NANOTECHNOLOGY
·
2018
·Vol. 30
·期 7
·075101
·
IF 3.404
Hongying Guo,Xiaoshuang Zhao,Hongmei Sun,Hongda Zhu,Honghao Sun
Development of a safe, efficient and inexpensive multifunctional nanoplatform using a facile approach for multimodal imaging and therapeutic functions becomes more and more practically relevant but challenging. In this work, we demonstrated a novel nanocomposites (Bi2S3-Gd) for computed tomography (CT)/magnetic resonance (MR) imaging-guided photothermal therapy (PTT) for cancer in vitro. It was achieved by modification of hydrophobic Bi2S3 with a smart amphiphilic gadolinium-chelated ligand. The as-prepared nanocomposites composed of low-cost Bi2S3 and gadolinium complexes, showed high stability, excellent biocompatibility and good photostability. It was observed that Bi2S3-Gd nanocomposites can efficiently convert the NIR light into heat, and then suppressed the growth of tumor cells under NIR laser irradiation. Apart from serving as an effective photothermal agent, the as-prepared nanomaterials could induce an efficient contrast enhancement for both CT and MR imaging at low concentrations of Bi and Gd, rendering more accurate diagnosis. This work suggests the potential of Bi2S3-Gd nanomaterials as a novel multifunctional nanoplatform for CT/MR imaging-guided PTT for cancer.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
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DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2018
·Vol. 18
·期 4
·2931-2937
·
IF 1.354
Zhu Changhao,Ma Xiaoe,Ma Dandan,Zhang Tianzhu,Gu Ning
For computed tomography (CT) angiography and drug release application, a kind of novel dextran hydrogel microspheres were prepared. β-cyclodextrin (β-CD) grafted poly(methyl vinyl ether-altmaleic acid) (PMVE-alt-MA-g-β-CD) and succinic acid modified
dextran (Dex-SA) were first prepared, and then PMVE-alt-MA-g-β-CD was further used as the cross-linking agent to cross link Dex-SA for the formation of dextran hydrogel microspheres by using an inverse suspension polymerization method for the potential interventional embolization.
The average diameter of the dextran hydrogel microspheres was 35 μm with 90% ranging from 20 μm to 50 μm. The obtained microspheres showed a rather high swelling rate and loading capacity of drug doxorubicin hydrochloride with content of 9.2 wt%. The results of
in vitro experiments showed that about 35.5% of the total amount of the encapsulated doxorubicin hydrochloride can be released after 4 h at 37 °C. The microspheres had a good mechanical stiffness with Young’s modulus of about 20.0 kPa. Iodine molecules (I2) can
be incorporated within the cavity of grafted cyclodextrin only through simply soaking in I2 aqueous solution, and these I2-loaded microspheres can preliminarily realize the function of CT angiography. This kind of dextran hydrogel microspheres with good biocompatibility would be
a promising embolization material.
研究领域:
生物材料学
·
医学影像学
·
药剂学
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Xiangsheng Wang,Ai Ai,Ziyou Yu,Mingwu Deng,Wei Liu,Guangdong Zhou,Wei Li,Wenjie Zhang,Yilin Cao,Xiansong Wang
Biodegradable scaffolds play an important role in tissue engineering, and appropriate degradation and resorption rates of these scaffolds are necessary to accommodate tissue growth. Synthetic polymers are frequently used because of their ease of production, good biocompatibility and controllable degradation rates. However, monitoring the degradation of these polymers in vivo by a noninvasive approach remains limited. In this study, we designed a composite scaffold by labeling poly(lactic-co-glycolic acid) (PLGA) with gold nanoclusters (Au NCs), which were used for tracking in vivo degradation through dual-modal fluorescence/computed tomography (CT) imaging. The diameter of the Au NCs was approximately 2.5 nm, and the emission peak was at a wavelength of 700 nm. After labeling PLGA with the Au NCs, the fluorescence intensity of the Au NC/PLGA composite scaffold reached 9.0 × 10 9 (p/s/cm 2 /sr)/(μW/cm 2 ), and the CT density of the scaffold increased to 200 HU. After the composite scaffold was implanted subcutaneously into nude mice, a continuous decrease in the fluorescence signal and CT value was observed. The mean fluorescence intensity was 8.3 × 10 9 , 3.17 × 10 9 , 2.26 × 10 9 , 2.11 × 10 9 , and 1.82 × 10 9 (p/s/cm 2 /sr)/(μW/cm 2 ) from the first week to the fifth week, respectively. The mean CT value changed from 222.6 to 185.9, 149.1, 112.5, and 55.2 (Hounsfield unit, HU) at the different timepoints. Compared with the change in the fluorescence intensity, the change in the CT value was similar to the change in the weight, and the Pearson correlation coefficient between the change in the CT value and weight was 0.8626. Furthermore, the structure and morphology of the scaffolds at different timepoints were analyzed by three-dimensional (3-D) reconstruction. This novel method of noninvasive dynamic monitoring of biodegradable polymers in vivo provides insight into choosing suitable biomaterials for tissue engineering and regenerative medicine.
研究领域:
生物材料学
·
医学影像学
·
组织工程学
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DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
·
2022
·
IF 0
Yu Tong Han,Da Gang Li,Kang Jie Shi,Dan Ma,Yu Tang,Chao Qun Ma
In the context of carbon neutrality, it is of good economic and ecological value to replace synthetic fibres with natural fibres as reinforcing materials in the preparation of composites. The effect of the hot pressing process parameters on the physical and mechanical properties of the LBF/PP composites was further investigated. The distribution of LBF in the composites was observed by CT. The experimental results show that the hemicellulose content of the BF decreases and the lignin content decreases after the alkali treatment. The mechanical properties of the LBF/PP composites were better at a hot pressing temperature of 180°C, a hot pressing pressure of 8 MPa, a hot pressing time of 15 min and a mass fraction of 70% LBF, with bending strength and bending modulus reaching 226.1 MPa and 15.1 GPa respectively. CT results show that the fibres are evenly distributed in the composites and that the hot pressing process allows the molten PP to penetrate the pores of the LBF surface, forming a good physical and mechanical bond. These composites can be used in various applications such as construction, automotive, consumer goods etc. They are considered to be a suitable alternative to solid plastic products and materials.
研究领域:
材料科学
·
生态学
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DOI
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Leyang Li,Ruiyang Sun,Rui Yuan,Manpeng Lin,Linlin Wang,Qi Wang,Jiguo Tu,Handong Jiao,Shuqiang Jiao
Molten-salt electrorefining (MSE) is currently the primary method for purifying many elements, offering promise for the sustainable upcycling of spent metals in the future. However, the conventional constant-current electrolysis protocol inevitably leads to deterioration of the microenvironment near the electrode, leading to reaction runaway and process inefficiency. In this work, we comprehensively studied for the first time the effect of constant- and pulse-electrolysis protocols on environmental evolution in electrode–electrolyte interfaces during the MSE of Ti, using a computer model. The results showed that compared to constant electrolysis, pulse-electrolysis protocols could effectively regulate the interfacial microenvironment and improve the electrorefining efficiency. Furthermore, a correlation between interfacial reconstruction and pulse parameters was established, indicating that the duty ratio was the key factor in inhibiting the deterioration of the interfacial microenvironment. To further verify the simulation results, the real-time morphological evolution of the electrodes during electrolysis was monitored by a novel in situ X-ray computed tomography (CT) technology under pulse-electrolysis protocols. The experimental results indicated that the pulse-electrolysis protocols enhanced the interfacial microenvironment and promoted electrolysis efficiency. Collectively, this work demonstrated that MSE could be effectively advanced by rationally designing the pulse-electrolysis protocols, facilitating its large-scale application in industry.
研究领域:
材料科学
·
冶金工程
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产品关联
DOI
高影响因子
Small Methods
·
2026
·
IF 8.7
Gang Shu,Yibo Wei,Wenjing Hou,Nan Liu,Jinbin Pan,Dong Li,Shao-Kai Sun,Dingbin Liu,Cai Zhang
Precise diagnosis and subtyping of acute kidney injury (AKI) are crucial for clinical decision-making and prognosis. However, current in vivo imaging techniques lack the necessary precision, sensitivity, and resolution to meet this demand. Here, we report a renal-clearable, tantalum-rich carbon dot (Ta-rCD) contrast agent that enables high-performance computed tomography (CT) imaging for noninvasive visualization and differentiation of multiple AKI subtypes. The Ta-rCDs are synthesized via a simple and efficient air-assisted carbonization method, featuring ultrahigh Ta content (48%), gram-scale production capacity, ultrasmall hydrodynamic size (∼2.8 nm), excellent water solubility (>500 mg mL −1 ), and strong x-ray attenuation capability. Benefiting from their renal-clearable nature, Ta-rCDs avoid long-term retention in vivo while enabling effective renal imaging. Notably, Ta-rCDs enable high-resolution anatomical and functional CT imaging across pre-renal, renal, and post-renal AKI models, facilitating precise detection of renal dysfunction beyond the reach of conventional biochemical markers. Furthermore, this approach allows accurate differentiation of AKI subtypes based on their distinct CT imaging features. In vitro and in vivo studies confirm their favorable biocompatibility. Our work provides a new paradigm for the development of sensitive and high-resolution CT imaging contrast agents and offers a promising method for the accurate diagnosis of kidney diseases.
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DOI
PubMed
高影响因子
Nano Today
·
2023
·
IF 17.4
Zhichao Deng,Wenqi Ma,Chenguang Ding,Chaojun Wei,Bowen Gao,Yuanyuan Zhu,Yujie Zhang,Feng Wu,Mingxin Zhang,Runqing Li,Mingzhen Zhang
Intestinal inflammation, such as ulcerative colitis (UC), is a condition in which there is chronic or recurring inflammation of the gastrointestinal tract . Designing safe, effective, and multifunctional nanomedicines is one of the current difficulties in the treatment of UC. Here we developed a delivery nanosystem based on metal polyphenol network/cerium oxide artificial enzymes (MPN@CeOx) to manage UC and evaluate the severity of inflammation by MRI/CT imaging. MPN@CeOx was engineered by Fe 3+ and epigallocatechin gallate (EGCG) wrapped around CeOx. Increased levels of oxidative stress in the inflammatory lesion facilitated the release of Fe 3+ and EGCG from MPN and liberated CeOx. EGCG with anti-oxidative and anti-inflammatory effects plus CeOx with superoxide dismutase (SOD)-like activity effectively scavenged reactive oxygen species (ROS) and reduced pro-inflammatory cytokines to protect cells from oxidative damage . In addition, H 2 O 2 -responsive releasing of Fe 3+ at the site of inflammation and Ce elements in CeOx enable MRI/CT imaging of UC. In mice colitis models, oral administration of enteric-coated MPN@CeOx alleviated intestinal inflammation and intestinal barrier dysfunction. RNA sequencing analysis revealed that MPN@CeOx ameliorated UC symptoms mainly through inflammation-related signaling pathways . MPN@CeOx with multilevel inflammation management and multimodal imaging capabilities represents an innovative diagnosis and treatment approach for UC.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qizhi Zhang,Wenmei Yu,Zhenhua Liu,Hui Li,Yihui Liu,Xin Liu,Zhaoshun Han,Jun He,Yaofu Zeng,Yu Guo,Yunmei Liu
Photodynamic therapy is a promising novel tumor treatment method. In this study, novel porphyrin-chrysin photosensitizer derivatives were synthesized. Most of the compounds showed antitumor activity against human cervical cancer HeLa cells and human lung cancer A549 cells, among which compound 4c had the best photodynamic therapy effect on HeLa cells and A549 cells, with IC 50 values of 6.26 μM and 23.37 μM, respectively. Free-base porphyrin-chrysin derivatives bind to DNA through surface self-stacking, and zinc metalloporphyrin-chrysin derivatives bind to ct-DNA through intercalation. Notably, the tightness of compound binding to ct-DNA was positively correlated with its antitumor activity. What's more, three-dimensional quantitative conformation studies have shown that increasing the positive charge of the porphyrin ring and introducing a strong electron-withdrawing group at the meso position of the porphyrin ring at the para-position of the benzene ring or reducing the space volume of the compound can enhance the antitumor activity.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Xiaolei Zhang,Ziying Wang,Yangsai Lyu,Jia Li,Kun Song,Ningning Xing,Dickon H.L. Ng
Near-infrared (NIR) light-powered nanomotors with active motion have attracted extensive attention in the chemo-photothermal therapy of cancer. However, there are also some limitations such as complicated synthesis process, low permeability of drugs and viscous physiological environment. Herein, we developed a facile route to synthesize novel NIR light-powered DOX/Au-m-HTAS nanomotor based on natural halloysite (HNTs) for active chemo-photothermal therapy. Such nanomotor exhibited NIR light controlled on/off motion with a maximum speed of 64.5 μm/s. Owing to the synergetic NIR light-powered motion and chemo-photothermal therapy, DOX/Au-m-HTAS nanomotor could effectively adhere tumor cells, leading to deeper cell penetration, higher cellular uptake, and better ablation of tumor cells. Meanwhile, DOX/Au-m-HTAS nanomotors also had enhanced ability for CT imaging of local tumor, demonstrating the enhanced anticancer efficiency. This strategy provided a new insight into the chemo-photothermal synergistic therapy of tumors.
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产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2022
·Vol. 80
·期 3
·2697-2711
·
IF 2.843
Yin Peinan,Wei Chengxiong,Jin Xin,Yu Xiaogang,Wu Chengwei,Zhang Wei
Trans-catheter arterial embolization, as a minimally invasive therapy strategy, has become a choice for treating liver cancer. Development of embolic agents integrated with therapy and imagining functions is desired. Herein, magnetic polyvinyl alcohol (PVA) microspheres as embolic agents are prepared by emulsification method. The diameter of the magnetic PVA microspheres ranges from 10 to 110 μm, and the required size can be obtained by sieving. The temperature of magnetic PVA microspheres suspension could stabilize at 49 °C under the applied magnetic field, which indicates the microspheres have self-regulating temperature hyperthermia characteristic due to the application of magnetic nanoparticles with low Curie point. In addition, magnetic PVA microspheres possess obvious contrast effects on CT and T2-weighted imaging due to the existence of magnetic nanoparticles. Cytotoxicity assay indicates the survival rate of cells cultured with leach liquor of 30 mg/mL PVA/MNPs microspheres is 97.4%, which shows the magnetic microspheres have good cell biocompatibility. The developed magnetic microspheres have the potential to realize embolization, self-regulating temperature hyperthermia, and CT/MR imaging simultaneously in interventional therapy.
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高影响因子
Journal of Functional Biomaterials
·
2022
·Vol. 13
·期 3
·87
·
IF 4.901
Chuanxue Yang,Tianxiao Mei,Qingge Fu,Yifan Zhang,Yang Liu,Ran Cui,Gang Li,Yibin Wang,Jianguo Huang,Junqiang Jia,Bo Chen,Yihui Hu
The development of multifunction nanoplatforms integrating accurate diagnosis and efficient therapy is of great significance for the precise treatment of tumors. Gold nanoparticles (AuNPs) possessing hallmark features of computed tomography (CT) imaging and photothermal conversion capability hold great potential in tumor theranostics. In this study, taking the advantages of outstanding biocompatibility, interesting anti-inflammatory and immunomodulatory properties, and abundant amino acid residues of silk fibroin (SF), a multifunctional Gd-hybridized AuNP nanoplatform was constructed using SF as a stabilizer and reductant via a facile one-pot biomimetic method, denoted as Gd:[email protected]The obtained Gd:[email protected]possessed fascinating biocompatibility and excellent photothermal conversion efficiency. Functionalized with Gd, Gd:[email protected]exhibited super tumor-contrasted imaging performance in magnetic resonance (MR) and CT imaging modalities. Moreover, Gd:[email protected], with strong NIR absorbance, demonstrated that it could effectively kill tumor cells in vitro, and was also proved to successfully ablate tumor tissues through MR/CT imaging-guided photothermal therapy (PTT) without systemic toxicity in Pan02 xenograft C57BL/6 mouse models. We successfully synthesized Gd:[email protected]for MR/CT dual-mode imaging-guided PTT via a facile one-pot biomimetic method, and this biomimetic strategy can also be used for the construction of other multifunction nanoplatforms, which is promising for precise tumor theranostics.Keywords:silk fibroin;AuNPs;biomimetic synthesis;MR/CT imaging;PTT
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DOI
PubMed
高影响因子
Science China-Chemistry
·
2021
·Vol. 64
·期 4
·558-564
·
IF 9.445
Xue Dongzhi,Liu Yang,Jin Longhai,Wang Yinghui,Cui Fengzhi,Liu Jianhua,Li Xiaoqing,Zhang Songtao,Zhao Ying,Yin Na,Niu Rui,Wang Daguang,Zhang Hongjie
Because of the intrinsic defects of traditional treatment of cancer, it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer. Herein, we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites (AHF@PDA) for dual-modality bioimaging (magnetic resonance imaging (MRI) and computed tomography (CT)) owing to the high X-ray attenuation feature and magnetic property of Ho 3+ . Moreover, PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility, leading to good treatment effect in vitro and in vivo . All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future.
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高影响因子
危险品化学品经营许可证（带存储）