Nanomaterials
·
2022
·Vol. 12
·期 12
·2068
·
IF 5.719
Minjie Gao,Zehua Han,Xu Zhang,Xueyan Zou,Lichao Peng,Yanbao Zhao,Lei Sun
The design and preparation of multifunctional drug carriers for combined photothermal–chemotherapy of cancer have attracted extensive attention over the past few decades. However, the development of simple-structured stimuli-responsive theranostic agents as both photothermal agents and chemotherapeutic agents remains a big challenge. Herein, a novel double-shelled nanocarrier composed of hollow Ag2S (HAg2S) nanospheres and a mesoporous polydopamine (MPDA) exterior shell was fabricated through a facile process. Notably, HAg2S possesses both fluorescence and photothermal properties. MPDA acts as a drug carrier and photothermal agent. Meanwhile, the cavity structure between HAg2S and MPDA provides more space for drug loading. The nanocarrier presents a high drug loading rate of 23.4%. It exhibits an apparent pH-responsive DOX release property due to the acidic sensitivity of PDA. In addition, the release of DOX is promoted under NIR irradiation, which is attributed to the heating action generated by the photothermal effect of HAg2S and MPDA. The cytotoxicity test shows that the nanocarriers possess good biocompatibility. Compared with single photothermal therapy or chemotherapy, the combined treatment represents a synergistic effect with higher therapeutic efficacy. In addition, the nanocarriers exhibit excellent fluorescence imaging capability and can target HepG2 cells. These simple-structured smart nanocarriers have a great potential for fluorescence-mediated combination cancer therapy.Keywords:hollow Ag2S nanospheres;mesoporous polydopamine;fluorescence imaging;photothermal–chemotherapy;smart drug delivery
研究领域:
纳米技术
·
癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IONICS
·
2018
·Vol. 25
·期 4
·1921-1927
·
IF 2.347
Shen Feng-xia,Shi Jin,Shi Feng,Chen Tian-you,Li Yun-fei,Li Qing-yuan,Dai Yong-nian,Yang Bin,Qu Tao
Electro-reduction of carbon dioxide (CO 2 ) to carbon monoxide (CO) has been extensively studied on metal and alloy electrodes for many decades. However, owing to their disadvantages of low current density and high over-potential, the practical application of these electrodes has been limited. Hence, it is highly desirable to explore new and high efficient electrode for CO 2 reduction to CO. Ag 2 S has been widely studied as electrode material in electrochemistry due to its unique properties, such as high conductivity, chemical stability, and easy to be prepared. In this work, we have fabricated an Ag 2 S electrode via electro-oxidation of Ag in aqueous solution. X-ray diffraction (XRD) and scanning electron microscope (SEM) confirm that Ag 2 S has been modified on Ag foil, which made the electrode surface roughness. And then, we have evaluated the performance of Ag 2 S electrode as the cathode for CO 2 reduction in propylene carbonate/tetrabutylammonium perchlorate. The cathodic current density reaches to 9.85 mA/cm 2 , with the faradic efficiency for CO formation remaining stable at 92% during 4 h long-term electrolysis.
研究领域:
电化学
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材料科学
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环境科学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Meixin Li,Pengfei Yu,Shanshan Li,Mati Ullah Khan,Shuang Liu,Jun Yang,Jiaqi Cui,Ling Kong,Zhiwei Chen
Cow’s milk allergy is a prevalent food allergy, with β-lactoglobulin (β-Lg) identified as one of the major allergenic proteins in cow’s milk. The accurate detection of β-Lg is crucial for reducing the risk of allergic reactions. In this study, a novel label-free photoelectrochemical (PEC) aptasensor was developed for the detection of β-Lg in milk, utilizing an In 2 O 3 /BiOBr heterojunction composite material. Sensitization of the heterojunction with Ag 2 S quantum dots (QDs) enhanced the photosensitivity, leading to a significant increase in photocurrent response. The In 2 O 3 /BiOBr heterojunction improved solar energy utilization and enhanced light absorption across the visible spectrum. The photocurrent signal intensity decreased proportionally with increasing β-Lg concentration due to the specific binding with the aptamer. Under optimized experimental conditions, the PEC aptasensor exhibited a wide linear detection range from 0.001 ng/mL to 100 ng/mL and achieved a detection limit of 2.31 pg/mL. The sensor proved excellent selectivity, stability, reproducibility, and a broad linear range, offering a promising method for β-Lg detection in real milk samples.
研究领域:
食品科学
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生物传感技术
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材料科学
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产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2018
·Vol. 148
·期 9
·2765-2776
·
IF 2.911
Chang Libin,Zhu Gangqiang,Lu Huan,Hojamberdiev Mirabbos,Zhang Zengping,Gao Jianzhi,Wang Chenghui,Yang Woochul
Abstract The Ag 2 S/CdS composite photocatalyst with a leaf-like structure was synthesized by loading the Ag 2 S nanoparticles on the surface of the hydrothermally synthesized CdS particles. The UV–Vis–NIR absorption spectroscopy results reveal that the Ag 2 S/CdS composite photocatalyst exhibits a wide-spectrum response from ultraviolet (UV) to near-infrared (NIR), demonstrating its potential for effective utilization of solar energy. The scanning and transmission electron microscopic observations show that Ag 2 S nanoparticles with the size of about 20 nm are successfully embedded on the surface of leaf-like structure of CdS. Among the samples loaded with different molar percentages of Ag 2 S nanoparticles, the 5%-Ag 2 S/CdS composite photocatalyst exhibits a higher photocatalytic efficiency than the individually synthesized CdS and Ag 2 S for the degradation of Rhodamine B (RhB) and methyl orange (MO) under LED visible light irradiation. Furthermore, the 5%-Ag 2 S/CdS composite photocatalyst also exhibits a photocatalytic activity for the degradation of RhB under 850 and 940 nm monochromatic light irradiation. The results of the photocatalytic activity tests performed with various scavengers confirm that ·O 2 − plays a key role in the photodegradation of RhB. An enhanced photocatalytic performance of the Ag 2 S/CdS composite photocatalyst is directly attributed to the formation of a heterojunction between Ag 2 S and CdS. The developed composite photocatalyst can harness a greater share of the solar spectrum from visible to near infrared region and generate the photoinduced charge carriers more efficiently. Graphical Abstract
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 19
·11147-11156
·
IF 6.739
Guoxing Zhu,Chunlin Bao,Yuanjun Liu,Xiaoping Shen,Chunyan Xi,Zheng Xu,Zhenyuan Ji
Developing hybrid nanocrystals is a hot topic in materials science. Herein, a ternary hybrid nanocrystal, Ag–Ag2S–CdS, combining near infrared emission and photothermal conversion properties was demonstrated. The ternary Ag–Ag2S–CdS hybrid nanocrystals with cubic shape and uniform size were synthesized by a simple one-pot and one-step colloidal method. The growth process is self-regulated with the formation order of Ag2S, Ag, and CdS, sequentially. The formation of Ag originates from the partial reduction of Ag2S, while the formation of CdS is through an Ag2S catalytic mechanism based on its superionic feature. The obtained ternary hybrid nanocrystals show near infrared emission and photothermal conversion properties in a lab-on-a-particle system. Importantly, an enhanced effect is observed for the photothermal conversion, which is mainly due to the presence of heterointerfaces among the crystals. This work will not only advance the synthesis chemistry of multi-component hybrid nanocrystals but also provide a possible route for the design of advanced multi-model materials used in bio-related fields.
研究领域:
材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Yun Shu,Jinlong Gao,Jingyuan Chen,Jing Yan,Jiawei Sun,Dangqin Jin,Qin Xu,Xiaoya Hu
Near−infrared (NIR) emitting Ag 2 S quantum dots (QDs) are excellent fluorescent nanoprobes for bioassays with low toxicity. A novel fluorescent sensing platform which employing NIR fluorescent Ag 2 S QDs and MnO 2 2D nanosheets as NIR emitters and quenchers is designed for rapid and selective determination of glutathione (GSH). A facile and efficient approach was demonstrated for the synthesis of NIR fluorescent Ag 2 S QDs with the emission of 845 nm. Then the NIR fluorescent nanoprobe of Ag 2 S QDs−MnO 2 nanosheets is obtained by adsorbing Ag 2 S QDs onto the surface of MnO 2 nanosheets which have atomically thick two−dimensional structure and high specific surface area. And the NIR fluorescence of Ag 2 S QDs is quenched by the MnO 2 nanosheets. The presence of GSH could reduce MnO 2 to Mn 2+ that results in the restoration of NIR fluorescence for Ag 2 S QDs. The NIR fluorescent nanoprobe could be used for highly selective detection of GSH. Also a low detection limit of 60 μmol/L was obtained. Because NIR fluorescence of the Ag 2 S QDs can efficiently reduce the interferences from background scattering and autofluorescence. The NIR fluorescent nanoprobe was directly applied to monitor the GSH level in human serum sample with high accuracy and precision.
研究领域:
生物传感
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纳米医学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Lixiang Zhang,Luping Feng,Pan Li,Xi Chen,Chenchen Xu,Sheng Zhang,Anchao Zhang,Guofu Chen,Hua Wang
A near-infrared (NIR) light-driven photoelectrochemical (PEC) sensing platform was established for the quantitative assay of Hg 2+ using Ag@Ag 2 S nanocomposites. Ag 2 S quantum dots (QDs) with the bead-chain-like nanostructure were fabricated simply via one-step oil-bath route to be further deposited with metallic Ag through the photo-reduction method to yield Ag@Ag 2 S nanocomposites. It was found that Ag@Ag 2 S-based sensor could present more than twice larger PEC responses than the Ag 2 S-based one, due to the synergetic combination of metallic Ag with the surface plasmon resonance (SPR) effects and Ag 2 S QDs with the NIR-light-irradiated PEC properties. More importantly, the developed PEC sensor could display the photocurrent responses that are selectively inhibited in the presence of Hg 2+ by forming Ag-Hg amalgam to accelerate the recombination of photo-induced electron-hole pairs. Under NIR light, it can detect Hg 2+ in the concentrations linearly ranging from 0.0010 to 5.0 nM, with a limit of detection of about 0.50 pM. This work may guide a promising combination of Ag 2 S of NIR QDs with metallic Ag of SPR effects for designing various PEC sensing platforms for the complex environmental monitoring of different heavy-metal ions like Hg 2+ .
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2019
·Vol. 25
·期 31
·7553-7560
·
IF 5.16
Kai Cheng,Xiao-Shuai Zhang,Jie An,Cheng Li,Ruo-Yun Zhang,Run Ye,Bang-Jiao Ye,Bo Liu,Yuan-Di Zhao
Graphical Ag 2 S quantum dots are shown to be capable of killing tumor cells by photodynamic therapy with near-infrared light irradiation, and after modification with polydopamine, they can induce more reactive oxygen species as a result of the regulation of polydopamine, which is demonstrated by experiments. Given their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag 2 S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near-infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA-Ag 2 S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag 2 S had more opportunities to react with surrounding O 2 , which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag 2 S and PDA-Ag 2 S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA-Ag 2 S showed distinctly better therapeutic effects than Ag 2 S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto-unexplored photodynamic function of Ag 2 S quantum dots, which extended and enhanced the regulatory effect originating from PDA.
研究领域:
纳米技术
·
癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2021
·
IF 4.833
Minjie Gao,Haodong Zhao,Zhihua Wang,Yanbao Zhao,Xueyan Zou,Lei Sun
Although Ag 2 S quantum dots (QDs) have attracted extensive attention in the fields of diagnosis and therapy, it is still a challenge to prepare Ag 2 S QDs with well-controlled size distribution. Herein, size-tunable Ag 2 S QDs with glutathione (GSH) as ligands were prepared via a facile aqueous precipitation method. The QDs are precisely prepared through carefully controlled growth of Ag2S QDs by varying the heating time. Morphology and structure characterization verify that Ag 2 S QDs with 2.0–5.8 nm in diameter are coordinated with GSH through thiol group. The as-prepared Ag 2 S QDs exhibit broad absorption spectra and narrow fluorescence emission spectra in the near-infrared region. Meanwhile, the QDs perform excellent and stable photothermal effect with a photothermal conversion efficiency up to 58.6%. More importantly, it is found that the size of Ag 2 S QDs has a significant influence on the fluorescence intensity and photothermal effect. The cell viability evaluation in vitro demonstrates that Ag 2 S QDs have low cytotoxicity to 293 T cells and Hela cells by methyl thiazolyl tetrazolium test. This paper proposes a convenient route to prepare unique Ag 2 S QDs, which are capable to act as ideal theranostics probes for photothermal therapy and simultaneously monitoring the therapeutic effect for effective cancer treatment.
研究领域:
纳米技术
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材料科学
·
生物医学工程
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Shixin Huang,Wei Liu,Hailong Lin,Zhicheng Wen,Chunjin Hang,Rong An,Yongfeng Li,Yanhong Tian
The design of materials for the detection of n-butanol at low operating temperatures is of great significance for the reduction of power consumption and the improvement of the safety of the gas sensor. In this study, the solvothermal method and subsequent Ag-loading treatment were employed to synthesise hierarchical flower-like Cu-doped SnO 2 /Ag 2 S heterojunctions decorated with Ag (CSAA). The morphological and structural characterisation demonstrated that the amount of Cu 2+ doping and the duration of electroless Ag plating played a pivotal role in the morphological evolution of the SnO 2 -based hierarchical structure. The optimal CSAA composite exhibits the highest response of 1136 and the shortest response time of 6 s to 50 ppm n-butanol at 80°C, accompanied by superior selectivity, repeatability, humidity and long-term stability. The enhanced sensing performances of the CSAA sensor can be mainly ascribed to the hierarchical porous structure, the doping of Cu 2+ , the construction of SnO 2 /Ag 2 S heterostructures and the decoration of Ag nanoparticles (Ag NPs). Furthermore, the density functional theory simulation was employed to investigate the influence of Ag NPs and Ag 2 S on the adsorption properties and electronic behaviour of n-butanol on the surface of SnO 2 . This work proposes a friendly strategy and theoretical support for enhancing the sensing performance of MOS sensors in the practical detection of n-butanol.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-10
·
IF 5.3
Yu Pengfei,Li Meixin,Wang Shun,Li Shanshan,Cui Jiaqi,Yang Jun,Liu Shuang,Kong Ling,Chen Zhiwei
Fumonisin B 1 (FB 1 ) is a mycotoxin mainly found in corn, peanuts, and wheat crops, which affects human health. Based on bismuth sulfide/bismuth oxychloride (Bi 2 S 3 /BiOCl) composite material, silver sulfide (Ag 2 S) was grown in situ as a quantum dot sensitization signal, and a photoelectrochemical (PEC) aptasensor was designed by layer upon layer modification to detect FB 1 . Bi 2 S 3 /BiOCl has a wide range of visible light absorption, stable chemical properties, and a simple synthesis method. In the construction process, L-ascorbic acid (AA) is selected to provide electrons and inhibit photogenerated electron-hole (e - /h + ) recombination. Under the optimal experimental conditions, the detection range of the fabricated PEC aptasensor was 0.001 ~ 100 ng/mL, and the detection limit was 0.016 pg/mL. The prepared PEC aptasensor has high sensitivity, stability, and reproducibility. The combination of aptamer and PEC sensor provides a novel method for the application of PEC sensor in mycotoxin detection. Graphical
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2021
·
IF 5.373
Qiying Zhu,Canguo Li,Huiqin Chang,Meng Jiang,Xiaokai Sun,Wei Jing,Haowei Huang,Di Huang,Ling Kong,Zhiwei Chen,Feng Sang,Xiuzhen Zhang
Prostate cancer is one of the most common cancers in the world, and its early detection is vital to saving the lives of patients. In this research, a novel label-free photoelectrochemical immunosensor was designed for sensitive detection of prostate specific antigen (PSA). Ag 2 S sensitized on Ag/AgBr/BiOBr heterojunction could effectively inhibit photogenic holes recombination and improve photocurrent response and sensitivity. Ascorbic acid was an effective electron donor, which can effectively eliminate photo-generated holes. The photocurrent reduced linearly with the logarithm of PSA concentration ranged from 0.001 to 50 ng·mL −1 and the limit of detection was 0.25 pg·mL −1 . The designed sensor had the advantages of wide linear range, good stability, high reproducibility, and good selectivity. This study not only provided a method for efficient and sensitive detection of PSA, but also provided valuable reference ideas for the detection of other tumor markers.
研究领域:
医学
·
生物技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）