Advanced Science
·
2025
·
IF 14.1
Zhenru Li,Li-Peng Sun,Yanzhen Tan,Zhiwei Wang,Xiao Yang,Tiansheng Huang,Jie Li,Yi Zhang,Bai-Ou Guan
Flexible wearable biosensors have emerged as a promising tool for tracking dynamic glycemic profiles of human body in diabetes management. However, it remains a challenge to balance the shrunken device space and multiple redundant sensing arrays for further advancement in miniaturization of multimodal sensors. Herein, this work proposes an entirely new optoelectronic hybrid multimodal optical fiber sensor which is composed of laser patterning of polydimethylsiloxane (PDMS) to form laser-induced graphene (LIG) as the interdigital electrodes, and a long period grating (LPG) prepared from an optical microfiber encapsulated into the PDMS modulated by periodical structure of LIG electrodes. This operation can simultaneously integrate two heterogeneous sensing mechanisms, optical and electrical, into a single sensor in a compact manner. Combining the LIG electrode with conductive hydrogel, a flexible glucose biosensor based on electrical mechanism is constructed by loading glucose oxidase into the hydrogel. Meanwhile, the microfiber LPG can also be served as a spectroscopically available sensor for biomechanical monitoring. Optical and electrical sensors can work simultaneously but independently of each other, particularly in the scene of wound healing for rat model and movement for human exercise. This platform represents a pivotal step toward multifunctional sensors that enable measurements of biomechanical information and glucose.
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PubMed
高影响因子
Microorganisms
·
2025
·Vol. 13
·期 4
·798
·
IF 4.2
Xiaoyu Cao,Yu Zhang,Qianqian Xu,Hai Yan
Hyperuricemia is a metabolic disorder owing to the underexcretion and/or overproduction of uric acid (UA). Recent studies have shown that probiotics have many potential applications as functional foods to ameliorate hyperuricemia. In this study, we have successfully isolatedBacillus paranthracisYC03 with urate-lowering potential from Jiangshui. The in vitro results indicated that YC03 exhibited strong biodegradation capacities toward UA and its precursors (inosine and guanosine). Meanwhile, the cell-free extracts of YC03 were also found to catalyze and remove inosine and guanosine. To further explore the application potential of this strain in developing functional foods, we evaluated its probiotic properties through in vitro assays and whole genome analysis.B.paranthracisYC03 has excellent abilities, with tolerance to acid and bile salt and good adhesion. In addition, hemolytic assays, along with antibiotic resistance and biogenic amine production tests, have also preliminarily confirmed the safety of using YC03 in food. We have also annotated the key enzyme genes, includingauaG,hpt,rih,punAanddeoD, which are involved in the biodegradation of UA and nucleosides. The results of nucleoside biodegradation product detection will be valuable for exploring the metabolic pathway for biodegrading nucleosides with YC03. These findings provide meaningful insights for the development of functional foods to improve hyperuricemia usingB.paranthracisYC03.
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高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
He-He Tian,Yu-Lian Li,Xu-Song Wang,Xu-Hui Huang,Yu-Ying Zhang,Zi-Chun Zhang,Da-Yong Zhou,Lei Qin
Abalone ( Haliotis spp.) is a shellfish known for its exceptional nutritional value and significant economic worth. This study investigated the dynamic characteristics of non-volatile compounds over a year, including metabolites, lipids , nucleotides, and free amino acids (FAAs), which determined the nutritional quality and flavor of abalone. 174 metabolites and 371 lipids were identified and characterized, while 20 FAAs and 11 nucleotides were quantitatively assessed. These non-volatile compounds of abalone were fluctuated with months variation, which was consistent with the fluctuations of environmental factors, especially seawater temperature. Compared with seasonal variation, gender had less influence on these non-volatiles. June and July proved to be the optimal harvesting periods for abalone, with the levels of overall metabolites, lipids, FAAs, and nucleotides in abalone exhibiting a higher value in June and July over a year. Intriguingly, taurine covered 60% of the total FAAs and abalone could be used as dietary taurine supplementation.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Le Yang,Hong Zhang,Chang Wang,Yunhong Jiao,Xiuyan Pang,Jianzhong Xu,Haiyun Ma
The construction of supramolecular aerogels still faces great challenges. Herein, we present a novel bio-based supramolecular aerogel derived from G-Quadruplex self-assembly of guanosine (G), boric acid (B) and sodium alginate (SA) and the obtained GBS aerogels exhibit superior flame-retardant and thermal insulating properties. The entire process involves environmentally friendly aqueous solvents and freeze-drying. Benefiting from the supramolecular self-assembly and interpenetrating dual network structures, GBS aerogels exhibit unique structures and sufficient self-supporting capabilities. The resulting GBS aerogels exhibit overall low densities (36.5–52.4 mg/cm 3 ), and high porosities (>95 %). Moreover, GBS aerogels also illustrate excellent flame retardant and thermal insulating properties. With an oxygen index of 47.0–51.1 %, it can easily achieve a V-0 rating and low heat, smoke release during combustion. This work demonstrates the preparation of intrinsic flame-retardant aerogels derived from supramolecular self-assembly and dual cross-linking strategies, and is expected to provide an idea for the realization and application of novel supramolecular aerogel materials.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Tong Ren,Zhen Feng,Fang Jiang,Xingtong Liu,Tingting Chen,Yanli Guo,Lei Tian,Xiao-Feng Kang,Fujun Yao
Guanine and its derivatives play fundamental roles in many biological processes and their abnormal changes are closely related to diseases. Thus, accurate and sensitive detection of them is beneficial for the early diagnosis and clinical medicine. Herein, a novel nanopore-based sensor is proposed to detection guanine and its derivatives by using a vacancy G-quadruplex (vG4) probe. In this design, the incomplete G-tetrad in vG4 probe can be filled in by guanine derivatives through Hoogsteen hydrogen bond interactions, resulting in stabilization of the G-quadruplex. Based on the different electronic signals between vG4 probe and its binding complexes, the nanopore sensor was able to achieve the detection of six guanine derivatives, including 2΄-dG, Guanine, Guanosine, GMP, GDP and GTP. To demonstrate the analytical performance of the method, a guanine analogue drug was determined as model analyte. The detection limit of acyclovir was 0.0061 μM (3 σ / k ), with a linear range of 0.01 μM – 0.1 μM. This sensing strategy offers a new pathway for label-free detection of nucleobases and derivatives.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 7
·4909-4914
·
IF 3.201
Yuanyuan Xu,Yue Yang,Aifang Xue,Hao Chen,Shengqing Li
Pure titanium dioxide (TiO2) adsorbent failed to selectively capture ribonucleosides in biological samples, as reported in previous studies, although it was expected to display a specific recognition of cis-diol compounds by the Lewis acid sites on its surface. However, in this work, our results showed for the first time that hydrous titania (TiO2·nH2O), obtained through hydrolysis of tetrabutyl titanate (TBOT) in aqueous solution, exhibited a high affinity for cis-diol-containing ribonucleosides. The adsorption efficiency of A, C and G by TiO2·nH2O can reach about 90% even in a 100% water matrix. On the other hand, the 2′-deoxynucleosides could only be adsorbed in a water–acetonitrile solution with a water content of less than 10%. Subsequently, an in situ-generated TiO2·nH2O-based dispersive micro solid-phase extraction (d-μ-SPE) process was developed and evaluated. The whole d-μ-SPE process takes only about 7 minutes (2 min for extraction and 5 min for centrifugation) and no pre-synthesized or commercial TiO2 powder is required. The hydrous TiO2-based d-μ-SPE with a two-step elution strategy was successfully performed for the extraction and separation of ribonucleosides (A, U) and 2′-deoxynucleosides (2′-dC, 2′-dG) in porcine plasma samples. The proposed TiO2·nH2O-based d-μ-SPE method is effective, simple and rapid, and will have wide application for the selective extraction of cis-diol molecules in environmental and biological samples.
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CHEMISTRY OF MATERIALS
·
2018
·
IF 9.89
Feng Chen,Qiang Chen,Lin Zhu,Ziqing Tang,Qingfeng Li,Gang Qin,Jia Yang,Yanxian Zhang,Baiping Ren,Jie Zheng
Low-molecular-weight gelator (LMWG)-based supramolecular hydrogels, self-assembled by small molecules via noncovalent interactions, have recently attracted great attention due to their unique structure–property relationship and potential applications spanning from functional materials to biomedical devices. Unfortunately, many LMWG-based supramolecular hydrogels are mechanically weak and can not even be handled by conventional tensile and tearing tests. Here, we propose several design principles to fabricate new LMWG-based hydrogels with a true double-network structure (G4·K+/PDMAAm DN gels), consisting of the supramolecular self-assembly of guanosine, B(OH)3 and KOH as the first, physical G4·K+ network and the covalently cross-linked poly(N,N′-dimethyacrylamide) (PDMAAm) as the second, chemical network. Different from those LMWG-based supramolecular hydrogels, G4·K+/PDMAAm DN gels exhibit high tensile properties (elastic modulus = 0.307 MPa, tensile stress = 0.273 MPa, tensile strain = 17.62 mm/mm, and work of extension = 3.23 MJ/m3) and high toughness (tearing energies = 1640 J/m2). Meanwhile, the dynamic, noncovalent bonds in the G4·K+ network can reorganize and reform after being broken, resulting in rapid self-recovery property and excellent fatigue resistance. The stiffness/toughness of G4·K+/PDMAAm DN gels can be recovered by 65%/58% with 1 min resting at room temperature, and the recovery rates are further improved with the increase of temperatures and resting times. Interestingly, G4·K+/PDMAAm DN gels also exhibit UV-triggered luminescence due to the unique G4-quartet structure in the G4·K+ supramolecular first network. A new toughening mechanism is proposed to interpret the high strength and toughness of G4·K+/PDMAAm DN gels. We believe that our design principles, along with new G4·K+/PDMAAm DN gel system, will provide a new viewpoint for realizing the tough and strong LMWG-based gels.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Wanying Zhu,Xin Shen,Chunhong Zhu,Bingzhi Li,Junli Hong,Xuemin Zhou
In this work, based on purifying the analysis system by magnetic separation, we constructed a turn-on fluorescent assay for highly sensitive detection of possible biomarkers, employing adenosine as the model target analyte. Aptamer labeled-carbon dots (Apt-CDs) was applied as fluorescence probes as well as selective recognition elements, while Fe 3 O 4 @polypyrrole (Fe 3 O 4 @PPY) was used as fluorescence quenching and magnetic separating materials for system purification. In absence of adenosine, the Apt-CDs were attached to the surface of PPY through π-π stacking and hydrophobic interaction and its fluorescence was quenched by Fe 3 O 4 @PPY. In presence of adenosine, the aptamer could specifically bind with adenosine to form a three dimensional Apt-CDs-adenosine complex and detach from PPY, leading to the fluorescence recovery of Apt-CDs. More importantly, with analysis system purification via twice convenient magnetic separations of free CDs and Apt-CDs-adenosine complex respectively, the detection limit could be reduced from 8 nmol L −1 to 0.15 nmol L −1 . This concept offers potential application for simple, rapid, cost-effective, and highly sensitive assay of biological samples.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 3
·2288-2294
·
IF 3.201
Yanan Pan,Xiumei Guo,Shanshan Li,Xiaoyan Liu,Haixia Zhang
In this study, a new boronate affinity porous carbon absorbent derived from a home-made zinc-based metal–organic framework (Zn-MOF) was successfully fabricated. This absorbent was prepared by calcination of the Zn-MOF material and further modified with boronic acid groups. The resulting material was used to selectively enrich cis-diol-containing nucleosides in complex samples, and it exhibited superior binding capacity (26.0 mg g−1 for adenosine). The material coupled with high-performance liquid chromatography was successfully applied to analyze four cis-diol nucleosides (cytidine, uridine, guanosine, and adenosine) in injection and cell samples. Under optimized conditions, the method exhibited excellent extraction performance. The limits of detection of the method were 4.73–14.6 μg L−1 for the four nucleosides based on the signal-to-noise ratio of 3 : 1. Spiked recoveries were found between 88.2 and 108.2% (the relative standard deviation was in range of 1.3–11.3%, n = 3). This study improved the selectivity of porous carbon derived from MOF material and presented a promising thought for effective capturing of analytes on MOF materials.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Min Zhang,Dandan Guo,Yan Zhu,Shaohua Huang
Inspired by prebiotic reactions derived from wet-cool/dry-hot cycles, a green and efficient dry-wet cycling modification method was proposed for preparing peptide-modified polymer matrices, which are used as mixed-mode stationary phases for HPLC. Using polystyrene-divinylbenzene-glycidyl methacrylate (PS-GMA) as the matrices, alanine monomers were polymerized into peptide on the PS-GMA substrate surface through the dry-wet cycle reaction. By varying the number of dry-wet cycles, the length and density of peptides modified on PS-GMA were easily manipulated. The surface structures of the synthesized stationary phases were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, element analysis, Brunauer-Emmett-Teller test and liquid chromatography-mass spectrometry. Chromatographic separation results demonstrated that the stationary phase after six cycle reactions (PS-GMA-Ala-6C) exhibited the satisfactory selectivity for separating both hydrophilic and hydrophobic analytes. Using PS-GMA-Ala-6C column as the research object, the effects of chromatographic conditions on retention behavior were investigated. The retention mechanisms of the proposed mixed-mode chromatography were deeply analyzed through comparative studies with commercial reversed phase chromatography column, HILIC column and the unmodified PS-GMA column by Tanaka test. Finally, the proposed stationary phase was successfully applied to the qualitative and quantitative analysis of the dihydromyricetin in a real vine tea sample. This work not only presents a green and economically viable method for preparation but also achieves the controllable fabrication of the mixed-mode stationary phase, which is of great significance for the future development of chromatographic stationary phases.
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ACS Applied Polymer Materials
·
2024
·
IF 4.4
Xusheng Zhang,Ying Tang,Nanxin Luo,Xin Wang,Zhiyuan Liu,Hui Peng,Guofu Ma,Ziqiang Lei
Flexible zinc–air batteries (ZABs) have attracted attention because of their intrinsic flexibility, high energy density, and excellent safety performance. However, the hydrogel electrolyte in ZABs usually suffers from shortcomings such as unsatisfactory tensile properties, low ionic conductivity, and poor water retention. Herein, a supramolecular-polymer dual-network hydrogel (G-PBA/PAAm SPDH) with excellent stretchability (>1000%) is prepared by combining a covalent self-assembled guanosine–phenylboronic acid tetramer supramolecular (G-PBA) network with a polyacrylamide (PAAm) network. What is more, the KOH (6 M)-filled G-PBA/PAAm SPDH shows remarkable freezing resistance (completely transparent at −40 °C), superior low- and high-temperature ionic conductivity (186 mS cm–1 at −40 °C and 195 mS cm–1 at 40 °C), good interfacial adhesion, and a satisfactory water retention rate of 70.06% after exposure to room temperature for 1 week. All these excellent properties strongly satisfy the application of G-PBA/PAAm SPDH as a multifunctional hydrogel electrolyte for flexible ZAB. As a result, the flexible ZAB assembled with the G-PBA/PAAm SPDH electrolyte can resist bending at different angles, maintain good electrochemical stability, and reach a high specific capacity (618 mA h gZn–1 at −40 °C and 680 mA h gZn–1 at 40 °C).
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TALANTA
·
2011
·
IF 3.722
Junxia Hao,Fuqiang Wang,Xiaojun Dai,Bolin Gong,Yinmao Wei
A novel stationary phase for weak cation exchange (WCX) and hydrophilic interaction chromatography (HILIC) was prepared with surface-initiated atom transfer radical polymerization (SI-ATRP). Vinyltetrazole was grafted onto the surface of the beads in water medium with the polyglycidylmethacrylate beads (P GMA/EDMA ) previously modified with 2-bromoisobutryl bromide as the macromolecule initiators and CuCl as catalyst. The poly(vinyltetrazole)-grafted beads obtained with different atom transfer radical polymerization (ATRP) formulations were tried as chromatographic packings in ion-exchange chromatography. The results showed that the prepared columns could separate the tested proteins with high efficiency and high capacity, and the retention time of protein had a positive relationship with increasing the chain lengths of the grafted poly(vinyltetrazole) (PVT). The prepared column was also found to be able to separate nucleosides by hydrophilic interaction chromatographic mode.
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高影响因子
危险品化学品经营许可证（带存储）