JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2026
·Vol. 114
·期 8
·e70141
·
IF 3
Yue Shu,Meizi Zhang,Bo Li,Ziyi Yan,Lingfei Liu,Yiran Wang,Congyan Xia,Zhongning Liu,Yanlin Chen
Critical-sized bone defects (CSDs) represent a major clinical challenge due to their limited self-healing capacity. Conventional hydrogels incorporating crystalline hydroxyapatite (HA) often fail to recapitulate the hierarchical nanostructure of native bone, leading to suboptimal regeneration outcomes. To overcome this, we developed a biomimetic hydrogel by molecularly integrating amorphous calcium phosphate oligomers (CPO) into gelatin methacryloyl (GelMA), enabling a bone-like organic–inorganic hybrid network. This composite exhibits outstanding performance: an ultimate strength of 192 kPa at 18 wt% CPO confirms robust mechanical reinforcement, while 54% mass retention after 56 days underscores exceptional degradation resistance and dose-dependent bioactivity, evidenced by a two-fold upregulation of alkaline phosphatase (ALP) activity. The amorphous CPO facilitates biomimetic HA nucleation within the GelMA matrix, mimicking the natural mineralization process. In a rat calvarial CSD model, the hydrogel promoted 60% bone volume regeneration within 12 weeks, significantly outperforming conventional composites, through seamless host integration, vascularized trabecular bone formation, and a collagen–mineral hierarchy resembling native osteogenesis. This study establishes CPO as a transformative component that converts passive scaffolds into bioactive osteogenic microenvironments, offering a clinically viable strategy for complex bone regeneration.
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Clinical Oral Investigations
·
2026
·Vol. 30
·期 9
·390
·
IF 3.6
Zhang Zhenzhen,Chen Yadong,Zhong Qi,Xu Jiajia,Cheng Yajie,Shu Chang,Luo Qiaojie
Objectives The hybrid layer formed during dentin bonding remains susceptible to degradation. This study aimed to develop a CaCl₂/AgF treatment strategy for in situ deposition of Ca–Ag hybrid nanoparticles within the demineralized dentin matrix (DDM) and to evaluate its effects on interface-confined water regulation, antibiofilm activity, mineral deposition, and ultimately bonding durability. Materials and methods DDM was sequentially treated with CaCl₂ and AgF solutions. Interface-confined water regulation was assessed by surface potential, water uptake, and thermogravimetric analysis (TGA). Antibiofilm activity against Streptococcus mutans ( S. mutans ) and saliva-derived microcosm biofilms was evaluated by confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). Mineral deposition was examined by transmission electron microscopy (TEM) and selected area electron diffraction (SAED). Adhesive infiltration, nanoleakage, and microtensile bond strength (1 day and 12 months) were tested. Results Ca–Ag deposition was associated with reduced interfacial hydration, as indicated by reduced surface potential, decreased water uptake, and lower mass loss below 200 °C in TGA. It inhibited biofilm formation and disrupted established biofilms. Enhanced mineral deposition occurred within 1 h in the Ca–Ag group, with SAED patterns showing crystalline mineral phases, whereas controls remained unmineralized. Enhanced adhesive infiltration, reduced nanoleakage, and improved 12-month bond strength were observed. Conclusions Sequential CaCl₂/AgF treatment induced the in situ deposition of Ca–Ag hybrid nanoparticles within the DDM, which was associated with reduced interfacial hydration, antibiofilm activity, mineral deposition, and improved bonding performance in vitro. Clinical Significance This in vitro study suggests that CaCl₂/AgF treatment may represent a potential strategy for improving resin–dentin interface stability. Further investigations are required to evaluate its clinical applicability.
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TRIBOLOGY INTERNATIONAL
·
2026
·
IF 7.6
Jinbao Feng,Chen Zhao,Yi Liu,Xingwei Wang,Shuang Sun,Shuangshuang Yang,Zhenjun Peng,Qiangliang Yu,Feng Zhou,Weimin Liu
To meet the lubrication requirements of advanced mechanical systems operating over a wide temperature range, a composite self-lubricating coating based on combined B 2 O 3 /SiO 2 -modified aluminum chromium phosphate (ACP) was developed. The effects of the combined incorporation of B 2 O 3 and SiO 2 on the high-temperature structural evolution of the ACP adhesive and the tribological performance of the coating were systematically investigated. The simultaneous incorporation of B 2 O 3 and SiO 2 promoted the formation of B-O and Si-O tetrahedral units, thereby improving the oxidation resistance and thermal stability of the adhesive. Meanwhile, the residual amorphous phase at elevated temperatures enhanced the toughness and interfacial bonding of the coating. The resulting coating exhibited an average pull-off bond strength of 4.60 MPa. After heat treatment at 300 and 800 °C, its room-temperature friction coefficients under loads of 2 and 5 N remained low, ranging from 0.120 to 0.196. During in situ high-temperature tribological tests, the average friction coefficients at 350, 500, 650, and 800 °C were 0.139, 0.311, 0.215, and 0.173, respectively. Furthermore, no obvious corrosion was observed after 3624 h of salt-spray exposure. These results demonstrate that the ACP-based coating prepared using the combined B 2 O 3 /SiO 2 -modified adhesive possesses excellent wide-temperature-range lubricity, thermal stability, and corrosion resistance, making it a promising candidate for complex service environments involving coupled thermal, mechanical, and corrosive conditions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jiang Chang,Weimin Guo,Lixin Sun,Qiang Wang,Jingyuan Zhang,Xiaoyu Zhao,Xiangrui Meng,Kuo Zhang,Qiu Fu,Lijian Sun
A simple and scalable method is used to prepare multifunctional bio-based films. • Natural gardenia yellow was first used as a UV and blue light absorber. • The films exhibit high transparency and excellent protection against harmful light. • Integrated fire safety and antibacterial properties were achieved. • The films exhibit excellent mechanical strength and biodegradability. The integration of multiple functionalities into a single material system, while simultaneously ensuring sustainable processing and high transparency, remains a critical challenge in materials design. Herein, a multifunctional cellulose film is developed through a supramolecular engineering strategy that orchestrates the synergistic interplay of carboxymethylated cellulose, gardenia yellow (GY), and phosphorylated chitosan (PCS). The process involves alkali/urea assisted regeneration of cellulose into hydrogel matrix, followed by incorporation of a pre-assembled GY-PCS complex. The resulting films exhibit exceptional optical management capabilities, achieving light shielding efficiencies of 52.5–69.9% for UV-A, 55.6–68.3% for UV-B, and 72.5–91.1% for high-energy blue light (HEBL). The films demonstrate superior blue light filtering performance compared to commercial counterparts. Encouragingly, the films exhibit high transmittance of 90–90.8% and low haze of 1.8–2.0% at 600 nm. In practical applications, the films effectively block blue light radiated by illumination system, computer screen and smartphone screen. Notably, the incorporation of PCS imparts ideal flame-retardant properties, increasing the limiting oxygen index (LOI) from 19.2% to 32.1%. Moreover, the films exhibit excellent antimicrobial activity. Benefiting from the synergistic hydrogen-bonding network, the tensile strength of the films achieves a substantial increase ranging from 11.1% to 18.7%. This simple strategy would direct cellulose films toward diversified applications.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·Vol. 60
·期 30
·21310-21319
·
IF 12.2
Xia Lingxi,Wu Qinghao,Zhou You,Zhao Ruixue,Chen Sijia,Liu Ziwei,Meng Xinran,Zhang Nannan,Liu Huan,Liu Yuanfeng,Zhong Zihan,Sun Xiaoqi,Huang Xia,Xia Xue,Zuo Kuichang
The anaerobic digestate generated from municipal sludge
treatment
contains abundant volatile fatty acids (VFAs), which hold great recovery
value due to their wide utility in the food, pharmaceutical, and chemical
industries. However, conventional recovery technologies are confronted
with inferior purity and low concentration of the VFA product because
of their poor VFA selectivity over competing species and low efficiency
in separating VFAs from water. In this study, a novel dual-stage membrane
distillation (MD) coupled with alkali adsorption was designed to achieve
one-step VFA separation, concentration, and simultaneous water recovery.
When treating real anaerobic digestion wastewater, the system achieved
a VFA recovery of 86.2%, VFA concentration of 103.3 g L –1 , concentration factor of 20.3, and water recovery of 62.8%, which
were the best performances reported to date. A literature review elucidates
that the concentration, concentration factor, and purity of the obtained
VFA product are far superior to those of the state-of-the-art technologies.
Moreover, the system also exhibited excellent stability during 192
h of continuous operation with real wastewater. This study demonstrates
the great potential of the dual-stage MD for separating and concentrating
VFAs from anaerobic digestion wastewater, providing a novel solution
for volatile component recovery.
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PubMed
高影响因子
LANGMUIR
·
2026
·Vol. 42
·期 30
·22338-22349
·
IF 4.4
Gao Xing,Xiang Yan,Guo Wenjun,Xu Tao,Wang Zhoujie,Xu Longhua,Sun Wei,Xie Lei
Hetero-aggregation between serpentine and sulfide minerals
represents
a persistent challenge in the efficient recovery of valuable metals
from complex ores, while most existing depressants suffer from limited
selectivity, insufficient suppression efficiency, or environmental
and toxicity concerns, restricting their application in sustainable
mineral processing. Herein, we report for the first time the use of
a phosphorylated nanocellulose biopolymer as a highly selective and
environmentally benign depressant to overcome serpentine-induced interference
in sulfide flotation, and elucidate the selective depression and interfacial
mechanism. Phosphorylated cellulose nanofibers (P-CNF) and phosphorylated
cellulose nanocrystals (P-CNC) were synthesized by introducing phosphate
functional groups, resulting in a marked enhancement in pyrite flotation
performance, with recoveries exceeding 88.0% and reaching 89.6% for
P-CNF. The exceptional separation efficiency arises from the highly
selective adsorption of phosphorylated cellulose on the serpentine
MgOH plane, with a surface coverage of 96.32% on serpentine compared
to only 0.28% on the pyrite surface. This pronounced selectivity induced
a reversal of the serpentine surface charge, thereby transforming
pyrite–serpentine interactions from electrostatic attraction
to strong repulsion. Force-resolved atomic force microscopy measurements
provided direct nanoscale evidence for this transition, revealing
a dramatic reduction in adhesion forces from ∼9.81 mN m –1 to ∼1.25 mN m –1 (P-CNC)
and ∼0.10 mN m –1 (P-CNF). Moreover, phosphorylated
nanocellulose promoted the flocculation of fine serpentine particles
via polymer-bridging effects, leading to the enlarged aggregates and
effective suppression of mechanical entrainment. This work establishes
phosphorylated nanocellulose as a novel green depressant platform
and provides molecular insights into interfacial interactions governing
complex mineral separation, thereby enabling the rational design of
sustainable reagents and advancing resource-efficient environmentally
interfacial responsible mineral processing.
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LANGMUIR
·
2026
·Vol. 42
·期 28
·20126-20142
·
IF 4.4
Xiang Xinyue,Wang Yaning,Shi Xincui,Zhou Chen,Zou Chenyang
Water-based anticorrosion coatings offer advantages such
as low
volatile organic compound emissions and sustainable processing. However,
their inherent hydrophilicity and tendency to form microcracks limit
their long-term barrier performance. In this study, we developed a
water-based polyaniline based smart coating, PD@PANI/P-PVA, by encapsulating
photothermal-responsive polydopamine nanoparticles and fluorescent
indicators in PANI-shell microcapsules. This coating provides both
active corrosion protection and real-time damage visualization. We
systematically investigated the effects of the microcapsule contents
on the coating’s dispersion and anticorrosion performance.
The results showed that the dispersion of PANI in the aqueous system
was significantly improved with the incorporation of poly(vinyl alcohol)
and polystyrenesulfonate. Due to the corrosion inhibition effects
of polyaniline and polydopamine, the coating containing 1 wt % PD@PANI/P-PVA
exhibited enhanced anticorrosion performance. After 20 days of immersion,
its impedance modulus was 2 orders of magnitude higher than that of
the blank coating. By utilizing the synergistic photothermal effect
between polyaniline and polydopamine, the PD@PANI/P-PVA coating showed
a significant temperature increase after 10 min of UV irradiation,
indicating its potential for photothermal-assisted defect repair and
triggered release behavior. These results suggest a preliminary self-healing
capability and stimulus-responsive functionality rather than fully
validated autonomous healing. These coatings exhibit broad potential
for applications in fields such as shipping and construction. Future
work could focus on further improving their photothermal response
efficiency and long-term environmental stability, thereby advancing
their engineering applications in highly corrosive environments.
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AICHE JOURNAL
·
2026
·
IF 4.4
Yue Zhao,Shan Ni,Wang Yao,Yafeng Liu,Wenjie Wang,Huizhou Liu,Liangrong Yang
The development of uranium separation materials is essential to ensure a stable uranium supply for energy and to mitigate environmental risks. We report a two-dimensional ferrocene-vanadyl phosphate composite (fc-VOP) with expanded interlayer spacing (9.8 Å) and adsorption–reduction coupling function, made by solvent-assisted intercalation. This enables efficient uranium capture via optimized interlayer structure and interfacial properties. Interlayer expansion facilitates uranyl ion transport, accelerating adsorption kinetics, while the coupling function elevates interfacial concentration gradients to enhance ion binding, boosting capacity. The fc-VOP shows a theoretical adsorption capacity of 1968.60 mg/g (pH = 4, pure nitrate solution) with equilibrium in 30 min. It also performs well in spiked matrices, achieving 336.4 mg/g in leachate and 248.2 mg/g in seawater. This work provides a viable route to improve 2D phosphate materials for uranyl adsorption and offers mechanistic insights into designing adsorption–reduction coupling materials.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Yuqing Ding,Yuwen Zhao,Ni Zhao,Haoran Zhang,Shuyun Duan,Xiaoyi Pan,Xia Gao,Xialin Chen,Liang Cao,Chenfeng Zhang,Zhenzhong Wang,Wei Xiao
Although spectral and chromatographic analysis are broadly applied to compound detection, the quality characterization of complex multicomponent systems remains a persistent challenge. Current analytical paradigms emphasize single-component quantification, lacking compositional coherence in highly coupled chemical systems. Therefore, it is crucial to develop an integrative strategy that enables effect-oriented variable selection and quantitative prediction based on information-rich but low-cost measurements. Using Reduning Injection as a representative case, this study quantitatively characterized 18 components by multi-wavelength fused high-performance liquid chromatography, evaluated antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, and identified 11 antioxidant activity-associated components based on spectrum-effect relationship analysis. These components were further analyzed by network pharmacology and molecular docking, providing theoretical mapping of biological networks. Prediction models were then developed using ultraviolet, near-infrared, and UV-NIR fusion spectral data for the selected components. Low, Mid, and High-level data-fusion strategies were subsequently employed to optimize the model performance. Among the three UV-NIR fusion levels, all fusion strategies outperformed the single-spectrum models. Mid-level data fusion showed the best overall predictive performance, with MLPRegressor yielding the optimal results among the tested models (mean R 2 p = 0.951, RMSEp = 0.036, and RPDp = 4.398). These results suggest that the predictive advantage of UV-NIR fusion depended not only on inter-spectral complementarity, but also on effective optimization of the fused feature space. Overall, this study developed an activity-oriented quality evaluation framework that integrates chemical profiling, effect-related component screening, and rapid spectral prediction, providing an integrative approach for the quality characterization and consistency evaluation of TCM preparations.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Rongjie Lin,Hai Zhang,Zhuhang Dai,Zihong Wei,Sihui Zhong,Chenghao Xiong,Weilang Hu,Yuansong Feng,Yuhao Dong,Yaxiaer Yalikun,Chenjing Shang,Huaping Wu,Yang Yang
Flexible pressure sensors offer unique advantages for deep-sea exploration, yet balancing sensitivity, range, and environmental robustness—especially under extreme hydrostatic pressure and temperature gradients that induce signal drift—remains challenging. Here, we report a fully integrated iontronic pressure sensor for ocean exploration. Through co-design of a gradient-microstructured ionogel with a linear-elastic polyurethane spacer, the sensor achieves an unprecedented broad linear sensing range of 0–10 MPa, sensitivity of 98.4 kPa −1 , and exceptional linearity ( R 2 = 0.996). Notably, the sensor retains repeatability and signal stability under hydrostatic loading up to 55 MPa. Field deployments on a remotely operated vehicle and a manned submersible at depths of ∼1353 and ∼2359 m confirmed stable performance in the bathyal zone. An ultra-low-power embedded system (quiescent current: 4 µA) integrated with a thermal compensation algorithm enables autonomous data acquisition, suppressed temperature-induced drift, and correction accuracy exceeding 95%. This integrated iontronic platform addresses unmet needs for next-generation deep-sea monitoring and enables reliable in situ oceanographic sensing.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xiaoyang Fu,Suozhu Wu,Qianda Zhang,Hongli Pian,Xiu Zhao,Xiayu Song,Zhuo Shi,Chunyong Li,Yanfen Cheng,Junlong Meng,Shurong Wang
An electrochemical sensor was fabricated via a one-step electrodeposition method. • An ultra-wide response range (1.00 × 10 −12 M to 1.00 × 10 −4 M) was obtained. • An ultra-low detection limit (2.14 × 10 −13 M) was achieved. • This sensor was simple, highly selective and practical. A gold nanoparticle-poly(2-aminophenylboronic acid) composite modified gold electrode (AuNPs-poly(2-APBA)/Au) was fabricated for the first time by electrodeposition, which achieved the measurement of picomolar-level fluoride ions (F − ). Using potassium ferricyanide (K 3 Fe(CN) 6 ) as the redox probe, the specific binding of F − to the boronic acid groups in poly(2-APBA) generated negatively charged complexes, which hindered the electron transfer of K 3 Fe(CN) 6 on the electrode surface. Quantitative analysis of F − was realized by monitoring the decline in the K 3 Fe(CN) 6 reduction peak current. The sensor exhibited an ultra-wide response range (1.00 × 10 −12 to 1.00 × 10 −4 M), an ultra-low limit of detection (2.14 × 10 −13 M) and limit of quantification (5.35 × 10 −12 M) with good robustness, precision, ruggedness, and shelf life, and high selectivity. This sensor demonstrated significant advantages in fabrication simplicity, detection sensitivity, response range, and practical applicability, which could be successfully applied to determine F − in Agrocybe aegerita , shrimp and tap water samples, providing an efficient and sensitive analytical method for food safety assessment and environmental monitoring. Download: Download high-res image (137KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jiahui Liu,Xiaorui He,Yue Wang
One-step MXene/CNTs-COOH/CS/IL sensing interface was constructed. • CNTs-COOH alleviated MXene restacking and promoted electron transport. • CS and ionic liquid enhanced metal-ion enrichment and ionic transport. • The sensor simultaneously determined Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ . • Real-water results agreed well with ICP-MS measurements. Rationally coordinating ion accessibility, electron transport, metal-ion enrichment, and film stability within a facile electrode architecture remains challenging for multiplex electrochemical analysis. Herein, an MXene-based multicomponent sensing interface was constructed through the one-step integration of carboxylated carbon nanotubes (CNTs-COOH), chitosan (CS), and an ionic liquid (IL) with Ti 3 C 2 T x nanosheets. CNTs-COOH act as conductive nano-spacers that alleviate MXene restacking and improve electronic connectivity, while CS provides coordination-active amino and hydroxyl groups for metal-ion enrichment and contributes to film stability. The incorporation of IL improves component dispersion and ionic transport and partially mitigates the interfacial transport limitation associated with the CS-containing layer. Structural and electrochemical characterization results collectively support complementary roles of the four components in regulating interfacial accessibility, analyte accumulation, and charge-transfer behavior. Under the optimized conditions, the resulting electrode enabled the simultaneous determination of Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ by differential pulse anodic stripping voltammetry over linear ranges of 0.5–22.5, 0.5–60, 0.5–87, and 0.5–62 μM, respectively. The corresponding detection limits were 0.1539, 0.0746, 0.2279, and 0.0931 μM. The sensor also exhibited satisfactory selectivity, reproducibility, and long-term stability, retaining approximately 92–95% of its initial response after 30 days. Recoveries of 92.2–96.0% were obtained in spiked tap-water and river-water samples, and the measured concentrations were consistent with those obtained by ICP-MS. These results demonstrate a functionally coordinated interface-engineering strategy for the simultaneous electrochemical determination of multiple heavy metal ions. Download: Download high-res image (139KB) Download: Download full-size image
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