JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2025
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IF 4.2
Tianyu Zhou,Zhixiang Xing,Longtai Qi,Yecheng Liu
A B S T R A C T Ammonium polyphosphate was successfully encapsulated within a urea-formaldehyde resin shell via in-situ polymerization, yielding flame-retardant microcapsules. The synthesized microcapsules exhibited effective flame retardancy, as confirmed by various characterization techniques and ignition tests. The synthesized flame-retardant microcapsules (APP@UF) were uniformly integrated into the electrolyte matrix and subsequently assembled into electrochemical cells for performance evaluation. During thermal runaway in lithium-ion batteries, the internal temperature escalates. Upon reaching 210 °C, the microcapsule shell undergoes rupture, releasing APP to suppress the thermal runaway reactions within the battery, thereby achieving lithium-ion battery safety based on the concept of active protection. Furthermore, the microcapsules demonstrated stable dispersion in commercial lithium-ion electrolytes. Coin cells were assembled using electrolyte mixtures containing varying mass fractions of the microcapsules. At an addition level of 2 wt%, the battery retained 85.52 % of its capacity after 100 cycles under constant current charge-discharge conditions. The incorporation of microcapsules enhances battery safety without compromising electrochemical performance, presenting a viable strategy for improving the initial safety of lithium-ion batteries during thermal runaway.
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高影响因子
LAB ON A CHIP
·
2025
·
IF 5.4
Tianhao Xue,JiaNing Shen,Wanting Lin,Jiahui Zhou,Xiaofang Zhang,Jen-Tsai Liu,Ching-Jung Chen,Guixian Zhu
Ketone bodies are key products of fat metabolism, primarily consisting of acetoacetate (AcAc), β-hydroxybutyrate (BHB), and acetone (Acetone). Monitoring the concentration of ketone bodies in sweat can reflect the metabolic status of the body, it is also particularly significant in areas such as diabetes management, exercise monitoring, and the evaluation of the ketogenic diet. This paper presents a microfluidic patch for sweat collection and multiplex detection of AcAc, BHB and glucose. The microfluidic patch can achieve time-sequential sensing through Tesla valves, hydrophilic coatings, and unique chamber structural design. The concentrations of the three substances are quantified using colorimetric methods. Additionally, this study has designed a colorimetric app which can achieve automatic framing and detect the grayscale value of the colored area. Experimental results show that the patch can accurately detect changes in the concentrations of the three substances within specific ranges. The linear detection range for AcAc is 0.25 mM to 8 mM, the limit of detection (LOD) is 0.08 mM; for BHB, linear detection range is 0.05 mM to 0.80 mM, LOD is 0.02 mM; and for glucose, linear detection range is 62.50 μM to 1000 μM, LOD is 20.83 μM. In the future, this technology is expected to be applied to portable metabolic monitoring devices, offering a convenient solution for personal health management
研究领域:
生物医学工程
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代谢监测
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健康科技
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PubMed
高影响因子
Frontiers in Pharmacology
·
2025
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IF 4.8
Jia-Ming Bai,Tong Li,Xue Di,Jing-Xian Yang,Zhao-Qi Cui,Dong-Yu Min,Yu-Feng Shen,Si-Yu Shan,Ye-Xin Zhang,Yi-Jun Shi,Zhi-Li Xu,De-Qiang Dou,Hong-He Xiao
Introduction: Alzheimer’s disease (AD), the most common form of dementia, currently has no effective cure. Epimedii Folium (EF), a traditional Chinese medicine known as Yin-yang-huo, has demonstrated significant neuroprotective properties.Methods: In this study, neural stem cells overexpressing the APPswe gene (APP-NSCs) were used as an in vitro AD model. The CCK-8, LDH, neurosphere formation, and BrdU incorporation assays were employed to identify the most effective bioactive metabolite of EF in promoting NSC proliferation. Subsequently, JC-1 staining, ATP quantification, and ROS assays were conducted to evaluate the protective effects of Icariside II (ICS II)-identified as the most effective metabolite-on mitochondrial function. APP/PS1 transgenic mice received an oral administration of 10 mg/kg ICS II for 7 weeks. Cognitive function was assessed using the Morris water maze and nest-building tests, while H&E and Nissl staining were used to evaluate brain tissue pathology. Transmission electron microscopy (TEM) examined the ultrastructural integrity of hippocampal neurons, immunofluorescence assessed hippocampal neurogenesis, and Western blotting quantified proteins involved in mitochondrial dynamics. Additionally, Rotenone (Rot), a mitochondrial respiratory chain inhibitor, was applied to disrupt mitochondrial function, allowing an evaluation of whether the neurogenesis-promoting effect of ICS II depends on maintaining mitochondrial structure and function.Results and discussion: The results demonstrated that ICS II exhibited the strongest capacity to promote APP-NSC proliferation (P < 0.01, η2 = 0.845), followed by Icariin and Icaritin. ICS II treatment significantly ameliorated cognitive deficits (P < 0.01, η2 = 0.883), neuronal damage, and impairments in neurogenesis in adult APP/PS1 mice. Moreover, ICS II rescued mitochondrial damage by upregulating fusion proteins (Mfn1 and Mfn2) and downregulating fission proteins (p-Drp1/Drp1 and Mff); however, these protective effects were negated by Rot administration. In conclusion, this study identifies ICS II as one of the most effective metabolites of EF, promoting hippocampal neurogenesis and alleviating mitochondrial dysfunction in APP/PS1 mice, thereby offering promising therapeutic potential for AD.
研究领域:
神经科学
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药理学
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分子生物学
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PubMed
高影响因子
ACS Omega
·
2022
·
IF 4.132
Xiaolu Xiong,Chengwang Guo,Gengyang Yan,Bingxin Han,Zan Wu,Yueqian Chen,Shiqi Xu,Peng Shao,Hong Song,Xiyan Xu,Junfeng Han
Water quality guarantee in remote areas necessitates the development of portable, sensitive, fast, cost-effective, and easy-to-use water quality detection methods. The current work reports on a microfluidic paper-based analytical device (μPAD) integrated with a smartphone app for the simultaneous detection of cross-type water quality parameters including pH, Cu(II), Ni(II), Fe(III), and nitrite. The shapes, baking time, amount, and ratios of reaction reagent mixtures of wax μPAD were optimized to improve the color uniformity and intensity effectively. An easy-to-use smartphone app was established for recording, analyzing, and directly reading the colorimetric signals and target concentrations on μPAD. The results showed that under the optimum conditions, the current analytical platform has reached the detection limits of 0.4, 1.9, 2.9, and 1.1 ppm for nitrite, Cu(II), Ni(II), and Fe(III), respectively, and the liner ranges are 2.3–90 ppm (nitrite), 3.8–400 ppm (Cu(II)), 2.9–1000 ppm (Ni(II)), 2.8–500 ppm (Fe(III)), and 5–9 (pH). The proposed portable smartphone-app integrated μPAD detection system was successfully applied to real industrial wastewater and river water quality monitoring. The proposed method has great potential for field water quality detection.
研究领域:
环境科学
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分析化学
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DOI
PubMed
高影响因子
BEHAVIOURAL BRAIN RESEARCH
·
2026
·
IF 2.9
Xinyao Zhang,Xu Yang,Dongpei Zhuang,Zhiyi Mu,Chuanxia Ju
Neuronal hyperexcitability is crucial to the pathogenesis of Alzheimer's disease (AD). Activating the Kv7 channel is an effective way to reduce neuronal excitability. The Kv7 channel opener retigabine (RTG) has been demonstrated to alleviate spatial memory deficits in APP/PS1 transgenic mice. However, the mechanism by which RTG reduces cognitive deficits in APP/PS1 mice remains unclear. In this study, we revealed that RTG could ameliorate learning and spatial memory deficits in APP/PS1 mice during novel object recognition and Morris water maze tests. Meanwhile, RTG increased NeuN neuronal fluorescence intensity, increased the expression of the synaptic proteins postsynaptic density protein 95 (PSD95) and synaptophysin (SYN), improved synaptic plasticity, increased insulin-degrading enzyme (IDE) expression, decreased beta-secretase 1 (BACE1) expression, reduced Aβ 1–40 and Aβ 1–42 levels, and increased pAKT (ser473) and pGSK-3β (ser9) expression. These results indicated that RTG alleviates learning and spatial memory deficits in APP/PS1 mice, with potential mechanisms involving a reduction in neuronal loss, attenuation of synaptic damage, a decrease in β-amyloid (Aβ) deposition, and activation of the AKT/GSK-3β pathway.
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RSC Advances
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2019
·Vol. 9
·期 40
·23267-23275
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IF 3.049
Jianhua Wang,Lishen Zhang,Xiaochun Li,Xiaoliang Zhang,Hua-Zhong Yu
Nowadays quantitative chemical analysis is usually costly, instrument-dependent, and time-consuming, which limits its implementation for remote locations and resource-limited regions. Inspired by the ancient papercutting art (kirigami), we herein introduce a novel cut-and-paste protocol to fabricate 3D microfluidic paper-based analytical devices (μPADs) that are suitable for on-site quantitative assay applications. The preparation of the device is fast, simple, and independent of any lithographic devices or masks. Particularly designed reaction “channels” were pre-cut from a piece of filter paper, then assembled back to the silanized, superhydrophobic paper pads. The different layers of the device were assembled using a chemically-inert adhesive spray. The fabricated device has high efficiency of liquid handling (up to 60 times faster than conventional methods) and it is particularly inexpensive. Beyond the benchtop fabrication advantage, in conjunction with a custom mobile app developed for colorimetric analysis, we were able to quantify representative environmental contaminants (i.e., the amount of Cr(VI) and nitrite ions) in various water samples with the cut-and-paste μPADs (namely kPADs). Their detection limits (0.7 μg mL−1 for Cr(VI) and 0.4 μg mL−1 for nitrite ions, respectively) are comparable with conventional spectrophotometric methods, which confirm the potential of kPADs for on-site environmental/sanitary monitoring and food toxin pre-screening.
研究领域:
分析化学
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环境科学
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生物医学工程
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PubMed
高影响因子
ENERGY
·
2022
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IF 8.857
Qi Zhao,Yi Li,Xianfeng Chen
The study aims to examine the suppression performance of an inhibitor after a methane/coal dust explosion. The design of an explosion suppression system included the carrier gas of nitrogen (N 2 ) with an inhibitor of ammonium polyphosphate (APP). The study investigated fire extinguishing and explosion suppression of methane/coal dust by N 2 /APP in a vertical pipe. Flame propagation characteristics were measured by a high-speed camera, micro-thermocouple, and pressure sensor . The residues after the explosion were characterized chemically by X-ray photoelectron spectroscopy, and the thermal decomposition characteristics of coal dust and APP in the N 2 atmosphere were analyzed by synchronous thermal analysis. Experimental results show that the explosion suppression system can effectively hinder the flame propagation of methane/coal dust explosion. The flame height, bottom velocity, and temperature were all weakened significantly. The optimum level of suppressant minimizes the explosion pressure and suppresses the flame significantly. In addition, the fire extinguishing and explosion suppression mechanisms of N 2 /APP were summarized. The suppression method used in this study blocks the explosion after it occurs rather than preventing it through premixed inerting.
研究领域:
安全工程
·
化学工程
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高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2019
·Vol. 458
·期 1
·71-78
·
IF 2.884
Ba Fang,Zhou Yuxin,Zhou Jie,Chen Xueyun
Repetitive transcranial magnetic stimulation (rTMS) is a technique protecting neurons against diverse neurodegenerative disorders by delivering magnetic stimuli into the brain through the intact scalp. In the current study, the protection effect of rTMS on Parkinson’s disease (PD) and the associated mechanism driving the treatment were explored. The PD symptoms were induced using 6-OHDA in mice, and the effect of rTMS of two frequencies (1 Hz and 10 Hz) on the cognitive behaviors and neuron viability was detected. Afterwards, the level of Aβ 1–42 and activity of MKK7-ERK-Fos-APP axis under the administration of rTMS were recorded as well. The intracranial injection of 6-OHDA impaired the cognitive behaviors of the mice in the test of Morris water maze as well as reducing the viability and number of neurons in PD mice. After the treatment of rTMS of both frequencies, the cognitive function of mice was improved and the neuron viability and number were restored in mice brain tissues. The administration of rTMS also increased the cerebrospinal fluid (CSF) level of Aβ 1–42 in PD mice, which was accompanied by the suppressed levels of p-MKK7, p-ERK1/2, p–c-Fos, and APP. Moreover, the effect of rTMS on mice nerve system was all exerted in a frequency-dependent manner. In conclusion, the findings outlined in the current study affirmed the protection effect of rTMS against PD. The anti-PD function of rTMS was associated with the suppression of MKK7-ERK-Fos-APP axis, which subsequently resulted in the increased CSF Aβ 1–42 level and decreased brain Aβ 1–42 level.
研究领域:
神经科学
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药理学
·
神经退行性疾病
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PubMed
高影响因子
Neurotherapeutics
·
2021
·Vol. 18
·期 2
·1064-1080
·
IF 7.62
Wang Ni-Ya,Li Jin-Nan,Liu Wei-Lin,Huang Qi,Li Wen-Xing,Tan Ya-Hong,Liu Fang,Song Zi-Hua,Wang Meng-Yue,Xie Ning,Mao Rong-Rong,Gan Ping,Ding Yu-Qiang,Zhang Zhi,Shan Bao-Ci,Chen Li-Dian,Zhou Qi-Xin,Xu Lin
Brain capillaries are crucial for cognitive functions by supplying oxygen and other nutrients to and removing metabolic wastes from the brain. Recent studies have demonstrated that constriction of brain capillaries is triggered by beta-amyloid (Aβ) oligomers via endothelin-1 (ET1)-mediated action on the ET1 receptor A (ETRA), potentially exacerbating Aβ plaque deposition, the primary pathophysiology of Alzheimer’s disease (AD). However, direct evidence is still lacking whether changes in brain capillaries are causally involved in the pathophysiology of AD. Using APP/PS1 mouse model of AD (AD mice) relative to age-matched negative littermates, we identified that reductions of density and diameter of hippocampal capillaries occurred from 4 to 7 months old while Aβ plaque deposition and spatial memory deficit developed at 7 months old. Notably, the injection of ET1 into the hippocampus induced early Aβ plaque deposition at 5 months old in AD mice. Conversely, treatment of ferulic acid against the ETRA to counteract the ET1-mediated vasoconstriction for 30 days prevented reductions of density and diameter of hippocampal capillaries as well as ameliorated Aβ plaque deposition and spatial memory deficit at 7 months old in AD mice. Thus, these data suggest that reductions of density and diameter of hippocampal capillaries are crucial for initiating Aβ plaque deposition and spatial memory deficit at the early stages, implicating the development of new therapies for halting or curing memory decline in AD.
研究领域:
神经科学
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药理学
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阿尔茨海默病研究
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DOI
PubMed
高影响因子
Frontiers of Chemical Science and Engineering
·
2025
·Vol. 19
·期 4
·1-11
·
IF 4.5
Shao Siqing,Jin Liping,He Siyuan,Feng Yijing,Guo Wenwen
To achieve fire-resistant epoxy resin (EP), a UiO-66-based novel flame retardant coating (CS@APP@UiO-66) was prepared by modifying UiO-66 with chitosan (CS) and ammonium polyphosphate (APP) through a layer-by-layer (LbL) self-assembly method, which was then introduced into an EP system to improve its fire safety. The results of scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy show that the unsaturated Zr atoms in the UiO-66 framework provide many active sites conducive to modification, so that the UiO-66 particles, which originally had a regular octahedral structure, are more dispersed by LbL modification without causing doping or distortion issues. The thermogravimetric analysis results indicate that the char residue of EP/2% UiO-66 is increased by 2.52% compared with that of pure EP, indicating that the thermal properties of the EP composite are improved after modification. In addition, the cone test results indicate that EP/2%UiO-66-5L has good flame retardancy and smoke suppression properties, and the peak heat release rate, total smoke production and rate of CO generation values are 25.2%, 5.7% and 38.5% lower than those of the unmodified EP. Moreover, it can be concluded from the Raman test that the graphitization degree of the modified EP composite is strengthened. The above results indicated that after the incorporation of CS@APP@UiO-66 into the EP composites, more char layers formed as physical barriers to prevent the transfer of mass and heat, thus reducing the speed of flame propagation. Therefore, the flame resistance and smoke suppression of the EP composites improved. These favorable characteristics, including high flame retardant efficiency and good smoke suppression, make LbL-functionalized UiO-66 promising for flame retardant polymer applications.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
Journal of Coatings Technology and Research
·
2023
·
IF 2.3
Zhao Chengshou,Jiang Yisong,Fu Wang,Liu Zhuangyuan,Liu Siyuan,Peng Huaqiao,Esmaeili Nima
A novel epoxy-based self-intumescent fire protective coating has been developed by formulating a combination of ammonium polyphosphate (APP) and copper (I) oxide (Cu 2 O) in epoxy resin (EP). The effects of various combinations on fire protective performance for steel plate were evaluated using a lab-scale simulated big panel test. Formulations with different mass ratios of APP to Cu 2 O ranging from 10:0 to 2:8 exhibit good fire protective performance for steel plate. While the final equilibrium backside temperature of un-protected steel plate reached 529 °C, it did not exceed 282 °C for the protected plates with 2 mm thick coatings, which is much lower than the failure temperature of steel (ca. 500 °C). The lowest final equilibrium backside temperature of coated steel plate was 234.5 °C for the optimal formulation (EP/24APP/16Cu 2 O) with an APP/Cu 2 O mass ratio of 6/4 in EP. Interestingly, the limiting oxygen index (LOI) value (46.8%) for the optimized formulation (EP/24APP/16Cu 2 O) is not the highest, being lower than those of (EP/40APP/0Cu 2 O) and (EP/32APP/8Cu 2 O) formulations. The fire behavior of the optimized formulation (EP/24APP/16Cu 2 O) and control EP was compared using the cone calorimetry. The main fire hazard parameters such as peak heat release rate, total smoke production and peak CO production for EP/24APP/16Cu 2 O are reduced by 80.0%, 59.5% and 75.0%, respectively, relative to those for EP. This indicates that the EP/24APP/16Cu 2 O formulation provides significantly better fire safety than does control EP alone. A possible mode of action for the combination of APP/Cu 2 O in terms of the expansion ratio and heat insulation degree of the formed intumescent char layer may be proposed. Thus, this work contributed a reference for developing intumescent fire protective coating with high fire safety.
研究领域:
材料科学
·
消防安全
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高影响因子
FITOTERAPIA
·
2023
·
IF 3.4
Saijuan Li,Fangge Wu,Pengcheng Gao,Can Jin,Yuyong Wang,Wenfeng Liao,Kan Ding
The accumulation of amyloid β (Aβ) containing senile plaques is one of the key histopathological hallmarks of Alzheimer's disease (AD). Increasing evidences demonstrated the important role of autophagy in Aβ clearance. Recent studies implied that extracts from Semiaquilegia adoxoides (DC.) Makino could ameliorate the memory of D-galactose induced aging mice. However, the bioactive substance and underlying mechanism remains unknown. Thus, the present study sought to explore the effects of a novel homogenous peptidoglycane on Aβ 42 secretion and the underlying mechanism. Briefly, we extracted a novel peptidoglycan named SA02C using hot water extraction and alcohol precipitation with the Mw of 13.72 kDa. SA02C contains 73.33% carbohydrate and 27.83% protein. The structure characterization revealed that its glycan part might mainly composed of galacturonic acid with minor rhamnose in backbone, and branched with glucose, galactose, arabinose, xylose and galacturonic acid. The protein or peptide moiety in SA02C was bonded to the polysaccharide via threonine. Bioactivities test showed that SA02C could reduce Aβ 42 production in a dose dependent manner with no obvious cytotoxicity. Mechanism study demonstrated that SA02C could modulate APP processing by upregulating the expression of ADAM10, sAPPα and downregulating BACE1, sAPPβ. Furthermore, SA02C also could stimulate autophagy by promoting the expression of the markers of autophagy such as LC3B and ATG5, resulting in the promotion of Aβ 42 phagocytosis.
研究领域:
药理学
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神经科学
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分子生物学
·
植物化学
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PubMed
高影响因子
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