CELL RESEARCH
·
2017
·Vol. 28
·期 1
·48-68
·
IF 15.606
Xu Xingxing,Li Chuanyin,Gao Xiaobo,Xia Kun,Guo Hui,Li Yali,Hao Zijian,Zhang Lei,Gao Daming,Xu Chenfan,Xu Huatai,Xiong Zhi-Qi,Qiu Zilong,Mei Ling,Xie Xiaoduo,Ruan Kangcheng,Hu Ronggui
The autism spectrum disorders (ASDs) are a collection of human neurological disorders with heterogeneous etiologies. Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incompletely characterized. Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is negatively regulated by UBE3A in a ubiquitylation-dependent manner. Excessive UBE3A dosage was found to impair RA-mediated neuronal homeostatic synaptic plasticity. ASD-like symptoms were recapitulated in mice by overexpressing UBE3A in the prefrontal cortex or by administration of an ALDH1A antagonist, whereas RA supplements significantly alleviated excessive UBE3A dosage-induced ASD-like phenotypes. By identifying reduced RA signaling as an underlying mechanism in ASD phenotypes linked to UBE3A hyperactivities, our findings introduce a new vista of ASD etiology and facilitate a mode of therapeutic development against this increasingly prevalent disease.
研究领域:
神经科学
·
分子生物学
·
遗传学
✓ 已验证
DOI
PubMed
高影响因子
ChemCatChem
·
2021
·Vol. 13
·期 16
·3601-3610
·
IF 5.686
Bing Xu,Minghui Tan,Xuemei Wu,Hailun Geng,Shengying Zhao,Jie Yao,Qingxiang Ma,Guohui Yang,Noritatsu Tsubaki,Yisheng Tan
Graphical Catalytic propane aromatization : Post-introducing Cr species to Ga/Z5 catalyst had the maximum dehydrogenated active Cr 3+ species. Propane was effectively converted, and more light alkenes from propane dehydrogenation were converted into BTX on 2Cr/GaZ5 catalyst. Active Cr 3+ species and strong interaction between Ga species and ZSM-5 zeolite on 2Cr/GaZ5 catalyst accelerated the dehydrogenation step in propane aromatization. Accelerating propane dehydrogenation in propane aromatization is vital because it is the first and rate control step. In this study, we introduced Cr to Ga/ZSM-5 by tuning its impregnation sequence and amount, which was expected to accelerate the dehydrogenation step and improve aromatization performance. The impregnation sequence of Cr on catalyst not only affected the interaction between Ga and ZSM-5, but also tuned the amount of dehydrogenation active species Cr 3+ . Due to the plenty of Cr 3+ species and strong interaction between Ga species and ZSM-5, 2Cr/GaZ5 catalyst accelerated the dehydrogenation step and improved the aromatization process. More light hydrocarbons were preferred to be produced and were further converted into BTX on 2Cr/GaZ5 catalyst. Excessive Cr on catalyst caused the formation of Cr 2 O 3 particles with worse dispersion. The aggregated Cr 2 O 3 decreased the strong acidity of catalyst, which could not further promote propane conversion and decreased the aromatization ability of catalyst.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
International Journal of Refrigeration
·
2025
·
IF 3.8
Shuyi Yao,Zhongbao Liu,Shijie Li,Zhipeng Qie
Improving water vapor adsorption performance at low humidity and enhancing thermal conductivity are beneficial for the performances of adsorption refrigeration materials. In this study, MIL-101(Cr) was integrated with graphene oxide (GO) and calcium chloride (CaCl₂) to develop high-performance composite adsorbents. The materials were characterized by XRD, Raman spectroscopy, nitrogen adsorption-desorption, and thermal conductivity measurements. Adsorption and desorption tests revealed that the MIL-101(Cr)/2% GO + 20% CaCl₂ composite exhibited the best performance, achieving a dynamic adsorption capacity of 0.368 g/g and a 36% increase in thermal conductivity compared to pure MIL-101(Cr). Meanwhile, the heat and mass transfer performance of the materials and the COP and SCP of the system were analyzed by modeling the adsorbent and the system under the corresponding operating conditions, and MIL-101(Cr)/2% GO + 20% CaCl₂ showed the best performance among all the samples of the present study in all these models. Furthermore, the composite demonstrated excellent stability after 50 adsorption-desorption cycles, retaining a desorption efficiency above 93%. The synergistic effects of GO and CaCl₂ significantly improved both water vapor adsorption and thermal conductivity, making this composite a promising candidate for energy-efficient adsorption refrigeration systems.
研究领域:
材料科学
·
能源工程
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shaoan Cheng,Yangxi Li,Zhen Yu,Yuqing Su
Adsorption can be used as a pollutant removal method to solve the increasingly serious problem of synthetic dye pollution and metal organic framework (MOF) is considered as a novel adsorbent for its unique structure. However, the high cost and high toxicity during the synthesis procedure of MOFs like MIL-101(Cr) limited their potential on the large-scale production and application. In this paper, waste PET plastic was depolymerized to prepare terephthalic acid (TPA) as an organic linker to synthesize MIL-101(Cr). Besides, Hydrofluoric acid (HF) was not added during the synthesis to avoid poisonous pollution. MIL-101(Cr) was applied to the adsorption of anionic dyes reactive red 2 (RR2) and reactive blue 19 (RB19). The batch experiments exhibited kinetic data best fitted the pseudo-first-order model (PFO) with the adsorption capacity of 662.87 (RR2) and 863.67 mg g -1 (RB19). The isotherm adsorption data fitted well with the Freundlich isotherm, indicating formation of multilayer coverage over the surface of MIL-101(Cr). The highest regeneration rate of MIL-101(Cr) at the fourth cycle was 91.18 and 91.44 % after RR2 and RB19 adsorption. X-ray photoelectron spectroscopy (XPS) technique and Fourier Transform Infrared (FTIR) spectroscopy both indicated the possible adsorption mechanism of MIL-101(Cr) toward RR2 and RB19 could be attributed to electrostatic interactions, hydrogen bonding, and the π-π stacking. This work proposed a novel method using waste plastics as raw materials to synthesize eco-friendly pollutant adsorbent, which had an enlightening effect on pollutant treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2024
·Vol. 14
·期 10
·848
·
IF 4.4
Jun Wu,Gaofeng Shao,Xiaodong Wu,Sheng Cui,Xiaodong Shen
A novel Cr-doped BaTiO3aerogel was successfully synthesized using a co-gelation technique that involves two metallic alkoxides and a supercritical drying method. This freshly prepared aerogel has a high specific surface area of over 100 m2/g and exhibits improved responsiveness to the simulated sunlight spectrum. Methyl orange (MO) was chosen as the simulated pollutant, and the results reveal that the Cr-doped BaTiO3aerogel, when modified with the noble metal silver (Ag), achieves a pollutant removal rate approximately 3.2 times higher than that of the commercially available P25, reaching up to 92% within 60 min. The excellent photocatalytic performance of the Ag-modified Cr-doped BaTiO3aerogel can be primarily attributed to its extensive specific surface area and three-dimensional porous architecture. Furthermore, the incorporation of Ag nanoparticles effectively suppresses the recombination of photo-generated electrons and holes. Stability and reusability tests have confirmed the reliability of the Ag-modified Cr-doped BaTiO3aerogel. Therefore, this material emerges as a highly promising candidate for the treatment of textile wastewater.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 18
·
IF 1.86
Shizhen Zhao,Xun Song,Xiuming Bu,Chong Zhu,Gang Wang,Fang Liao,Siwei Yang,Miao Wang
Because of the great demand for fluorescent materials, fluorescent dyes, semiconductor quantum dots, and carbon-based quantum dots have been studied extensively. However, the poor photostability and potential biological toxicity need to be resolved. In this study, we demonstrated the synthesis of a new biomass quantum dot, the polydopamine dot (PDADs), via a simple hydrothermal method under an acidic environment. This new biomass quantum dot showed not only remarkable photoluminescence properties (quantum yield = 0.93) but also a high stability and low toxicity. Moreover, these PDADs could be used as a fluorescent probe for the rapid detection of Cr(VI) (response time = 0.01 s). The detection limit (1 × 10 −11 M ) is the lowest detection limit reported for Cr(VI) fluorescent probes. The mechanism efficient quenching progress could have been due to the fast redox progress between the PDADs and Cr(VI). Moreover, we also showed a practical application of PDADs for Cr(VI) detection in vitro . © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44784.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Micro & Nano Letters
·
2020
·Vol. 16
·期 1
·58-63
·
IF 0.975
Junying Si,Hong Wang,Baoshuang Wu,Guangshuo Wang,Jiajia Yang,Zhongchao Huo,Tian Tian,Xuelin Zhao,Shuai Han
A new type of orange emission carbon dots (OCDs) was prepared by hydrothermal method using 1,2,4-triaminobenzene and p-aminobenzenesulphonic acid as precursors. TEM characterization showed that the new OCDs were uniform in size with an average particle size of 4–7 nm. Infrared spectroscopy and XPS analysis showed that the surface of the OCDs were rich in hydrophilic functional groups. Fluorescence spectroscopy results showed that the obtained OCDs exhibited excellent fluorescence with an absolute quantum yield as high as 14.9%. The OCDs were further applied to the detection of metal ions. It was found that the fluorescence of OCDs could be effectively quenched by Cr(Ш) with a detection limit of 0.38 μ m . Notably, the obtained OCDs have been successfully used for fluorescence detection of Cr 3+ ions in cell level.
研究领域:
材料科学
·
生物医学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xiaohong Hu,Jia Wen,Haibo Zhang,Qian Wang,Caiya Yan,Lang Xing
The most important thing to do with hexavalent chromium (Cr(VI)) removal in wastewater through adsorption-reduction method is to find an adsorbent that has both strong adsorbability and reducibility. Herein, an eco-friendly material ZIF-8-EGCG, which was a combination of epicatechin gallate (EGCG) and ZIF-8, was synthesized to treat Cr(VI)-containing wastewater. At room temperature, the maximum adsorption amount of Cr(VI) reached 136.96 mg·g −1 , and the Cr(VI) reduction rate (96%) was much better than that of the original ZIF-8 (37%). Such outcome was among the best in the existing studies using MOFs to treat Cr(VI). In addition, the characterization results showed that the surface of ZIF-8-EGCG was electronegative. The material was irregular sphere with pore size of 7.12 nm and BET surface area of 113.02 m 2 ·g −1 . The well-fitted Langmuir adsorption isotherm and pseudo first/second-order kinetics model suggested that the adsorption of Cr(VI) on ZIF-8-EGCG was governed by both physical and chemical processes. Stability results revealed that the overall stability of ZIF-8-EGCG due to the etched structure was slightly inferior to ZIF-8, especially at higher temperatures (>35 °C). Simultaneously, the reaction between ZIF-8-EGCG and Cr(VI) was a spontaneous, exothermic, entropic decrease process.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2021
·
IF 3.975
Yiran Sun,Qilin Gui,Andong Zhang,Shuxian Shi,Xiaonong Chen
There are huge demands for the development of green, environmentally friendly, and easily prepared cationic adsorbents for treatment of chromium-contaminated water. In this research, we demonstrate the fabrication of a novel polyvinylamine-grafted polypropylene membrane (PPM-PVAm) for Cr(VI) adsorption. Based on a rapid two-step method, polypropylene membrane (PPM) was grafted with high biomedical safety N-vinylformamide (NVF), and then amino groups were generated via hydrolysis of the poly(N-vinylformamide) (PNVF) and these amino groups could be protonated under acidic condition as Cr(VI) adsorbing sites. The effects of both the PNVF grafting rate and its degree of hydrolysis on the adsorption performance of PPM-PVAm were investigated. The membrane with a PNVF grafting rate around 55% (wt) and a degree of hydrolysis around 70–80% exhibits the best performance for Cr(VI) adsorption under the optimal conditions, i.e. pH 2 at about 40 °C. The adsorption of Cr(VI) on PPM-PVAm matches the Langmuir model, showing a maximum Cr(VI) adsorption capacity of 208.3 mg per gram dry membrane. PPM-PVAm could be deprotonated under alkaline condition so the adsorbed Cr(VI) could be easily removed by NaOH/NaCl aqueous solution. The membrane shows excellent recycling performance, and 90.6% of the adsorption capability remains even after 10 cycles of adsorption-desorption test. Combining the unique performance and eco-friendly process in the fabrication of the membrane, PPM-PVAm shows great potential in adsorptive removal of Cr(VI) from water.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Qiaoyuan Gao,Dagang Lin,Yongjie Fan,Qin He,Qi Wang
Visible-light-active Fe-2MI assemblies were prepared at room temperature using 2-Methylimidazole (2MI) as organic ligand to form complex with Fe(II) or Fe(III). TGA and XRD characterizations indicated that Fe(II) can form more stable complex and higher coordinating percentage with 2MI relative to Fe(III). Besides, Fe(II)-2MI displayed amorphous state with larger BET surface area and higher photocurrent response. At very low catalyst dosage (0.1 g/L), highest activity for Cr(VI) reduction can be achieved using Fe(II)-2MI as photocatalyst. The estimated pseudo-first-order rate constant (0.021 min −1 ) was 1.4 and 2.1 times that on Fe(III)-2MI and Fe(II)-NaOH, respectively. The well-known ZIF-67 (Co-2MI), ZIF-7 (Zn-2MI) and Fe-MOFs with other organic ligands (H 2 BDC, NH 2 -H 2 BDC or FA) were also used as control samples. Optimal activity for photocatalytic reduction of Cr(VI) was achieved by Fe(II)-2MI. The operating factors was optimized at acidic pH (2.0), higher catalyst dosage (0.3 g/L) and appropriate concentration of coexisting organics (2.0 mM) within the tested range. The stability of Fe(II)-2MI was investigated at different pH values (2, 3 and 4.64), which all displayed good stability. Mechanism study indicated that Fe(II)-2MI has adequate conduction and valence band positions for Cr(VI) reduction and organics oxidation, respectively. Therefore, the as-prepared amorphous Fe(II)-2MI assemblies may be cheap, stable and easy available candidate for the photocatalytic disposal of Cr(VI)-containing wastewaters.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2022
·
IF 7.926
Xiaodong Wang,Yongxun Dai,Chen Tian,Huize Zhang,Xiwen Li,Wenlong Liu,Weibing Li,Shaoping Kuang,Hongtao Tong
Photocatalysts can be effectively recovered and reused by compounding with magnetic nanostructures. How to further improve the photocatalytic performance of magnetic heterojunction photocatalysts remains a great challenge. In this work, g-C 3 N 4 /ZnFe 2 O 4 (CN/ZFO) magnetic heterojunction photocatalyst was first prepared and then modified with ultrathin MoS 2 (CN/ZFO/MoS 2 ) by simple ball-milling method. Then the photocatalytic removal of Cr(Ⅵ) performance of the prepared series photocatalysts was evaluated in detail. The optimum CN/ZFO/MoS 2 can achieve 99.3% Cr(Ⅵ) removal under 200-min simulated sunlight illumination, which is much higher than CN/ZFO (54.0%). The enhanced photocatalytic performance benefits from the modification of MoS 2 , which improves the light absorption performance, facilitates the transfer of photogenerated carriers , increases the concentration of photogenerated carriers and promotes the effective separation of photogenerated carriers. This work provides a theoretical basis for further preparation of magnetic recyclable photocatalysts with high photocatalytic performance.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Cai Zhengwei,Liang Jie,Li Zixiao,Yan Tingyu,Yang Chaoxin,Sun Shengjun,Yue Meng,Liu Xuwei,Xie Ting,Wang Yan,Li Tingshuai,Luo Yongsong,Zheng Dongdong,Liu Qian,Zhao Jingxiang,Sun Xuping,Tang Bo
Electrocatalytic H 2 production from seawater, recognized as a promising technology utilizing offshore renewables, faces challenges from chloride-induced reactions and corrosion. Here, We introduce a catalytic surface where OH – dominates over Cl – in adsorption and activation, which is crucial for O 2 production. Our NiFe-based anode, enhanced by nearby Cr sites, achieves low overpotentials and selective alkaline seawater oxidation. It outperforms the RuO 2 counterpart in terms of lifespan in scaled-up stacks, maintaining stability for over 2500 h in three-electrode tests. Ex situ / in situ analyses reveal that Cr(III) sites enrich OH – , while Cl – is repelled by Cr(VI) sites, both of which are well-dispersed and close to NiFe, enhancing charge transfer and overall electrode performance. Such multiple effects fundamentally boost the activity, selectively, and chemical stability of the NiFe-based electrode. This development marks a significant advance in creating durable, noble-metal-free electrodes for alkaline seawater electrolysis, highlighting the importance of well-distributed catalytic sites.
研究领域:
电化学
·
材料科学
·
可再生能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）