ANALYTICAL CHEMISTRY
·
2014
·
IF 5.825
Abdukader Abdukayum,Cheng-Xiong Yang,Qiang Zhao,Jia-Tong Chen,Lu-Xi Dong,Xiu-Ping Yan
The development of multimodal nanoprobes that combined properties of near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) within a single probe is very important for medical diagnosis. The NIR-emitting persistent luminescent nanoparticles (PLNPs) are ideal for optical imaging owing to no need for in situ excitation, the absence of background noise, and deep tissue penetration. However, no PLNP based multimodal nanoprobes have been reported so far. Here, we report a novel multimodal nanoprobe based on the gadolinium complexes functionalized PLNPs (Gd(III)-PLNPs) for in vivo MRI and NIR luminescence imaging. The Gd(III)-PLNPs not only exhibit a relatively higher longitudinal relaxivity over the commercial Gd(III)-diethylenetriamine pentaacetic acid complexes but also keep the superlong persistent luminescence. The prepared Gd(III)-PLNPs multimodal nanoprobe offers great potential for MRI/optical imaging in vivo.
研究领域:
医学影像学
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纳米医学
·
生物材料学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Guomeng Li,Xudong Zheng,Xi Zhang,Youming Zhu,Lin Guo,Jinfeng Mei,Xiukun Ge,Zhongyu Li
The development of high technology has elevated industry’s dependence on rare earth resources. The hydrometallurgical process is widely used for the separation of rare earth elements (REEs) from rare earth ores, producing acidic leachate with trace amounts of REEs. Recovery of REEs from rare earth leachate not only mitigates the negative impact of leachate on the environment, but also contributes to the realization of sustainable resource utilization. In this study, two novel imprinted cryogel adsorbents, methyltrioctylammonium chloride-derivative carboxymethylated cellulose nanocrystal imprinted cryogel (LR-ICMC) and ethylmethylimidazolium bromide-derivative carboxymethylated cellulose nanocrystal imprinted cryogel (LM-ICMC), were constructed by using carboxymethylated modified cellulose nanocrystals as a backbone structure, and successfully branched ionic liquids (ILs) methyltrioctylammonium chloride-derivative and ethylmethylimidazolium bromide-derivative, respectively, for the separation of gadolinium ions (Gd(III)) from rare earth leachate. Firstly, SEM and TEM results showed that the incorporation of ILs retained part of the pore structure of carboxymethylated cellulose nanocrystals (CMCNCs). BET and TG results illustrated that the incorporation of ILs effectively increased the specific surface area and thermal stability of LR-ICMC and LM-ICMC. FT-IR and XPS results showed that LR-ICMC and LM-ICMC could adsorb Gd(III) by electrostatic and chelating effects. Secondly, adsorption isotherm experiments demonstrated the adsorption capacities of 66.880 mg/g and 75.895 mg/g for LR-ICMC and LM-ICMC, respectively; adsorption kinetic experiments demonstrated the ability of LR-ICMC and LM-ICMC to rapidly adsorb 85.152 % and 87.989 % of the maximum adsorption capacity, respectively, within the initial first 40 min. Finally, cycling experiments demonstrated the advantages of LR-ICMC and LM-ICMC in reuse, maintaining 89.245 % and 90.734 % of the original performance after five adsorption–desorption cycles, respectively. Based on these results, LR-ICMC and LM-ICMC were demonstrated to be highly efficient and reusable adsorbents for selective recovery of Gd(III) from rare earth leachate. This study deepens the application of ILs in solid-phase adsorbents and highlights the great potential of LR-ICMC and LM-ICMC in the field of REEs recovery.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Zheng Gong,Jian Yang,Hancheng Zhu,Duanting Yan,Chunguang Liu,Changshan Xu,Yuxue Liu
Gd 3+ and Cr 3+ codoped zinc gallogermanate (ZGGO:Cr 3+ , Gd 3+ ) nanoparticles were prepared by a hydrothermal method in combination with a subsequent vacuum annealing. It is found that Gd 3+ doping not only endows ZGGO:Cr 3+ nanoparticles with magnetic property, but also results in the decreased nanoparticle size and the enhanced near infrared (NIR) afterglow intensity. Strikingly, amino group functionalized SiO 2 layer coating enabling Gd 3+ doped ZGGO:Cr 3+ nanoparticles well dispersed in water enhances persistent luminescence which is because of the weakened quenching effect of OH − groups in water. Validation of high-quality bioimaging was demonstrated using the surface functionalized Gd 3+ doped ZGGO:Cr 3+ nanoparticles dispersed in human serum albumin (HSA). In particular, it is found that the longitudinal relaxivity (7.33 s −1 (mM) −1 ) of Gd 3+ doped ZGGO:Cr 3+ nanoparticles is higher than that of commercial magnetic resonance imaging (MRI) contrast agent (Gd-DTPA) and it leads to the high-quality in vitro T 1 -weigthed images.
研究领域:
材料科学
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医学影像学
·
纳米技术
✓ 已验证
DOI
高影响因子
Materialia
·
2022
·
IF 0
Jianfeng Yang,Qingling Zhao,Zehao Zang,Shuquan Zhang,Ziwu Wang,Lanlan Li,Xiaofei Yu,Xiaojing Yang,Zunming Lu,Xinghua Zhang
Magnetic resonance imaging (MRI) contrast agents with high relaxivity is of great importance for clinical diagnosis. Here we propose an effective method to enhance the relaxivity of MRI contrast agents. Ultra-small gadolinium oxide nanoparticles (Gd 2 O 3 NPs) with different surface ligands were prepared by coprecipitation method, and the polyacrylic acid (PAA) modulated Gd 2 O 3 NPs (PAA-Gd 2 O 3 ) have the high r 1 relaxivity of 53.34 mM –1 s –1 , which is mainly induced by the strong affinity between PAA and water molecules. In addition, PAA modulated Gd 2 O 3 NPs were successfully loaded on Au@MSNs (Au nanorod coated with mesoporous silica , Gd 2 O 3 /Au@MSNs) with enhanced affinity between Gd 3+ and water molecules, as well as increased motional time of Gd 3+ . Therefore, the r 1 relaxivity of Gd 2 O 3 /Au@MSNs can be up to 64.53 mM –1 s –1 , which is 17 times of the commercial agent Gd-DTPA. The Gd 2 O 3 /Au@MSNs NPs also have a low r 2 /r 1 of 1.04 and good computed tomography (CT) imaging performance, as well as good biocomatibility, which have great potential applications in multimodal bioimaging.
研究领域:
医学影像学
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纳米医学
·
生物材料学
✓ 已验证
DOI
Advanced Healthcare Materials
·
2024
·
IF 10
Ting Zhou,Yanzhi Dong,Xiaoyi Wang,Ruxia Liu,Ran Cheng,Jinbin Pan,Xuejun Zhang,Shao-Kai Sun
Iron oxide nanoprobes exhibit substantial potential in magnetic resonance imaging (MRI) of kidney diseases and can eliminate the nephrotoxicity of gadolinium-based contrast agents (GBCAs). Nevertheless, there is an extreme shortage of highly sensitive and renal clearable iron oxide nanoprobes suitable for early kidney damage detection through MRI. Herein, a renal clearable ultra-small ferrite nanoprobe (UMFNPs@ZDS) is proposed for highly sensitive early diagnosis of kidney damage via structural and functional MRI in vivo for the first time. The nanoprobe comprises a ferrite core coated with a zwitterionic layer, and possesses a high T 1 relaxivity (12.52 m m −1 s −1 ), a small hydrodynamic size (6.43 nm), remarkable water solubility, excellent biocompatibility, and impressive renal clearable ability. In a rat model of unilateral ureteral obstruction (UUO), the nanoprobe-based MRI can not only accurately visualize the locations of renal injury, but also provide comprehensive functional data including peak value, peak time, relative renal function (RRF), and clearance percentage via MRI. The findings prove the immense potential of ferrite nanoprobes as a superior alternative to GBCAs for the early diagnosis of kidney damage.
研究领域:
医学影像学
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生物材料学
·
肾脏病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2019
·Vol. 43
·期 13
·7614-7626
·
IF 3.343
Mangmang Shi,Yinglin Yan,Yiqi Wei,Yiming Zou,Qijiu Deng,Juan Wang,Rong Yang,Yunhua Xu,Tong Han
Summary Carbon aerogel (CA), possessing abundant pore structures and excellent electrical conductivity, have been utilized as conductive sulfur hosts for lithium-sulfur (Li-S) batteries. However, a serious shuttle effect resulted from polysulfide ions has not been effectively suppressed yet due to the weak absorption nature of CA, resulting in rapid decay of capacity as the cycle number increases. Herein, ultrafine (~3 nm) gadolinium oxide (Gd 2 O 3 ) nanoparticles (with upper redox potential of ~ 1.58 V versus Li + /Li) are uniformly in-situ integrated with CA through directly sol-gel polymerization and high-temperature carbonization. The Gd 2 O 3 modified CA composites (named as Gdx-CA, where x means molar ratio of Gd 2 O 3 nanoparticles to carbon) are incorporated with S. Then, the products (S/Gdx-CA) are acted as sulfur host materials for Li-S batteries. The results demonstrate that adding ultrafine Gd 2 O 3 nanoparticles can dramatically improve the electrochemical properties of the composite cathodes. The S/Gd2-CA electrode (loading with 58.9 wt% of S) possesses the best electrochemical properties, including a high initial capacity of 1210 mAh g −1 and a relatively high capacity of 555 mAh g −1 after 50 cycles at 0.1 C. It is noteworthy that the performance of long-term cycle (350 cycles) for the S/Gd2-CA (317 mAh g −1 after 100 cycles and 233 mAh g −1 after 350 cycles at 1 C) is improved significantly than that of S/CA (150 mAh g −1 after 150 cycles at 1 C). Overall, the enhancement of electrochemical performances can be due to the strong polar nature of the ultrafine Gd 2 O 3 nanoparticles, which provide strong adsorption sites to immobilize S and polysulfide. Furthermore, the Gd 2 O 3 nanoparticles present a catalytic effect. Our research suggests that adding Gd 2 O 3 nanoparticles into S/CA composite cathode is an effective and novelty method for improving the electrochemical performances of Li-S batteries.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米科技
·
无机非金属材料
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Hang Liu,Jinkai Zhang,Chuanyu Yang,Runkang Lv,Yihao Wen,Yuhong Zhang
In this paper, the nanosheet structure of Gd-doped ZnO nanosheets is prepared by single-step hydrothermal method. The gas sensitive performance of Gd-doped ZnO nanosheets is investigated. The Gd-ZnO sensor not only improves the response to ethanol gas by a factor of 11.8 compared to a pure ZnO sensor, but also reduces the optimal working temperature by 20 °C. The response/recovery time are also reduced to varying degrees. In addition, the Gd-ZnO sensor maintain a certain performance to ethanol gas under different humidity conditions. This article elaborates on the sensing mechanism of the Gd-ZnO sensor for ethanol gas. The research in this paper opens up a new idea for improving zinc oxide sensors.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Chunling Yang,Qianhong Ren,Xiaomei Liu,Yi Liu,Botao Zhang,Ping Zhou,Hua Li
Artificial bone fillers are essentially required for repairing bone defects, and developing the fillers with synergistic biocompatibility and anti-bacterial activity persists as one of the critical challenges. In this work, a new agarose/gadolinium-doped hydroxyapatite filler with three-dimensional porous structures was fabricated. For the composite filler, agarose provides three-dimensional skeleton and endows porosity, workability, and high specific surface area, hydroxyapatite (HA) offers the biocompatibility, and the rare earth element gadolinium (Gd) acts as the antibacterial agent. X-ray photoelectron spectroscopy detection showed the doping of Gd in HA lattice with the formation of Gd-HA interstitial solid solution. Attenuated total reflection Fourier transform infrared spectroscopy imaging suggested chemical interactions between agarose and Gd-HA, and the physical structure of agarose was tuned by the Gd-doped HA. Cytotoxicity testing and alizarin red staining experiments using mouse pro-osteoblasts (MC3T3-E1) revealed remarkable bioactivity and osteogenic properties of the composite fillers, and proliferation and growth rates of the cells increased in proportion to Gd content in the composites. Antibacterial testing using the gram-positive bacteria S. aureus and the gram-negative bacteria E. coli indicated promising antibacterial properties of the fillers. Meanwhile, the antibacterial properties of composite filles were enhanced with the increase of Gd content. The antibacterial fillers with porous structure and excellent physicomechanical properties show inspiring potential for bone defect repair.
研究领域:
生物材料
·
组织工程
·
生物医学工程
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Fuhuan Wang,Weifeng Zhang,Xiaojie Cheng,Yanmin Wang,Yuechao Yao,Jun Zhang,Ting Chen,Yucun Zhou,Shaorong Wang,Hewu Wang,Liangfei Xu,Minggao Ouyang,Jianqiu Li
Solid oxide fuel cells (SOFCs) are pivotal in addressing global energy and environmental challenges, but their durability and maintenance costs are often limited by interface issues between yttria-stabilized zirconia (YSZ) electrolytes and active cathodes at high operating temperatures. Cerium-based oxides, particularly gadolinium-doped ceria (GDC), have proven effective in mitigating these challenges by acting as efficient buffer layers. In this study, we present a one-step spin-coating method for fabricating a thin, dense GDC buffer layer using GDC nanoparticles. A ∼1 μm thick, high-density (density >80 %) buffer layer is achieved by calcining at 1250 °C, forming a continuous and cohesive interface with the electrolyte. Single cells incorporating this buffer layer exhibit an ohmic resistance of 0.15 Ω cm 2 and achieve a peak power density of 0.81 W cm −2 at 800 °C. Stability is demonstrated by operating the cell at 0.4 A cm −2 and 750 °C for over 200 h with stable performance. Furthermore, the fabrication method has been successfully scaled up for 10 × 10 cm 2 large-area cells, yielding a power output of 31.6 W at 0.7 V at 750 °C. The proposed scalable and cost-effective fabrication technique offers significant potential for the large-scale production of high-performance SOFCs.
研究领域:
材料科学
·
能源工程
·
电化学
·
陶瓷学
·
功能材料
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Chunyan Pan,Shiqin Zhang,Yi Fang,Fuxiang Wei,Shan Huang,Qi Xiao
Catalase, a vital antioxidant enzyme, plays a pivotal role in maintaining cellular redox homeostasis. Dysregulation of its activity in tumor cells has emerged as a promising target for cancer therapy. Given the ultra-small size and unique physicochemical properties of carbon dots, which enable effective binding to catalase, this study aimed to investigate the inhibitory mechanism of gadolinium-doped red carbon dots (Gd-CDs) on catalase activity and their resultant biological effects. To achieve this, an integrated approach combining multispectral technology, molecular docking, dynamic simulation, and cellular experiments was employed. Computational modeling revealed that Gd-CDs form stable complexes with catalase through van der Waals forces, hydrogen bonds, and hydrophobic interactions, with a binding free energy (Δ G ) of −5.25 kcal·mol −1 . Enzyme activity assays further demonstrated that the inhibition of Gd-CDs followed a mixed-type competitive mechanism. Cellular experiments showed distinct cytotoxic effects: Gd-CDs exhibited a significantly lower survival rate in HeLa tumor cells (58.95 %) compared to normal GES-1 cells (82.80 %). In vitro analyses revealed that Gd-CDs reduced catalase activity by 53.74 % and induced abnormal cellular morphology, leading to cytotoxicity and cellular damage. Collectively, this study elucidates the binding mechanism between Gd-CDs and catalase, offering novel insights into nanomaterial-mediated enzyme regulation. Moreover, it highlights the potential of modulating catalase levels via Gd-CDs as a promising strategy for tumor treatment, opening new avenues in cancer therapeutics.
研究领域:
纳米技术
·
生物化学
·
计算生物学
·
癌症研究
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Libo He,Yongkun Wang,Guoxiang Zhang,Wei Zhao,Lu Zhang,Peipei Li,Chen Su,Zhifeng Wu,Xiaowei Liu
In this work, we report a facile strategy for synthesizing hydrophilic Gd(OH)3 sheets via a Gd-based interfacial precipitation reaction at the interface of organosilane-modified Gd2O3 nanoparticles and a cation exchange resin. This strategy, independent of the specific organosilane used, produces two-dimensional sheets with a distinct lamellar structure and excellent aqueous dispersibility. Characterization confirms the formation of Gd(OH)3 sheets with promising fluorescent and magnetic properties.
研究领域:
无机纳米材料
·
生物医学成像
·
纳米化学
·
功能材料
·
稀土材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Donglin Cai,Fangze Chen,Juntao Pan,Ze Wei,Weichuang Kuang,Xiyong Chen,Yihui Liu,Nengneng Luo,Xiaoming Shen
The perovskite ceramics La 1- x Gd x BaCo 2 O 5+ δ with double lanthanide at A site was synthesized by a traditional solid phase reaction method. The structure and properties of La 1- x Gd x BaCo 2 O 5+ δ were investigated by experiment and analysis. It can be seen from the X-ray diffraction (XRD) that the crystal structure changes from single perovskite to double perovskite with the increase of Gd 3+ content. Refined by Rietveld method, it is found that with the increase of Gd, the crystal structure of La 1- x Gd x BaCo 2 O 5+ δ oxides changes from cubic phase for x = 0 to tetragonal phase for x = 0.5 and then to orthorhombic for x = 1.0. The La 1- x Gd x BaCo 2 O 5+ δ ceramics shows good toxicity resistance in CO 2 and good thermal compatibility with Ce 0.9 Gd 0.1 O 2- δ (GDC) at 1100 °C. Through the X-ray photoelectron spectroscopy (XPS) test, it is found that this series of ceramic materials have good oxygen catalytic reduction activity, and the electronic conductivity is better than LaBaCo 2 O 5+ δ (LBCO) and GdBaCo 2 O 5+ δ (GBCO). Combined with the thermal expansion test and the electrochemical AC impedance analysis, it is found that the thermal expansion coefficient (TEC) of La 0.5 Gd 0.5 BaCo 2 O 5+ δ (LG-55) is closer to that of GDC electrolyte than LBCO, and the specific area resistance is smaller than GBCO. All these findings indicate that it can be used as a potential cathode material for intermediate-temperature solid oxide fuel cell (IT-SOFC).
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）