CHEMOSPHERE
·
2023
·
IF 8.8
Lijie Liu,Bing Zhao,Dedong Wu,Xiangxue Wang,Wen Yao,Zixuan Ma,Hairui Hou,Shujun Yu
Both environment and human beings were menaced by the widespread application of radioactive uranium, high-performance and effective elimination of uranium from wastewater is of important meaning for development of environmental sustainability in the future. In this study, the water-stable MOF material and the highly crystalline COF were compounded by a mild hydrothermal strategy, which achieved efficient removal of U(VI) through the synergistic effect. The composites showed the characteristics of both COFs and MOFs, which will possess higher stability, larger surface area and faster adsorption efficiency that cannot be carried out by a single component. Batch experiments and characterizations (SEM, TEM, XRD, FT-IR, BET, XPS, etc.) indicated that UiO-66-NH 2 @LZU1 had more stable and multi-layer pore structure and rich active functional groups. The Langmuir model and the pseudo-second-order kinetics fitting was more suitable for the U(VI) elimination process. The greatest uranium adsorbing capacity of UiO-66-NH 2 @LZU1 (180.4 mg g −1 ) was observed to exceed the UiO-66-NH 2 (108.8 mg g −1 ) and COF-LZU1 (65.8 mg g −1 ), which reached the excellent hybrid effects. Furthermore, FT-IR and XPS analyses confirmed that the most nitrogen-containing group from COF-LZU1 and oxygen-containing group of UiO-66-NH 2 could be combined with U(VI). In addition, electrostatic interaction was also a mechanism during the removal process. This work displayed that UiO-66-NH 2 @LZU1 was a prospective hybrid material for radioactive waste remediation. The compound method and application mentioned in this work had provided a theoretical basis for designing and developing multi-functional composite adsorbents, which contributed to the development of new materials for radioactive wastewater treatment technologies.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yingying Wang,Taipeng Jiang,Shangmin Si,Jian Wu,Lan He,Weijie Wei,Lingling Zeng,Sheng Chen,Meng Li,Zhuwei Gao
Photothermal materials have attracted considerable attention for efficient solar energy conversion. A promising strategy involves leveraging the photothermal effect to reduce crude oil viscosity, thereby facilitating efficient oil–water separation. In this study, we reported the in-situ polymerization of covalent organic framework (COF) layers on cotton wool (CW). Subsequently, polydopamine (PDA) and polydimethylsiloxane (PDMS) were sequentially coated to obtain a novel sandwich-structured composite (PDMS@PDA@COF@CW). The composite exhibited excellent superhydrophobic properties with a water contact angle of 153.5°. Furthermore, it maintained an oil–water separation efficiency of 98.1 % even after 50 consecutive cycles. The material also demonstrated remarkable chemical stability under various harsh environmental conditions and possessed excellent flame retardancy. Critically, the synergistic interaction between the PDA coating and the COF framework significantly enhanced photothermal performance. Consequently, the surface temperature of PDMS@PDA@COF@CW rapidly reached 83.8 °C within 180 s under 1.0 kW/m 2 light irradiation. This study presents a highly promising solution for mitigating crude oil spills, offering valuable insights into the design of multifunctional materials for environmental remediation.
研究领域:
环境科学
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材料科学
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化学工程
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纳米技术
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Xiaokang Liu,Mengyao Hu,Minghua Wang,Yingpan Song,Nan Zhou,Linghao He,Zhihong Zhang
Owning to the misuse of the antibiotics in animal husbandry and agriculture, it is highly urgent to determine the quantification of antibiotics in biological systems by the simple, sensitive, and fast method. In this work, a novel nanoarchitecture of Co-based metal-organic frameworks (Co-MOF) and terephthalonitrile-based covalent organic framework (TPN-COF) was synthesized (represented by [email protected] ), followed by the exploitation as the bioplatform of non-label aptasensor for detecting the most frequently used β-lactam antibiotics, ampicillin (AMP). The new porous hybrid material of [email protected] was synthesized by adding the as-prepared TPN-COF into the Co-MOF preparation system. The multilayered [email protected] nanosheets exhibit a high specific surface area (52.64 m 2 g −1 ), nitrogen-rich groups and excellent electrochemical activity. As a result, large amounts of aptamer strands can be bound over the [email protected] nanosheets owning to the strong π–π stacking and hydrogen bonds . When detecting AMP by the electrochemical impedance spectroscopy , the fabricated [email protected] aptasensor exhibits an ultra-low detection limit of 0.217 fg mL −1 within the AMP concentration from 1.0 fg mL −1 to 2.0 ng mL −1 , which was superior to those previously reported in literatures. In addition, this proposed aptasensor also shows high selectivity , good reproducibility and stability, acceptable regenerability, and favorable applicability in human serum, river water and milk. Therefore, the proposed [email protected] aptasensor has a great promise to be applied as a powerful tool in the fields of food safety.
研究领域:
分析化学
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材料科学
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生物技术
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2021
·Vol. 28
·期 3
·895-903
·
IF 2.496
Xue Rui,Gou Hao,Liu Yinsheng,Rao Honghong
A layered triazinyl-COF(COF-TP) linked by − NH − bond was synthesized by condensation of 2,4,6 − trichloro − 1,3,5 − triazine and p − phenylenediamine. The BET specific surface area of COF-TP was 43.65 m 2 ·g − 1 and the pore size was about 13.658 Å. A N-doped porous carbon material(COF−TP − C) was prepared by heating the COF-TP at 700 °C under nitrogen protection. The BET specific surface area of COF−TP − C was 398.15 m 2 ·g − 1 and the pore size was about 10 Å. COF−TP exhibited a significant pseudocapacitance characteristic in 6 M K(OH) 2 electrolyte with the highest specific capacitance of 283 F·g − 1 at 1 A·g − 1 current density in three electrode configuration. The specific capacitance retention was about 88 % after 20,000 cycles. COF−TP − C showed the maximum specific capacitance of 449.5 F·g − 1 at the current density 1 A·g − 1 and a good cyclic performance of 77 % after 3000 GCD cycles(93 % after 1000 cycles) at the current density of 5 A·g − 1 , and retained 99.2 % after 5000 cycles at the current density of 1 A·g − 1 . Both COF−TP and COF−TP − C showed good capacitance performance and potential application in supercapacitors.
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
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IF 8.4
Tianci Feng,Xiansong Shi,Tong Ju,Jianghai Long,Qinghua Liu,Ming Liu,Yong Wang
Covalent organic frameworks (COFs), with their regularly organized structures and solvent resistance, offer distinct advantages for constructing liquid-phase separation membranes. In nearly a decade of development, research has mainly focused on two-dimensional (2D) COFs, which yet give insufficient molecular selectivity due to inherent large pores. Here, we present a mixed-dimensional strategy of growing three-dimensional (3D) COFs on 2D COFs to build bilayered membranes for efficient organic solvent nanofiltration (OSN). The pores of 3D COFs interlace with those of 2D counterparts, resulting in a subnanoporous composite. We develop this 3D-/2D-COFs composite as robust membranes with a nanoscale thickness. The optimal bilayered membrane yields ethanol permeance of 12.2 L m −2 h −1 bar −1 with a molecular weight cutoff as low as ∼400 g mol −1 , surpassing conventional COF-based OSN membranes. Importantly, the designed 3D-/2D-COFs membrane exhibits stable separation performance and excellent sieving ability to discriminate molecular mixtures. This exceptional molecular selectivity ultimately allows the separation of bioactive pharmaceuticals from impurities through our membrane. Overall, this work provides a design strategy for producing mixed-dimensional COF membranes to advance molecular separation in liquids.
研究领域:
材料科学
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化学工程
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药学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Jiating Zheng,Shuyao Huang,Yuanjun Tong,Songbo Wei,Guosheng Chen,Siming Huang,Gangfeng Ouyang
The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiological changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it’s of great significance for accurate detection of sex hormones in human body. In this work, TpPa-1 COF solid-phase microextraction (SPME) fiber was prepared using high-efficient in-situ synthesis strategy and coupled with HPLC-MS/MS to detect three sex hormones, including Progesterone (P), testosterone (T) and dehydroepiandrosterone (DHEA) in human serum. The thickness of the coating reached 7 μ m within 2 h. Under the optimal conditions, the established method presented low limit of detections (LODs, ≤ 0.75 ng/mL), wide linear ranges (0.100–100 ng mL −1 ) and good reproducibility, and three sex hormones (T, P, DHEA) were successfully detected and quantified in human serum. In conclusion, the established SPME method presented high-efficient fiber preparation and good analytical performances of sex hormone detection, therefore was in great potential for application in clinical.
研究领域:
分析化学
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医学检测
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF IMMUNOLOGICAL METHODS
·
2022
·
IF 2.287
Ren Qiu,Wendi Mu,Chunyan Wu,Mengdie Wu,Jing Feng,Shengzhong Rong,Hongkun Ma,Dong Chang,Hongzhi Pan
CA125 is a tumor marker which mainly exists in ovarian, the detection for it with high sensitivity is conducive to improve the effectiveness of tumor prevention and control at early state. Multi-layer graphene oxide derivatives from graphene, and has poor conductivity and high stacked properties that limit its further application. Multi-layer reduced graphene oxide frame (MrGOF) was composed of single-layer graphene sheet and exhibited 3D structure with good dispersion, better conductivity and electrochemical properties after multi-layer graphene oxide underwent alkaline peeling and thermally reduction, the modified graphene are easy to load and combine functional groups and metal nanoparticles. Covalent organic frameworks (COFs) presents a stable frame and through covalent bond connection and has porous properties to adsorb biomolecules , which allows the immobilization of antibody molecules by the porosity and improve the sensitivity of the detection in sensing field. Through the adsorption of COFs for antibody and the probe labeled with functional graphene, we constructed a sandwich type immunosensor with the new material COF-LZU1 as the platform to anchor the CA125 first-antibody and MrGOF combined with amino group and loaded with silver nanoparticles (AgNPs) as the probe to detect tumor marker CA125. The linear range of detection was from 0.001 U/mL to 40 U/mL, with the detection limit was calculated to be 0.00023 U/mL (S/N =3). The prepared immunosensor showed a good application ability for real human serum, which can be attributed to the adsorption of COF-LZU1 for the CA125 first-antibody, and ability to deliver electrons and signal amplification of AgNPs anchored on the sheet structure of MrGOF.
研究领域:
生物传感器
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材料科学
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分析化学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-13
·
IF 3.8
Dezhakam Ehsan,Vayghan Roya Faraghi,Dehghani Sarina,Kafili-Hajlari Taha,Naseri Abdolhossein,Dadashpour Mehdi,Khalilzadeh Balal,Kanberoglu Gulsah Saydan
Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (MOF) were coated by a crystalline covalent organic frameworks (COF) through covalent bonding and created core-shell-like structures. The active part of the working electrode was modified in two consecutive steps. First, MIL-156 MOF@COF and then Au nanoparticles were electrodeposited on the glassy carbon electrode (GCE). The porosity of nanocomposite has significantly increased the surface area and improved the conductivity. Au nanoparticles also form an acceptable substrate for bonding antibodies due to their high affinity with amino groups. In addition, Au nanoparticles amplify the EC signal of the biosensor with their undeniable conductivity. Nanocomposite was characterized with XRD, SEM, and EDAX techniques. To investigate the proposed biosensor, differential pulse voltammetry (DPV) was used as an analytical technique. The CA15-3 calibration provided a linear range between concentrations of 30 and 100 nU/mL, thus expressing the powerful diagnostic potential of the designed biosensor. Furthermore, the suggested biosensor has been used in serum samples and discriminate breast cancer sufferers from healthy individuals with high confidence levels.
研究领域:
医学诊断
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材料科学
·
生物传感技术
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Quanbin Fu,Bingbing Sun,Jun Fan,Minglin Wang,Xin Sun,Geoffrey I.N. Waterhouse,Peng Wu,Shiyun Ai
A novel mixed matrix of MOF@COF hybrid was firstly formed by coating of hexahedral cage structure MOF with lightweight porous COF, and applied in dispersive solid-phase extraction of the phenoxy carboxylic acids (PCAs) from water and vegetable samples. Combined with liquid chromatography-tandem mass spectrometry, an excellent method with low limits of detection (0.69–1.79 ng·L −1 /0.002–0.006 ng·g −1 ), good reproducibility (1.32%–7.02%/1.81%–6.71%), and excellent linearities (10–1000 ng·L −1 , R ≥ 0.9955/0.04–50 ng·g −1 , R ≥ 0.9966) was established. The adsorption mechanisms deduced that the π-π interaction, hydrophobic effects, hydrogen bond, and halogen bond may promote the excellent adsorption of the PCAs. Finally, the applicability of the method was verified by spiking four kinds of water and vegetable samples with PCAs, and satisfying recoveries were obtained (between 83.3% and 104.9%).
研究领域:
分析化学
·
环境科学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Ying Tang,Shanliang Jiang,Wenyuan Li,Syed Jalil Shah,Zhenxia Zhao,Lie Pan,Zhongxing Zhao
Construction of highly-active nanozymes featuring merits of enzymes and nanomaterials is challenging for biomimetic catalysis. Herein, “confined coordination” strategy was proposed to engineer a novel laccase-nanozyme supported on mesoporous COF-OMe (Cu-Cys@COF-OMe) for the effective degradation of phenolic pollutants. In-situ L -Cysteine modification and confined Cu-coordination implanted unique Cys-multicopper (Cu + /Cu 2+ ) cluster in COF-OMe mesopores, and engineered biomimetic active pockets to which achieved efficient synergistic diffusion-adsorption-catalysis. Cu-Cys@COF-OMe realized 1.9 times higher enzymatic activity than that of laccase and 2.1–17.0 times higher monatomic copper activity than that of reported state-of-the-art laccase nanozymes, respectively. Besides, Cu-Cys@COF-OMe displayed catalytic merits of nano-materials over laccase, which demonstrated enhanced catalytic activity with temperature and excellent stability under variable reaction conditions. Cu-Cys@COF-OMe nanozyme exhibited 1.4 times faster degradation kinetics (of laccase) for phenolic pollutants, which was further intensified (3.4 times) after exposure to NaCl. This work opens a promising avenue for better design of laccase nanozymes to realize effective phenolic pollutants degradation for large-scale applications.
研究领域:
环境科学
·
生物化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Ruiwen Li,Jintao Yan,Bin Feng,Min Sun,Chuanfan Ding,Hao Shen,Jianhua Zhu,Shaoning Yu
The widespread use of antibiotics has made multidrug-resistant bacteria (MDRB) one of the greatest threats toward global health. Current conventional microbial detection methods are usually time-consuming, labor-intensive, expensive, and unable to detect low concentrations of bacteria, which cause great difficulties in clinical diagnosis and treatment. Herein, we constructed a versatile biosensing platform on the basis of boric acid-functionalized porous framework composites (MOF@COF-BA), which were able to realize highly efficient and sensitive label-free MDRB detection via fluorescence. In this design, MDRB were captured using aptamer-coated nanoparticles and the fluorescent probe MOF@COF-BA was tightly anchored onto the surface of MDRB due to interactions between boric acid groups and glycolipids on bacteria cells. Benefitting from the remarkable fluorescence performance of MOF@COF-BA, rapid and specific detection of MDRB, such as methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii (AB), was realized with a detection range of 20–108 CFU/mL (for both) and limits of detection of 7 CFU/mL (MRSA) and 5 CFU/mL (AB). The feasibility of using the developed platform to selectively detect MRSA and AB from complex urine, human serum, and cerebrospinal fluid samples was also demonstrated. This work provides a promising strategy for accurate MDRB diagnosis, avoiding serious infection using rational antibiotic therapy.
研究领域:
微生物学
·
生物医学工程
·
临床诊断
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Jin Wu,Tao Meng,Xiaoqian Zhang,Songtao Tang,Lei Liu,Jing Xue,Xiaohui Liu,Junjun Wang,Jiyue Wen,Danyou Hu,Guiyang Zhang
Effective glycemic control is paramount for optimal wound healing in diabetic patients. Traditional antibacterial and anti-inflammatory treatments, while important, often fall short in addressing the hyperglycemic conditions of diabetic wounds. Therefore, the development of novel therapeutic strategies for accelerating diabetic wound healing has garnered escalating attention. Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers constructed through strong covalent bonds. Their exceptional structural tunability renders them as an ideal platform for advanced therapeutic applications. Herein, two redox-responsive Zn(II)-coordinated porphyrin COF hydrogels are constructed, which demonstrate rapid blood glucose reduction in localized tissues, along with improved angiogenesis, reactive oxygen species (ROS) scavenging, and photothermal antimicrobial capacities within the hyperglycemic blood environment of diabetic patients, thereby effectively controlling infections and concurrently promoting wound healing. Specifically, COFs with built-in dual active sites, i.e., disulfide or diselenide moieties, can be cleaved by ROS, releasing Zn(II) ions that possess antibacterial and tissue-repairing properties. Furthermore, the Zn(II)-porphyrin COF exhibits glucose oxidase (GOX)-like activity, catalyzing the conversion of glucose into non-glucose metabolites. This synergistic combination of glucose-responsive Zn(II) release and GOX-like activities effectively restores tissue redox balance and improves the wound microenvironment, offering a promising strategy for the diagnosis and treatment of diabetic wounds.
研究领域:
生物材料学
·
医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）