Biomaterials Research
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2025
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IF 9.6
Yuchao Cao,Shangfeng Shen,Jiahui Xiang,Yan Qiu,Jiajun Guo,Yuqing Zhang,Dairong Li,Yonghong Du
As lung cancer is still the deadliest cancer worldwide, there is an urgent need for safer and more efficient therapies. This study aims to address the challenges posed by tumors in reducing the efficacy of sonodynamic therapy (SDT) through mechanisms such as hypoxia and abnormal blood vessel formations. In this study, manganese-containing DNA nanoflowers (DHA-DDF) loaded with doxorubicin (DOX) were functionalized with an AS1411 aptamer and a hypoxia-inducible factor-1α (HIF-1α) antisense sequence. The in vitro tests confirmed their stability and pH-responsive drug release properties. The combined treatment of DHA-DDF and ultrasound could induce apoptosis, inhibit the migration and invasion of Lewis lung carcinoma (LLC) cells, and down-regulate the expression of HIF-1α and VEGF in LLC cells. The in vivo studies using subcutaneous LLC in mice showed that ultrasound enhanced the tumor-targeted accumulation and penetration of DHA-DDF. The combined approach markedly reduced tumor development and extended the survival of tumor-bearing mice, effectively down-regulated the expression of hypoxia-related genes, inhibited cell proliferation, and blocked tumor angiogenesis. The programmable, biocompatible, and multifunctional nanoflowers demonstrate a notable improvement in the efficacy of SDT and provide robust tumor inhibition in both cellular and animal models. The findings highlight the potential of DNA nanotechnology in advancing innovative cancer therapies.
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高影响因子
Journal of Materials Chemistry A
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2025
·
IF 9.5
Jiawen Hu,Linwen Jiang,Hang Liu,Jiawei Jin,Anhua Wu,Xiaofeng Zhang
High entropy alloys (HEAs) show great potential in electromagnetic-wave absorption (EMA), but impedance matching and environmental stability are still difficult problems to solve. Solid-solution strengthening is an effective means to enhance the performances of EMA materials. The multi-element co-penetrated FeCoCrMn HEAs are prepared using urea (CH4N2O) as the multi-element source by a green mechanochemical approach. The phase structure, magnetic properties, corrosion and oxidation resistance, and EMA properties of HEAs are investigated in detail. The results show that the crystal structure of HEAs is significantly altered by multi-element introduction. It is noteworthy that Ms is significantly enhanced on increasing the multi-element co-penetration level. The dielectric loss and magnetic loss of HEAs are significantly enhanced to optimize the impedance matching and attenuation properties, so as to achieve excellent EMA performances. Multi-element co-penetrated FeCoCrMn HEAs achieve a reflection loss (RL) of −59.6 dB at 6.06 GHz while achieving an ultra-wide effective absorption bandwidth (EAB) of 6.86 GHz at 1.32 mm. In addition, HEAs exhibit excellent corrosion resistance, indicating suitability in harsh environments. This study provides a new strategy for the design of highly effective EMA materials.
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ACS Applied Energy Materials
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2025
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IF 5.5
Hezhang Li,Hualu Zhuang,Jincheng Yu,Bowen Cai,Ruiheng Liu,Yi Niu,Jing Jiang,Jing-Feng Li,Chao Wang
Heusler alloys have attracted increasing attention due to their rich functionalities, among which Co2MnSi, a half-metallic full-Heusler, is expected to be a promising n-type thermoelectric material with a superior power factor. However, the intrinsically high thermal conductivity of Heusler alloys due to their metallic nature limits the enhancement in thermoelectric performance. Therefore, it is crucial to reduce the thermal conductivity while maintaining the high power factor, which is a key strategy to fabricate high-performance Co2MnSi alloys. Here, by incorporating a small amount of SiC nanoparticles into the Co2MnSi matrix, the thermoelectric figure of merit is enhanced by approximately 5-fold from 0.03 to 0.15 at 1025 K, due to a significant reduction in thermal conductivity from 22 to 5 W/mK. The electrical transport properties do not suffer any obvious degradation after incorporation of a significant amount of SiC, while the mechanical strength of Co2MnSi-based alloys is further improved. The thermoelectric device fabricated with Co2MnSi as the thermoelectric legs is validated for solid-state refrigeration. It is also expected to promote the development of Co2MnSi-based thermoelectrics with strong magnetism for new applications with multiple functionalities.
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JOURNAL OF SOLID STATE CHEMISTRY
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2025
·
IF 3.5
Zhenduo Fan,Haohang Xu,Jinggeng Zhao,Yaohui Zhang,Xianjie Wang,Yu Sui,Zhe Lv,Jian Liu,Sida Jiang,Zhiguo Liu
As the first intrinsic magnetic topological insulator , MnBi 2 Te 4 has provided a material platform for the realization of various novel physical phenomena arising from the interaction between magnetism and band topology. Here, transition element Zn - doped MnBi 2 Te 4 crystals of millimeter size, synthesized by using self-flux method, are reported. With increasing Zn content, the hexagonal lattice shrinks, and the Raman frequencies show a red shift. All samples undergo a transition from A - type antiferromagnetic (A - AFM) to canted antiferromagnetic (CAFM) to ferromagnetic (FM) under magnetic field . The antiferromagnetic ordering temperature slightly increases from 24.2 K for MnBi 2 Te 4 to 25.2 K for Mn 0.75 Zn 0.25 Bi 2 Te 4 . The transition field from AFM to CAFM decreases from 3.4 T for x = 0–3.07 T for x = 0.25. Isothermal magnetization data suggest that the single - ion anisotropy of Mn 2+ decrease and the interlayer magnetic interaction increase slightly due to the diluted magnetic ions and unit cell shrinkage. Samples Mn 0.9 Zn 0.1 Bi 2 Te 4 and Mn 0.8 Zn 0.2 Bi 2 Te 4 show metallic conduction with a cusplike anomaly at around T N ≈ 24 K, corresponding to a long - range antiferromagnetic (AFM) transition. The increase of T N and decrease of transition field ( H c S F ) upon Zn doping, make it possible to manipulate magnetic and electrical properties in topological insulators by non - magnetic element substitution, which is of great significance for further application in quantum information storage and spintronics .
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Advanced Science
·
2025
·Vol. 12
·期 27
·2502832
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IF 14.1
Kai-Yu Yang,Xiaoyuan Li,Yuanxin Jiang,Liangliang Wang,Kai Guo,Lei Miao,Junliang Chen,Jiye Zhang,Lin Li,Yusong Du,Guang-Hui Rao,Jun Luo,Jing-Tai Zhao
Segmentation is a widely adopted strategy to enhance the efficiency of medium- and high-temperature thermoelectric devices by capitalizing on the distinct properties of materials across various temperature ranges. Establishing a highly compatible matching relationship is crucial for maximizing conversion efficiency. In this study, the concepts of materials’ compatibility factor and relative current density into the screening process are emphasized for universal adaptability. The effectiveness and practicality of the theoretical model for optimal segmented combinations are validated through COMSOL finite element simulations and experimental results. A segmented thermoelectric power generation device is constructed that integrates the environmentally friendly n-type Mg 3 (Sb,Bi) 2 with the optimal segmented pairing of Bi 0.5 Sb 1.5 Te 3 -GeTe. Notably, at a temperature difference of Δ T = 440 K, this device achieves a maximum conversion efficiency of 10.4% and a peak output power of 0.41 W. These findings provide a solid theoretical foundation for the development of efficient combinations of thermoelectric materials.
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ADVANCED MATERIALS
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2025
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IF 26.8
Dashuai Li,Qi Wu,Changhua Wang,Zhehao Sun,Yingying Li,Zongyou Yin,Yichun Liu,Xintong Zhang
Transition metal high-entropy alloys (HEAs) demonstrate exceptional catalytic performance due to their structural complexity, featuring rich local atomic configurations, tunable electronic structures, and abundant active sites. However, this structural versatility poses both thermodynamic and kinetic challenges to conventional wet-chemical synthesis routes. Herein, we develop a novel solution plasma strategy that enables the direct synthesis of HEA catalysts in aqueous media. Through the FeCoNiCrMn electrode discharge in pure water, uniform HEAs nanoparticles (≈200 nm) are successfully anchored onto a variety of oxide substrates. The HEAs/TiO 2 catalyst achieves a CO generation rate of 298.1 mmol/g HEAs /h, representing ca. an order-of-magnitude higher activity than single-metal catalysts under both thermocatalytic and photothermal conditions. Advanced structural characterization reveals a dual-phase core-shell architecture consisting of a metallic alloy core and surface oxides preferentially enriched at CrMn sites. This spatially resolved structure enables cooperative catalysis, where CrMn-rich oxide domains promote H 2 dissociation, CoNi metallic regions facilitate CO 2 reduction, and Fe sites present in mixed valence states serve as electron and oxygen transfer bridges. We further identify a self-limiting oxidation mechanism intrinsic to plasma synthesis, which ensures charge redistribution at the metal-oxide interfaces and synergistically enhances photothermal catalysis. This work establishes an energy-efficient synthetic route for HEAs and elucidates structure-function relationships critical for advancing multimetallic catalytic systems.
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Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Qin Guo,Ying Cao,Jin Jiang,Juan Li
The permanganate/sulfite (Mn(VII)/sulfite) process has shown promise for degrading recalcitrant organic micropollutants, yet current methods to differentiate the roles of intermediate manganese species (IMS) and sulfate radicals (SO₄ •- ) show limitations. In this study, atrazine (ATZ) - a widely detected and oxidation-resistant herbicide - was used as a probe compound to investigate the reactivity of IMS and SO₄ •- generated in the Mn(VII)/sulfite system. ATZ exhibited negligible degradation by Mn(VII) alone but underwent rapid transformation within seconds in the presence of sulfite, with degradation efficiency increasing at lower pH and optimal [Mn(VII)]/[sulfite] ratios. Using stopped-flow spectrophotometry, pseudo-first-order kinetics were confirmed. Six major transformation products were identified, among which atrazine amide (CDIT) and desethyl-atrazine (DEA) were predominant. The molar ratio of CDIT to DEA ([CDIT]/[DEA]) was evaluated as a mechanistic indicator. A consistent ratio of ~4.8 at low sulfite levels indicated Mn(V)-dominated oxidation, while lower ratios at higher sulfite concentrations reflected increasing contributions from Mn(III) and SO 4 •− . This trend was supported across pH 3, 5, and 7. Water matrix components such as natural organic matter and nitrite were found to inhibit ATZ degradation, likely due to their scavenging of reactive species. This study establishes the [CDIT]/[DEA] ratio as a novel mechanistic indicator in manganese-activated oxidation and highlights the Mn(VII)/sulfite process as an effective strategy for degrading recalcitrant micropollutants in water treatment.
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ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Jingyuan Guo,Guo Wang,Yunfan She,Kai Li,Yujia Liu,Zhiyi Sun,Zhengbo Chen
Single-atom nanozymes have made important progress in the field of sensors, but their catalytic performance as natural enzyme substitutes is far from satisfactory. We describe here a FeFe dual single-atom nanozyme (Fe2N6/CN) with a Fe loading of 0.89 wt %, and it shows a synergistic effect and a peroxidase (POD)-like activity. Especially, the Fe2N6/CN nanozyme shows an excellent specific activity (315.4 U μmol–1). The values of catalytic rate constant (kcat) and catalytic efficiency (kcat/Km) for the Fe2N6/CN with 3,3′,5,5′-tetramethylbenzidine (TMB) are 23.8 s–1 and 8.24 × 104 M–1 s–1, respectively, and with H2O2, they are 30.8 s–1 and 0.919 × 103 M–1 s–1, respectively. Density functional theory calculations reveal that Fe2N6/CN possesses excellent POD-like activity. Based on the POD-like activity of Fe2N6/CN, we design a Fe2N6/CN nanozyme chemical tongue for the colorimetric recognition of aromatic amines using three wavelengths as array’s channels. The data interpretation using linear discriminant analysis, clustering heat map, etc., shows excellent clustering separation and classification of aromatic amines. Furthermore, this chemical tongue can simultaneously recognize mixtures of different molar ratios, quantitatively determine different concentrations of individual aromatic amines, and even identify unknown samples. This preparation strategy not only provides a promising pathway for the utilization of nanozymes but also highlights the potential of dual single atoms as an attractive platform for design of sensor arrays.
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