ChemistrySelect
·
2023
·Vol. 8
·期 48
·e202303437
·
IF 2.1
Ms. Menghan Li,Xuan Luo,Tongming Su,Xinling Xie,Hongbing Ji,Zuzeng Qin
Graphical Preparation of NiZr/N-doped TiO 2 /Ti 3 C 2 catalyst for catalytic cinnamaldehyde (CAL) hydrogenation by KBH 4 reduction. N-doped TiO 2 on Ti 3 C 2 , and N-doping substituted O in the TiO 2 lattice to create oxygen vacancies on the surface, increase the surface acidity, and adsorb C=O bonds, which resulted in high cinnamaldehyde conversion and cinnamyl alcohol (COL) selectivity after reaction 8 h. An NiZr/N-doped TiO 2 /Ti 3 C 2 catalyst was prepared by KBH 4 reduction for cinnamaldehyde hydrogenation. Characterization results showed that the synthesis of N-doped TiO 2 on Ti 3 C 2 and the uniform dispersion of TiO 2 on the Ti 3 C 2 surface increased the specific surface area of NiZr/Ti 3 C 2 by 164.4 m 2 /g. N-doping at a level of 19.03 % was used to replace O in the TiO 2 lattice; the Ti−O−Ti peak in the XPS spectrum of the undoped catalyst was shifted by 0.3 eV in the spectrum of the doped catalyst; as a result, there was a 15.40 % increase in the number of surface oxygen vacancies of the NiZr/Ti 3 C 2 catalyst. The synthesis of N-doped TiO 2 on Ti 3 C 2 converted the moderately acidic sites of NiZr/Ti 3 C 2 to strong Lewis acid sites and increased the total number of acid sites by approximately 0.8-fold. The active Lewis acid sites on the surface of NiZr/N-doped TiO 2 /Ti 3 C 2 adsorbed only C=O bonds and inhibited the adsorption of C=C bonds, resulting in a high cinnamaldehyde conversion of 90.69 % and a cinnamyl alcohol selectivity of 91.87 %.
研究领域:
催化
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化学工程
·
材料科学
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DOI
高影响因子
Neural Regeneration Research
·
2025
·
IF 6.7
Gu Xinyi,Huang Chen,Wang Shen,Deng Jin,Guo Shuhang,Yin Xiaofeng
To perform various functions in the body, skeletal muscle is controlled and coordinated as a whole by nerves. However, there has been little research into whether the nerve control characteristics of different muscles are different, and the importance of these potential differences. In the present study, we used a three-dimensional imaging of solvent-cleared organ-compatible multi-tracer technique to explore the spatial distribution patterns of sensory and sympathetic neurons that innervate limb muscles. We integrated transcriptome sequencing datasets from mouse limb muscles in public databases and performed correlation analysis with neuronal spatial distribution data to reveal the unique effects of different types of neurons on muscle functional pathways. In terms of spatial distribution patterns, sympathetic neurons exhibited a more concentrated distribution than sensory and motor neurons. In addition, the neuronal innervation of limb muscles exhibited four different characteristics: sympathetic neuron-rich muscle, sensory neuron-rich muscle, neuron-sparse muscle, and motor neuron-rich muscle. Sensory neuron density was mainly associated with muscle contractile structure and cell pH, whereas sympathetic neuron density was associated with protein kinase activity, muscle vasculature, muscle calcium-dependent protein kinase activity, lipid transport, and vesicle release. Motor neuron density was mainly associated with protein kinase activity, cell adhesion, oxidoreductase activity, and exocytosis. These findings may contribute to a deeper understanding of how nerves cooperate to endow muscles with diverse physiological functions, thereby providing new insights and experimental evidence for the treatment of various neuromuscular diseases.
研究领域:
神经科学
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肌肉生理学
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系统生物学
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分子生物学
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解剖学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yangyang Ma,Ju Lin,Miaoyun Li,Yaodi Zhu,Lijun Zhao,Dong Liang,Dong Hyun Cho,Gaiming Zhao
In order to explore the influence of wood types on formation of polycyclic aromatic hydrocarbons (PAHs) in traditional smoked and grilled meat products, the effect of lignin in woods on formation of PAHs was investigated in meat model systems. The results showed that PAHs formation was much dependent on the heating conditions. The addition of lignin led to significantly increased PAHs, which being connected with lignin structure. In comparison, the formation of PAHs was more facilitated by lignin with G structure than that with G/S structure. However, further study of adding lignin precursors demonstrated that lignin precursors with S structure were more favorable to the formation of PAHs than those with G structure. It was proposed that the relative content and activity of G/S structure of lignin in wood played a significant role in the formation of PAHs, which might provide theoretical reference for inhibition of PAHs fundamentally.
研究领域:
食品科学
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化学
·
环境科学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Wantao Zhuge,Xi Ding,Wenhui Zhang,Dagan Zhang,Huan Wang,Jie Wang
Building units play an important and critical role in muscle tissue engineering, which has aroused increasing attention in recent decades. The current muscle units are suffering from over-simplified constructions and complicated fabrication approaches. Thus, we proposed a kind of helical micromotor with the technique of microfluidics to build tissue constructions for muscle tissue engineering. The desired micromotors were achieved by encapsulating muscle cells together with magnetic iron oxide nanoparticles (Fe 3 O 4 NPs) in helical microfibers with biocompatible materials. The helical structures and encapsulated Fe 3 O 4 NPs imparted micromotors with the capacity of advancing in rotation under magnetic fields; while biocompatible components made it possible for cell adhesion, proliferation, and migration. By adjusting the intensity of magnetic fields, the helical pitch of microfibers, or/and the concentration of Fe 3 O 4 NPs, the movement speed of the achieved micromotors could be changed correspondingly. Benefiting from the controllable movement and sufficient cell cultivation, the generated micromotors were capable of assembling together to form a cell mass construction in a relatively safe and convenient environment. Furtherly, fibroblasts could be cultured on the surface of the assembled cell units to achieve complex muscle tissue structures, which would be more similar to in vivo tissue units. These characteristics indicated that the desired helical micromotors had a great application prospect in tissue regeneration, artificial muscle, cell cultured meat and other fields.
研究领域:
组织工程
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生物医学工程
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材料科学
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细胞生物学
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DOI
高影响因子
Discover Oncology
·
2025
·Vol. 16
·期 1
·1-13
·
IF 2.9
Liu Guo,Fang Yu,Li Jiamiao,Chen Zhaofei
Osteosarcoma, the most common primary bone malignancy, poses significant management challenges due to its aggressiveness and metastatic potential. This study investigates the role of anoikis-related genes, particularly phospholipase C beta 4 (PLCB4), as a prognostic biomarker in osteosarcoma. We analyzed transcriptome data from the TARGET and GSE21257 cohorts using bioinformatics tools, identifying 15 significant genes, with PLCB4 as a key marker linked to decreased survival. Our findings indicate a negative correlation between PLCB4 and immune microenvironment scores and checkpoint molecules, suggesting its impact on immunotherapy responses. Drug sensitivity analyses revealed that high PLCB4 expression correlates with lower IC50 values for several chemotherapeutic agents. In vitro experiments showed that silencing PLCB4 inhibited cell proliferation and reduced PD-L1 expression. This study underscores the critical role of PLCB4 in osteosarcoma progression and its potential as a therapeutic target, offering insights into the molecular mechanisms of osteosarcoma biology and improving prognostic accuracy and treatment strategies.
研究领域:
肿瘤学
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分子生物学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Processes
·
2020
·Vol. 8
·期 8
·897
·
IF 2.753
Yangfan Xu,Chongxing Huang,Xiujie Dang,Muhammad Rafiullah Khan,Haohe Huang,Yuan Zhao,Shuangfei Wang
The mesoporous silica wall materials can achieve controlled load and sustained-release of active agents. An antimicrobial nanoscale silica microcapsule containing cinnamaldehyde (CA) was prepared by the sol-gel method and applied in poly (butyleneadipate-co-terephthalate) (PBAT) film. The surface morphology, physical and chemical properties, and antibacterial properties of microcapsules and films were studied. The effects of different temperatures and humidities on the release behavior of microcapsules were also evaluated. Results showed that CA was successfully encapsulated in silica microcapsule which had a diameter of 450–700 nm. The antibacterial CA agent had a long-lasting release time under lower temperature and relative humidity (RH) environment. At low temperature (4 °C), the microcapsules released CA 32.35% in the first 18 h, and then slowly released to 56.08% in 216 h; however, the microcapsules released more than 70% in 18 h at 40 °C. At low humidity (50%RH), the release rates of microcapsules at the 18th h and 9th d were 43.04% and 78.01%, respectively, while it reached to equilibrium state at 72 h under 90% RH. The sustained release process of CA in SiO2-CA microcapsules follows a first-order kinetic model. Physicochemical properties of PBAT films loaded with different amounts of microcapsules were also characterized. Results showed that the tensile strength and water vapor transmission rate (WVTR) of the composite film containing 2.5% microcapsules were increased by 26.98% and 14.61%, respectively, compared to the raw film, while the light transmittance was slightly reduced. The crystallinity of the film was improved and can be kept stable up to 384.1 °C. Furthermore, microcapsules and composite film both exhibited distinctive antibacterial effect onEscherichia coliandListeria monocytogenes. Therefore, SiO2-CA microcapsules and composite films could be a promising material for the active packaging.Keywords:cinnamaldehyde;PBAT;antibacterial materials;composite film
研究领域:
材料科学
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生物技术
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DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 51
·36098-36106
·
IF 3.9
Meng Cao,Feng Xu,Li Li,Honglian Zhang,Xin Liang,Tao Xu,Qian Li
The objective of this study was to establish a novel method for the detection of lean meat powder (salbutamol sulfate and terbutaline sulfate) residues in commercially available pig liver based on diazo coupling reaction by combining thin layer chromatography (TLC) with surface-enhanced resonance Raman scattering (SERRS). TLC was used to separate samples; after determining the spots of each component, diazo coupling reaction was carried out on the spots in situ to generate azo compounds, and then the spots of azo compounds mixed with silver sol on the TLC plate were qualitatively detected by SERRS. The limit of detection (LOD) of salbutamol sulfate was as low as 0.14 μg kg−1, and that of terbutaline sulfate was as low as 0.04 μg kg−1. The influence of the sample matrix in TLC-SERRS detection of salbutamol sulfate and terbutaline sulfate was investigated by experiment on a simulated positive sample, and salbutamol sulfate and terbutaline sulfate in commercially available pig liver were detected. Compared with the reported method (HPLC-MS/MS), this method has the advantages of strong specificity, high sensitivity, rapidity and low cost. It provides a new reference method for establishing and perfecting the safety system of veterinary drug residues.
研究领域:
食品安全
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分析化学
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兽医学
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Yuqing Xiang,Yuxiao Hu,Wang Yu,Rong Huang,Xuhong Guo,Zhonghai Tang,Chen Xing,Zhijian Tan
Pork releases a large amount of exudate during storage, leading to microbial contamination, thereby shortening its shelf life. In this work, we designed an aerogel constructed of kenaf cellulose nanofiber (KCNF) and polyvinyl alcohol (PVA) as a support for cinnamon essential oil (CEO). This aerogel features low density (27.5 mg/cm 3 ), high porosity (96.6%), and strong water absorption (3067.82 wt%), while simultaneously possessing the functions of adsorbing pork exudate and sustaining the release of (CEO). The CEO-loaded aerogel, serving as a meat preservation pad, can simultaneously achieve water absorption, antibacterial, and antioxidant functions during the storage of chilled pork. Aerogel preservation experiments on chilled pork showed that it can prolong the preservation period of chilled pork by 6 days. Release kinetics studies revealed that the CEO within the aerogel was released continuously and evenly into the fatty food simulant, with this process primarily governed by Fickian diffusion. The designed aerogel shows great potential in meat preservation, providing a innovative idea for natural fibers used in sustainable packaging.
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DOI
高影响因子
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 9
·e70449
·
IF 2.8
Dai Lizhi,Yu Tong,Wang Jingxuan,Li Youchong,Cao Zheyuan,Xiao Jianhua
2-ethylhexyl diphenyl phosphate (EHDPHP), a ubiquitous organic phosphorus flame retardant, is extensively employed in food packaging, flame retardancy applications, and other industrial processes as a crucial chemical. However, recent discoveries have underscored its diverse toxic effects, posing a severe potential threat to biological health. Skeletal muscle, vital for locomotion, relies heavily on proper differentiation during development and maintenance for strength and functionality. This study investigated the impact of EHDPHP on skeletal muscle differentiation by culturing C2C12 cells with varying concentrations of EHDPHP during induction of differentiation, as well as constructing a mouse muscle injury repair model through oral administration of 30 μg/kg EHDPHP for 7 weeks. Exposure to EHDPHP was found to impede skeletal muscle differentiation in mice. Utilizing techniques such as western blot analysis, RNA-seq, and qRT-PCR, our preliminary analysis revealed that low concentrations of EHDPHP inhibited the expression of ACTC1, subsequently suppressing MyoG and MYH2 expression levels, thereby hindering C2C12 myoblast differentiation. Furthermore, EHDPHP exposure disrupted the repair process of muscle injury in mice and compromised the integrity of the repaired tissue. In conclusion, these findings elucidate the detrimental effects of EHDPHP exposure on muscle differentiation, uncovering its muscle toxicity.
研究领域:
毒理学
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分子生物学
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细胞生物学
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药理学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Foods
·
2024
·Vol. 13
·期 8
·1215
·
IF 4.7
Jiaojiao Yuan,Cheng Yang,Jialing Cao,Lianfu Zhang
A combined pretreatment method of “low temperature-ultrasound-papain” (LTUP) was proposed to remove the purine of pork loins. Compared with untreated pork loin, under optimal conditions (temperature 58 °C, ultrasound density 100 W/cm2, and papain concentration 0.085%), the purine removal rate of treated pork loin could reach 59.29 ± 1.39%. The meat quality of pork loin treated with the LTUP method such as hardness and chewiness decreased by 58.37% and 64.38%, respectively, and the in vitro protein digestibility was increased by 19.64%; the cooking loss was decreased by 15.45%, compared with the simulated household blanching process (HT). In view of the high purine removal rate, the losses of free amino acids and soluble peptides were acceptable and reasonable. SEM and LF-NMR results showed that low temperature and ultrasound combined with papain treatment opened a channel for purine transfer and promoted purine dissolution by affecting the protein structure of pork loin. In addition, the migration of water within the muscle tissue was also related to purine removal. In summary, LTUP is recommended as an efficient and green way for the meat industry to remove purine.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
THERMOCHIMICA ACTA
·
2020
·
IF 2.762
Jing Fan,Qinglong Meng,Fenhong Song
Biodiesel which is comprising of Fatty Acid Methyl Esters (FAMEs) or Fatty Acid Ethyl Esters (FAEEs) mixtures, has attracted tremendous attention as a potential renewable and biodegradable fuel in internal combustion engines, because of their beneficial effects on pollution emission and engine performance. In this work, the liquid thermal conductivity of two binary mixtures containing a diesel compound n-dodecane + biodiesel compounds: methyl caprate and ethyl caprate was measured by means of transient hot-wire method at the teamperature range between 292 K and 362 K at atmospheric pressure. Based on the experimental data of two binary mixtures, the correction about three useful correlations which are available to calculate the liquid thermal conductivity of mixtures have been conducted.
研究领域:
能源科学
·
化学工程
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Tianle Wu,Peng Wang,Yuyu Zhang,Ping Zhan,Yu Zhao,Honglei Tian,Wanying He
Mutton possesses a typical flavor, known as “muttony” or “goaty”, which significantly limits consumers’ acceptability and its further popularization. Generally, this unpleasant flavor originates from mutton tallow. Thus, we first characterized the key volatiles of the cooked mutton tallow (CMT) via gas chromatography-mass spectrometry/olfactometry (GC–MS/O) and odor activity value (OAV). Combined with aroma recombination and omission tests, eleven compounds, involving 4-methyloctanoic acid, 4-methynonanoic acid, octanoic acid, decanoic acid, hexanal, heptanal, ( E )-2-octenal, ( E )-2-nonenal, ( E )-2-decenal, 2-nonanone and 2-penty-furan, were screened out to be responsible for the “muttony” flavor. The objective of this study was to investigate the sensory property and acceptability of CMTs, elaborated with 4 different levels of thyme phenolic extract (TPE), through descriptive sensory analysis and key muttony-related compounds identification. The results showed that, of different TPEs employed, CMT plus TPE3 was the most effective strategy to control the key “muttony” contributors, thereby to improve flavor profile of CMT.
研究领域:
食品科学
·
风味化学
·
感官评价
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）