platform involved a mouse model of RA and bioinformatics analysis. MLT-Gel@HC-EA treatment restored Th17/Treg-mediated immunity balance, reduced inflammatory factor release (TNF-α, IL-6, IL-1β), and alleviated inflammation at the lesion site. This novel combination of modified acupuncture needle and medication, specifically melittin hydrogel, holds promise as a therapeutic strategy for RA treatment. Graphical abstract
研究领域:
风湿病学
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生物医学工程
·
药学
·
免疫学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Zhuo-Jun Wu,Longjiang Xu,Xiaoting Xu,Jun Hou,Wenlin Li,Guibin Luo,Yufan Xu,Qiu Chen,Fengmei Cui
Radionuclide-contaminated wounds face clinical dilemmas such as repeated erosion and ulceration and are difficult to heal. In this work, we aim to develop a biodegradable hydrogel with a beneficial effect on radionuclide-contaminated wounds and initially investigate the mechanism of action of the hydrogel. The hydrogel was produced by the ring-opening polymerization of Polycaprolactone (PCL) triggered by Polyethylene glycol (PEG), and its physicochemical properties were characterized by gel permeation chromatography, nuclear magnetic resonance, and rheological properties testing, etc. The low critical solution temperatures were 30℃ and 46℃, which are suitable for the human body, to realize the degradable properties. The establishment of a radionuclide contaminated wound model confirms that biodegradable hydrogels have good healing properties, do not form secondary lesions, and are superior to the clinical use of EGF or VB12. Pathological results showed that mature granulation tissue formed on the 7th day after the injury, and by the 10th day after the injury, the scab had completely fallen off, the epithelial coverage had reached over 70% and the wound was essentially completely healed. In addition, this hydrogel affects immune metabolism, regulates the function of immune cells, promotes vascular neovascularization, promotes the development of the immune system and the development of immune cells, and facilitates the development of the immune system. Additionally, the hydrogel affects immune metabolism, regulates immune cell function, promotes the formation of new blood vessels and granular tissue, and effectively accelerates the healing process of radionuclide-contaminated wounds.
研究领域:
生物医学工程
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伤口愈合
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免疫学
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辐射生物学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2017
·Vol. 218
·期 8
·1600560
·
IF 2.5
Fang Wang,Wei Ji,Jinying Liu,Jiye He,Chuanliang Feng
Hydrogel as a carrier for drug delivery system has been developed, but it is hard to change the load and release of drugs through a simple way. Herein, the authors report a novel pH-sensitive supramolecular binary hydrogel based on Phe-Gly derivative gelator (LPPG) and 4,4′-dipyridine disulfide (DPDS). Fourier transform infrared spectroscopy, circular dichroism, and 1 H NMR confirm that the driving force for the coassembly process is intermolecular hydrogen bonds. The composite hydrogel can improve the dye adsorption capacity relative to LPPG hydrogel. Moreover, the controllable absorption of the dyes is studied by varying the pH and concentration of dye solutions. LPPG-DPDS hydrogel can also release of entrapped dyes at physiological pH. The two-component hydrogel should be a promising system for controllable drug delivery.
研究领域:
材料科学
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生物医学工程
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药学
✓ 已验证
DOI
高影响因子
Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-19
·
IF 23.655
Liang Yuning,Ding Qiongling,Wang Hao,Wu Zixuan,Li Jianye,Li Zhenyi,Tao Kai,Gui Xuchun,Wu Jin
A general strategy of fabricating thickness-controllable hydrogel films with diverse polymer networks for humidity sensing is proposed. The hydrogel film humidity sensor displays an unprecedented sensitivity up to 13,462.1%/%RH.
The stretchable humidity sensor can work normally under large tensile strains with even enhanced sensitivity, which makes the humidity responding property of hydrogel mechanically programmable.
A wireless respiratory interruption detection mask with Bluetooth transmission function is developed based on the sensor, enabling the real-time, wireless and accurate acquisition of user's breathing state, such as the interval and breathing frequency and apnea.
研究领域:
材料科学
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生物医学工程
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传感器与执行器
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无线通信
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产品关联
DOI
PubMed
高影响因子
POLYMER SCIENCE SERIES B
·
2016
·Vol. 58
·期 5
·594-600
·
IF 0.737
Wang Yan,Wei Nuo,Feng Qingling,Li Sha,Yang Chang,Liu Zhiqiang,Zhang Wenming,Li Qing
Novel luminescent bio-based hydrogels comprising cellulose and Y 4 Si 2 O 7 N 2 :Ce 4+ (YC) were prepared in an alkali/urea aqueous system using epichlorohydrin as a cross-linker. The structure, characteristics and properties of the hydrogels were investigated by various techniques, including FTIR spectroscopy, wideangle X-ray diffraction, scanning electron microscopy, etc. The results showed that when the content of YC was less than 0.05 g, the YC particles were tightly embedded in the macro porous of cellulose matrix, which not only supplied cavities for YC immobilization, but also supplied the pore wall to protect the structure and character of YC. Hence, the cellulose–YC hybrid hydrogels exhibited strong cyan fluorescence under a UV lamp. However, excess of YC particles were enshrouded in the cellulose matrix resulted in smaller pores, weaker fluorescence intensity, lower swelling ratio and higher mechanical properties.
研究领域:
材料科学
·
生物材料
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 39
·2204823
·
IF 19.924
Wei Cui,Yong Zheng,Ruijie Zhu,Qifeng Mu,Xiaoyu Wang,Zhisen Wang,Shengqu Liu,Min Li,Rong Ran
Ion is one of the most common additives that can impart electrical conductivity to insulating hydrogels. The concurrent toughening effect of ions, however, is often neglected. This work reports the extreme toughening of hydrogels via the synergistic effect of cations and anions, without the need for specific structure design or adding other reinforcements. The strategy is to equilibrate a physical double network hydrogel consisting of both multivalent cation- and kosmotropic anion-sensitive polymers in specific salt solutions that can induce cross-linking and salting-out simultaneously. Both effects are proven positive to boost the mechanical performance and electrical conductivity of the original weak gel, and result in a tough conductive gel with exceptional physical properties, achieving significant enhancements in fracture stress, fracture energy, and ionic conductivity by up to 530-, 1100-, and 4.9-folds, respectively. The optimal fracture stress and toughness reach approximately 15 MPa and 39 kJ m –2 , exceeding most state-of-the-art tough conductive hydrogels. Meanwhile, a satisfactory ionic conductivity of 1.5 S m –1 is attained. The presented simple strategy is also found generalizable to other salt ions and polymers, which is expected to expand the applicability of hydrogels to conditions involving demanding mechanical durability.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiang-Shu Hu,Xin Jing,Jing-Wen Mei,Fu-Xiang Liu,Pei-Yong Feng,Jiayi Xu,Yue-Jun Liu
Hydrogels have emerged as ideal materials for sensor fabrication due to their tunable mechanical properties, flexibility, and biocompatibility. However, their high-water content makes them prone to freezing at low temperatures, which compromises their conductivity and mechanical integrity, limiting their use in cold environments. To address this issue, we present a novel hydrogel system consisting of a polyacrylamide (PAM) backbone, a binary solvent system of water and ethylene glycol (EG), and functional materials including polyvinyl alcohol (PVA) and modified MXene. The addition of modified MXene as a conductive filler significantly enhances the hydrogel's conductivity, enabling it to maintain its performance even at low temperatures. Furthermore, the introduction of EG effectively lowers the freezing point of the hydrogel to −36.9 °C, ensuring robust frost resistance. The resulting hydrogel not only shows exceptional low-temperature stability but also exhibits high sensitivity. Moreover, the hydrogel demonstrates rapid responsiveness and high accuracy when being integrated as sensors to detect human motion and ammonia concentrations. These results highlight the potential of MXene-enhanced hydrogels for applications in freshness detection of raw meat and human motion tracking, particularly in cold environments.
研究领域:
材料科学
·
传感器技术
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Micromachines
·
2023
·Vol. 14
·期 7
·1327
·
IF 3.4
Kun Yang,Chenhui Bai,Boyuan Liu,Zhoutong Liu,Xiaojing Cui
Thermogalvanic hydrogel, an environmentally friendly power source, enable the conversion of low-grade thermal energy to electrical energy and powers microelectronic devices in a variety of scenarios without the need for additional batteries. Its toxicity, mechanical fragility and low output performance are a hindrance to its wide application. Here, we demonstrate thermoelectric gels with safe non-toxic, recyclable, highly transparent and flexible stretchable properties by introducing gelatin as a polymer network and SO3/42−as a redox electric pair. When the temperature difference is 10 K, the gel-based thermogalvanic cell achieves an open-circuit voltage of about 16.2 mV with a maximum short-circuit current of 39μA. Furthermore, we extended the application of the Gel-SO3/42−gel to monitor the temperature of hot or cold food, enabling self-powered sensing for food temperature detection. This research provides a novel concept for harvesting low-grade thermal energy and achieving safe and harmless self-driven temperature monitoring.Keywords:hydrogel;thermogalvanic;gelatin;self-powered
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2023
·Vol. 15
·期 10
·2503
·
IF 5.4
Yuchen Zhou,Jie Liu,Peng Xue,Jianjun Zhang
GSK2606414 is a new, effective, highly selective PERK inhibitor with adenosine-triphosphate-competitive characteristics. It can inhibit endoplasmic reticulum stress and has the possibility of treating periodontitis. However, owing to its strong hydrophobicity and side effects, highly efficient pharmaceutical formulations are urgently needed to improve the bioavailability and therapeutic efficacy of GSK2606414 in the treatment of periodontitis. Herein, a novel local GSK2606414 delivery system was developed by synthesizing GSK2606414 nanoparticles (NanoGSK) and further loading NanoGSK into a collagenase-responsive hydrogel. The drug release results showed that the drug-loaded hydrogels had outstanding enzymatic responsive drug release profiles under the local microenvironment of periodontitis. Furthermore, in vitro studies showed that the drug-loaded hydrogel exhibited good cellular uptake and did not affect the growth and proliferation of normal cells, while the drug-loaded hydrogel significantly improved the osteogenic differentiation of inflammatory cells. In the evaluations of periodontal tissue repair, the drug-loaded hydrogels showed a great effect on inflammation inhibition, as well as alveolar bone regeneration. Therefore, this work introduces a promising strategy for the clinical treatment of periodontitis.Keywords:GSK2606414;nanoparticles;PERK;hydrogel;periodontitis
研究领域:
药学
·
牙科材料
·
组织工程
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Xiaoli Zhao,Ya-feng Huang,Xuan Tian,Jinni Luo,Huanxia Wang,Jinfei Wang,Yuan Chen,Pengxiang Jia
Adhesive hydrogels have been considered as one of the most ideal materials for wound dressing. However, most existing adhesive hydrogels still have disadvantages such as low mechanical properties, poor biological activity (antibacterial and hemostatic ability), and low biocompatibility, which largely limit their application. Thus, it is highly desired to prepare a hydrogel-based wound dressing with good self-healing, ideal adhesive properties, rapid hemostasis, and excellent wound infection prevention activity. In this study, a simple method was presented to prepare a PAM-Lignin-CS-Laponite-SA hydrogel for wound dressing. The obtained hydrogel displayed excellent self-healing ability and repeatable adhesive performance, benefiting from the introduction of hydrogen bonding and electrostatic interactions inside the hydrogel network. In addition, the PAM-Lignin-CS-Laponite-SA hydrogel also exhibited low cell cytotoxicity, good antibacterial activity, and outstanding hemostatic properties. In conclusion, the PAM-Lignin-CS-Laponite-SA hydrogel demonstrated good tissue adhesion, excellent self-healing ability, effective bleeding control, and good antibacterial activity to prevent wound infection, which provides a new idea for developing a multifunctional hydrogel-based tissue adhesive hemostatic dressing.
研究领域:
材料科学
·
生物医学工程
·
生物材料
✓ 已验证
DOI
PubMed
高影响因子
Bioactive Materials
·
2025
·
IF 20.3
Lingling Ren,Yong Luo,Yanjuan Huang,Xianmin Shi,Huanxin Lin,Tao Zhang,Yujun Gong,Yao Liu,Dong Zheng,Wanzhen Li,Danni Xiao,Shengzhi Wang,Chunshun Zhao
Postoperative adhesions are common and severe complications, which affect up to 90 % of patients undergoing abdominal surgery. Despite the application of various strategies to minimize adhesions, the clinical outcomes remain far from satisfactory. Herein, we engineered a ROS-responsive and scavenging double-network hydrogel (PD-OHN) with multiple biofunctions and good mechanical properties for effective PAA prevention. First, a novel ROS-cleavable dithiothreitol (DTT) crosslinking monomer (DPBA) was synthesized. Subsequently, PD-OHN hydrogel was fabricated within 5 s by forming phenylborate ester bond networks between DPBA and polyvinyl alcohol (PVA), and acylhydrazone bond networks between oxidized hyaluronic acid (OHA) and adipic acid dihydrazide-modified hyaluronic acid (HA-ADH). After spraying, it can form a uniform and stretchable hydrogel film. Results showed that PD-OHN had good mechanical properties with a storage modulus about 20 kPa, satisfactory tissue adhesion strength of approximately 8 kPa, and an appropriate in vivo cecum retention time of about 21 days with good biosafety. More importantly, DPBA in PD-OHN hydrogel scavenged ROS via phenylboronate bond cleavage and the subsequent release of DTT, which intelligently alleviated oxidative stress according to the ROS levels in wound sites and induced pro-inflammatory M1 macrophages to polarize into anti-inflammatory M2 phenotype to alleviate inflammation. Further, the fibrinolytic system balance was recovered and fibrosis was reduced. Consequently, PD-OHN hydrogel effectively prevented adhesion formation in a cecum-sidewall abrasion rat model, and provided a promising whole course care anti-adhesion barrier for effective PAA prevention.
研究领域:
生物医学工程
·
材料科学
·
生物化学
·
药剂学
·
外科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）