DYES AND PIGMENTS
·
2023
·
IF 4.5
Yutong Xiong,Weiren Zhong,Xuedan Zhang,Yuting Lin,Zhenguo Tang,Shouji Li,Xu-Min Cai
The petrochemical-based multi-stimuli responsive materials have been widely explored as advanced functional materials in the past several decades, but they inevitably face problems like complicated synthesis, non-renewability, and non-sustainability. On this basis, the bio-based materials used to construct multi-stimuli responsive due to the unique natural structures have come to the fore. In this work, three novel triphenylamine-based salicylideneanilines have been simply designed with aggregation-induced emission (AIE) properties. Among all, DAMB-TPAOH and DAMB-TPA possessing the natural structure of dehydroabietic acid from rosin are bioproduct-inspired AIE luminogens (BioAIEgens). Derived from the excited-state intramolecular proton transfer (ESIPT) and restriction of intramolecular motion (RIM) dual-mechanism caused by the hydroxyl group and rigidification of alicyclic moiety, respectively, the solid-state DAMB-TPAOH exhibits red-shifted (compared to DAMB-TPA ) and stronger (compared to BA-TPAOH ) emission, endowing this BioAIEgen with the best fluorescence behavior. Further, the introduction of the natural skeleton, propeller TPA, and imine group results in the high-contrast mechanochromic and acidichromic properties of DAMB-TPAOH . The multi-stimuli responsive properties endow DAMB-TPAOH with potential utilization in the manufacture of rewritable paper and multi-color ink. The current work contributes greatly to the development of BioAIEgens with both mechanochromism and acidichromism.
研究领域:
材料科学
·
有机化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Fanyong Yan,Xiaodong Sun,Tengchuang Ma,Yan Zhang,Yingxia Jiang,Ruijie Wang,Cong Ma,Junfu Wei,Li Chen,Yali Cui
Carbon dots (CDs) as a fluorescent nanomaterial plays an important role in bioimaging and light-emitting devices, and its multifunctionalization will be a promising evolution. Here, by a freely rotatable single bond to connect materials with complementary functions together, a dual-function aggregation-induced emission (AIE) CDs ( V-CDs ) is obtained to visually monitor the dead of cancerous cells and inhibit the production of vascular endothelial growth factor (VEGF). The fluorescence of V-CDs will change between blue and green as the changes of environment viscosity based on the restriction of intramolecular rotation (RIR) effect. For another, the VEGF content decreased by about 3 times compared with the blank group after V-CDs was introduced. The co-administration group shows the best anti-cancer effect among the rest of control groups after Taxol was involved, and the same result are achieved in vitro and vivo . The performances of V-CDs make it possible to realize the potential of visualizing anti-cancer process.
研究领域:
纳米技术
·
生物成像
·
肿瘤学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2021
·
IF 15.881
Xindong Wang,Xinyu Wang,Bo Qu,Nuernisha Alifu,Ji Qi,Ruiyuan Liu,Qinrui Fu,Ruifang Shen,Qi Xia,Lijun Wu,Bing Sun,Jibin Song,Youping Lin,Xin Huang,Anjun Qin,Jun Qian,Ben Zhong Tang,Guanying Chen
Molecular organic dyes are classic fluorescent nanoprobes finding tremendous uses in biological and life sciences. Yet, they suffer from low brightness, poor photostability, and lack of functional groups for bioconjugation. Here, we describe a class of biocompatible dye–protein optical nanoprobes, which show long-time photostability, superbrightness, and enriched functional groups. These nanoprobes utilize apoferritin (an intracellular protein for iron stores and release) to encase appropriate molecular organic dyes to produce on-demand fluorescence in aqueous solution. A pH-driven dissociation–reconstitution process of apoferritin subunits allows substantial incorporation of hydrophilic (aggregation caused quenching, ACQ) or hydrophobic (aggregation induced enhancement, AIE) dye molecules into the protein nanocavity (8 nm), producing monodispersed dye–apoferritin nanoparticles (apo-dye-NPs, ∼12 nm). As compared with single dye monomer, single apo-dye-NPs possess hundreds of times larger molar extinction coefficient and 2 orders of magnitude higher absolute luminescence quantum yield (up to 45-fold), multiplying fluorescence brightness up to 2778-fold. We show that varying the type of incorporated dyes entails a precise control over nanoprobe emission profile tunable in a broad spectral range of 370–1300 nm. Mechanical investigations indicate that the diversified microstructures of nanocavity inner surface are able to conform ACQ dyes at reasonable space interval while providing protein-guided-stacking for AIE dyes, thus enhancing fluorescence quantum yield through confining intermolecular quenching and intramolecular rotation. Moreover, apo-dye-NPs are able to emit stable fluorescence (over 13 min) without quenching in confocal imaging of HepG2 cancer cell under ultrahigh laser irradiance (1.3 × 106 W/cm2). These superb properties make them suitable, as demonstrated in this work, for long-term super-resolved structured illumination microscopic cell imaging (spatial resolution, 117 nm) over 48 h, near-infrared (NIR) fluorescence angiography imaging of whole-body blood vessels (spatial resolution, 380 μm), and NIR photoacoustic imaging of liver in vivo.
研究领域:
生物化学
·
分子生物学
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Wei Liu,Tengfei Wang,Liwen Wang,Yan Wang,Sheng Hu,Dating Tian
The development of fluorescent probes capable of detecting abnormal changes in cellular mitochondrial viscosity is of great significance, as these changes have been connected to many diseases. In this study, the conventional tetraphenylethylene (TPE) molecule was modified to fabricate a novel near-infrared fluorescent, TTPB, which was then used to measure the mitochondrial viscosity. Due to the introduction of TPE and pyridine groups, TTPB had an AIE effect and mitochondrial targeting function. Meanwhile, TTPB was extremely sensitive to variations in viscosity for the twisted intramolecular charge transfer (TICT) phenomenon. The logarithm of fluorescence intensity (log I 620 ) of the probe demonstrated an excellent linear connection with the logarithm of viscosity (log η ) in the viscosity range of 1.2 ∼ 956.0 cP, indicating the probe could quantitatively detect viscosity. Moreover, TTPB was able to visually track autophagy in addition to detecting the mitochondrial viscosity in the inflammatory cell model. These results showed that the probe was anticipated to be employed for the early diagnosis of related diseases.
研究领域:
生物化学
·
医学诊断
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2023
·Vol. 29
·期 68
·e202302567
·
IF 4.3
Ming Hu,Feng-Ying Ye,Wei Yu,Kang Sheng,Weizhou Wang,Yan-Song Zheng
Graphical New TPE derivatives bearing p -AP groups : Among 5 kinds of crystals of TPE derivative, it is found for the first time that strong intermolecular ArH-pi interactions cause ACQ effect while weak ArH-pi interactions induce AIE phenomenon. The interactions also arouse photochromism, photodeformation and even the first forward rolling movement of crystal by UV light irradiation, providing promising materials in multimode anti-counterfeiting, photo-actuator and light-driven micro-vehicle. Aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) are two classes of opposite luminescence phenomena. It is almost impossible to show both AIE and ACQ effect simultaneously by the same molecule. However, here we report that a simple TPE derivative TAP-TPE grows into both AIE crystals and ACQ ones. It is found that equatorial, contact distance-longer and weak ArH-π interactions exist in AIE crystals while vertical, contact distance-shorter and strong ArH-π interactions appear in ACQ crystals. Theoretical calculation of electron density on the interaction atoms unveils that ACQ crystals have much larger change in electron density than AIE ones, suggesting that the intermolecular electron transfer aroused by the strong ArH-π hydrogen bonds leads to ACQ phenomenon. This result provides a new insight into the emission mechanism in aggregation state. Interestingly, due to the ArH-pi interactions difference, only one of five kinds of crystals shows rapid photochromism, and can act as multimode anti-counterfeiting materials. Very exceptionally, for the first time we find that the photochromic micrometric rod-like crystal even makes forward rolling movement as it repeatedly bends and straightens by responding to on and off of the ultraviolet light irradiation, displaying potential for photo-actuator and light-driven micro-vehicle.
研究领域:
材料化学
·
光化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-8
·
IF 11.878
Yang Yang,Zhang Shuai,Zhang Xiqi,Gao Longcheng,Wei Yen,Ji Yan
Vitrimers are one kind of covalently crosslinked polymers that can be reprocessed. Topology freezing transition temperature (T v ) is vitrimer’s upper limit temperature for service and lower temperature for recycle. However, there has been no proper method to detect the intrinsic T v till now. Even worse, current testing methods may lead to a misunderstanding of vitrimers. Here we provide a sensitive and universal method by doping or swelling aggregation-induced-emission (AIE) luminogens into vitrimers. The fluorescence of AIE-luminogens changes dramatically below and over T v , providing an accurate method to measure T v without the interference of external force. Moreover, according to this method, T v is independent of catalyst loading. The opposite idea has been kept for a long time. This method not only is helpful for the practical application of vitrimers so as to reduce white wastes, but also may facilitate deep understanding of vitrimers and further development of functional polymer materials.
研究领域:
高分子科学
·
材料科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Bio
·
2026
·
IF 11
Yujun Zhang,Fengfei Zhao,Feiyi Sun,Haiyan Chen,Lingling Wang,Rendy Hosea,Zheng Zhao,Ben Zhong Tang,Fei Sun,Xinghua Yu
The emergence of aggregation-induced emission (AIE) luminogens has revolutionized biomedical theranostics, yet the exploration of natural AIE-active therapeutics remains nascent. Herein, we propose a novel “AIE-Pharmacology” paradigm, employing the natural flavonoid acacetin as an intrinsic AIEgen with pharmacological activity for self-monitored therapy of asthenozoospermia. Overcoming traditional aggregation-caused quenching (ACQ), acacetin utilizes its aggregation-enhanced emission and excited-state intramolecular proton transfer (ESIPT) properties to enable simultaneous treatment, high-contrast imaging, and tracking. We developed an extracellular vesicles (EVs)-based co-delivery system loaded with acacetin and β-Nicotinamide mononucleotide (NMN). This nanoplatform (EVs@N + A) exhibits inherent affinity for the testicular microenvironment. Upon targeted accumulation, released acacetin triggers a potent anti-ferroptotic response by upregulating GPX4 and SLC7A11 and suppressing lipid peroxidation. In parallel, NMN elevates intracellular NAD + levels, reprogramming cellular metabolism and restoring ATP production. This dual strategy—inhibiting ferroptosis and rejuvenating metabolism—effectively rescues sperm function, enhancing sperm count, motility, and progressive movement in vivo . Our work reports acacetin as a multifunctional AIEgen in reproductive medicine and establishes a traceable theranostic platform, introducing the “AIE-Pharmacology” paradigm as a promising approach for treating male infertility and other diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Photonics
·
2025
·
IF 6.7
Qiuyi Zhang,Qi Huang,Zikai Zhu,Dacheng Xia,Chenxu Sheng,Shoaib Awan,Ziyang Song,Fengxian Xie,Chunxiao Cong,Zhi-Jun Qiu,Laigui Hu,Ran Liu
Although organic light-emitting diodes (OLEDs) have been widely employed in displays and flexible electronics, the implementation of micro-OLED arrays still remains a challenge due to the limitations of the mainstream fine metal mask (FMM) technology. Pixel sizes below 30 μm are typically hard to achieve in order to match the requirement (i.e., sub10 μm) of the emerging near-eye displays mainly due to the so-called “screen-door effect”. Conventional lithography used for high-resolution inorganic micro patterns cannot be directly applied owing to the instability of organic materials. Furthermore, damage-free techniques such as inkjet printing also encounter resolution limitations. Self-assembled monolayer (SAM)-assisted patterning and surface-microstructure-assisted patterning techniques, though promising, have so far only been applied to fabricate single-color micro-OLEDs. In this work, high-resolution micro-OLED arrays with dual-color emission were demonstrated using a phase-change material (PCM) or an aggregation-induced emission (AIE) material. Fabricated via the SAM-assisted patterning technique, the PCM dot array exhibits red emission in its amorphous phase and transitions to green emission upon annealing-induced crystallization. Leveraging this unique dual-color capability, micro-OLEDs with 5 μm pixels (2600 PPI) and dual-color emission were achieved after the preparation of other functional layers.
研究领域:
材料科学
·
显示技术
·
光电子学
·
纳米技术
·
薄膜器件
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Na Liang,Yingxue Xu,Wei Zhao,Zhenrong Liu,Gang Li,Shaoping Sun
In this study, an amphiphilic polymer FA-CS-DBA-CHO with aggregation-induced emission (AIE) feature was prepared by introducing 4-(diphenylamino)benzaldehyde derivative (DBA-CHO), imine bond and folic acid (FA) to the molecular structure of chitosan (CS). The amphiphilicity drove the polymer to self-assemble into micelles, and paclitaxel (PTX) could be solubilized in the hydrophobic core. Due to the excellent AIE effect, FA-CS-DBA-CHO exhibited strong cellular imaging capability. The pH-sensitive imine bond in the polymer allowed for accurate drug release in acidic environment. Both in vitro and in vivo studies demonstrated that the PTX-loaded FA-CS-DBA-CHO micelles could significantly inhibit the growth of tumor cells but without any notable toxicity. This micellar system was excellent carrier for bioimaging and chemotherapeutic drug delivery.
研究领域:
材料科学
·
生物学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BMC CANCER
·
2024
·Vol. 24
·期 1
·1-9
·
IF 3.4
Wang Zigui,Li Guilin,Zhao Qiaohui,Fu Guangyu,Yang Zengli,Zhang Guojun
Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately controlling drug and probe release from the nanoparticles and determining the loading content of drug and probe. To address these issues, we have developed a reduction-responsive Pt(IV) prodrug-based polymeric delivery system that can be dynamically monitored using aggregation-induced emission luminogens (AIE) based bioprobes. These polymeric micelle can self-assemble into nanoparticles and release both bio-active Pt(II) drug and bio-probe upon reduction activation. TPE molecules released in the inner endo/lysosomal microenvironment aggregate and fluoresce upon irradiation, thus allowing real-time tracking of drug biodistribution without additional contrast agents. Advantages of this system include position-specific chemical bond cleavage, control of platinum content, and monitoring of drug reduction and biodistribution.
研究领域:
药物递送
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FARADAY DISCUSSIONS
·
2016
·Vol. 196
·91-99
·
IF 3.544
Feng Zhang,Tianye Zhou,Guogang Liu,Jianbing Shi,Haizheng Zhong,Yuping Dong
The surfaces of semiconductor nanocrystals have been known to be a very important factor in determining their optical properties. The introduction of functionalized ligands can further enhance the interactions between nanocrystals, which is beneficial for the assembly of nanocrystals. In a previous report, we developed a ligand-assisted reprecipitation method to fabricate organometal halide perovskite nanocrystals capped with octylamine and oleic acid. Here, a TPE derivative 3-(4-(1,2,2-triphenylvinyl)phenoxy)propan-1-amine, which shows a typical aggregation induced emission feature, is applied to replace octylamine to fabricate CH3NH3PbBr3 nanocrystals. The obtained CH3NH3PbBr3 nanocrystals were nanocubes (average diameter ∼ 11.1 nm) and are likely to assemble into ordered superstructures. By adjusting the chain length of the TPE derivative, we found that the assembly of the CH3NH3PbBr3 nanocrystals was correlated with the interactions between the TPE groups. This provides a new platform to investigate the ligand effects in nanocrystal solids and may potentially achieve enhanced optical and electrical properties.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
Pharmaceutics
·
2022
·Vol. 15
·期 1
·103
·
IF 6.525
Junliang Zhou,Haiyang Wang,Wen Wang,Zhiwei Ma,Zhenguo Chi,Siwei Liu
Mitochondria are important organelles that play key roles in generating the energy needed for life and in pathways such as apoptosis. Direct targeting of antitumor drugs, such as doxorubicin (DOX), to mitochondria into cells is an effective approach for cancer therapy and inducing cancer cell death. To achieve targeted and effective delivery of antitumor drugs to tumor cells, to enhance the therapeutic effect, and to reduce the side effects during the treatment, we prepared a cationic amphiphilic polymer with aggregation-induced emission (AIE) characteristic. The polymer could be localized to mitochondria with excellent organelle targeting, and it showed good mitochondrial targeting with low toxicity. The polymer could also self-assemble into doxorubicin-loaded micelles in phosphate buffer, with a particle size of about 4.3 nm, an encapsulation rate of 11.03%, and micelle drug loading that reached 0.49%. The results of in vitro cytotoxicity experiments showed that the optimal dosage was 2.0 μg/mL, which had better inhibitory effect on tumor cells and less biological toxicity on heathy cells. Therefore, the cationic amphiphilic polymer can partially replace expensive commercial mitochondrial targeting reagents, and it can be also used as a drug loading tool to directly target mitochondria in cells for corresponding therapeutic research.Keywords:mitochondrial targeting;mitochondrial fluorescent probe;cationic amphiphilic polymer
研究领域:
药学
·
材料科学
·
生物医学工程
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）