NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Ziwei Zhao,Qi Ling,Shangkun Deng,Ziliang Li,Jianguo Lv,Lei Yang,Chunbin Cao,Zhaoqi Sun,Miao Zhang
A type II heterostructured BiVO4/MIL-88B(Fe) composite was successfully synthesised for the photocatalytic degradation of tetracycline hydrochloride (TC-HCl) by a simple hydrothermal method. Thin film materials avoid secondary pollution of powder materials. The samples were characterised by XRD, SEM, TEM, XPS, UV-Vis DRS, and PL. The samples were also characterised for their optoelectronic properties. 3-BV/MIL-88B(Fe) (3 mmol BiVO4) was the most effective catalyst for the degradation of TC-HCl, achieving 92.1% removal at 75 min with a degradation rate constant of 22.79 × 10−3 min−1. Moreover, durability evaluation and TC-HCl degradation potential evaluation were also performed. We looked into how TC-HCl concentration, pH and ions affect the degradation results. In order to determine the active ingredients, experiments for trapping free radicals and EPR tests were performed. The results indicated that the main active species were h+ and ˙OH. It is proposed that a reasonable type-II heterostructure can help to explain the photocatalytic mechanism. The current study creates a stable photocatalytic system by compositing electrocatalytic and photocatalytic materials to achieve efficient antibiotic degradation and provides a viable strategy for future applications.
研究领域:
材料科学
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环境科学
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化学
·
纳米技术
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Rui Liu,Yingzhang Shi,Linghui Lin,Zhiwen Wang,Cheng Liu,Jinhong Bi,Yidong Hou,Sen Lin,Ling Wu
Ultrathin Bi 2 WO 6 nanosheets with a high concentration of surface oxygen vacancies (BWO-OVs) are successfully constructed for the degradation of levofloxacin (LVX) under visible light irradiation and show a high degradation efficiency of LVX (≈100 %). It is revealed that the oxygen vacancies (OVs) over BWO-OVs nanosheets can not only accelerate the separation of photo-induced electrons and holes, but also activate the O 2 molecules to form O 2 – species. The FTIR spectra and density functional theory deeply demonstrate that piperazine ring and C O groups (carboxylic acid) in LVX can be chemisorbed and activated by surface Lewis acid sites. The EPR results reveal that photo-generated holes, O 2 – and OH species are reactive oxygen species for the photocatalytic degradation of LVX. The possible intermediate is well investigated by LC-MS results combined with the FTIR spectra results. This work provides a new perspective for understanding photocatalytic degradation from the interaction between the active sites of a photocatalyst and antibiotics molecules.
研究领域:
环境科学
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材料科学
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化学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2024
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IF 5.8
Qin Wang,Xuedan Nie,Yifan Song,Haiyan Qiu,Liting Chen,He Zhu,Xueli Zhang,Mengru Yang,Xiaohui Xu,Peidan Chen,Chao Zhang,Jia Xu,Yeping Ren,Wenting Shang
Immune-mediated glomerular diseases lead to chronic kidney disease (CKD), primarily through mechanisms such as immune cell overactivation, mitochondrial dysfunction and imbalance of reactive oxygen species (ROS). We have developed an ultra-small nanodrug composed of Mn3O4 nanoparticles which is functionalized with biocompatible ligand citrate (C-Mn3O4 NPs) to maintain cellular redox balance in an animal model of oxidative injury. Furthermore, this ultra-small nanodrug, loaded with tacrolimus (Tac), regulated the activity of immune cells. We established a doxorubicin (DOX)-induced CKD model in SD rats using conditions of oxidative distress. The results demonstrate the ROS scavenging capability of Mn3O4 NPs, which mimics enzymatic activity, and the immunosuppressive effect of tacrolimus. This combination promotes targeted accumulation in the renal region with sustained drug release through the enhanced permeability and retention (EPR) effect. Tac@C-Mn3O4 protects the structural and functional integrity of mitochondria from oxidative damage while eliminating excess ROS to maintain cellular redox homeostasis, thereby suppressing the overexpression of pro-inflammatory cytokines to restore kidney function and preserve a normal kidney structure, reducing inflammation and regulating antioxidant stress pathways. This dual-pronged treatment strategy also provides novel strategies for CKD management and demonstrates substantial potential for clinical translational application.
研究领域:
纳米医学
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药理学
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免疫学
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肾脏生理学
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氧化应激研究
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xu Liu,Peide An,Yide Han,Hao Meng,Xia Zhang
Cu-based nanozyme shows good oxidase-like activities due to the changeable states of Cu(II) and Cu(I), which are proven to be effective in the electron transfer in the redox process. Herein, the self-made MOF-818 with more Cu(II) loading was synthesized through a modified two-steps hydrothermal routes, which was then used as a sacrificial precursor to construct copper/zirconium composite oxides nanozymes (CN-MOF-818). The pyrolysis temperature was varied to obtain the best enzyme-like activities of the resulting CN-MOF-818. The laccase-like and catecholase-like activities were evaluated by using the oxidation of the mixture of 4-aminoantipyrine (4-AAP) and 2,4-dichlorophenol (2,4-DP), and 3,5-Di- tert -butylcatechol (3,5-DTBC) respectively. The enzyme-like activities were optimized through altering the catalytic conditions, and the corresponding enzyme catalytic kinetics including K m and V max were also determined. The enzyme-like mechanism of the CN-MOF-818 were also discussed based on EPR technique and the in-situ FT-IR analyses. In comparison with the pristine MOF-818 and the other reported Cu-based mimics, the as-prepared CN-MOF-818 exhibits the higher oxidase mimetic activities. These CN-MOF-818 can also be employed to detect the epinephrine with a low detection limit of 1.63 μM.
研究领域:
纳米技术
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催化
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分析化学
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生物化学
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产品关联
DOI
高影响因子
Aggregate
·
2024
·
IF 13.9
Jundong Lin,Xiaoxia Cai,Fen Zou,Wenjie Xie,Zhihao Zou,Muqi Chen,Yixun Zhang,Huichan He,Qianfeng Xu,Guowei Zhong,Shanghua Cai,Zhenjie Wu,Jianming Lu,Jianheng Ye,Yingke Liang,Yaqiang Huang,Yangjia Zhuo,Huikang Yang,Weide Zhong
The efficacy of photothermal therapy (PTT) in antitumor applications is often limited by inadequate tumor targeting and low photothermal conversion efficiency (PCE) of photosensitizers. In this study, we designed a photothermal nanoparticle, MPF@IR780, to enhance photosensitizers' targeting and PCE. First, MPF@IR780 improves the delivery of photosensitizers to tumor tissue through the enhanced permeability and retention (EPR) effect. Furthermore, hydrophobic ferrocene was incorporated into the nanoparticle core to increase structural compactness, leading to a strong aggregation-caused quenching (ACQ) effect and an improved PCE of the photosensitizer under near-infrared (NIR) irradiation. Mechanistically, MPF@IR780 induces PANoptosis and ferroptosis in cancer cells through thermal damage and oxidative stress, providing an efficient approach for oncotherapy. This strategy of amplifying the effects of PTT by enhancing the ACQ of photosensitizers offers a promising method for advancing the next generation of PTT.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Haiqiu Wu,Cun Wang,Jiaxin Sun,Luyan Sun,Jiaxun Wan,Siying Wang,Dishui Gu,Chengtao Yu,Chen Yang,Jia He,Zihao Zhang,Yuanyuan Lv,Hui Wang,Ming Yao,Wenxin Qin,Changchun Wang,Haojie Jin
Liver cancer is a leading cause of cancer morbidity and mortality worldwide, especially in China. Sorafenib (SRF) is currently the most commonly used systemic agent against advanced hepatocellular carcinoma (HCC), which is the most common type of liver cancer. However, HCC patients have only limited benefit and suffer a serious side effect from SRF. Therefore, new approaches are urgently needed to improve the therapeutic effectiveness of SRF and reduce its side effect. In our current study, we developed a self-imaging and self-delivered nanodrug with SRF and indocyanine (ICG) to improve the therapeutic effect of sorafenib against HCC. With the π–π stacking effect between SRF and ICG, a one-step nanoprecipitation method was designed to obtain the SRF/ICG nanoparticles (SINP) via self-assembly. Pluronic F127 was used to shield the SINP to further improve the stability in an aqueous environment. The stability, photothermal effect, cell uptake, ROS production, cytotoxicity, tumor imaging, and tumor-targeting and tumor-killing efficacy of the SINP were evaluated in vitro and in vivo by using an HCC cell line Huh7 and its xenograft tumor model. We found that our designed SINP showed monodisperse stability and efficient photothermal effect both in vitro and in vivo. SINP could rapidly enter Huh7 cells and achieve potent cytotoxicity under near-infrared (NIR) laser irradiation partly by producing a great amount of reactive oxygen species (ROS). SINP had significantly improved stability and blood half-life, and could specifically target tumor via the enhanced permeability and retention (EPR) effect in vivo. In addition, SINP showed improved cytotoxicity in both subcutaneous and orthotopic HCC implantation models in vivo. Overall, this rationally designed sorafenib delivery system with a very high loading capacity (33%) has considerably improved antitumor efficiency in vitro and could completely eliminate subcutaneous tumors without any regrowth in vivo. In conclusion, our self-imaging and self-delivered nanodrug could improve the efficacy of SRF and might be a potential therapy for HCC patients.
研究领域:
肿瘤学
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药学
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纳米技术
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Qiuxing Liu,Xin Ding,Xiaoyu Xu,Hualu Lai,Zishan Zeng,Ting Shan,Tao Zhang,Meixu Chen,Yanjuan Huang,Zeqian Huang,Xiuling Dai,Meng Xia,Shengmiao Cui
Tumor cells with innate oxidative stress are more susceptible to exogenous ROS-mediated oxidative damage than normal cells. However, the generated ROS could be scavenged by the overexpressed GSH in cancer cells, thus causing greatly restricted efficiency of ROS-mediated antitumor therapy. Herein, using cinnamaldehyde (CA) as a ROS generator while β-phenethyl isothiocyanate (PEITC) as a GSH scavenger, we designed a tumor-targeted oxidative stress nanoamplifier to elevate intracellular ROS level and synchronously suppress antioxidant systems, for thorough redox imbalance and effective tumor cells killing. First, an amphiphilic acid-sensitive cinnamaldehyde-modified hyaluronic acid conjugates (HA-CA) were synthesized, which could self-assemble into nano-assembly in aqueous media via strong hydrophobic interaction and π-π stacking. Then, aromatic PEITC was appropriately encapsulated into HA-CA nano-assembly to obtain HA-CA/PEITC nanoparticles. Through enhanced permeability retention (EPR) effect and specific CD44 receptor-mediated endocytosis, HA-CA/PEITC nanoparticles could accumulate in tumor tissues and successfully release CA and PEITC under acidic lysosomal environment. Both in vitro and in vivo results showed that the nanoparticles could efficiently boost oxidative stress of tumor cells via generating ROS and depleting GSH, and finally achieve superior antitumor efficacy. This nanoamplifier with good biosafety provides a potential strategy to augment ROS generation and suppress GSH for enhanced oxidation therapy.
研究领域:
纳米技术
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药学
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肿瘤学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Hengxi He,Weirui Chen,Jiaxin Zhou,Xukai Li,Jing Wang,Laisheng Li
The sluggish Me (n+m)+ / Me n+ redox cycle greatly restrained the catalytic ozonation performance of metal-based catalysts. To break this bottleneck, we adopted an interfacial oxidation reaction to create electron-deficient/rich centers within carbon skeleton derived from MOF (C-MOF) by utilizing the electronegativity difference between cerium (Ce) and manganese (Mn), and evaluated its catalytic ozonation activity with ibuprofen (IBP) as model pollutant. XPS, H 2 -TPR, LSV and EPR characterizations as well as DFT calculation demonstrated that there existed electron-deficient Ce sites and electron-rich Mn sites on CeO x /MnO x /C-MOF. Under the co-function of Ce and Mn sites, CeO x /MnO x /C-MOF/O 3 process achieved 100% IBP removal in 90 min, which was 3.1 times of sole ozonation process. IBP could be absorbed at the electron-deficient Ce center and directionally donate its electron to the O 3 around electron-rich Mn center. Singlet oxygen ( 1 O 2 ) played the major role in IBP degradation. Cl − , HCO 3 − , NO 3 − and SO 4 2− demonstrated limited inhibitions on IBP degradation. This work provided a sustainable strategy for breaking the rate-limiting step in the traditional catalytic ozonation.
研究领域:
环境科学
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催化
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
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IF 21.1
Shufan Yu,Zhao Sun,Zhiqiang Sun
Methanol steam reforming is a promising approach for real-time hydrogen production, while its practical application is hindered by catalyst deactivation and undesired CO byproduct formation. In this study, we propose a self-activation approach to anchoring a series of x CuO/YCrO 4 catalysts by employing methanol and steam as reductants. The self-activated 0.8CuO/YCrO 4 catalyst achieves a high hydrogen production rate of 22.3 μmol H 2 ·g −1 cat ·s −1 and demonstrates exceptional stability over 3000 min at 220°C. TEM-EDS, XPS, EPR, and XAS collectively reveal the promotion of generating Cu δ + /Y-O v -Cr interfacial sites and oxygen vacancies via self-activation, and in situ Raman spectroscopy confirms the structural stability of the Y-O v -Cr framework. In situ DRIFTS analysis further confirms that Cu δ + /Y-O v -Cr interfacial sites effectively anchor and promote the hydrogenation of bidentate formate intermediates, mitigating active site blockage by byproduct species and enhancing catalytic efficiency. This work provides new insights into the self-activation mechanism of Cu-based catalysts and offers a promising strategy for developing highly active and durable catalysts.
研究领域:
催化化学
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制氢技术
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材料科学
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表面化学
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化学工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 9
·1-16
·
IF 2.4
Hu Rui,Wang Haiyin,Luo Jiahui,Song Jianjun,Jia Haiyuan
Peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs) have been proven to be an effective method for the removal of tetracycline in water. In this study, the Co 3 O 4 /molecular sieve catalyst synthesized by the incipient wetness impregnation method was used for PMS activation. The effect of specific surface area on the catalytic performance of Co 3 O 4 /molecular sieve catalyst was investigated and analyzed in detail by characterization techniques. In the Tetracycline hydrochloride (TCH) degradation experiment, the Co 3 O 4 /13X catalyst exhibited the highest specific surface area (490.584 m 2 /g) and provide abundant active sites, enabling 98.0% TCH degradation within 30 min under optimal conditions (1.5 g catalyst, 0.3 mM PMS, pH 8.0, 25℃), with a reaction rate constant (k obs ) of 0.0977 min -1 . In addition, the degradation mechanism of TCH was explored using electron paramagnetic resonance (EPR) spectroscopy and quenching experiments. It was confirmed that free radicals (SO 4 •− , •OH, O 2 •− ) and non-free radical species ( 1 O 2 ) generated during the reaction play a crucial role in the degradation process of TCH. In summary, the Co 3 O 4 /13X catalyst, when activating PMS, exhibits a remarkable synergistic effect on the degradation of TCH, and shows good repeatability and environmental adaptability. This study provides valuable insights into the design and optimization of catalysts for degrading antibiotic pollutants in water treatment processes. Graphical
研究领域:
环境科学
·
催化
·
水处理
·
化学工程
·
污染物降解
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产品关联
DOI
高影响因子
CARBON
·
2021
·
IF 9.594
Daochang Li,Yucai Zhang,Jing Xu,Fumi Yoshino,Huazhen Xu,Xiao Chen,Li Zhao
Multifunctional nanodevices have shown great promise as robust tools in cancer theranostics. Carbon nanohorns (CNHs) of large specific surface area, low toxicity and unique physicochemical properties are among one of ideal platforms to fabricate the nanodevices. Herein, we develop a water-dispersible carbon nanohorn−polyglycerol−gold (CNH-PG-Au) nanohybrid through surface engineering of CNHs, which is further loaded with chemotherapeutic drug doxorubicin (DOX) to afford [email protected] nanodevice. Benefiting from the excellent hydrophilicity of PG, as-prepared multifunctional [email protected] possesses good aqueous dispersibility and colloidal stability enabling biomedical applications. [email protected] nanoparticles are taken up by 4T1 mouse breast cancer cells and mainly disperse in the lysosomes, where the mild acidic condition promotes the release of DOX. [email protected] induces more cell apoptosis under X-ray irradiation than [email protected] of the same DOX concentrations, which is attributed to increased DNA damage by synergistic effect of DNA intercalation of DOX and radiosensitization of Au nanoparticles. Upon intravenous administration, [email protected] nanoparticles steadily accumulate in 4T1 tumor through enhanced permeability and retention (EPR) effect, and the tumor can be clearly observed by photoacoustic imaging. In vivo tumor treatment using [email protected] together with X-ray irradiation effectively inhibits tumor growth through radiochemotherapy. Our work demonstrates the great potential of [email protected] nanodevice in cancer theranostics.
研究领域:
纳米技术
·
癌症研究
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生物医学工程
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诊疗学
·
成像技术
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Hao Zhu,Shunyan Ning,Zengzhiqiang Li,Xinpeng Wang,Toyohisa Fujita,Yuezhou Wei,Xiangbiao Yin
Here, a nano disc-shaped bimetallic organic framework (NbCo-piperazine) was prepared by the solvothermal method for the activation of PMS for the degradation of contaminants. The effects of Nb/Co ratio, synthesis time and temperature on the morphology, structure and performance of the NbCo-piperazine catalyst were characterized by XRD, FT-IR, SEM-EDS and TEM. The optimum conditions for NbCo-PZ to activate PMS degradation of tetracycline were investigated by adjusting the dosage of catalyst, tetracycline concentration, pH and PMS concentration. The catalytic performance of NbCo-PZ in the presence of co-existing anions (Cl − , NO 3 – , HCO 3 2– , H 2 PO 4 − ) was also evaluated. XPS explained that cyclic changes in the valence states of Nb 4+ /Nb 5+ and Co 2+ /Co 3+ accelerated the activation of the PMS degradation process. EPR results showed the presence of free radicals (SO 4 ·− , ·OH and O 2 ·− ) and non-free radicals ( 1 O 2 ) in the degradation process, with free radicals playing a major role in the degradation process. The degradation rate of tetracycline after three cycles was 92.2%. In addition, NbCo-piperazine showed good catalytic performance for other organic pollutants such as methyl blue, tylosin tartrate and tetracycline with the degradation rate of 97.8%, 95.2% and 95.5%, respectively. Moreover, it also has good catalytic properties in various water systems such as river water and sea water.
研究领域:
环境化学
·
催化
·
水处理
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）