MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 219
·期 8
·1700558
·
IF 2.492
Hengchang Liu,Yujun Feng
Multicompartment micelles (MCMs), whose cores have at least two compartments, show potential applications in various areas, but the synthesis of polymers for preparing MCMs is usually tedious and time-consuming. In this work, two well-defined telechelic fluorocarbon-terminated triblock copolymers, F 8 -PEO 100 -PPO 65 -PEO 100 -F 8 (F 8 -F127-F 8 ) and F 8 -PEO 132 -PPO 50 -PEO 132 -F 8 (F 8 -F108-F 8 ), are synthesized via a single-step coupling reaction of Pluronics F127 or F108 with perfluoro-1-octanesulfonyl fluoride and characterized by Fourier-transform infrared and NMR spectroscopies, as well as gel permeation chromatography and surface tensiometry. Both of these fluorocarbon-terminated Pluronics can self-assemble into spherical MCMs with Janus-core in aqueous solution, as evidenced by transmission electron microscopy imaging. Since the lipophilic block (PPO) and fluorophilic segments (F 8 ) are separated by the hydrophilic blocks (PEO), these fluorocarbon-terminated Pluronics will loop to give rise to flower-like MCMs, and the calculations based on thermodynamics and dynamics support the formation of such unique aggregates. A “pre-self-assembly” mechanism is proposed to explain the formation process of flower-like MCMs with Janus-core prepared by these telechelic fluorocarbon-terminated triblock copolymers.
研究领域:
材料科学
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化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2017
·Vol. 69
·期 8
·967-977
·
IF 2.405
Shu Chang,Sabi-mouka Eboka M B,Wang Xiaoliang,Ding Li
ObjectivesIn this work, we designed the self-assembly peptide hydrogels to multiply therapeutic agents for improving anticancer effect and lowering adverse reaction of paclitaxel (PTX).MethodsThe folate (FA)-peptide-PTX hydrogels consist of self-assemble peptide hydrogel as nanoscale carrier, FA and RGD peptide as targeting moieties and paclitaxel as anticancer drug. The properties of hydrogels, such as morphology, size distribution, zeta potential and rheology, were investigated. Targeted specificity, biodistribution and anticancer effect were studied both in vitro and in vivo.Key findingsFolate-peptide-PTX hydrogel nanoparticles were spherical in shape with hydrodynamic diameter of approximately 137.3 ± 15.2 nm. The hydrogels could only target monolayer cancer cells but also penetrated the nuclei of cells in vitro. The in-vivo real-time imaging further demonstrated that the hydrogels preferentially accumulated in tumour and sustained release. Compared to free paclitaxel, the FA-peptide-PTX hydrogels had higher anticancer effect and lower side effect.ConclusionsThe dual-targeted drug delivery possessed strong capability of synergistic targeted delivery, long-term drug release and better biocompatibility than paclitaxel both in vitro and in vivo. The results obtained demonstrated a high potential of the proposed drug delivery system in improving the therapeutic efficacy of paclitaxel.
研究领域:
药学
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生物材料
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肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2018
·Vol. 102
·期 6
·3307-3317
·
IF 2.956
Dandan Zhang,Jing Li,Jianye Liang,Heping Li,Youwei Yan
We report α-MoO 3 flowers as a highly effective organics adsorbent for the first time. With α-MoO 3 microfibers (MFs), α-MoO 3 flowers uniformly self-assemble on a carbon cloth, serving as a great organics scavenger. They not only provide a high specific surface area but also possess van der Waals force, both of which guarantee a high adsorption efficiency for multiple organics. Nearly 100% of Rhodamine B (RhB), methylene blue (MB), and crystal violet (CV) are rapidly adsorbed while flowing through the designed α-MoO 3 flower-based filtration device. Even after five recycling times, its high adsorption efficiency toward RhB remains unaffected. The adsorption capacity of α-MoO 3 flowers for RhB, MB, and CV reaches up to 4974, 6217, and 3886 mg/m 2 , respectively. Additionally, this novel adsorbent can adapt to a wide pH range, maintaining the excellent capacity of 4774 and 4473 mg/m 2 toward RhB at pH of 2.0 and 12.0. The α-MoO 3 flowers can also adsorb other organics, including MO, noroxin, and tetracycline hydrochloride. Moreover, the free-standing α-MoO 3 flowers on a carbon cloth realize the adsorptive filtration for organics removal, which not only require no conditions and no energy consumption but also avoid secondary pollution to the water as compared to the powdery adsorbents.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2013
·
IF 4.187
Panpan Li,Xu Chen,Wensheng Yang
Controlling the macroscopic organization of self-assembled peptide nanostructures on a solid surface is a key challenge in enabling their technological applications. Here, we report a simple approach to achieve the horizontally organized self-assembly of dipeptides by introducing graphene sheets. We show at the first time the formation of a macroscopic-scale, high-density, and ordered interlaced array of peptide nanowires and graphene composite (PNWs-G) on a silicon surface under mild conditions. The action of graphene sheets in the formation of the organized bionanostructure was preliminarily investigated. Furthermore, due to the introduction of graphene, the electronic conductivity of the bionanostructures was greatly improved, which is very beneficial for their applications in bioelectrochemical and nanoelectronic devices. As an applied example, the significantly enhanced electrochemical sensing performance for dihydronicotinamide adenine dinucleotide (NADH) was also demonstrated at the PNWs-G modified electrode relative to the alone component and unordered composite modified electrodes. The simple and mild approach described here opens a new avenue for the fabrication of macroscopic-scale organized self-assembled peptide bionanostructures on a solid surface, which should be capable of being extended to other biosystems based on graphite surface-template assembly, allowing a variety of functional bionanostructures to be fabricated and used in practical applications.
研究领域:
生物纳米技术
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材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2013
·
IF 4.814
Xiaoyu Sun,Ke Ding,Yi Hou,Zhenyu Gao,Wensheng Yang,Lihong Jing,Mingyuan Gao
Monodispersed superparticles (SPs) consisting of hydrophobic CuInS2@ZnS quantum dots (QDs) were prepared through a self-assembling process induced by introducing ethanol into the cyclohexane solution of the QDs stabilized by 1-dodecanethiol. The solvent polarity-dependent size and size distribution of the resultant SPs were carefully characterized by using scanning electron microscopy, transmission electron microscopy, and dynamic light scattering. The formation and the growth mechanism of the SPs were investigated. By manipulating the nucleation and the growth kinetics through the addition rate of ethanol, the size was effectively tuned without broadening the size distribution of the SPs. By overcoating the SPs with amphibious Fe3O4 nanocrystals (NCs) stabilized by poly(4-vinylpyrollidone), aqueous dispersible SPs were obtained. Inheriting the fluorescent and magnetic properties from the corresponding mother particles, the resultant SPs presented excellent fluorescent and magnetic properties and, thus, may potentially be useful for bioseparation, detection, etc.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2015
·Vol. 8
·期 12
·8701-8713
·
IF 2.651
Kaikai Wang,Juan Wang,Wenwen Hu,Yifan Zhang,Feng Zhi,Zaigang Zhou,Jinhui Wu,Yiqiao Hu
Hemoglobin is a promising drug carrier but lacks extensive investigation. The chemical conjugation of hemoglobin and drugs is costly and complex, so we have developed curcumin-loaded hemoglobin nanoparticles (CCM-Hb-NPs) via self-assembly for the first time. Using the acid-denaturing method, we avoid introducing denaturants and organic solvents. The nanoparticles are stable with uniform size. We have conducted a series of experiments to examine the interaction of hemoglobin and CCM, including hydrophobic characterization, SDS-PAGE. These experiments substantiate that this self-assembly process is mainly driven by hydrophobic forces. Our nanoparticles achieve much higher cell uptake efficiency and cytotoxicity than free CCM solutionin vitro. The uptake inhibition experiments also demonstrate that our nanoparticles were incorporated via the classic clathrin-mediated endocytosis pathway. These results indicate that hemoglobin nanoparticles formed by self-assembly are a promising drug delivery system for cancer therapy.Keywords:drug carrier;hydrophobic forces;self-assemble;cell uptake
研究领域:
生物化学
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药剂学
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肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energetic Materials
·
2022
·
IF 2.421
Dongyu Hao,Yinghui Hu,Fang Wang,Debin Xia,Dakang Wang,Ruiqing Fan,Yulin Yang,Kaifeng Lin
In this work, a novel Al2O3-free core-shell structured nAl@aluminum-perfluorooctanoate (F-x) nanocomposite has been prepared via a self-assembly approach. The Al2O3 shell was first removed by hydrofluoric acid (HF) solution, and then the perfluorooctanoic acid (PFOA) was coated on the surface of nAl by a self-assemble reaction. The thickness of the obtained F-x layer can be easily tuned by using different amount of PFOA based on the chemical interaction between nAl and PFOA molecules. The obtained nAl@F-x nanocomposite showed an enhanced exothermic and combustion performance due to the synergetic effect between F-x and nAl and the mesoporous structure in situ formed during the combustion process. This work demonstrated that nAl@F-x nanocomposite prepared by PFOA coating on nAl could effectively solve the detrimental effect of in situ formed Al2O3, thus enhancing the combustion and thermal reaction performances, which showed great potential to be applied in solid rocket propellant.
研究领域:
材料科学
·
燃烧与推进
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Yong Liu,Kangjie Zhou,Zhuo Huang,Heng Luo,Zhengping Fang,Shuaiyuan Wang,Huiyu Yang,Hai Liu
Conventional hydrogels often face inherent limitations such as dehydration sensitivity, mechanical brittleness, and optical opacity, which severely restrict their advanced applications. In this study, we report a controlled evaporation–freeze/thaw self-assembly strategy for fabricating biomimetic poly(vinyl alcohol)/graphene oxide nanosheet (PG) organohydrogels with tunable architectures. Inspired by natural nacre, homogeneous layered PG organohydrogels are engineered to simultaneously achieve superior mechanical properties and optical transparency, enabled by a nacre-mimetic “brick-and-mortar” microstructure with aligned polymer–nanosheet interfaces. Remarkably, post-treatments combining prolonged evaporation and UV-induced reduction synergistically enhance the mechanical performance, yielding a tensile strength of 6.3 MPa and toughness of 43.0 MJ/m3, surpassing those of many reported poly(vinyl alcohol) (PVA)-based hydrogels. Furthermore, the humidity-regulated self-assembly process enables the creation of skin-like gradient PG organohydrogels, mimicking epidermal–dermal structural hierarchies to achieve optimized water retention and mechanical stability. This work establishes a universal platform for designing high-performance hydrogels that reconcile traditionally conflicting properties, offering great potential for applications in flexible electronics, soft robotics, and biointegrated devices that require environmental adaptability.
研究领域:
材料科学
·
高分子科学
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纳米技术
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柔性机器人
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柔性电子器件
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AICHE JOURNAL
·
2023
·Vol. 69
·期 5
·e18023
·
IF 3.7
Qing Sun,Yan Dong,Shuai Wang,Zhanfang Cao,Xin Ma,Hong Zhong
Modified surfactants can regulate their adsorption at the target surface and are essential for various separation applications such as froth flotation. Thioether-containing hydroxamic acid (BTHA) is an excellent oxidized-ore collector with poor dispersibility. Herein, acylamino, which possesses the ability to improve the surfactants' self-assembly and dispersion, was introduced to synthesize N-[6-(hydroxyamino)-6-oxohexyl] benzylthioacetamide (BTAHA); thus, applying it to cassiterite flotation. Surface tension, adsorption capacity, in situ AFM, and surface energy results reveal BTAHA displays strong bubble stability and readily adsorbs onto the mineral's surface, promoting hydrophobic flotation. BTAHA is an effective cassiterite collector and has good separation effects on cassiterite against calcite. It can form Van der Waals forces and five-membered hydroxamate-(O,O)-Sn rings with Sn atoms on cassiterite surfaces via thioether and hydroxamate groups. Meanwhile, the presence of intermolecular hydrogen bond between the amide groups facilitates the self-assembly of the collectors on the cassiterite surface, and has broad industrial application prospects in various separation processes.
研究领域:
矿物加工工程
·
界面化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHOTOENERGY
·
2014
·
IF 0
Sujing Yu,Juncheng Hu,Jinlin Li
Self assembly of TiO2/CdS mesoporous microspheres was synthesized via hydrothermal method. The samples were characterized by X-ray powder diffraction (XRD), ultraviolet-visible diffuse reflectance spectroscopy (DRS), transmission electron microscopy (TEM), energy-dispersive spectroscopy analysis (EDS), high-resolution transmission electron microscopy (HRTEM), Brunauer-Emmett-Teller (BET), X-ray photoelectron spectroscopy (XPS), and photoluminescence spectra (PL). The as-synthesized TiO2/CdS mesoporous microspheres showed superior photocatalytic activity for the degradation of RhB under either visible light or simulated sunlight irradiation; the 10 wt% TiO2/CdS sample showed the best performance. Moreover, this catalyst showed improved stability, and the activity did not decrease significantly after four recycles. The heterojunction between TiO2 and CdS may be favorable for the transport of photoinduced electrons from CdS to TiO2. In addition, the mesoporous structure could increase the utilization of light energy and facilitate the diffusion of reactants and products during the photocatalytic reaction.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
MACROMOLECULAR RAPID COMMUNICATIONS
·
2010
·Vol. 31
·期 21
·1886-1891
·
IF 4.263
Wei Xiong,Hanfu Wang,Yanchun Han
Novel dendritic triblock co-oligomer (14G2A3) consisting of ester dendrons and aniline oligomer was synthesized and found to self-assemble into fibrils in THF. Studies reveal that the formation of the fibrils originates from both of the amphiphilic interactions between the ester dendrons and oligoaniline, as well as the intermolecular π-π stacking among oligoanilines. The shape effect of dendrons on molecular packing was comparatively analyzed with packing parameter against its linear analogous compound. At the same time, the driving forces that dominate the final aggregating state of the block oligomer were separately investigated using the bulky-group protecting method, which allows release of the intermolecular π-π stacking of oligoaniline in a controlled manner. Results show that both the introduction of dendrons and the intermolecular π-π stacking will increase the packing parameter of the block oligomer and, consequently, cause the self-assembly morphology to evolve step by step from micelles to vesicles and finally to fibrils. The fibrils can form complexes with SWNTs to increase solubility in THF. The effective fluorescence quenching accompanied also opens a gate for the block co-oligomer to have potential applications in organic electronic devices.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
iScience
·
2023
·Vol. 26
·期 7
·107048-107048
·
IF 5.8
Li Li,Zuxian Xu,Ruipin Cao,Jiaxin Li,Chang-Jer Wu,Yinglu Wang,Hu Zhu
We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of structurally similar cyclic dipeptides, namely cyclo( L -Pro- L -Tyr), cyclo( L -Hyp- L -Tyr), and cyclo( L -Pro- L -Phe), against Pseudomonas aeruginosa PAO1. Cyclo( L -Pro- L -Phe), lacking hydroxyl groups, displayed higher virulence factor inhibition and cytotoxicity, but showed less inhibitory ability in biofilm formation. Cyclo( L -Pro- L -Tyr) and cyclo( L -Hyp- L -Tyr) suppressed genes in both the las and rh l systems, whereas cyclo( L -Pro- L -Phe) mainly downregulated rhl I and pqs R expression. These cyclic dipeptides interacted with the QS-related protein LasR, with similar binding efficiency to the autoinducer 3OC12-HSL, except for cyclo( L -Pro- L -Phe) which had lower affinity. In addition, the introduction of hydroxyl groups significantly improved the self-assembly ability of these peptides. Both cyclo( L -Pro- L -Tyr) and cyclo( L -Hyp- L -Tyr) formed assembly particles at the highest tested concentration. The findings revealed the structure-function relationship of this kind of cyclic dipeptides and provided basis for our follow-up research in the design and modification of anti-QS compounds.
研究领域:
微生物学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
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