Materials
·
2025
·Vol. 18
·期 21
·4828
·
IF 3.2
Jingwen Wang,Zunzhi Liu,Jingmei Zhang,Yang Liu,Chunjing Hou,Hui Cheng,Yaru Wang,Xiang Liu
This study introduces a novel fabrication method for high-strength, self-cleaning photocatalytic membranes through the integration of hot-pressing and TiO2/chitosan/SiO2nanofibers. The innovation of this research lies in the hot-pressing technique, which significantly enhances the mechanical properties and photocatalytic efficiency by improving the adhesion, dispersion, and uniformity of the TiO2/chitosan coating on SiO2nanofibers. SiO2nanofibers with an initial diameter of 0.79 ± 0.29 μm were coated and hot-pressed, resulting in a final diameter of 1.07 ± 0.57 μm, which corresponds to an approximate increase of 35.4%. In addition, the 1 wt% TiO2-CTS sample showed the highest adhesion and surface energy, with values of 0.1 nN/nm2, indicating the closest intermolecular binding. 3 wt% SiO2-CTS exhibits a maximum hardness of 5.23 Pa. The 3 wt% TiO2-chitosan coating demonstrated outstanding mechanical performance, achieving a fracture stress of 0.53 MPa, approximately five times that of the untreated SiO2nanofibers, a Young’s modulus of 0.63 MPa, and a toughness to triple of 0.27 MJ/m3—representing substantial improvements over uncoated membranes. Photocatalytic efficiency was significantly enhanced, with grayscale values increasing approximately 36% UV light exposure, indicating the superior degradation of pollutants.
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高影响因子
POLYMER SCIENCE SERIES A
·
2020
·Vol. 62
·期 5
·494-501
·
IF 0.968
Fei Liang,Zhao Jing,Deng Chunyu
Abstract— Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this work, chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier, temperature sensitive N -isopropylacrylamide (NIPAm) and pH sensitive 2‑acrylamido-2-methylpropane (AMPS) as monomers. The adsorption and drug release properties of chitosan hydrogel are discussed emphatically.The adsorption performance of chitosan hydrogel on copper ions showed that the temperature and the concentration of copper ions had influence on the adsorption. When the concentration of copper ions was 800 mg/L at 25°C, the equilibrium adsorption capacity was 225.8 mg/g, quasi-second order kinetic equation was suitable for describing the adsorption process. With the methylene blue as the drug model, the controlled release results showed that the temperature and the initial drug dosage had great effect on controlled release performance, and the cumulative release rate of 48 h was about 70%, which could achieve sustained release and controlled release to a certain extent.The experimental results also showed that the chitosan hydrogel can be completely degraded for about 20 days with excellent degradation performance. In conclusion, chitosan hydrogel has broad application prospects in drug controlled release, tissue engineering, environmental engineering and so on.
研究领域:
生物医学工程
·
材料科学
·
环境工程
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Journal of Biobased Materials and Bioenergy
·
2017
·Vol. 11
·期 6
·533-542
·
IF 0.975
Kong Song,Bai Yunxia,Wang Lijun,Liu Xinliang,Wang Shuangfei
In this study, a multilayered natural polysaccharide coating consisting of aldehyde-nanocellulose and chitosan was established on the base paper using the layer-by-layer assembly technique. The physical and barrier properties of the base and assembled paper were investigated. The results
shown that the smoothness of base paper assembled with 20 bilayers was significantly increased to 941.7 s/s and the moisture permeability was also improved. The assembled paper was characterized by FT-IR spectrometer and scanning electron microscope (SEM). In order to further understand the
capacity of chitosan and nanocrystalline cellulose blended with each other, molecular dynamics (MD) simulations of CS and DANC were conducted based on Force field, which implied the hydrogen bonding enhanced binding between CS and DANC, with the binding energy increased slightly from 1.42
to 1.56 kcal/(mol Å2) at 298 and 398 K. All results indicate that nanocellulose and chitosan have a positive effect on paper which can be used to prepare barrier and other functional papers.
研究领域:
材料科学
·
生物化学
·
计算模拟
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JOURNAL OF NANOPARTICLE RESEARCH
·
2013
·Vol. 15
·期 12
·1-10
·
IF 2.175
You Jie,Li Wenfeng,Yu Chang,Zhao Chengguang,Jin Langping,Zhou Yili,Xu Xuzhong,Dong Siyang,Lu Xincheng,Wang Ouchen
A series of amphiphilic N -(2-hydroxy)propyl-3-trimethylammonium-chitosan-cholic acid (HPTA-CHI-CA) polymers were synthesized by grafting cholic acid (CA) and glycidyltrimethylammonium chloride onto chitosan. The self-assembly behavior of HPTA-CHI-CA was studied by fluorescence technique. The polymers were able to self-assemble into NPs in phosphate buffered saline with a critical aggregation concentration (CAC) in the range of 66–26 mg/L and the CAC decreased with the increasing of the degree of substitution (DS) of CA. The size of cationic HPTA-CHI-CA NPs ranges from 170 to 220 nm (PDI < 0.2). It was found that doxorubicin (DOX) could be encapsulated into HPTA-CHI-CA NPs based on self-assembly. The drug loading content and efficiency varies depending on the DS of CA and feeding ratio of DOX to polymer. In vitro release studies suggested that DOX released slowly from HPTA-CHI-CA NPs without any burst initial release. Besides, the confocal microscopic measurements indicated that DOX-HPTA-CHI-CA NPs could easily be uptaken by breast cancer (MCF-7) cells and release DOX in cytoplasm. Anti-tumor efficacy results showed that DOX-HPTA-CHI-CA NPs have a significant activity of inhibition MCF-7 cells growth. These results suggest cationic HPTA-CHI-CA may have great potential for anticancer drug delivery.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
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高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2012
·
IF 0.887
Yanming Sun,Xiaofei Liang,Mingjie Zhu,Jungong Zhao,Yingsheng Cheng,Yourong Duan
Poly-L-lysine (PLL) can be replaced successfully by quaternized chitosan to prepare alginate-Ca microcapsules. By changing the compontent of quaternized chitosan mixture, including N-trimethylated chitosan, octadecyl quaternized carboxymethyl chitosan (OQC) and Poly(ethylene glycol) (PEG) modified OQC (PEG-OQC), different alginate-Ca microcapsules as carriers of cell transplantation can be obtained with diverse properties. Compared with alginate-PLL (AP), the mechanical strength of the alginate-quaternized chitosan (AQC) microcapsules was encouraging, and there was no apparent difference between AQC and AP microcapsules (
P
< 0.05). The permeability of both microcapsules was observed in the presence of fluorescein isothiocyanate (FITC), immunoglobulin and bovine serum albumin (BSA) by fluorescent microscopy. Both microcapsules membranes were permeable to FITC, part-permeable to IgG and impermeable to larger molecule proteins such as BSA. The AQC and AP microcapsules entrapping L929 cells were cultured properly. L929 cells were retrieved from microcapsules and grew well after being recultured for 3 days.
研究领域:
生物材料
·
药物递送
·
组织工程
·
高分子科学
·
生物医学工程
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Chang Liu,Jiajing Yu,Junyang You,Zhihua Wang,Meiling Zhang,Lei Shi,Xupin Zhuang
Sponges with large protein adsorption capacity are highly desired in various fields such as biosensors, biofuel cells, biocatalysis, and protein chromatography. However, the use of environmentally friendly materials and mass production still face enormous challenges. Herein, a novel and facile method to fabricate an environmentally friendly monolithic cellulose/chitosan composite sponge (CECSS) with remarkable performance is designed using the mature viscose process. The obtained highly efficient adsorption sponge exhibits a hierarchical porous structure with open-pore structures with a diameter range of 200–1000 μm and small micro/nanocellular structures (0.5–2 μm), which endow it with remarkable porosity (62.95%) and water adsorption capacity (1409%). Based on the abovementioned unique porous structure and reactive groups of chitosan, the CECSS exhibits a high bovine serum albumin adsorption capacity of 200.56 mg/g at pH 5.5 for 10 h. In addition, the adsorption of the CECSS can be well described by the pseudo-second-order kinetic model and the Langmuir isotherm model. This work provides a new sponge-forming process for the fields of protein adsorption, which may achieve the production of natural protein adsorbents at the industrial level.
研究领域:
生物材料
·
生物医学工程
·
环境友好材料
·
蛋白质分离
·
吸附动力学
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Desalination and Water Treatment
·
2024
·
IF 1
Bangchang Wei,Zheng Ji,Ya Xu,Shengnan Kong,Yansong Zhang,Chuanrun Li,Huchuan Wang
In this paper, we successfully prepared magnetic modified chitosan composites by mixing hydroxyapatite with polypropylene glycol modified chitosan and wrapping magnetic nanoparticles. The adsorption study of Cr(VI) revealed that the adsorption process was more in accordance with the pseudo-second-order kinetic and followed the Langmuir isotherm adsorption process, which indicated that the adsorption process was monolayer adsorption, and the fitted calculations showed that the maximum adsorption capacity of Cr(VI) was 795.14 mg·g –1 . Thermodynamic model reflected that the adsorption process was spontaneous heat absorption.
研究领域:
环境科学
·
材料科学
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Gels
·
2025
·Vol. 11
·期 4
·285
·
IF 5.3
Lin Zhang,Xiaoling Lu,Hao Li,Hongjie Chen,Qi Yin,Xuehan Hu,Kang Yang,Fang Yang,Liya Chen,Zeng Yang,You Long,Chao Shen,Bo Yao,Chenghong Huang
The medicinal value of vanillin and its isomers has not been well developed, so it is necessary to prepare crystals of vanillin and its isomers as well as to investigate their crystallization rules in detail using advanced crystallization techniques in polymer gel. Based on molecular simulation, the maximum number of hydrogen bonds between CMCS with Van, IsoVan and oVan were reached at molar ratios of 1:9 and 1:4 and 1:5, respectively. The gel hardness and apparent viscosity of CMCS/Van isomers were proportional to the mole ratio, while elongation at break and tensile strength decreased with an increase in molar concentration depending on the position of the side chain group of the Van isomer, exposure of the benzene ring, steric resistance and the number of hydrogen bonds formed. The crystallization of Van, IsoVan and oVan in CMCS gel unexceptionally follow classical supersaturation theory in the case that nVan mainly exhibits a unique growth pattern from needle to strip, IsoVan’s growth style changes from plate to bulk and oVan adapts growth pattern from needle to branch bifurcating. It was also found that the Van crystal changed from II-type to I-type under long-term heating. Studies have further confirmed that the discrepancy of physicochemical characteristics of CMCS/Van blend gel can be attributed to differences in the number of hydrogen bonds compared to CMCS with given group positions of Van isomers. This study provides powerful technical support for the gel crystallization of van isomers.
研究领域:
材料科学
·
药剂学
·
高分子化学
·
分子模拟
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yefeng He,Siqi He,Hongji Wang,Xiaoyu Li,Liying Cui,Zhongkai Liu,Shengkai Liu,Xiaoshuai Wang,Mengqi Liu,Yujie Fu,Zhiguo Liu
Cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) are promising biocompatible nanocarrier. However, it faces the problem of poor stability in aqueous solution. This study explores camptothecin delivery using a natural polymer-based shell (chitosan/carboxylated cellulose nanofibers) modified γ-CD-MOF core, establishing a novel strategy for safe and efficient CPT delivery. The γ-CD hydrophobic cavities significantly enhance CPT solubility and loading. The fabricated nanocarrier achieve CPT loading and encapsulation efficiencies of 26.4 ± 2.52 % and 70.2 ± 2.88 % respectively. Furthermore, the CPT load nanocarrier demonstrate <5 % hemolysis at the concentration of 800 μg/mL, exhibit drug release behavior conforming to the Higuchi equation, and show significant antiproliferative effects against MDA-MB-231 cells.
研究领域:
药剂学
·
纳米技术
·
材料科学
·
生物医学工程
·
肿瘤学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Zhaoyu Zhang,Boya Weng,Zhang Hu,Zhenyu Si,Lefan Li,Ziming Yang,Yu Cheng
Bacterial infections have always been a major threat to public health, and the development of effective antibacterial substances from natural polymers is crucial. 2-Aminoisonicotinic acid (AN) was grafted onto chitosan by 1-ethyl-(3-dimethylaminopropyl)carbodiimide-mediated coupling reactions, and then modified chitosan‑iodine (CSAN-I) complexes were prepared by solvent-assisted grinding. The samples were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy , Raman spectroscopy , proton nuclear magnetic resonance spectroscopy , and X-ray diffraction, confirming that CSAN-I complexes had been successfully prepared. Thermogravimetric (TG) analysis indicated that the chemical modification of chitosan and iodine complexation reduced the thermal stability ; X-ray photoelectron spectroscopy (XPS) analysis revealed that 81 % of the iodine in CSAN-I complex was in the form of triiodide ions. The iodine contents of three CSAN-I complexes (CSAN-I-1, CSAN-I-2 and CSAN-I-3) were 1.59 ± 0.22 %, 3.18 ± 0.26 %, and 5.56 ± 0.41 %, respectively. The antibacterial effects were evaluated in vitro, and the results indicated that CSAN-I complexes had strong antibacterial activities against both E. coli and S. aureus . In particular, CSAN-I-3 exhibited the best antibacterial effect. In addition, CSAN-I-3 was nontoxic to L929 cells with good cytocompatibility. Therefore, CSAN-I complexes can be considered as promising candidates for wound management in clinical applications.
研究领域:
生物材料学
·
微生物学
·
药剂学
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高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Junjie Deng,Rufang Wei,Haofeng Qiu,Xiang Wu,Yanyu Yang,Zhimao Huang,Jiru Miao,Ashuang Liu,Haiyang Chai,Xiao Cen,Rong Wang
Restoration of the lubrication functions of articular cartilage is an effective treatment to alleviate the progression of osteoarthritis (OA). Herein, we fabricated chitosan- block -poly(sulfobetaine methacrylate) (CS-b-pSBMA) copolymer via a free radical polymerization of sulfobetaine methacrylate onto activated chitosan segment, structurally mimicking the lubricating biomolecules on cartilage. The successful copolymerization of CS-b-pSBMA was verified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and 1 H nuclear magnetic resonance. Friction test confirmed that the CS-b-pSBMA copolymer could achieve an excellent lubrication effect on artificial joint materials such as Ti6Al4V alloy with a coefficient of friction as low as 0.008, and on OA-simulated cartilage, better than the conventional lubricant hyaluronic acid, and the adsorption effect of lubricant on cartilage surface was proved by a fluorescence labeling experiment. In addition, CS-b-pSBMA lubricant possessed an outstanding stability, which can withstand enzymatic degradation and even a long-term storage up to 4 weeks. In vitro studies showed that CS-b-pSBMA lubricant had a favorable antibacterial activity and good biocompatibility. In vivo studies confirmed that the CS-b-pSBMA lubricant was stable and could alleviate the degradation process of cartilage in OA mice. This biomimetic lubricant is a promising articular joint lubricant for the treatment of OA and cartilage restoration.
研究领域:
材料科学
·
生物医学工程
·
骨科
·
组织工程
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tao Meng,Zhengyu Zhao,Mengqiang Song,Rui Wang,Xu Xu,Min Yang,Weihua Li,Shiyong Song
Viscosupplementation treatment of osteoarthritis with sodium hyaluronate (HA) is prevalent in clinical practice but always associated with rapid degradation. Another natural polysaccharide chitosan (CS) has the potential to be used in viscosupplementation but is limited by the poor aqueous solubility. Herein, we formulated a viscosupplementation agent with a zwitterionic polymer modified chitosan (CS-CBAA), which featured with bottle-brush structure and poly(carboxybetaine acrylate) side chains. It was found that the incorporation of zwitterionic sidechains greatly enhanced chitosan's solubility up to approximately 130 mg/ml in solutions of pH 7.4. A gel-like behavior was also found in CS-CBAA solution due to intermolecular interactions between zwitterionic sidechains. Compared to HA, the viscosity of CS-CBAA solutions was obviously retained when subjected to hyaluronidase degradation tests. CS-CBAA was also approved comparable protection effect to cartilage and prior effect to ceramic materials. In a papain induced osteoarthritis mice model, CS-CBAA solutions of 120 mg/ml offered comparable cartilage protection to HA. This work presented a systematic study on a new viscosity supplement CS-CBAA, which exhibits exceptional lubricating properties and holds promise as a potential replacement for the current HA-based viscosity supplement in the treatment of early-stage OA.
研究领域:
生物医学工程
·
药学
·
骨科
·
高分子化学
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高影响因子
危险品化学品经营许可证（带存储）