Micro & Nano Letters
·
2019
·Vol. 14
·期 11
·1192-1197
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IF 0.975
Minyuan Yin,Yusong Pan,Chengling Pan
In the present study, the adsorption properties of graphite oxide (GO) for Rhodamine B (RhB) under different conditions was investigated. The specific surface area of the GO adsorbent decreased from 71.5 m 2 g −1 for before adsorption of RhB to 4.9 m 2 g −1 for after adsorption of RhB. The maximum adsorption capacity was 578.0 mg g −1 at 303.15 K. Moreover, the pH value has a great influence on the adsorption properties of GO. The adsorption capacity of GO for RhB increased first and then decreased with the rise of pH value. Study on the adsorption kinetics verified that the adsorption process conformed to the pseudo-second-order model adsorption process. The isothermal model is consistent with the Langmuir isothermal model and belongs to the monolayer chemical adsorption.
研究领域:
材料科学
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环境科学
·
化学工程
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DOI
高影响因子
Biomaterials Science
·
2017
·Vol. 6
·期 1
·179-188
·
IF 4.21
Jing Li,Cuiting Zhang,Weiming He,Hongzhi Qiao,Jiahui Chen,KaiKai Wang,David Oupický,Minjie Sun
Kidney-specific delivery is critically important for the treatment of renal fibrosis with drugs such as salvianolic acid B (Sal B). Here we report a kidney-specific nanocomplex formed by the coordination-driven assembly of catechol-modified low molecular weight chitosan (HCA-Chi), calcium ions and Sal B. The prepared HCA-Chi-Ca-Sal B (HChi-Ca-Sal B) nanocomplex reversed the TGF-β1-induced epithelial–mesenchymal transition (EMT) in HK-2 cells. In vivo imaging demonstrated a kidney-specific biodistribution of the nanocomplex. The anti-fibrosis effect of HChi-Ca-Sal B was tested in a mouse model of unilateral ureteral obstruction (UUO). Significant attenuation of the morphological lesions and the levels of extracellular matrix (ECM) proteins in the tubulointerstitium was observed in mice treated with HChi-Ca-Sal B, suggesting that the nanocomplex was able to prevent fibrosis better than the treatment with free Sal B. It was concluded that the HChi-Ca-Sal B nanocomplex showed a specific renal targeting capacity and could be utilized to enhance Sal B delivery for treating renal fibrosis.
研究领域:
药理学
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生物医学工程
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肾脏病学
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jianglu Teng,Xibin Shen,Guohua Hang,Yuan Gao,Jiawei Hu,Sixun Zheng
The reaction of 4-(hydroxymethyl)phenylboronic acid with triethanolamine was carried out to synthesize a boronic ester diol featuring boron–nitrogen (B–N) coordination. This diol served as a chain extender, allowing B–N-coordinated boronic ester bonds to be introduced into polyurethane (PU) networks. Toward this end, we first synthesized a series of α,ω-dihydroxyl polyurethane telechelics with α,ω-dihydroxypropyl poly(dimethylsiloxane) as the polymeric diol. By varying the molar ratio of the boronic ester diol to 1,4-butane diol, the α,ω-dihydroxyl polyurethane telechelics were synthesized with variable contents of the dynamic covalent bonds. Thereafter, the reaction of α,ω-dihydroxyl PU telechelics with 3-isocyanatopropyl triethoxysilane was carried out to gain α,ω-ditriethoxysiloxane PU telechelics. The latter were readily cross-linked via the sol–gel process to afford the mechanically robust PU networks, with Young’s modulus and tensile strength as high as 302.7 and 35.4 MPa, respectively. More importantly, the reprocessing properties were imparted to the PU networks. Compared to the control PU network, the reprocessing temperature was depressed to 120 °C. In the meantime, the shape memory properties of PU networks were significantly improved through the introduction of dynamic covalent bonds. Furthermore, the shape memory networks featured reconfigurability with the introduction of B–N-coordinated boronic ester bonds.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
Future Medicinal Chemistry
·
2019
·Vol. 11
·期 20
·
IF 3.617
Hongmei Xu,Fangfang Teng,Feilong Zhou,Li Zhu,Yi Wen,Runliang Feng,Zhimei Song
Aim: To encapsulate amphotericin B (AmB) with reduced toxicity and comparable activity. Results & methodology: The α-linolenic acid (ALA)-modified monomethoxy polyethylene glycol-g-PEI-g-ALA conjugate was employed to prepare AmB-loaded micelles (AmB-M). In vitro activity and release behavior of AmB-M were investigated. AmB-M enhanced AmB's water-solubility to 1.2 mg/ml, showing good storage stability. AmB-M could achieve a sustained and slow release of AmB, low hemolysis activity and negligible kidney toxicity when compared with commercial AmB injection. Antifungal activity and biofilm inhibition experiments confirmed that the antifungal activity of AmB-M against Candida albicans was similar to that of AmB injection. Conclusion: Monomethoxy polyethylene glycol-g-PEI-g-ALA micelles could be a preferable choice to treat systemic fungal infections as an efficient drug delivery system.
研究领域:
药剂学
·
抗感染研究
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 10
·期 3
·804-814
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IF 7.779
Hu Yao,Yinan Zheng,Siliang Yue,Songjie Hu,Wenyu Yuan,Xiaohui Guo
The oxygen evolution reaction (OER) has slow chemical dynamics in the electrochemical decomposition of water. Herein, we demonstrate that B-site substitution engineering on ABF3 is an efficient strategy to boost the OER activity due to the modified electronic structure. A series of perovskite fluorides with the formula NaCo1−2xFexNixF3 were fabricated via a simple hydrothermal process, in which Co was partially substituted by both Fe and Ni. The optimized perovskite fluoride exhibited a low overpotential of 265 mV at a current density of 10 mA cm−2 and outstanding electrochemical stability after 100 h continuous electrocatalysis for the OER. These results are superior to the state-of-the-art perovskite-based OER catalysts. The X-ray photoelectron spectroscopy (XPS) and X-ray absorption fine structure (XAFS) results showed that the dual-substitution of Fe and Ni atoms not only produced higher valence Co3+ ions but also generated the more active species Fe3+. In addition, the produced metal oxyhydroxides (MOOH, M = Co, Fe, Ni) on the catalyst surface during OER activation could contribute both excellent catalytic activity and ultralong stability.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 17
·3976
·
IF 3.267
Tingting Wu,Xianying Fang,Jiahui Xu,Yan Jiang,Fuliang Cao,Linguo Zhao
Ginkgo biloba extract (EGB) has many pharmacological activities. In the quality standard of EGB, the main quality control indexes are total flavone (content ≥ 24%) and total lactone (content ≥ 6%). There are no specific limits for nearly 70% of “other components”. In recent years, in order to pursue the production of a high-ketone ester, some enterprises removed the unwanted components, including some organic acids. Protocatechuic acid (PCA), as an important organic acid, has been reported to have a variety of biological activities. It is necessary to explore whether it can promote the biological activities of the main functional components of EGB. In this study, PCA was selected to be combined with Ginkgolide B (GB) for the treatment of Parkinson’s disease. In vitro, rotenone (rot) was used to induce PC12 cells. The survival rate was tested by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dimethyltetrazolium bromide (MTT) assay. Reactive oxygen species (ROS) and antioxidase were detected to analyze the effects of drugs on oxidative stress. The apoptosis was tested via Western blot. The results show that the cell viability was increased, morphology was improved, the oxidative stress level decreased, and the apoptosis was inhibited after the combination treatment of GB and PCA, and the effect was better than GB or PCA alone. In vivo, MPTP (30 mg/kg) was used to induce Parkinson’s disease (PD) in male C57BL/6 mice. The motor ability of the mice was measured by pole-climbing and the suspension. The injury of nerve cells was indicated by HE staining. Oxidative stress levels were tested via antioxidant enzyme activity. The number of dopaminergic neurons was reflected by TH staining. Results show that the combination treatment of GB and PCA could significantly restore the motor ability of PD mice, reduce the injury of nerve cells, improve the activity of the antioxidant enzyme in the brain tissue, and increase the expression of TH in the substantia nigra of midbrain. Our study shows that PCA increases the efficacy of GB (the main functional ingredient of EGB) in the treatment of Parkinson’s disease, which provides a new idea for the treatment of nervous system diseases and a new concept for the efficient utilization of active components inGinkgo bilobaleaves.Keywords:Ginkgolide B;protocatechuic acid;synergistic effect;Parkinson’s disease
研究领域:
药理学
·
神经科学
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分子生物学
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DOI
PubMed
高影响因子
RSC Advances
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2021
·Vol. 11
·期 49
·30503-30509
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IF 3.361
Xiupei Yang,Lin Zhang,Dan Wang,Qian Zhang,Jie Zeng,Run Zhang
Developing a new photocatalyst for fast and highly efficient organic dye degradation plays an essential role in wastewater treatment. In this study, a photocatalyst graphite phase carbon nitride (g-C3N4) containing nitrogen defects (CN) is reported for the degradation of rhodamine B (RhB). The porous g-C3N4 photocatalyst is facilely synthesized through a polycondensation method and then characterized by X-ray diffraction (XRD), infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), N2 isotherm adsorption line, and X-ray photoelectron spectroscopy (XPS). The photocatalytic activity of the g-C3N4 is evaluated through the degradation of RhB under visible light irradiation. The results show that photocatalytic activity of the nitrogen-defective g-C3N4 can be improved by optimizating washing conditions, including washing temperature, washing dosage, drying time, and drying temperature. With the prepared nitrogen-defective g-C3N4, decolourization of RhB is able to be completed within 20 minutes, in which the degradation rate is 1.7 times higher than that of bulk g-C3N4. Moreover, the nitrogen-defective g-C3N4 has high stability and reusability in the degradation of RhB. Photocatalytic degradation mechanism investigations by ultraviolet-visible absorption spectroscopy, radical trapping experiments and high-performance liquid chromatography (HPLC) reveal that RhB achieved complete mineralization through the photocatalytic degradation reaction mediated by superoxide radicals (˙O2−). This work thus provides a new approach for the preparation of photocatalysts for organic pollutants treatment in wastewater samples.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Biomolecules
·
2020
·Vol. 10
·期 2
·231
·
IF 4.082
Rabia Durrani,Faez Iqbal Khan,Shahid Ali,Yonghua Wang,Bo Yang
Phospholipase B (EC 3.1.1.5) are a distinctive group of enzymes that catalyzes the hydrolysis of fatty acids esterified at thesn-1andsn-2positions forming free fatty acids and lysophospholipids. The structural information and catalytic mechanism of phospholipase B are still not clear. Herein, we reported a putative phospholipase B (TmPLB1) fromTalaromyces marneffeiGD-0079 synthesized by genome mining library. The gene (TmPlb1) was expressed and the TmPLB1 was purified usingE. colishuffle T7 expression system. The putative TmPLB1 was purified by affinity chromatography with a yield of 13.5%. The TmPLB1 showed optimum activity at 35 °C and pH 7.0. The TmPLB1 showed enzymatic activity using Lecithin (soybean > 98% pure), and the hydrolysis of TmPLB1 by31P NMR showed phosphatidylcholine (PC) as a major phospholipid along with lyso-phospholipids (1-LPC and 2-LPC) and some minor phospholipids. The molecular modeling studies indicate that its active site pocket contains Ser125, Asp183 and His215 as the catalytic triad. The structure dynamics and simulations results explained the conformational changes associated with different environmental conditions. This is the first report on biochemical characterization and structure dynamics of TmPLB1 enzyme. The present study could be helpful to utilize TmPLB1 in food industry for the determination of food components containing phosphorus. Additionally, such enzyme could also be useful in Industry for the modifications of phospholipids.Keywords:free fatty acids (FFAs);NMR (nuclear magnetic resonance);phospholipase B;Talaromyces marneffei;affinity chromatography
研究领域:
生物化学
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分子生物学
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食品科学
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产品关联
DOI
PubMed
高影响因子
FLOW MEASUREMENT AND INSTRUMENTATION
·
2022
·
IF 2.42
Jiahui Zhang,Jingquan Luo,Yiwei Wang,Bo Dong,Zhen Xu,Lin Wang,Aixian Liu,Xuqiang Guo
Hydrodynamic cavitation (HC) commonly occurs within industrial pipelines and its unsteady flow characteristics are of great significance for energy conservation and efficiency improvement. This study investigates the effects of methanol concentration (0–20 wt%) on the cavitating flow characteristics and the degradation of Rhodamine B (RhB) under operating conditions of a 0.7 MPa pressure drop, temperature of 30 °C, 200 passes through a venturi reactor, and an initial RhB concentration of 40 μmol/L. The transient cavitation behavior was monitored using a high-speed camera. The cavitation images show that the presence of methanol generates more stable bubbles, which results in less violent bubble collapse. The pressure pulsation and vibration induced by cavitation flow were synchronously measured using high-frequency pressure and acceleration sensors. The spectral analyses of the pressure pulsation indicate that methanol has no effect on the dominant frequency (∼5.5 Hz) at different positions, and the amplitude initially increases with increasing methanol concentration and then stabilizes. The pressure pulsation intensity increases due to the increased vapor pressure of the solution. The vibration spectral analyses show that methanol has little effect on the peak frequencies, which occur near 4.0 kHz and 14.3 kHz of the low and high-frequency bands, respectively, whereas the peak amplitude decreases with increasing methanol concentration. The per-pass degradation model of RhB in methanol solution considering pyrolysis of methanol was verified for the first time and show to adequately describe the experimental data. The degradation percentage and per-pass degradation factor decrease with increasing methanol concentration. The reduced surface tension of the solution prolongs the bubble lifespan and prevents bubble coalescence , thus weakening the vibration and degradation performance . The results provide important insight for cavitation applications and degradation modeling of mixed solutions.
研究领域:
流体力学
·
环境工程
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产品关联
DOI
高影响因子
Green Processing and Synthesis
·
2025
·Vol. 14
·期 1
·
IF 3
Fuhua Wei,Yan Wang,Qinhui Ren,Qin Zhang,Hongliang Chen,Zhao Liang
Cr/Co-MOFs were synthesized via a solvothermal method using chromium acetate and cobalt chloride hexahydrate as metal ions, and trimeric acid as the organic ligand. The structures of Cr/Co-MOFs were characterized using Fourier infrared spectroscopy, X-ray diffraction, and scanning electron microscopy techniques. These Cr/Co-MOFs were used for removing organic contaminants in wastewater treatment. Fleroxacin and Rhodamine B (RhB) were specifically selected as target molecules in this study to evaluate the removal efficiency based on the mass of Co/Cr-MOFs, concentrations of organic contaminants, and adsorption time. Experimental findings indicated that at a Co/Cr-MOFs dosage of 100 mg, with initial concentrations of Fleroxacin (30 ppm) and RhB (20 ppm), removal efficiencies achieved were 95% and 99%, respectively. Within a timeframe of 5 h, Co/Cr-MOFs attained adsorption capacities amounting to 269.6 mg·g −1 for fleroxacin and 289.5 mg·g −1 for RhB. The interaction between Co/Cr-MOFs and fleroxacin, as well as RhB, is primarily attributed to factors such as pore size, hydrogen bonding, electrostatic charge, and π–π interactions. Moreover, theoretical analysis corroborated these experimental results by demonstrating conformity between the adsorption process and both second-order kinetic model equations alongside Langmuir isotherm model equations. Collectively, the experimental data combined with theoretical investigations underscore the practical significance associated with employing Co/Cr-MOFs for effective eradication of organic pollutants.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Congjie Liang,Jian Ma,Yixi Cao,Taisong Zhang,Chanyu Yang,Yingfeng Wu,Huaming Li,Hui Xu,Yingjie Hua,Chongtai Wang
Adsorption and its influence are often neglected during photocatalytic degradation of organic pollutants . To call attention to these issues, a novel bismuth oxybromide (BiOBr) microsphere with hierarchical flower-like structure was fabricated through a facile hydrothermal process using polyvinyl pyrrolidone (PVP) as additive in this work, and then the adsorption of the BiOBr microspheres to RhB and its influence on the photocatalytic degradation of RhB were investigated in detail. Experimental results show that the BiOBr microspheres have a very strong adsorption capacity to RhB. The adsorption behavior follows the Langmuir model and the quasi second order kinetic equation . Tests of the photocatalytic degradation of RhB under visible irradiation verify that the adsorption of the BiOBr microspheres to RhB greatly boosts the degradation of RhB due to the “enriching effect”, and a complete degradation of 20 mg L −1 RhB only requires 37 min.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Yongmin Chen,Shulan Pu,Dongying Wang,Yongchao Zhang,Guojiang Wan,Qiang Zhao,Yan Sun
Zeolitic imidazolate framework-8 (ZIF-8) was coupled with AgBr using a facile deposition–precipitation method to synthesize AgBr@ZIF-8 composites. The photocatalytic activity of prepared photocatalysts was evaluated by the degradation of Rhodamine B (RhB). As expected, the photocatalytic activity of the AgBr@ZIF-8 photocatalysts was superior to that of ZIF-8 and AgBr. Among the AgBr@ZIF-8 photocatalysts, AgBr@ZIF-8 with a ZIF-8 loading of 5 wt% exhibited the highest photocatalytic efficiency of 99.5 % within 15 min. The remarkable photocatalytic activity of the AgBr@ZIF-8 composites was attributed to the heterojunction between ZIF-8 and AgBr, which reduced the recombination rate of electron-hole pairs, thereby enhancing the photocatalytic efficiency of the catalysts. According to the trapping experiment, superoxide radicals (•O 2 - ) and holes (h + ) were certified as the main species in the efficient removal of RhB.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）