CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Dinh-Trinh Tran,Thi-Phuong-Thao Vu,Santi Kongmany
In this study, ZnFe 2 O 4 , BiVO 4 , and ZnFe 2 O 4 /BiVO 4 /rGO materials were synthesized using the hydrothermal method in mild conditions to study the oxytetracycline (OTC) degradation process. The results on surface morphology, functional group, structure, and optical and electrochemical characteristics revealed that ZnFe 2 O 4 /BiVO 4 /rGO were successfully prepared with high purity and good distribution of chemical elements. The impact of different parameters like pH, catalyst load, reaction time, initial OTC concentration, and the presence of ozone-nanobubbles on the OTC degradation efficiency was systematically examined to obtain optimal treatment conditions. Synergic effects between ozone-nanobubbles and ZnFe 2 O 4 /BiVO 4 /rGO heterojunction led to an enhancement of over 20 % of OTC degradation yield. The OTC degradation reached 96.3 % within 100 min at optimal conditions (pH 7.0, [Cat.] = 0.5 g/L, and [OTC] = 20 mg/L). The combination of ZnFe 2 O 4 and BiVO 4 allowed to benefit from the generation of both effective electrons and holes, which enhanced the generation rate of both superoxide and hydroxyl radicals responsible for degrading the pollutant in water while rGO sheets contributed to slowing down the recombination rate between electrons and holes and improving the photocatalytic activities of the ZnFe 2 O 4 /BiVO 4 /rGO. Liquid chromatography-mass spectrometry (LC-MS) analyses were deployed to figure out intermediate substances and possible degradation pathways of the OTC degradation process. The ZnFe 2 O 4 /BiVO 4 /rGO heterojunction exhibited a pretty good durability and stability, and was easily recovered with the aid of a magnet. The toxicity of the by-products was significantly declined compared to the OTC antibiotic.
研究领域:
环境科学
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材料科学
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微生物学
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产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
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2024
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IF 4.7
Mengqi Wang,Bo Chen,Yan He,Zhili Li,Yuanyuan Ge
Titanium silicalite-1 zeolite (TS-1) has been widely used as a catalyst for the epoxidation of 1-hexene. However, fast synthesis of TS-1 with high activity and stability remains a great challenge. In this study, a new strategy using sodium persulfate (SPS) as a crystallization modifier was proposed for the accelerated synthesis of anatase-free TS-1. The anatase-free TS-1 (TS-20-SPS) could be obtained after 20 h of hydrothermal crystallization. TS-20-SPS had a low Si/Ti ratio (31) and achieved a high conversion (20 %) in the epoxidation of 1-hexene at room temperature (298 K), which was 200 % higher than that of TS-1 synthesized without adding SPS. The addition of SPS not only accelerated the crystallization due to the generation of ·OH, but also reduced the pH value of the system to avoid the generation of anatase. This SPS-assisted approach offers an avenue for the accelerated synthesis of high-performance, anatase-free TS-1.
研究领域:
催化化学
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材料科学
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产品关联
DOI
高影响因子
CHEMOSPHERE
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2024
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IF 8.1
Yunzhan Ying,Shikun Liang,Fayang Zhang,Xiangwei Xu,Chenbo Qian,Long Jiang,Jing Zhou,Yulong Wan,Lie Wang,Yuyuan Yao
The harmful impact of organic pollutants on aquatic ecosystems underscores the pressing need for effective remediation. While activating peroxymonosulfate (PMS) with Fe catalyst offers a promising approach for eliminating these pollutants, its widespread use is hindered by the sluggish regeneration of Fe 2+ from Fe 3+ . Here, this study demonstrates for the first time that combining an Fe catalyst with Mo 2 C (Fe-Mo 2 C) enhances the Fe³⁺/Fe 2 ⁺ cycle, thereby improving PMS activation. The Fe-Mo 2 C/PMS system achieved near-complete degradation of carbamazepine (CBZ) within only 8 minutes, with an impressive observed rate constant ( k obs ) of up to 0.624 min -1 , about 15 times greater than that of Fe-C catalyst. It also exhibits the capability to degrade a broad range of common antibiotics, phenols, and dye-like organic compounds. Through electron paramagnetic resonance (EPR) analysis and quenching experiments, it was verified that hydroxyl radicals (·OH), sulfate radicals (SO 4 ·- ), singlet oxygen ( 1 O 2 ), and superoxide radicals (·O 2 - ) species during the reaction, with the former three serving as the primary active species. These findings offer a hopeful avenue for the systematic development and enhancement of catalysts specifically designed to efficiently remediate organic pollutants in wastewater.
研究领域:
环境科学
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化学工程
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催化
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水处理
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Qingchen Bai,Miao Wang,Kai Wang,Jingwei Liu,Fengyu Qu,Huiming Lin
Due to their rigid π-conjugated macrocyclic structure, organic sonosensitizers face significant aggregation in physiological conditions, hindering the production of reactive oxygen species (ROS). An acid-sensitive nanoassembly was developed to address this issue and enhance sonodynamic therapy (SDT) and emission. Initially, copper phthalocyanine (CuPc) was activated using a H 2 SO 4 -assisted hydrothermal method to introduce multiple functional groups (–COOH, –OH, and −SO 3 H), disrupting strong π–π stacking and promoting ROS generation and emission. Subsequently, negatively charged CuPc-SO 4 was incorporated into bovine serum albumin (BSA) to form CuPc-Fe@BSA nanoparticles (10 nm) with Fe 3+ ions serving as linkers. In acidic conditions, protonation of CuPc-SO 4 and BSA weakened the interactions, leading to Fe 3+ release and nanostructure dissociation. Protonated CuPc-SO 4 tended to self-aggregate into nanorods. This acidity-sensitive aggregation is vital for achieving specific accumulation within the tumor microenvironment (TME), thereby enhancing retention and SDT efficacy. Prior to this, the nanocomposites demonstrated cycling stability under neutral conditions. Additionally, the released Fe ions exhibited mimicry of glutathione peroxidase and peroxidase activity for chemotherapy (CDT). The synergistic effect of SDT and CDT increased intracellular oxidative stress, causing mitochondrial injury and ferroptosis. Furthermore, the combined therapy induced immunogenic cell death (ICD), effectively activating anticancer immune responses and suppressing metastasis and recurrence.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
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2024
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IF 7.7
Lu Qin,Peng She,Panlong Si,Suqin Liu,Gaopeng Dai,Cong Pan
Photocatalytic production of H 2 O 2 is indeed a safe, sustainable and cost-effective technology, offering an environmentally friendly solution to the energy crisis through solar photocatalysis. However, it still faces challenges such as reliance on organic electron donors and pure O 2 , as well as inefficiencies in hole utilization. To overcome these limitations, a dual-channel photocatalytic system has been developed. In this study, we showcase the efficiency of the CuO/Cu(OH) 2 @g-C 3 N 4 composite, derived from CuBTC/g-C 3 N 4 via NaOH treatment, as a high-performance dual-channel photocatalyst for H 2 O 2 production. Under visible light (λ ≥ 420 nm), this composite achieves a H 2 O 2 yield of 1354 μmol/L in 120 min without any sacrificial agent, outperforming g-C 3 N 4 by 8.4 times, CuO by 13.6 times and CuO@g-C 3 N 4 by 1.9 times. Quenching experiments and electron paramagnetic resonance spectra confirmed that HO • and O 2 •− are intermediate products in the photocatalytic process, following a two-step single-electron reaction pathway. The superior activity of CuO/Cu(OH) 2 @g-C 3 N 4 in H 2 O 2 generation can be attributed to the synergistic effects of OH bonds on the CuO@g-C 3 N 4 Z-type heterojunction and Cu(OH) 2 . This research presents a straightforward and promising approach for developing highly efficient photocatalysts for energy conversion.
研究领域:
材料科学
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环境科学
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能源化学
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产品关联
DOI
PubMed
高影响因子
ACS Omega
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2024
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IF 3.7
Hechen Sun,Lening Zhang,Nan Zhao,Hua Xin
Lung cancer poses a significant threat to human health. Surgical intervention is the preferred treatment modality for lung cancer, but a large number of patients are deprived of the opportunity for surgery for various reasons and are compelled to undergo radiotherapy and chemotherapy, which entail systemic adverse reactions. In recent years, with the advancement of nanomedicine, chemodynamic therapy (CDT) based on free radicals has been extensively investigated. In this study, we fabricated copper–citrate–chitosan composite nanoparticles (CuCC NPs) by encapsulating copper–citrate complexes with natural chitosan polymers, resulting in a substantial reduction in the biotoxicity of copper ions. The CuCC NPs selectively accumulated in tumor tissues through the enhanced permeability and retention effect (EPR) and gradually degraded within the acidic and glutathione (GSH)-rich microenvironment of the tumor, thereby releasing the loaded copper ions. Through CDT, the copper ions converted the overexpressed hydrogen peroxide (H2O2) in the tumor tissue into hydroxyl radicals (•OH), leading to the eradication of tumor cells. In animal experiments, CuCC NPs exhibited remarkable efficacy in CDT. Further histopathological and hematological analyses demonstrated that CuCC NPs could induce substantial apoptosis in tumor tissues while maintaining an extremely high level of safety.
研究领域:
肿瘤学
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纳米技术
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药学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2024
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IF 7.6
Jiawen Zhang,Shanjian Liu,Fupeng Huang,Dongmei Bi,Jie Song,Santao Chou
To investigate the impact of different H 2 O 2 concentrations on the Fenton-like systems of H 2 O 2 /biochar, this study examined the mechanism of the physical structure and environmental persistent free radicals (EPFRs) of biochar during diethyl phthalate (DEP) removal by the Fenton-like system. The peak-splitting method was utilized to differentiate EPFRs types in cotton stalk biochar produced at different temperatures. High-temperature environments promote π-electron delocalization, which facilitates phenyl π free radicals and σ-π oxygen-containing free radicals. By analyzing relationships between the removal rate K 1 and removal constant K obs of DEP with the structural properties of biochar, it was discovered that EPFRs concentrations in biochar had a significant positive correlation with K 1 (r = 0.92) and K obs (r = 0.97). Different H 2 O 2 concentrations added to the biochar removal system resulted in varied DEP removal efficiency. Among them, CS 500 , CS 550 , and CS 600 exhibited superior DEP removal efficiency when H 2 O 2 concentration was 5 mM.
研究领域:
环境科学
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化学
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产品关联
DOI
PubMed
高影响因子
Nano Research
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2024
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IF 9.5
Shen Huidong,Yang Chunming,Hong Song,Hao Leiduan,Xu Liang,Robertson Alex W.,Sun Zhenyu
Semiconductor-based photocatalysis by utilizing solar energy for sustainable organic pollutant elimination has been a promising tactic to alleviate environmental issues. Nevertheless, the development of robust and efficient photocatalysts to degrade organic pollutants still faces major challenges because of insufficient charge separation. Here we design and fabricate a heterojunction consisting of copper, carbon-modified TiO 2 , and sulfur-doped g-C 3 N 4 nanosheets (i.e., S-C 3 N 4 /Cu/C-TiO 2 ). The heterostructure affords a remarkable synergistic photocatalysis for tetracycline hydrochloride degradation, achieving an 82.6% removal efficiency within 30 min under visible light irradiation, about 15.4 and 7.3 times higher than that of S-C 3 N 4 and C-TiO 2 , respectively. The superior performance is attributed to the synergy between Cu doping and the Z-scheme heterojunction, which not only enhances the interfacial electric field effect, facilitating charge separation, but also boosts the redox capability. The charge carrier transfer between Cu/C-TiO 2 and S-C 3 N 4 follows a Z-scheme, as verified by trapping experiments, electron spin-resonance spectroscopy, and density functional theory calculations. Furthermore, the tetracycline hydrochloride degradation pathways are enunciated by liquid chromatograph mass spectrometry analysis. This work provides an effective approach for constructing high-performance photocatalysts that have potential in environmental remediation.
研究领域:
环境科学
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材料科学
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光催化
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化学工程
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2024
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IF 6
Xuzi Zhao,Ting Wang,Fucheng Shang,Jiangyu Yan,Mingyan Jiang,Xiaoyan Zou,Guorui Li,Zhibin Song,Jing Huang
ABSTRACT Organelle-targeted photosensitizers (PSs) offer valuable tools for improving photodynamic therapy (PDT), yet systematic studies on how different organelles influence phototherapeutic outcomes are limited. In particular, the connection between organelle targeting and various modes of programmed cell death remains unclear. In this study, we developed a series of PSs using the Coumarin-Quinazolinone ( CQ ) scaffold, each designed to target different organelles, including the mitochondria, endoplasmic reticulum (ER), lysosome, and nucleolus. Our results show that their PDT performance is highly dependent on their localization, with phototoxic index (PI) ranging from 2 to 245. Notably, the mitochondria-targeted CQ-Mito and ER-targeted CQ-ER exhibited profound phototherapeutic performances, with PI of 167 and 245 respectively. Our further study reveals that CQ-Mito causes cell death by both apoptosis and ferroptosis, while CQ-ER primarily triggers ferroptosis. This study not only provides new agents for PDT but also offers insights into how organelle targeting influences cell death mechanisms, which can shed light on the design of PSs for controlled cell death.
研究领域:
药理学
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肿瘤学
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细胞生物学
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光化学
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产品关联
DOI
PubMed
高影响因子
Food Bioscience
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2024
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IF 4.8
Wenwen Lv,Xinxin Jiao,Zhiwen Zhang,Luocheng Zhang,Jingyi Song,Hua Wu,Junsong Xiao
DHA with varying degrees of oxidation was obtained by the Schaal oven acceleration method. Then, the temporal changes in free radicals, volatile compounds, and carbonyl compounds in oxidized DHA was analyzed using HS-SPME-GC-MS, the content of which were increased with the oxidation time. RAW264.7 macrophages were used to evaluate the effects of DHA oxidation products on the oxidative stress, gene and protein expression of inflammatory factors at different oxidation times. With the increase of oxidation time, oxidized DHA stimulated cells with significantly higher levels of reactive oxygen species (ROS), nitric oxide (NO) and malondialdehyde (MDA), while superoxide dismutase (SOD) activity was significantly inhibited. It also stimulated a significant increase in the expression of tumor necrosis factor-α (TNF-α), interleukin (IL-1β) and inducible nitric oxide synthase (iNOS), which exacerbated the cellular inflammatory response. Data on DHA oxidation products were analyzed using OPLS-DA. The compound (E,E)-2,4-heptadienal was identified as a potential differential metabolite capable of distinguishing among six oxidation time points. Furthermore, the pro-inflammatory effects of oxidized DHA were accurately predicted using partial least squares regression (PLSR) and support vector regression (SVR) models. This study established a correlation between volatile oxidation products and their potential pro-inflammatory effects, which were readily detectable through high-throughput assays. It thereby provided a rapid and reliable method for assessing the predicted bioactivity of DHA at varying levels of oxidation.
研究领域:
营养学
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生物化学
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免疫学
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产品关联
DOI
高影响因子
Particuology
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2024
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IF 4.1
Ying Li,Nan Tang,Lingling Zhao,Xingfu Bao,Yuzhuo Wang,Zhanxin Wang,Min Hu
Oral infectious diseases caused by a variety of pathogenic bacteria seriously affect the quality of life. However, these diseases remain a clinical challenge because of the lack of simple, safe, and universal prophylactics. To address these limitations, we synthesize CuO x nanodots (CuO x NDs) with excellent Fenton-like reaction activity and utilize them in the treatment of oral bacterial infections. Different from other complicated approaches, CuO x NDs are rationally prepared using a facile one-pot aqueous synthesis. In the presence of H 2 O 2 , these well-developed CuO x NDs can efficiently catalyze the generation of hydroxyl radicals (·OH) around oral pathogens, leading to the death of various bacteria. Meanwhile, results of biosafety indicate the high biocompatibility and extremely low toxicity of these CuO x NDs. After understanding the admirable in vitro antibacterial effect of CuO x NDs in the presence of H 2 O 2 , we further explore their in vivo antibacterial performance on several classical animal models including oral mucosal wound model, intragingival bacteria-infected model, and the periodontal infection model. As expected, these CuO x NDs with wide-spectrum antibacterial activity can serve as high-performance antibacterial reagents for the treatment of various oral bacterial infections with the help of H 2 O 2 . In brief, current nanoplatform can act as efficient antibiotics against oral pathogens with broadening the biomedical applications of copper-based nanomaterials.
研究领域:
医学
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材料科学
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微生物学
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Cong Pan,Yunqiao Wang,Chenyang Fu,Jirong Lan
Smelt slag-based environmental catalytic materials offer a sus(tainable and valuable approach to solid waste management. In this study, a novel peroxymonosulfate (PMS) catalyst (MCT-2) was prepared from copper slag (MCT-1) by a non-calcined method. Subsequently, the MCT/PMS-AOP catalytic system was established. The copper slag, mainly composed of Si, Ca, Mg, Fe and O, was converted into MCT-2 by hydrothermal treatment, NaOH etching and edta-2na-induced crystallization, and finally, the molecular self-loading of MCT was achieved by the "one-pot method" under hydrothermal conditions. MCT-2 exhibits a layered surface morphology and CaFeO 3 phase. In the MCT-2/PMS system, the dominant reactive oxygen species (ROSs) generated were SO 4 •− and HO • . The performance of the system was evaluated using CBZ as a simulated pollutant and actual river water as a carrier, and it was found that MCT-2/PMS degraded CBZ, BPA, DCF and ATZ up to 99 %. Further mechanistic studies showed that MCT-2 has relatively high catalytic activity and the lowest reaction energy barrier compared with similar materials. The easy availability of raw materials, environmentally friendly preparation method, and high degradation efficiency make MCT/PMS-AOP have a broad application prospect.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）