CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Wenqian Zheng,Lina Wang,He Jiao,Zhixin Wu,Qi Zhao,Tao Lin,Hude Ma,Zhilin Zhang,Xinye Xu,Jie Cao,Jiang Zhong,Jingkun Xu,Baoyang Lu
First-aid burn wound patches play an essential role in reducing mortality by preventing hyperthermia and resisting wound infection. However, existing products still suffer from inferior cooling performance, limited therapeutic effect, weaker wound protection, and/or high cost, which hinder their widespread application in market. Herein, we design and fabricate a cost-effective multilayered topological hydrogel-based first-aid burn wound patch (FBP) for rapid cooling, efficient anti-inflammation, and wound protection. Such a hydrogel patch is fabricated from a polyacrylamide-chitosan (PAAm-CS) hydrogel as the soft antibacterial layer integrated with a topological poly(vinyl alcohol)-chitosan (PVA-CS) hydrogel as the stretchable cooling layer, as well as thin polyethylene films as encapsulated layers to prevent dehydration. As-fabricated FBP exhibits a unique combination of intriguing mechanical, thermal, and biological properties, including softness (Young’s modulus of 83 kPa), stretchability (fracture stain over 106%), high thermal conductivity (0.54 W m −1 K −1 ), instant cooling, effective antibacterial activity (96.2% for S. aureus, 92.2% for E. coli), and excellent biocompatibility (94.04% cell viability at 20 mg mL −1 extract in 24 h). A second-degree scald rat model further demonstrates that fast-cooling and anti-inflammatory FBP can effectively reduce the tissue damage and inflammation levels by showing less edema formation and higher collagen/blood vessel ratios. With a set of these interesting performances, the FBP may be useful as a first-aid burn wound product to alleviate patients’ sufferings and even rescue more lives in critical situation.
研究领域:
材料科学
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生物医学工程
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伤口愈合
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热管理
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抗菌材料
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Ze Lin,Limin Jin,Yanbiao Liu,Ying Wang
During the arsenic (As) adsorption process, amino-functionalization has been widely considered as one of the effective adsorbents optimization methods, while this study reveals that imide functional groups also play a non-negligible role. Herein, magnetic carbon dots (CDs) equipped with imide (FeCD-NH) or amino functional groups (FeCD-NH 2 ) were synthesized to deduce the relationship between different configurations of amino-like functional groups and As. The results showed that FeCD-NH exhibited extraordinary As(V) adsorption behavior (with 97.80 % As(V) removal within 5 min), outperformed that equipped with amino functional groups (FeCD-NH 2 ). An array of advanced characterization techniques and density functional theory (DFT) calculation collectively revealed a dual-configuration hydrogen bond synergistic mechanism of FeCD-NH toward As(V). Different from monomorphic hydrogen bond of amino functional group, imide functional group forms abundant adsorption sites through dual-configuration hydrogen bonds to realize the ultrafast adsorption of As(V). In addition, FeCD-NH can remove As(V) from other more complex water matrices to levels below the World Health Organization (WHO) drinking water standards and the Chinese surface water standards. Therefore, this work provides a promising strategy for As decontamination by fine-tune the surface chemistry of adsorbents.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 23
·5830
·
IF 3.1
Qing Qin,Lin Han,Gang Xiong,Zihan Guo,Junwei Huang,Yujuan Zhang,Zhen Shen,Changchun Ge
Digital light processing (DLP) 3D-printed Si₃N₄ ceramics, known for their exceptional performance, offer distinct advantages in meeting the high-strength and complex structural demands of industries such as aerospace, semiconductors, healthcare, automotive, energy, and machinery. However, due to Si₃N₄’s strong chemical stability, low diffusion rate, low self-sintering ability, and high melting point, achieving densification under conventional sintering conditions is challenging. As a result, sintering additives are essential to promote the sintering process, lower the sintering temperature, improve densification, and enhance performance. In this study, 45 vol% Si₃N₄ slurries were prepared using DLP 3D printing technology, incorporating nine different combinations of sintering additives, including aluminum oxide (Al2O3), yttrium oxide (Y2O3), and aluminum nitride (AlN), in various ratios with Si3N4. The slurries were then sintered at 1800 °C for 2 h under a 1 MPa N2atmosphere. Additionally, the phase composition, microstructure, grain distribution, and crack propagation of the materials. The results showed that a Si3N4to Al2O3and Y2O3ratio of 95:2.5:2.5 produced elongated β-Si3N4grain structures and enhanced density, achieving a maximum Vickers hardness of 12.88 ± 0.52 GPa. Additionally, the synergistic toughening effect of the rod-like β-Si3N4grains and sintering aids significantly improved the fracture toughness of the Si3N4ceramic matrix, with a flexural strength of 540.63 ± 10.05 MPa and a fracture toughness of 4.92 ± 0.07 MPa·m1/2. This study lays the foundation for the future application of 3D-printed Si3N4ceramics, optimization of sintering aid combinations at different ratios, and performance enhancement in extreme environments.
研究领域:
材料科学
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陶瓷工程
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增材制造
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机械工程
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Jiale Zhang,Mijia Yan,Yiwen Tang,Min Liu,Wenzhan Yao,Qiuhong Zhang,Hangrong Chen
Acute liver failure (ALF) represents a life-threatening medical emergency with high mortality, yet limited treatment is available clinically. Here, we report albumin-biomineralized nonstoichiometric copper sulfide nanoparticles serving as first-aid nanomedicine to combat ALF, conceptualized as NanoAID. The NanoAID exhibits an electron-donor nanoantioxidant property to scavenge reactive oxygen species and concurrent anti-inflammatory capacity to reprogram pro-inflammatory M1 macrophages into anti-inflammatory M2-phenotype, thereby mitigating excessive oxidative and inflammatory stress in ALF lesions. More interestingly, we found Cu ions release under an in situ oxidative stress switch and the resulting H2S gas generation by NanoAID degradation, which further enhance the biosynthesis of intrahepatic antioxidant enzyme SOD1 and the repolarization of M1-to-M2 macrophages, respectively, thereby self-reinforcing ALF therapy. Such microenvironment self-adaptive regulation confers NanoAID with effective prophylactic efficacy and significant ALF survival advantages over the FDA-approved N-acetyl cysteine in multiple animal models, extending the first-aid window to 6 h post APAP intoxication. Transcriptomics results reveal the molecular mechanisms of NanoAID by promoting antioxidative and inhibiting inflammatory pathways, underscoring its great potential as a next-generation first-aid nanomedicine for ALF management.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2016
·
IF 7.145
Xiaobo He,Fengxiang Yin,Yanhui Li,Hao Wang,Jinnan Chen,Yanhong Wang,Biaohua Chen
This work develops the NiMnO3/NiMn2O4 ilmenite/spinel hybrid oxides as highly efficient bifunctional catalysts toward both oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). They are prepared with the aid of pollen, using a two-step annealing method. The interaction between NiMnO3 and NiMn2O4 nanoparticles results in an enhanced charge transfer between nanoparticles and active species in electrolytes, which is favorable for their electrocatalytic activities. The surface oxidation states of Ni and Mn for the hybrid oxides can be tuned by pollen, which greatly influences the OER and ORR activities and the overall bifunctional activity. The surface Ni3+ facilitates OER activity, while the surface Mn3+ with a small amount of Mn4+ favors ORR processes. Through optimization, 0.61NiMnO3/NiMn2O4 shows the highest OER activity, while 1.57NiMnO3/NiMn2O4 can outperform the others in promoting ORR processes. Between them, 0.61NiMnO3/NiMn2O4 exhibits the higher overall bifunctional activity. Furthermore, both of the optimized hybrid oxides show excellent durability during both OER and ORR processes. They can be considered as promising bifunctional catalysts for OER/ORR.
研究领域:
材料化学
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电化学
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纳米催化
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能源材料
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无机功能材料
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2015
·
IF 2.752
Bo Guo,Huan Yu,Baoyu Gao,Hongyan Rong,Hongyu Dong,Defang Ma,Ruihua Li,Shuang Zhao
In this study, novel cationic polyamidine (Pa) was synthesized and used as coagulant aid with aluminum sulfate (AS) for kaolin-humic acid simulated water treatment. The effects of Pa on coagulation performance and floc properties were investigated. Results showed that Pa addition significantly enhanced the removal of turbidity, ultraviolet absorbance at 254 nm wavelength (UV 254 ) and dissolved organic carbon (DOC). AS–Pa exhibited high coagulation efficiency at border pH range and increased floc size and growth rate significantly. Floc recovery ability was also improved, while floc fractal dimension was lower with Pa addition. This would be attributed to high cationic charge density and long chain of Pa, which could enhance the effect of charge neutralization and adsorption bridging.
研究领域:
环境科学
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化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
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2019
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IF 7.467
Jianqiu Wang,Xu Chen,Shenkun Xie,Lei Chen,Yuan Wang,Jian Meng,Defeng Zhou
We demonstrate the utilization of bismuth tungstate (Bi 2 WO 6 , BW) as a sintering aid and reinforcement component into neodymium-doped ceria (Nd 0.2 Ce 0.8 O 3-δ , NDC) to fabricate bismuth tungstate/neodymium-doped ceria composite electrolyte for intermediate-temperature solid oxide fuel cells (IT-SOFC). The presence of BW lowers the sintering temperature of NDC electrolyte to 1000 °C. Moreover, at 600 °C, the electrical conductivity of 5 mol.% BW-incorporated NDC (5BW-NDC) composite electrolyte is 7.12 times higher than the NDC. It is worth mentioning that the enhanced electrical conductivity of 5BW-NDC composite electrolyte does not include the contribution from electronic conductivity . Furthermore, NDC and 5BW-NDC exhibit excellent compatibility with La 0.6 Sr 0.4 Co 0.8 Fe 0.2 O 3-δ cathode and NiO anode in terms of thermal expansion coefficient and chemical reactivity . The oxygen reduction reaction at 5BW-NDC composite electrolyte/cathode interface is significantly enhanced by ∼40% compared to NDC. Moreover, 5BW-NDC electrolyte-supported SOFC delivers a power density of 0.86 W cm −2 at 700 °C, which is 45.76% higher than the NDC-based SOFC. The output performance remains stable during high-temperature operation for 120 h, which indicates the stability and chemical compatibility of the as-synthesized composite electrolyte with other cell components. The results reveal that BW-NDC composite is a potential electrolyte material for stable and high-performance IT-SOFCs.
研究领域:
材料科学
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能源工程
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产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Xiangqian Li,Jiapei Gu,Zhan Zhou,Wanqiang Liu,Jinwei Gao,Qianming Wang
The versatility of the organic fluorophores enables us to track its emission curves and sharp luminescence changes under controllable conditions. A tetraphenylethylene-based fluorescent probe (1-methyl-4-(4-(1,2,2-triphenylvinyl)styryl)pyridin-1-ium iodide, abbreviated as TPE-py-I ) has been synthesized and yields efficient red emission in organic phase (DMSO). The incorporation of ClO − in its DMSO solution triggers efficient “on-off” quenching effect due to ions exchange from iodide to hypochlorite. The inactivation of the original red luminescence can be also realized by the addition of water and the typical aggregation-caused-quenching (ACQ) has been observed. Unexpectedly, such ACQ process will be suppressed and lead to an aggregation-induced-emission (AIE) effect, providing distinct fluorescent read-out from pale-red to bright yellow in the presence of hypochlorite. The limit of detection (LOD) has been calculated to be 0.25 μM via ratiometric operation with an excellent linear range from 1 μM to 50 μM. This non-invasive and in-situ detection of ClO − via AIE modes can be employed as an indicator for the evaluation of ions responses in real environments.
研究领域:
材料科学
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分析化学
·
光学传感
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2016
·
IF 4.219
Xiujuan Zhao,Si Chen,Zifeng Lin,Chang Du
We have prepared carboxymethyl chitosan-alginate dialdehyde (CMCS-ADA) nanofibers via a reactive electrospinning process with the aid of polyethylene oxide (PEO). The presence of PEO delayed the gelation of CMCS and ADA, thus providing ease of use to adjust the mixing of CMCS-PEO and ADA-PEO blended solution. The mixed solution can be adjusted to come out from the needle before the gel formation or when the gel was just about to form. Defect-free CMCS-ADA-PEO nanofibers with average diameters ranging from 100 nm to 900 nm were obtained using water as a solvent. The in situ cross-linked CMCS-ADA nanofibers were then obtained following the extraction of water-soluble PEO. After immersion in phosphate-buffered saline (PBS) at a pH of 7.4 for up to 15 days, the as-spun CMCS-ADA-PEO composite nanofibers maintained structural integrity, confirming the success of the crosslinking. The PEO-extracted CMCS-ADA nanofibers promoted the adhesion, proliferation and alkaline phosphatase activity of bone marrow stromal cells.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULAR POLYMERS
·
2022
·
IF 1.786
Ke Wang,Ya-qiong Huang,Xiao-han Cheng,Jen-taut Yeh
The micro foaming performance, moisture resistance and dynamic viscosity of scCO2-aid glutaraldehyde/hexametaphosphate/thermoplastic tapioca starch (GA/SHMP/TOS) foams were considerably improved by proper NaOH treatment. The expansion ratio, resilience rate, dynamic viscosity values of these NaOH modified foams improved to a maximum, as the time for NaOH treatment approached a proper value. The dynamic viscosity, expansion ratio and resilience rate of the scCO2-aid GA/SHMP/TOS foams modified using 110 atm scCO2-pressure, the proper alkali treatment time, SHMP loading and varying montmorillonite (MMT) loadings improved further, as their MMT loadings approached a proper value of 2.5 part per hundred parts of tapioca starch (PHTOS). Relatively large dynamic viscosity (7.1x104 Pa·s), extremely large expansion ratio (∼75), cell density (1.1x109 cells/cm3) and/or resilience rate (∼80%) were acquired for the scCO2-aid GA/SHMP/TOS/MMT foam modified using the proper alkali treatment time and MMT loading. Thermal analyses results showed that crystallization onset temperatures and crystallization rates of scCO2-aid GA/SHMP/TOS/MMT foams modified using the proper alkali treatment time and varying MMT loadings improved to a highest value by adding 2.5 PHTOS of MMT nano-platelets. Possible reasons accounting for the considerably improved micro foaming performance of scCO2-aid GA/SHMP/TOS/MMT foams modified using the proper alkali treatment time and MMT loading are proposed in this study.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
·
2022
·
IF 4.175
Qing Liu,Xin Fang,Zeng-Ping Chen,Cai-Xia Shi,Ru-Qin Yu
Herein, the hydrolysis patterns of DNase I against a DNA probe in both single-strand form and DNA/miRNA heteroduplex were experimentally investigated in detail by mass spectrometric technique. Based on the knowledge obtained in the experiments, DNase I-assisted signal amplification strategy was proposed and used to design a mass spectrometric platform for miRNA detection. As a proof of concept, the performance of the proposed platform was evaluated for the detection of miRNA-122 in cell lysate samples. An advanced calibration model was explicitly derived to model the relationships between the concentration of miRNA-122 and the mass spectral signals of mass spectrometrically detected fragments of the DNA probe produced in the DNase I-assisted signal amplification process. With the aid of the advanced calibration model, the proposed mass spectrometric platform achieved quite accurate quantification results for miRNA-122 in cell lysate samples of Huh-7 and HepG-2 cell lines with recovery rates ranging from 98% to 104%. It is noteworthy that the proposed mass spectrometric platform can differentiate the target miRNA from other non-target ones based on their mass spectral response patterns instead of mass spectral intensities, and hence possesses high specificity for the target miRNA. It is reasonable to expect that the combination of mass spectrometry based on DNase I-assisted signal amplification with the advanced chemometric model provides a competitive alternative for designing cost-effective and label-free miRNA detection methods.
研究领域:
生物化学
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分子生物学
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分析化学
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产品关联
DOI
高影响因子
GOLD BULLETIN
·
2023
·Vol. 56
·期 1
·1-7
·
IF 2.2
Wang Tao,Liu Qian,Shi Minshan,Chang Rong,Tang Jun,He Yalan,Wu Dongling
The high enhancement activity of litchi-like gold nanoparticles (Au NPs) is prepared in deep eutectic solvent (DES), and the prepared Au NPs as SERS active substrate exhibits excellent sensitivity when rhodamine 6G (R6G) is used as a probe molecule for detection. The enhancement factor (EF) is calculated to be about 1.8 × 10 12 , and the minimum detected concentration is outstanding in R6G aqueous solution at 10 −12 M. In addition, the microtrace determination of penicillin G sodium (PG) in camel milk powder produced in Xinjiang was successfully achieved by using the prepared Au NPs. This work provides an environmentally friendly, simple, and rapid method to prepare efficient and sensitive surface-enhanced Raman scattering (SERS) materials. Meanwhile, it also uncovers a new possibility for the development of various nanoparticles with SERS prepared using DES as reactive solutions. Graphical abstract
研究领域:
材料科学
·
分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）