SENSORS AND ACTUATORS B-CHEMICAL
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2017
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IF 5.401
Xiao Wang,Ying Zheng,Lan Xu
An electrochemical strategy for adenine detection was described. In order to generate a 3D net-work composite film, gold nanoparticles (Au NPs) capped with 3-thiophene acetic acid (3-TAA) were used to couple with molecular imprinting technique (MIT). In the presence of the 3-TAA capping Au NPs (Au NPs-T), the electrode-surface-tethered 3-TAAs were polymerized to form a homogeneous conductive material immobilized into the electrode. Through this sensor fabrication, Au NPs-T associating with the Au electrode resulted in enhanced sensitivity and MIT contributed to the specificity.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Biaobiao Ge,Jie Huang,Qianmin Dong,Fen Yang,Mengmeng Wang,Pei Liang
This work reveals a novel SERS enhancement mechanism of “satellite” structure. • Stable and uniform L-Au@ZIF-67@S-Au NPs were synthesized by self-assembly method. • L-Au@ZIF-67@S-Au NPs substrates was prepared with an enhancement factor of 3.4 × 10 6 . • Determination of fenpropathrin in citrus peel, and its LOD reached 0.995 μg/L. A new hybrid substrate of core-satellite plasma MOF, namely L-au @ ZIF-67 @ S au NPs, was developed in this study. The substrate aims to improve SERS performance by combining the molecular trapping layer of ZIF-67 with double electromagnetic hot spots distributed on the inner surface and the outer surface. The interface self-assembly strategy was adopted to combine MOF with plasma nanostructures, thus combining excellent molecular adsorption ability with strong local field enhancement effect. The results showed that the substrate had a low detection limit of 1.43 × 10 −10 M for rhodamine 6G, achieved rapid adsorption equilibrium within 10 min, and showed high signal reproducibility (relative standard deviation, RSD = 1.66%, n = 20). The substrate was applied to the detection of fenpropathrin residues in citrus peels, showing good sensitivity, and the detection limit was 0.995 μg·L −1 , with an enhancement factor of 3.4 × 10 6 and excellent reproducibility. This work builds a multifunctional and environment-friendly SERS platform, which effectively combines advanced nano-material design with practical applications of food safety monitoring Download: Download high-res image (146KB) Download: Download full-size image
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ANALYTICA CHIMICA ACTA
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2026
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IF 6
Chen Yang,Limin Zhang,Zijun Ma,Junhao Gao,Yang Zhou,Bing Li,Jianbo He,Fang Li
Background The detection and quantification of glucose in human biofluids are critical for the early diagnosis and management of metabolic disorders such as hypoglycemia and diabetes. Non-invasive wearable sensors for sweat glucose monitoring have emerged as promising alternatives to traditional blood glucose testing due to their ease of use, rapid response, and portability. However, the development of stable, cost-effective, and enzyme-free wearable platforms capable of reliable sweat glucose detection remains a significant challenge. Current enzyme-based sensors often suffer from poor stability under ambient conditions, complex fabrication processes, and high costs, limiting their widespread applicability in resource-constrained settings. Results Au NPs/Cu-TCPP(Fe) nanozymes exhibiting dual peroxidase-like and glucose oxidase-like catalytic activities were synthesized and characterized. These nanozymes catalyze a cascade reaction: glucose oxidation generates H 2 O 2 , which is then decomposed to produce hydroxyl radicals that oxidize 3,3′,5,5′-tetramethylbenzidine (TMB), yielding a blue-colored product for colorimetric detection. A flexible, multi-layer hydrophilic-hydrophobic array patch was fabricated by integrating the nanozymes and TMB into a paper-based matrix. This design enables efficient in situ sweat collection, concentration, and colorimetric analysis. The patch exhibits a linear detection range of 20–200 μM with a detection limit of 12.72 μM, suitable for physiological sweat glucose levels. Selectivity tests confirmed negligible interference from common sweat components. A smartphone application was developed to enable real-time, quantitative analysis of colorimetric signals. Clinical validation on multiple volunteers across different skin locations (chest, back, forearm, forehead) showed strong correlation with reference methods (HPLC-MS, commercial glucose detection kit), with relative errors <10 %. Significance This study presents a low-cost and enzyme-free sweat glucose detection platform based on Au NPs/Cu-TCPP(Fe) nanozymes. The integration of smartphone technology enables point-of-care testing, making the platform particularly suitable for personalized health monitoring. The successful validation in human subjects demonstrates its potential for real-world applications in diabetes management and early disease detection. This work bridges the gap between nanozyme catalysis and wearable sensor technology, providing a versatile platform for non-invasive biomarker detection.
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ANALYTICA CHIMICA ACTA
·
2022
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IF 6.911
Mengyang Li,Baoshan He,Haoyang Yan,Lingling Xie,Xiaoyu Cao,Huali Jin,Min Wei,Wenjie Ren,Zhiguang Suo,Yiwei Xu
A novel ultrasensitive electrochemical aptasensor was proposed for quantitative detection of Cd 2+ . To this end, flower-like polyethyleneimine-functionalized molybdenum disulfide-supported gold nanoparticles (PEI-MoS 2 [email protected] NPs) were used as substrates for the modification of bare gold electrodes (AuE). PEI-MoS 2 [email protected] NPs not only possessed excellent biocompatibility and large specific surface area to enhance the cDNA loading capacity, but also possessed good conductivity to accelerate the electron transfer rate. Furthermore, the preparation of dendritic platinum-palladium nanoparticles (PtPd NPs) can effectively load Cd 2+ -aptamer. Thionine and aptamers were loaded onto PtPd NPs to construct Thi-PtPd NPs-aptamer signal probes. The signal probes were captured by the cDNA immobilized on the electrode via base-pairing rule, and the signal of Thi was detected by differential pulse voltammetry (DPV). In the presence of Cd 2+ , aptamer-cDNA unwinded, and the combination of aptamer and Cd 2+ caused the signal probes to fall off the electrode and the electrical signal decreases. Under optimal conditions, the proposed aptasensor exhibited a linear relationship between the logarithm of Cd 2+ concentration and the current response over a wide range of 1 × 10 −3 nM to 1 × 10 2 nM, with a detection limit of 2.34 × 10 −4 nM. At the same time, the aptasensor was used to detect Cd 2+ in tap water with satisfactory results. In addition, it has good reproducibility, selectivity and stability, and has broad application prospects in heavy metal analysis.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Jingxuan Pei,Yibo Sun,Xiang Yu,Zhenfei Tian,Shuting Zhang,Songbo Wei,Yanfang Zhao,Rabah Boukherroub
Development of reliable sensing strategy combining surface-enhanced Raman scattering (SERS) and surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS) is of significant interest to distinguish cysteine enantiomers in body fluid for understanding their physiological roles and toxicity hazards. In this work, a SERS/SALDI-MS dual-mode sensing platform of gold nanoparticles (Au NPs) decorated holey carbon nitride (hg-C 3 N 4 ) was fabricated for sensitive detecting cysteine. The designed Au@hg-C 3 N 4 matrix featured a uniform distribution of Au NPs with the help of anchoring effect of hg-C 3 N 4 holey structure, which was conducive to produce highly repeatable signals. Moreover, the combination of Au NPs and holey g-C 3 N 4 endowed this matrix with superior enrichment capacity, enhanced charge transfer and strong UV absorption. These merits allowed the matrix to acquire high sensitivity and enhanced reproducibility for l -cysteine by means of SERS/SALDI-MS. Likewise, reliable detection of l -cysteine and efficient recognition of d -cysteine in human serum jointly revealed its prospect for detecting cysteine enantiomers in body fluids. This work offers a reliable SERS/SALDI-MS strategy for determining L/D-cysteine enantiomers, and the designed Au@hg-C 3 N 4 matrix becomes a potential application candidate for selective detection of bio-enantiomers.
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ELECTROCHIMICA ACTA
·
2017
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IF 4.798
Dingding Duan,Hua Yang,Yaping Ding,Daixin Ye,Li Li,Guohong Ma
A novel three-dimensional molecularly imprinted electrochemical sensor (MIECS) was fabricated for ultra-trace detection of biomacromolecules bovine serum albumin (BSA), which was based on 3D porous electrocatalytic framework materials (AuNPs@NH 2 -MIL-125(Ti) composites) and graphene modified glassy carbon electrode. The AuNPs supported amino-functionalized Ti-benzenedicarboxylate porous metal-organic frameworks (Au/NH 2 -MIL-125(Ti)) was prepared by a simple and rapid ultrasonic method. The stable proteins molecularly imprinted polymers (MIPs) films were fabricated by electropolymerization using l -cysteine (L-Cys) as functional monomers and BSA as templates. The monomer L-Cys interact with AuNPs by Au S bonds and interact with BSA by hydrogen bonding and electrostatic interaction , which was characterized with UV–vis spectra. The morphology of the MIP modified electrode was characterized by scanning electron microscopy, transmission electron microscopy and atomic force microscope. Under the optimal conditions, the 3D MIECS exhibited a wide linear range of 10 −18 g mL −1 to 10 −12 g mL −1 of BSA and an extremely low detection limit of 4.147 × 10 −19 g mL −1 . The 3D MIECS has been applied to the assay of BSA in liquid milk samples with satisfying results.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Jin Wang,Xu Guo,Qixiang Zhou,Yan Cai,Bing Lu,Yang Wang,Yong Yao
The functional photoelectric materials based on bismuth oxyhalides (BiOX, X = Cl, Br and I) have been widely used in the field of photo-electrochemistry (PEC) due to their excellent physical, chemical and optical properties. Herein, a series of BiOX nanoflowers conjugated water-soluble pillar[5]arenes functionalized Au (Au@WP5/BiOX) modified PEC sensor are constructed and investigated for the PEC detection of serotonin. Upon exploring the physical properties, such as size, visible light absorption capacity, band gap and impedance, of the three BiOX materials, it is discovered that BiOBr is more effective in detecting 5-HT due to its high redox ability, moderate band gap (∼2.03 eV), and low impedance. BiOBr can provide a high and stable starting photocurrent compared to the other two bismuth oxyhalides. When used in acidic or neutral environments, 5-HT with a positive charge can undergo electrostatic adsorption and host-guest complexation behavior with WP5, which has a negative charge. By using WP5, the recognition ability of the material to 5-HT molecules can be enhanced, and the adsorption of 5-HT molecules on Au@WP5/BiOBr can be accelerated. The local surface plasmon resonance effect (LSPR) of gold nanoparticles (Au NPs) can accelerate the electrochemical reaction rate and charge transfer rate, which ultimately leads to the amplification of the photocurrent signal. As a result, the 5-HT detection sensor based on Au@WP5/BiOBr has a wide detection range from 0.01 to 100 μM and a low detection limit of 3 nM (S/N = 3) compared to other sensors, including Au@WP5/BiOCl and Au@WP5/BiOI. The proposed PEC sensor also exhibits good stability and selectivity, making it a promising strategy for detecting biological small molecules using pillar[5]arene functionalized PEC active materials.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Yue Li,Junhao Zhou,Xiaoping He,Youzhou He,Jiajia Jing,Xingyan Liu,Siqi Li,Siping Wei
Under the global dual-carbon goal, photocatalysis technology is being employed as a green technology for NO removal and hydrogen production . However, the application of photocatalysts is often limited by the weak response to visible light and the low separation efficiency of photogenerated carriers. In this paper, we designed a simple and efficient photocatalyst Au@NM-125/PdTCPP for NO removal and hydrogen evolution . By adding PdTCPP molecule with excellent light absorption ability combine with MIL-125-NH 2 (Ti), the introduction of PdTCPP expands the absorption range of visible light. On the other hand, the introduction of Au NPs with surface plasmon resonance effect promotes electron transport between PdTCPP and MIL-125-NH 2 (Ti), thus greatly improving the photocatalytic performance. Compared with the NO removal efficiency of the original NM-125 (22.06 %), the NO removal rate of NM-125/PdTCPP was 63.72 %, while the NO removal rate of Au@NM-125/PdTCPP was the highest, reaching 73.23 %. What’s more, Au@NM-125/PdTCPP also demonstrated excellent hydrogen evolution performance (12.659 mmol/g, in 4 h), with a hydrogen evolution effect 2.14 times that of NM-125/PdTCPP (5.911 mmol/g, in 4 h) and 6.85 times that of the initial material NM-125 (1.848 mmol/g, in 4 h). Based on the results of UV-Vis spectroscopy, Mott-Schottky and XPS spectrum, we proposed a possible photocatalytic mechanism, the suitable band gap value of MIL-125-NH 2 (Ti) and PdTCPP makes them form a Z-scheme heterojunction , where electrons flow from PdTCPP to MIL-125-NH 2 (Ti), and Au NPs acts as an electron bridge to promote more electron transfer, thus improving the photocatalytic performance. It is a practicable strategy to achieve excellent photocatalytic performance by combining metalloporphyrin molecules as semiconductors directly with MOFs to form heterojunctions and adding Au NPs as electronic bridges, which is also valuable for environmental remediation and energy production.
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Analytical Methods
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2021
·Vol. 13
·期 24
·2659-2664
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IF 2.896
Haijian Liu,Libin Dong,Miao Wang,Guofu Huang
Herein, a novel and sensitive fluorescence method for cartap determination is established on the basis of the inner filter effect (IFE) of gold nanoparticles (Au NPs) on the fluorescence of glutathione protected Cu NCs (GSH-Cu NCs). In the presence of Au NPs, the fluorescence of GSH-Cu NCs was strongly quenched by the IFE because the absorption spectra of Au NPs overlap well with the emission spectra of GSH-Cu NCs. Upon addition of cartap, cartap could induce the aggregation of Au NPs whose absorption spectrum does not overlap with the emission spectrum of GSH-Cu NCs. Then, with the increase in cartap concentration, the IFE-decreased fluorescence was gradually recovered, realizing the fluorescence sensing of cartap. Under optimal conditions, the proposed method has a good linear relationship with cartap concentration in the range of 7–100 nM, and the detection limit is 3.34 nM. In addition, satisfactory results were obtained for cartap analysis using tap water and cabbage as real samples, which demonstrated that the method as-developed would have great practical application prospects.
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FOOD CHEMISTRY
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2024
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IF 8.5
Xiaobo Zhang,Zhiru Li,Yushu Shi,Bing Hu,Qiuyue Zheng,Yongzhe Piao,Liang Feng,Jijuan Cao
Aflatoxin B1 (AFB 1 ), a hepatotoxic and carcinogenic food contaminant, is commonly found in agricultural food. Herein, Au NPs anchored ZIF-8-derived porous carbon-ZnO (Au NPs/PC ZIF-8 -ZnO) was firstly synthesized to act as the sensing substrate. Then, a ratiometric electrochemical (EC) and “off–on” photoelectrochemical (PEC) dual-mode paper-based aptasensor was presented for AFB 1 detection based on a distance-modulation sensing strategy. The independent signal transduction mechanisms and output mode not only broaden the dynamic detection range but also provide a self-verification to assay results, improving the sensitivity and reliability. The wide detection ranges of 0.1 pg/mL-100 ng/mL (EC mode) and 0.02 pg/mL-100 ng/mL (PEC mode) were obtained using dual-mode aptasensor, with detection limits of 36.7 and 9.3 fg/mL, respectively. The fabricated aptasensor exhibited excellent selectivity, reproducibility and stability. Furthermore, it exhibited good practicability for AFB 1 assays in real samples, demonstrating great potential applications for food safety evaluation.
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ANALYTICA CHIMICA ACTA
·
2025
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IF 6
Xiaoshuo Zhang,Rui Dai,Faqiong Zhao,Baizhao Zeng
Background Epithelial cell adhesion molecules (EpCAM) protein is one of the most frequently and intensely studied tumor-associated antigens because of its overexpression in most cancer cells. Thus, it is regarded as a tumor biomarker associated with a wide variety of carcinomas and reflects the existence and growth of tumors in the human body. It is highly required to detect low concentrations of EpCAM in early stage for ensuring human health. Results In this study, a novel sandwich electrochemiluminescence (ECL) aptasensor was developed for EpCAM detection. Wherein oxalate-based Zn-MOF supported tris(2,2′-bipyridyl)ruthenium (II) (Ru(bpy) 3 2+ @Zn-MOF) was used as luminophore and gold nanoparticle modified o-phenylenediamine (PoPD@Au NPs) as quencher. The 3D Ru(bpy) 3 2+ @Zn-MOF generated self-enhanced ECL without additional co-reactants. Furthermore, it remained stable and had short electron transfer distance, ensuring high and stable ECL signal. The ECL signal could be effectively quenched by PoPD@Au NPs through resonance energy transfer (RET) and electron transfer (ET), due to its absorption spectrum overlapping with the ECL emission spectrum of Ru(bpy) 3 2+ @Zn-MOF. In the presence of EpCAM, the aptamer acted as a linker between the luminophore and quencher, forming a sandwich structure that had reduced ECL intensity. Under optimal conditions, EpCAM could be sensitively detected over the range of 1 pg mL -1 -100 ng mL -1 , with a detection limit of 0.34 pg mL -1 . Significance This work developed a ECL aptasensor with self-enhanced Ru(bpy) 3 2+ @Zn-MOF luminophore for EpCAM detection. The ECL system was simple, but ultrasensitive for EpCAM monitoring, thanks to the ECL-RET and ET between Ru(bpy) 3 2+ @Zn-MOF and PoPD@Au NPs. It also could be applied to detect other biomolecules by replacing the aptamer, offering significant potential in disease diagnosis.
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 28
·13980-13994
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IF 3.553
Li Wenjun,Yang Yue,Ma Chaoyun,Song Yiju,Hong Chenglin,Qiao Xiuwen
A novel sandwich-type electrochemical immunosensor based on cuprous oxide (Cu 2 O)@copper-metal organic framework (Cu-MOF)@gold nanoparticles (Au NPs) core–shell structure was proposed. Cu 2 O@Cu-MOF@Au attached with horseradish peroxidase (HRP) triple-catalyzed hydrogen peroxide (H 2 O 2 ) for detecting CEA antigen. In this work, 50 nm Cu 2 O nanospheres were prepared. Using Cu 2 O nanospheres as the core, Cu-MOF was coated on the surface of Cu 2 O nanospheres by reaction of Cu 2 O and ligands. Subsequently, chloroauric acid was reduced to Au NPs without adding any reducing agent and Au NPs dispersed on the surface of Cu-MOF. Finally, the Cu 2 O@Cu-MOF@Au-HRP-Ab 2 nanoprobe was successfully prepared. Immunosensors had good performance due to the following reasons. Firstly, Cu 2 O, Cu-MOF and HRP have excellent catalytic properties for hydrogen peroxide. In addition, the synergistic effect of Cu 2 O, Cu-MOF and HRP promoted the reduction of hydrogen peroxide and tripled amplification of electrical signals. Here, the successfully prepared immunosensor detected carcinoembryonic antigen (CEA) sensitively, the detection range was 50 fg/mL–80 ng/mL, and the detection limit was 17 fg/mL. Besides, the proposed immunosensor had good stability, selectivity and specificity. Detection in human serum samples had good results without matrix effect. This provided a new idea for the clinical detection of tumor markers: "metal oxide—metal organic framework—precious metal nanoparticles" (MMP). Graphic abstract
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危险品化学品经营许可证（带存储）