ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Jiabin Shen,Shanshan Xu,Cheng Zhao,Xiaopeng Qiao,Haiquan Liu,Yong Zhao,Jing Wei,Yongheng Zhu
In this work, we present a new metal oxide semiconductor gas sensor for detecting trimethylamine (TMA) by bimetal Au@Pt-modified α-Fe2O3 hollow nanocubes (NCs) as sensing materials. The structure and morphological characteristics of Au@Pt/α-Fe2O3 were evaluated through multiple analyses, and their gas-sensitive performance was investigated. Compared with the pristine α-Fe2O3 NC sensor, the sensor based on Au@Pt/α-Fe2O3 NCs exhibited faster response time (5 s) and higher response (Ra/Rg = 32) toward 100 ppm TMA gas at a lower temperature (150 °C). Furthermore, we also assessed the Au@Pt/α-Fe2O3 NC sensor for detecting the freshness of Larimichthys crocea which have been observed by headspace solid-phase microextraction and gas chromatography–mass spectrometry. The high performance of the Au@Pt/α-Fe2O3 NCs is attributed to the special hollow morphology with a high specific surface area (212.9 m2/g) and the synergistic effect of the Au@Pt bimetal. The Au@Pt/α-Fe2O3 sensor shows promising application prospects in estimating seafood freshness on the spot.
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PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 2
·027547
·
IF 3.721
Shuan Zhang,Yueyun Li,Chunyan Zhang,Yilei Jia,Ping Wang,Yunhui Dong,Xinjin Li,Qing Liu,Zengdian Zhao
Herein, urchin-like gold@platinum dendritic nanoparticles supported on molybdenum selenide@molybdenum disulfide (Au@Pt DNPs/MoSe2@MoS2) nanocomposite with multiple signal amplification capabilities was successfully synthesized as the matrix platform of label-free amperometric immunosensor for the quantitative detection of squamous cell carcinoma antigen (SCCA). Au@Pt DNPs/MoSe2@MoS2 consists of Au@Pt DNPs with splendid biocompatibility as well as catalysis and MoSe2@MoS2 with reformative peroxidase activity, which owned enhanced electrocatalysis toward hydrogen peroxide reduction and steady bioconjugation for bioprotein immobilization. Additionally, Au@Pt DNPs/MoSe2@MoS2 possessed satisfactory conductivity to accelerate electron transfer at the electrode interface. With the help of Au@Pt DNPs/MoSe2@MoS2, the immunosensor procured a good linear extent of SCCA detection between 100 fg ml−1 and 100 ng ml−1, reached a lower detection limit than previous reports. Moreover, the immunosensor with good stability and reproducibility achieved the specific detection of SCCA in the mixture containing interferents as well as in the real human serum sample, which testified to the proposed amperometric immunosensor was reliable in clinical detection of tumor biomarkers.
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高影响因子
RSC Advances
·
2019
·Vol. 9
·期 71
·41561-41568
·
IF 3.049
Cuifeng Jiang,Xiaoxiu Wei,Shuai Bao,Huajian Tu,Wei Wang
Nanomaterial-based artificial peroxidase has attracted extensive interests due to their distinct advantages over natural counterpart. Cu@Au/Pt and Cu@Ag/Pt nanocomposite with rambutan-like structure were prepared and discovered to function like peroxidase, which was illustrated by catalyzing the oxidation reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) accompanied with a blue color change. Steady-state investigation indicates that the catalytic kinetics of Cu@Au/Pt and Cu@Ag/Pt all followed typical Michaelis–Menten behaviors and Cu@Au/Pt showed a strong affinity for H2O2, while Cu@Ag/Pt showed strong affinity for TMB. The color change and absorbance intensity strongly depend on the concentration of H2O2, thus the direct determination of H2O2 and indirect detection of glucose were demonstrated using Cu@Au/Pt with a detection limit of 1.5 μM and 6 μM, respectively. What is more important, the method was applied for detection of glucose in 50% fetal bovine serum with a detection limit of 80 μM, which is much lower than the lowest glucose content in blood for diabetes (7 mM). Moreover, the Cu@Au/Pt nanocomposite were also successfully applied for sensing L-cysteine because of the inhibition effect. Considering the good peroxidase-like activity and novel structure, Cu@Au(Ag)/Pt is expected to have a wide range of applications in bioassays and biocatalysis.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 9
·1-10
·
IF 5.705
Sun Ying,Wang Ruixue,Liu Xuan,Shan Guiye,Chen Yanwei,Tong Ti,Liu Yichun
Platinum nanoparticles (PtNPs) were uniformly grown on the surface of gold nanorods (AuNRs) by a laser irradiation procedure. Transmission electron microscopy confirmed that the PtNPs are uniformly grown on the surface of the AuNRs. The formation of PtNPs on the AuNRs leads to a red-shift of the absorption maximum from 734 nm to 766 nm. In addition, the efficiency of surface enhanced Raman scattering (SERS) is increased, but the photothermal conversion efficiency is decreased compared to pure AuNRs. The result indicates that electron transfer occurs between gold and platinum. The peroxidase mimicking effect of PtNPs, AuNRs and Au/Pt NRs by catalyzing the oxidation of colorless 3,3’,5,5’-tetramethylbenzidine (TMB) to blue oxidized 3,3’,5,5’-tetramethylbenzidine (oxTMB; a quinone) in the presence of H 2 O 2 . The catalytic activity of Au/Pt NRs is higher than that of sole AuNRs or PtNPs by factors of 4.2 and 2.1, respectively. Thus, Au/Pt NRs have been used for the detection of peroxide and the limit of detection is 0.04 μM. This work provides an approach to integrate the peroxidase mimicking effect with SERS enhancement for potential application in detection.
A schematic diagram for the laser-induced growth of Au/Pt NRs and the colorimetric determination of hydrogen peroxide concentration with their peroxidase mimicking properties. The limit of detection is 0.04 μM based on the use of Au/Pt NRs as a catalyst.
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高影响因子
ACS Sensors
·
2020
·
IF 7.333
Wei Chen,Lijun Yang,Chao Yan,Bangben Yao,Jianfeng Lu,Jianguo Xu,Guodong Liu
Overuse and abuse of morphine (MOP), one of the main components of pericarpium papaveris, have attracted increasing attention in the medical field owing to its pharmacological and toxicological activity. Herein, we proposed a new electrochemical nano-biosensor for MOP detection based on surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wire-surrounded electroactive super-nanostructures. The center Au@Pt was flower-shaped and irregularly protruded, allowing substantial loading of multiple G-quadruplex wire/hemin complexes on its surface to accomplish the assembly of electroactive super-nanostructures. Interestingly, as the super-nanostructures were closely confined on the electrode surface, a significantly amplified electrochemical signal was thus obtained in the absence of MOP. In contrast, the introduction of target MOP can induce an intense competitive effect and strongly destroy the assembly process, resulting in the reduction of the electrochemical response that is correlated with the logarithmic concentration of MOP. Under optimal conditions, the electrochemical nano-biosensor is capable of highly sensitive detection of MOP in a dynamic concentration range from 1 ppt to 500 ppb. The limit of detection is achieved as low as 0.69 ppt, and the practical application was confirmed by examining MOP from chafing dish condiments. We expect the electrochemical platform utilizing this unique nanoarchitecture to provide rational guidelines to design high-performance analytical tools.
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高影响因子
NANOTECHNOLOGY
·
2015
·Vol. 26
·期 50
·505401
·
IF 3.821
Lingyu Tan,Lidong Li,Yi Peng,Lin Guo
Herein, a new type of uniform and well-structured Au@Pt bimetallic nanoparticles (BNPs) with highly active concave Au nanocuboids (NCs) as seeds was successfully synthesized by using the classic seed-mediated method. Electrochemical measurements were conducted to demonstrate their greatly enhanced catalytic performance in the ethanol oxidation reaction (EOR). It was found that the electrochemical performance for Au@Pt BNPs with the concave Au NCs as seeds, which were enclosed by {611}high-index facets, could be seven times higher than that of the Au@Pt bimetallic nanoparticles with regular spherical Au NPs as seeds. Furthermore, our findings show that the morphology and electrocatalytic activity of the Au@Pt BNPs can be tuned simply by changing the compositional ratios of the growth solution. The lower the amount of H2PtCl6 used in the growth solution, the thinner the Pt shell grew, and the more high-index facets of concave Au NCs seeds were exposed in Au@Pt BNPs, leading to higher electrochemical activity. These as-prepared concave Au@Pt BNPs will open up new strategies for improving catalytic efficiency and reducing the use of the expensive and scarce resource of platinum in the ethanol oxidation reaction, and are potentially applicable as electrochemical catalysts for direct ethanol fuel cells.
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Yukun Yang,Jian Liu,Rong Guo,Baoqing Bai,Tao Bo,Jinhua Zhang,Ligang Yu,Huilin Liu,Ying Zhang,Shuo Wang
A three-channel sensor array based on Au@Pt NPs was constructed. • Au@Pt NPs with dual-function characteristics was designed. • Discrimination of light aroma-type Baijiu (LAB) was achieved. • Different years, production processes, price gradients, and adulterated were analyzed. • This method highlighted simple to operate, rapid in detection. The development of light aroma-type Baijiu (LAB) industry proposes a growing need for developing rapid and accurate discrimination method for the quality control of LAB. This study innovatively constructed a dual-mode three-channel sensor array based on the gold/platinum nanoparticles (Au@Pt NPs) with surface engineering. In this case, two colorimetric sensor channels based on ascorbic acid/para-aminophenol-chloroauric acid-nanozyme (AA/ pAP-HAuCl₄-Au@Pt NPs) and one fluorescent sensor channel based on nanozyme‑hydrogen peroxide- o -phenylenediamine (Au@Pt NPs-H₂O₂-OPD) were established. Experimental results demonstrate the colorimetric and fluorescence mode can accurately quantify four organic acids and three aldehydes in Baijiu, respectively. Samples including 17 different years and 9 different production processes of basic liquors of LAB, 48 different price gradients of commercial LAB, and adulterated LAB were analyzed. Discrimination with an accuracy exceeding 96% by Linear Discriminant Analysis, Hierarchical Cluster Analysis, and leave-one-out cross-validation was achieved. The dual-mode three-channel sensor array is characterized by simplicity, rapidity and accuracy, providing a new idea for the quality discrimination and market regulation of Baijiu.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Li Ming,Ning Li,Hongyan Zhang,Xiaobo Zou,Can Zhang
A “all-in-one” nanolabel APZ was constructed. • High Nbs coupling, dual spectral overlap, visible absorption, pH-triggered catalysis. • The three orthogonal signals enhance reliability and enable flexible applicability. • ZIF-8 “enrichment–confinement–pH-triggered collapse” synergy boosts catalysis. • Stabilize Au Pt heterostructure via ZIF-8–enabled physical isolation and protection. Conventional lateral flow immunoassay (LFIA) suffers from limited sensitivity due to single-signal readout, low antibody conjugation efficiency, and steric hindrance associated with bulky conventional antibodies. Herein, we developed a multimodal LFIA employing Au@Pt@ZIF-8 (APZ) as a multifunctional nanolabel, prepared by encapsulating flower-like Au@Pt nanoparticles (Au@Pt NPs) within a ZIF-8 framework. Benefiting from its high specific surface area and mesoporous structure, APZ significantly enhanced the coupling efficiency and stability of anti-3-phenoxybenzoic acid nanobodies (3-PBA Nbs), achieving a coupling efficiency of 94.75% under identical conditions, compared with 69.61% for Au@Pt NPs. APZ further exhibits a broad absorption spectrum, fluorescence quenching due to dual spectral overlap, and high catalytic activity arising from the intrinsic peroxidase-mimicking activity of Au@Pt, synergistically enhanced by ZIF-8 enrichment/confinement and pH-triggered framework collapse. These features enabled the integration of three orthogonal readout modes, namely aggregation-induced coloration, catalysis-induced chromogenesis, and fluorescence quenching, into a single test strip. The resulting multimodal APZ-LFIA attains limits of detection (LOD) for 3-PBA of 0.004 ng/mL, 0.001 ng/mL, and 0.0003 ng/mL, respectively. By integrating multiple complementary signals, this strategy offers a flexible and reliable platform for trace 3-PBA analysis and shows great promise for on-site food safety monitoring. Download: Download high-res image (87KB) Download: Download full-size image
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高影响因子
ACS Agricultural Science & Technology
·
2022
·
IF 0
Can Zhang,Jinnuo Hu,Xiaoxiao Wu,Jiyong Shi,Bruce D Hammock
As a major metabolite of pyrethroid pesticides, 3-phenoxybenzoic acid (3-PBA) can be an indicator of health risk and human exposure assessment. A gold–platinum (Au@Pt) nanozyme is a kind of mimic enzyme with unique properties of nanomaterials and catalytic activity. The anti-3-PBA nanobodies were labeled with Au@Pt (Au@Pt-Nbs) by electrostatic adsorption. The Au@Pt-Nbs lateral-flow nanozyme immunoassay was established for the visual and rapid detection of 3-PBA. The visualization results were quantitatively analyzed by Adobe Photoshop CC and got a cutoff value of 0.005 ng/mL. The samples of milk- and lake water-spiked 3-PBA were also analyzed, and the recoveries ranged from 102 to 108% and 95 to 112%, respectively. The results were also validated by liquid chromatography–mass spectrometry and got good correlation (R2 = 0.945). The Au@Pt-Nbs lateral-flow nanozyme immunoassay was developed by the combination of nanobodies and nanozymes, which will be a promising application in the field of safety inspection.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2021
·
IF 3.101
Xiaofeng Wang,Yongfeng Chen,Runze Yu,Ruiqiang Wang,Zhixiang Xu
In this paper, a sensitive biomimetic enzyme-linked immunoassay (BELISA) method based on an Au@Pt@Au composite nanozyme label was developed for histamine (HA) detection. A molecular imprinted polymer prepared directly on the 96-well plate served as a biomimetic antibody. A BELISA method was developed for HA standard solutions at concentrations ranging from 0.01 to 100.00 mg/L. Under optimal conditions, the novel BELISA method had a low limit of detection (0.069 mg/L) and high sensitivity (7.20 mg/L). The HA spiked in yellow rice wine and liqueur samples were detected by this BELISA method with the recoveries ranging from 84.28% to 108.82%. There was no significant difference of the results between the BELISA method and HPLC for the detection of HA in the red and white grape wine samples.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 37
·16475-16480
·
IF 2.7
Xiaoxu Zhang,Xiangyu Cai,Yanqun Fei,Yuying Jia,Hongyan Shan,Yanfu Huan
In this article, a CRET-based chemiluminescent sensor was developed for ascorbic acid detection. Au/Pt@Cu2O/CuO NPs with peroxidase activity were prepared to catalyse the decomposition of H2O2 to produce free radicals, which led to the enhancement of the chemiluminescence (CL) signal, and the CRET between luminol and MnO2 NSs was able to take place and the CL signal was reduced; the presence of ascorbic acid would reduce MnO2 NSs, which was able to weaken the energy transfer between luminol and MnO2 NSs and restored the CL signal. Under the optimal experimental conditions, the detection range of ascorbic acid was 1–1000 μM, and the LOD was 0.35 μM. The method is sensitive and has a wide linear range, and is expected to be applied to the detection of ascorbic acid in more complex environments.
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高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 30
·4363-4370
·
IF 1.9
Chi-Fang Peng,Ying-Ying Zhang,Li-Ying Wang,Zheng-Yu Jin,Guang Shao
In this study, peroxidase-mimicking core–shell Au@Pt nanoparticles (Au@Pt NPs) were synthesized, and both Hg2+ and Ag+ were found to intensively inhibit the catalytic activity of the Au@Pt NPs. The interactions between the two metal ions and Au@Pt NPs were analyzed through characterization by TEM, DLS, EPR and XPS, etc. Based on the inhibition of both Hg2+ and Ag+ toward the catalytic activity of the Au@Pt NPs and the shielding of sodium dodecyl sulfate (SDS) toward interfering metal ions, a highly sensitive and selective colorimetric assay for Hg2+ and Ag+ was developed. In addition, L-cysteine can be used to mask Hg2+ in the presence of Ag+; therefore, a specific detection of Ag+ ions can be accomplished by this Au@Pt NP-based assay. The limits of detection (LODs) for Hg2+ and Ag+ are 3.5 nM and 2.0 nM, respectively. The linear ranges for detecting Hg2+ and Ag+ are from 10 nM to 200 nM and from 5.0 nM to 100 nM, respectively. Moreover, the colorimetric assay is highly selective toward Hg2+ and Ag+ over other common metal ions. This work demonstrates that the optimization of metal nanoparticle preparation and surface modification play very important roles in developing metal ion sensing based on metal NP enzyme mimics. In addition, the metallic nanozyme based colorimetric method here demonstrates advantages in practical applications as it is low-cost, simple, and highly sensitive and selective, although it needs a two-step reaction.
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高影响因子
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